LOCUS       NM_002031              13363 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens fyn related Src family tyrosine kinase (FRK), mRNA.
ACCESSION   NM_002031
VERSION     NM_002031.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13363)
  AUTHORS   Xiong,J., Wang,X., Fan,C., Yan,J., Zhu,J. and Cai,T.
  TITLE     Hemifacial microsomia is linked to a rare homozygous variant V162I
            in FRK and validated in zebrafish
  JOURNAL   Oral Dis 29 (8), 3472-3480 (2023)
   PUBMED   36070195
  REMARK    GeneRIF: Hemifacial microsomia is linked to a rare homozygous
            variant V162I in FRK and validated in zebrafish.
REFERENCE   2  (bases 1 to 13363)
  AUTHORS   Wang,Y., Wang,K., Fu,J., Zhang,Y., Mao,Y., Wang,X., Wang,X., Yu,R.
            and Zhou,X.
  TITLE     FRK inhibits glioblastoma progression via phosphorylating YAP and
            inducing its ubiquitylation and degradation by Siah1
  JOURNAL   Neuro Oncol 24 (12), 2107-2120 (2022)
   PUBMED   35723276
  REMARK    GeneRIF: FRK inhibits glioblastoma progression via phosphorylating
            YAP and inducing its ubiquitylation and degradation by Siah1.
REFERENCE   3  (bases 1 to 13363)
  AUTHORS   Zang,Q., Xu,L., Li,J. and Jia,H.
  TITLE     GATA6 activated long non-coding RNA PCAT1 maintains stemness of
            non-small cell lung cancer by mediating FRK
  JOURNAL   J BUON 25 (5), 2371-2381 (2020)
   PUBMED   33277858
  REMARK    GeneRIF: GATA6 activated long non-coding RNA PCAT1 maintains
            stemness of non-small cell lung cancer by mediating FRK.
REFERENCE   4  (bases 1 to 13363)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 13363)
  AUTHORS   Irie,K., Nagai,T. and Mizuno,K.
  TITLE     Furry protein suppresses nuclear localization of yes-associated
            protein (YAP) by activating NDR kinase and binding to YAP
  JOURNAL   J Biol Chem 295 (10), 3017-3028 (2020)
   PUBMED   31996378
  REMARK    GeneRIF: Furry protein suppresses nuclear localization of
            yes-associated protein (YAP) by activating NDR kinase and binding
            to YAP.
REFERENCE   6  (bases 1 to 13363)
  AUTHORS   Meyer,T., Xu,L., Chang,J., Liu,E.T., Craven,R.J. and Cance,W.G.
  TITLE     Breast cancer cell line proliferation blocked by the Src-related
            Rak tyrosine kinase
  JOURNAL   Int J Cancer 104 (2), 139-146 (2003)
   PUBMED   12569567
  REMARK    GeneRIF: Breast cancer cell line proliferation blocked by the
            Src-related Rak tyrosine kinase
REFERENCE   7  (bases 1 to 13363)
  AUTHORS   Craven,R.J., Cance,W.G. and Liu,E.T.
  TITLE     The nuclear tyrosine kinase Rak associates with the retinoblastoma
            protein pRb
  JOURNAL   Cancer Res 55 (18), 3969-3972 (1995)
   PUBMED   7664264
REFERENCE   8  (bases 1 to 13363)
  AUTHORS   Cance,W.G., Craven,R.J., Bergman,M., Xu,L., Alitalo,K. and Liu,E.T.
  TITLE     Rak, a novel nuclear tyrosine kinase expressed in epithelial cells
  JOURNAL   Cell Growth Differ 5 (12), 1347-1355 (1994)
   PUBMED   7696183
REFERENCE   9  (bases 1 to 13363)
  AUTHORS   Lee,J., Wang,Z., Luoh,S.M., Wood,W.I. and Scadden,D.T.
  TITLE     Cloning of FRK, a novel human intracellular SRC-like tyrosine
            kinase-encoding gene
  JOURNAL   Gene 138 (1-2), 247-251 (1994)
   PUBMED   7510261
REFERENCE   10 (bases 1 to 13363)
  AUTHORS   Cance,W.G., Craven,R.J., Weiner,T.M. and Liu,E.T.
  TITLE     Novel protein kinases expressed in human breast cancer
  JOURNAL   Int J Cancer 54 (4), 571-577 (1993)
   PUBMED   8099900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121963.10, AL357141.8 and
            AL021451.1.
            
            On Nov 26, 2018 this sequence version replaced NM_002031.2.
