LOCUS       NM_024919               5770 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens FERM domain containing 1 (FRMD1), transcript variant
            1, mRNA.
ACCESSION   NM_024919
VERSION     NM_024919.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5770)
  AUTHORS   Ebejer,J.L., Duffy,D.L., van der Werf,J., Wright,M.J.,
            Montgomery,G., Gillespie,N.A., Hickie,I.B., Martin,N.G. and
            Medland,S.E.
  TITLE     Genome-wide association study of inattention and
            hyperactivity-impulsivity measured as quantitative traits
  JOURNAL   Twin Res Hum Genet 16 (2), 560-574 (2013)
   PUBMED   23527680
REFERENCE   3  (bases 1 to 5770)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   4  (bases 1 to 5770)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589733.20.
            
            On Jan 22, 2020 this sequence version replaced NM_024919.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            sequence data because transcript sequence consistent with the
            reference genome assembly was not available for all regions of the
            RefSeq transcript. The extent of this transcript is supported by
            transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097179.1, BC137144.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283309.11/ ENSP00000283309.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               AL589733.20        102573-102903       c
            332-422             AL589733.20        98936-99026         c
            423-502             AL589733.20        91058-91137         c
            503-579             AL589733.20        90446-90522         c
            580-766             AL589733.20        88562-88748         c
            767-922             AL589733.20        87292-87447         c
            923-988             AL589733.20        86585-86650         c
            989-1163            AL589733.20        85498-85672         c
            1164-1460           AL589733.20        84452-84748         c
            1461-1525           AL589733.20        82815-82879         c
            1526-5770           AL589733.20        76786-81030         c
FEATURES             Location/Qualifiers
     source          1..5770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..5770
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /note="FERM domain containing 1"
                     /db_xref="GeneID:79981"
                     /db_xref="HGNC:HGNC:21240"
     exon            1..331
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1768
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /note="isoform 1 is encoded by transcript variant 1; FERM
                     domain-containing protein 1"
                     /codon_start=1
                     /product="FERM domain-containing protein 1 isoform 1"
                     /protein_id="NP_079195.3"
                     /db_xref="CCDS:CCDS5306.1"
                     /db_xref="GeneID:79981"
                     /db_xref="HGNC:HGNC:21240"
                     /translation="MAVPPRGRGIDPARTNPDTFPPSGARCMEPSPERPACSQQEPTL
                     GMDAMASEHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRN
                     NEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARH
                     LYYCHLKERVLRSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWII
                     TKRGIDYILRHMPTLHRERQGLSPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPT
                     VILGLALRGVHIYQGKKLEIQLDGLPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRV
                     RPTLQQLRQREEAEEKQHYRESYISDELELDLASRSFPGSGVSSQHCPHCLSRHSADS
                     HGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSSSPRTSRSHPSTRGDSQATR
                     QEPCTQVRTRGQSAEAVHQIQEMTAGVSEEQHSHGLDDMQLHQLALHPAPTSLSHTFH
                     RALDCRLAGPCETRATLPSKRSSNCLALDLFGEAPPQEFVV"
     exon            332..422
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..502
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..579