            
            Summary: The protein encoded by this gene belongs to the TYR family
            of protein kinases. This tyrosine kinase is a nuclear protein and
            may function during G1 and S phase of the cell cycle and suppress
            growth. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U00803.1, BC012916.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606080.2/ ENSP00000476145.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-924               AL121963.10        105524-106447
            925-1046            AL357141.8         70100-70221         c
            1047-1210           AL357141.8         34799-34962         c
            1211-1379           AL357141.8         33774-33942         c
            1380-1538           AL357141.8         22675-22833         c
            1539-1720           AL357141.8         10467-10648         c
            1721-1886           AL357141.8         9243-9408           c
            1887-10634          AL357141.8         101-8848            c
            10635-13363         AL021451.1         84478-87206         c
FEATURES             Location/Qualifiers
     source          1..13363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..13363
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /note="fyn related Src family tyrosine kinase"
                     /db_xref="GeneID:2444"
                     /db_xref="HGNC:HGNC:3955"
                     /db_xref="MIM:606573"
     exon            1..924
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..2098
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /EC_number="2.7.10.2"
                     /note="PTK5 protein tyrosine kinase 5; nuclear tyrosine
                     protein kinase RAK; protein-tyrosine kinase 5; fyn-related
                     kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase FRK"
                     /protein_id="NP_002022.1"
                     /db_xref="CCDS:CCDS5103.1"
                     /db_xref="GeneID:2444"
                     /db_xref="HGNC:HGNC:3955"
                     /db_xref="MIM:606573"
                     /translation="MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHG
                     HYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPS
                     NYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGA
                     VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFD
                     LSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR
                     EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDM
                     AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE
                     IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNY
                     RLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR"
     exon            925..1046
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1210
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1379
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1538
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1720
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1886
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..13363
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11344..11349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /note="hexamer: AATAAA"
     regulatory      11348..11353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /note="hexamer: AAGAAA"
     polyA_site      11366
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /note="major polyA site"
     polyA_site      11370
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
     regulatory      13261..13266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /note="hexamer: ATTATA"
     polyA_site      13282
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
     regulatory      13340..13345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
                     /note="hexamer: TATAAA"
     polyA_site      13363
                     /gene="FRK"
                     /gene_synonym="GTK; PTK5; RAK"
ORIGIN      
        1 acagtctgtt catagctcag aatgttaaag gcaacagcct ctgctggttg gttattcatt
       61 agcaaaaagg agagagccgt ccagatccgg actggtcgaa agacaggaac agacttgaaa
      121 cagggggaga gctcctggcg aaagcaagac gtggaggttt taccaggggt tagtagcttc