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..766
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..922
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..988
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1163
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1460
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1525
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..5770
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5753..5758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /note="hexamer: AATAAA"
     polyA_site      5770
                     /gene="FRMD1"
                     /gene_synonym="bA164L23.1"
                     /note="major polyA site"
ORIGIN      
        1 aattcccttc ccagtgagaa gctcggcaag ggcgggtccc ggaaagcaca gctgtgatct
       61 gggaggtgct gagcacccac ctgcgaccca tggcggggga gggccgagta acgacagcat
      121 ggcggtgccc ccgagaggga ggggcataga ccccgcccgg acaaaccctg acacgttccc
      181 tccttcaggg gcgcgatgta tggaacccag tcctgagagg cctgcatgca gtcagcagga
      241 gccgaccctg ggaatggacg cgatggcctc ggaacacagg gatgtcctcg tgctgctgcc
      301 cagccgggag caactgcggc tggccgtggg ggtgaaggct actggccgcg agcttttcca
      361 gcaagtgtgc aacgtggcga gcatcagaga cgcgcagttc tttggcctct gtgtggtcag
      421 aaacaatgag tatatattta tggatttgga gcaaaagctc agcaagtact tctcaaaaga
      481 ttggaagaaa gaaagaaatg aaggaaatga gaaacccaga gcccccttcg tggccttcct
      541 ccgagtgcag cactacgtgg aaaacggaag ggtcataagc gaccacaggg cacggcacct
      601 gtactactgc cacttgaagg agcgcgtgct gaggtcacag tgcgctcacc gggaggaagc
      661 ctacttcctg ctggctgcct gcgcgctgca ggctgacctg ggcgagcacc gggagtcggc
      721 ccatgccggg aggtacttcg agccacactc ctacttccca cagtggatca tcaccaagag
      781 ggggattgac tacatcctcc ggcacatgcc taccctgcac cgtgagcgcc agggcctgag
      841 ccccaaggag gccatgctgt gcttcatcca ggaggcctgc cggctggagg acgtgcccgt
      901 gcacttcttc aggctgcaca aggataagaa ggaaggtcgt cccaccgtga tcctgggact
      961 ggccctcagg ggagtgcaca tctaccaggg aaagaagctg gagatccagc tggatgggct
     1021 gcccgcagca cagaagctgg tttactacac ggggtgcacc tggcggtcca ggcacctgct
     1081 gcacctgctg cgcgccagcc accagctcca cctccgcgtg cggcccactc tgcaacagct
     1141 gcggcagcgg gaggaggcag aagagaagca gcactaccgg gagtcctata tcagcgatga
     1201 gctggagctg gacctggcca gcaggagctt cccgggcagt ggggtcagca gccagcactg
     1261 cccccactgc ctctcacgcc actccgccga cagccacggc agttcctaca cgtcaggcat
     1321 caaggccaac tcctggctca gggaatccag agagatgtct gtggacgtgc ccttggaggt
     1381 ccacgggctc catgagaagg agccgtcctc cagccccagg accagccgca gccaccccag
     1441 cacacgtggt gacagccaag ccactcgtca ggagccctgc acccaggtca ggaccagagg
     1501 ccagagcgcc gaggccgtgc accagatcca ggaaatgaca gccggggtca gtgaggagca
     1561 gcacagccat ggcctggacg acatgcagct gcaccagctg gccctgcacc cagcgcccac
     1621 ctcactcagc cataccttcc accgcgccct ggactgcagg ctggcaggcc cctgcgagac
     1681 cagggccact ctccccagca agaggtccag caactgtctc gccctggacc tgttcggaga
     1741 ggctccacca caggagtttg tggtgtaggc accacccacc cagcagtacc gtccgcaccg
     1801 ccaggctcag cccctgccca ccccacttcc acatggccct cgtcccttcc tgcccgccag
     1861 atgctgcctg cacttccgca gccagcacgc tccacaggtt cacctgtaag aggtgtggag
     1921 ctggctctga catcaacctg ggaggtaaca aacaggtccc gcacctcatg cctgtctgcc
     1981 atacacccgg gagctctttc cctcagggtc tcagggagcc agttcaaggt ctggctgtca
     2041 agtgtccaga gagccatggt gttggcccct gaggcagcct gtcacccatc ctaatctggg
     2101 agagaaggtg acacagctgg gcccagaccc tggagagaca gctctgcagt ttcccacact
     2161 gtcagctccc caagagacag tcctgatggg cacaggctgc cagagctccc aagccggagt
     2221 tcacagtcat cactgtgcag gacccaggtt cctcccagac ctgaacccct ctctgcaact
     2281 cctgtttgca agcgctgggc ctgccagaca gaggcccctc ttgtggtgca agcccagctc
     2341 tgtcacctga gatccagcca gagaccctcc tccaccatcc acagtcaatg gctgtgcttt
     2401 cccttccaag ccagggcttc caaagacccc actgccccgg agctgaagcc gactctgctc
     2461 ccatctcagc catgaggcct caggacccac tctgctcaca ggtggcttcc ttaagccatt
     2521 gccctggctg gggttgggct ggtgcagccc agctggcgga ggggcgaagc tttggtgaca
     2581 gacggagagt gggggactag ctgtgcatgg cacctgctct gatccggtgg gctccacggg
     2641 tagtgcgacc tcggttctgt gggctctgga aggccaccag ggtagggtct ccccagggct
     2701 cctccccctg cacaacactc ctgcacacgt gcaaacctgc tgtcctctgc atttagagga
     2761 atggcccgtg catccctgct agtctcaggc ccatcccaga gcactgagag gccacaatcg
     2821 ttcagccctg tgccctgaac accactgccc ccttcactgt ctgtgtgtgg tgaagaccac
     2881 gccacaccac cctccagctc actggagaca agcatgagct tgagccccat ggcctggtgc
     2941 agggctgcgt gcattgaggc cgcctctttg acgggtccat ccagggggac cctctccttt
     3001 ctgtgaaagg gaatcgtgtg tgtgccccag gcacgtgtaa taaagaaccc gagcagatgc
     3061 ctcctgcttg aaccaggacc agcctgcctg gggggctggt gagatgccgg ctgtaactca
     3121 ctcaggggca tcggccacag aaggctgcgt tctgtagatg gccacaagcc ccagtgctgc
     3181 cgagggcaag actgcccaca attcctgtgc ggcaggggag gtgcgcctag tgctggctca
     3241 gatgtgagca tgtgggcact tcccaaagcc attcccatta gtacaagatg attgatttgc
     3301 cccgctccgg ggcaatgact atcttcttcc tttgaagaaa cttggaagca agagcccagt
     3361 cccatggacc atgagggaag gtacacacca gtgttgggga gacacagcag gtggtgtcca
     3421 ccatgaagca gggtctgagc caagacctac atgcacacat gcacacatcc acatgcatgc
     3481 acacacatac atgcacacac gcacacatct gcacacagat gcacacgcat gcacacacac
     3541 acatgcacac atccatacat gcacactccc catgtccagg cttcccctgc cagtcacctt
     3601 cgccacacgc catagacccc aggggcagca aaggccgggc cagcccaccc ctaacttgtg
     3661 gaagcatcag tgaagctggc ccggcgcctt gtgtcctggc agaggcgagg cagccatggc
     3721 ccctggctga cccgagaagc ttctctggcc ccactgggga ttcctatttc tgtccttcct
     3781 ctgggccttg tggacagaca tggagaatta tgccagatgc ctgttaacta ccgggtaggg
     3841 ctgctccaaa gactctaatc tctggtgttc agggtatgtg gagaggacaa ttagaggccc
     3901 gctgccctga gacttgccca agaggggacg gccaggcagg ccacatgaag cccatgtggg
     3961 ctaccagctc agacacaccc agccggggcc ggggcagact cccctaaggc ttgagcctca
     4021 gctttgctca ccgcccctcc ccacagcccc cttccacgtc acccacacct ggaggggcag
     4081 gagcggagct ggaagcagaa ggccatcctg ggagggggct ccttcccaga cagaaagcag
     4141 cagagagcgg ggctgcggga agtcggggaa gccaaccttt ctttttgcac agattgagat
     4201 cagaggtctt ttaggcaata cggctatttt ccagaaaaat ggacaccgac tggtagggac
     4261 agggatgttt cctaagaagg agggtggggg gcagggctgg gggtggcctg caaacagcag
     4321 aagccgctgt gtacaggggg gcttgtggcc ttcaggtggc atgaggcagg ccggtggggg
     4381 aggggcacag ggtaaagtcc ccaatccctg tcttaccctg tcagtggaga ggaaaagaaa
     4441 accacctgtc ccagtccctg tggaccccca aggagcaggc caaggacctc cagcatcaca
     4501 gcctcgcatg agcccggctg gggtggtcag tcctgtggcc cgggccaggt cagcggtcaa
     4561 gctggcaggt ccagactcgc aagaacgacc cagagagctt gttcaggctg ggtttctcag
     4621 ccccccactg cgtctgcttc tgtgggtctc gctgggcccc ggaacctgca ttgctgctgc
     4681 gggggtctgg gtctgagggc gcagctctcc ctgctgggtg gggtgtggga ggcggcagac
     4741 cctgctcctg ggggcagttg gtctggagtg gtgacagggt ggccctgggc agggtgtggc
     4801 cggttccctc ttgcctgtgt tgaagcatgg actcctctgg gccctcagcc atcagcccag
     4861 cctccctcac ggaagatgga gaattccaga caaagctcat ccttcctcca ggaaagcctg
     4921 ctccatctgc agtaattgac ggcctgagaa gctctgctct tgggctgaac cccaagcagg
     4981 aggaggaggc cggggtcctc aggtgcccat ctgggaggcc cggggcagcc agcaactgcc
     5041 tgtgtgtctg ggatctcaca ggagaggtgg ttcccaagcc gagcatcagc ccgtcgtggc
     5101 ccatggactc tgggttcccc aggcggggga aatgtgccag agccacgggg aaagctgagc
     5161 tctgcggccc tgcgagtgca ttcacaaagg tttatcagtt tgtaaaactt gcagaaaaag
     5221 ccgtccgtgt ttgggacagg cggccccttc cactcagggt tcatccgtca cgctcctttc
     5281 gccttgaggg gcactgaggg ccctgtgggt gtgtggggcc cgcgtagggg aggctgaact
     5341 ggacacacac ttggctcggt ctgctgggag acgtttcggg gttcccagtc atgtcgtctc
     5401 tacctgtagg agcagcaggg agtctcagga caggatggcc agggccagag gtcacctggt
     5461 gaggcggaca tgtactccca acctgggagg tgtggggact ggaagagaaa cagagctggc
     5521 agtgggaggc tggacgtggt aggcaatgcc ggtcctgcag ccgggcccat gaccgttctc
     5581 acggcggcga gctgtgatgg ggaggctgcc ttccaggtgc caaggttaga aaacaaatcc
     5641 ggggcagccc tgccgggaga aagctggtat tctacaaagg cgcgtgaaga ggtgaacacg
     5701 cagtggggaa aatggcgcgg gttaattgtt tattaatcac aggcagctca ccaataaaac
     5761 cgtcaccaaa
//