      181 ctcttgctaa ctttttattg ggacaaaagg caagatggca ccattctgtt ctcagatatt
      241 tgtctaaata aagccctttt aattttattt tatttttgtt gtgggattct taagcagata
      301 agaagaaaag acaccttcct agtgagcagc tgcccagctc ctgctcagtt ttgcctcggg
      361 gtagcacctc cagccacaga aagcaagccg gtaagtctct ccaggtagga cttgctgcaa
      421 cccagctgct ggactgatct gaaacgggac tttgcatact ctccgaagta tggtgagttg
      481 gtgctgactt caaagttgcc tggtgaagga agataaggtg gatcgcagag actaagggga
      541 gagggagaag ccctgctcct cttctcccca ccaaggcaca atgagcaaca tctgtcagag
      601 gctctgggag tacctagaac cctatctccc ctgtttgtcc acggaggcag acaagtcaac
      661 cgtgattgaa aatccagggg ccctttgctc tccccagtca cagaggcatg gccactactt
      721 tgtggctttg tttgattacc aggctcggac tgctgaggac ttgagcttcc gagcaggtga
      781 caaacttcaa gttctggaca ctttgcatga gggctggtgg tttgccagac acttggagaa
      841 aagacgagat ggctccagtc agcaactaca aggctatatt ccttctaact acgtggctga
      901 ggacagaagc ctacaggcag agccgtggtt ctttggagca atcggaagat cagatgcaga
      961 gaaacaacta ttatattcag aaaacaagac cggttccttt ctaatcagag aaagtgaaag
     1021 ccaaaaagga gaattctctc tttcagtttt agatggagca gttgtaaaac actacagaat
     1081 taaaagactg gatgaagggg gattttttct cacgcgaaga agaatctttt caacactgaa
     1141 cgaatttgtg agccactaca ccaagacaag tgacggcctg tgtgtcaagc tggggaaacc
     1201 atgcttaaag atccaggtcc cagctccatt tgatttgtcg tataaaaccg tggaccaatg
     1261 ggagatagac cgcaactcca tacagcttct gaagcgattg ggatctggtc agtttggcga
     1321 agtatgggaa ggtctgtgga acaataccac tccagtagca gtgaaaacat taaaaccagg
     1381 ttcaatggat ccaaatgact tcctgaggga ggcacagata atgaagaacc taagacatcc
     1441 aaagcttatc cagctttatg ctgtttgcac tttagaagat ccaatttata ttattacaga
     1501 gttgatgaga catggaagtc tgcaagaata tctccaaaat gacactggat caaaaatcca
     1561 tctgactcaa caggtagaca tggcggcaca ggttgcctct ggaatggcct atctggagtc
     1621 tcggaactac attcacagag atctggctgc cagaaatgtc ctcgttggtg aacataatat
     1681 ctacaaagta gcagattttg gacttgccag agtttttaag gtagataatg aagacatcta
     1741 tgaatctaga cacgaaataa agctgccggt gaagtggact gcgcccgaag ccattcgtag
     1801 taataaattc agcattaagt ccgatgtatg gtcatttgga atccttcttt atgaaatcat
     1861 tacttatggc aaaatgcctt acagtggtat gacaggtgcc caggtaatcc agatgttggc
     1921 tcaaaactat agacttccgc aaccatccaa ctgtccacag caattttaca acatcatgtt
     1981 ggagtgctgg aatgcagagc ctaaggaacg acctacattt gagacactgc gttggaaact
     2041 tgaagactat tttgaaacag actcttcata ttcagatgca aataacttca taagatgaac
     2101 actggagaag aatatcaaat aataaagtag caaaacaaat tcaaataatc cattccaaaa
     2161 tacaatgtta tcaaccaact gcacaatcag tttatcctga catattcaag tgataggata
     2221 aagttggcca tgtattatga aaaagattat ttgtgcattt tattgactgg gcaacactgc
     2281 aggacagtca aggtgatata taatttcctc actgcctggt aaaattaagc acactaaacc
     2341 aagttatttt tctttttaag agatacttac atttccattt attgtttgaa atgtcgatca
     2401 agagaatcaa cagatgatag tccaattttt actcagtgac tgttgtagca ttttcctgtt
     2461 tactgattag agtggttatt cattattcct cagattgctg aatcccatca ggctgttatt
     2521 atgaaggaat ttgattgctt tgctgcacag caggacctgt gctttgagat ttttttttct
     2581 cttttaaaat atcctgtaac tacaatgatg gtaaagccat gttaaatgac ttgattgtac
     2641 ttggagtaat tgcacatttt tttctatgca taaaaaaatg atgcagctgt tgagaaaacg
     2701 aagtcttttt cattttgcag aaggaaatga tggaattttt ctgtacttca gtatgtgtca
     2761 actgagagtc atatacatta gttttaatct cttaatattg agaatcaggt tgcaaaacgg
     2821 atgagttatt atctatggaa atgtgagaaa tgtctaatag cccataaagt ctgagaaata
     2881 ggtatcaaaa tagtttagga aaatgagagg agaacagtag gattgctgtg gcctagactt
     2941 ctgagtaatt aataaagaaa aagaagtacc ctttggccta cagatcagag ttttatttat
     3001 tttttatttt ttacttttta ttatagttta agttctgggg tgcatgtgca gaatgtgcag
     3061 ttttgttaca taggtgtaca agtgccatgg tggtttgctg cacccatcaa cccgtcgtct
     3121 acattaggca tttctcctag tgctgttcct cccctagccc tccatcccct gacaggcccc
     3181 agtatgtgat gttcccctcc ttgtgtccat atgttctcat tgttcagctc ccacttatga
     3241 gtgagaacat gctgtgtttg gttttttgtt cttgtgttag tttgttaaga atgatggttt
     3301 ccagctttat ccatgtccct gtgaaggaca tgaactcatc cttttttatg gctgcatagt
     3361 attccatagt gtctatgtgc cacattttct ttatccagtc tatcgttgat gggcatttgg
     3421 gttggttcca agtctttgct attgtgaata gtgccacaat aaacatgcat gtgtctttat
     3481 agcagaatga tttataagcc tttaggtaca tacccagtaa tgggatcgct gagtcaaatg
     3541 gtatttctag ttctagatcc ttgaggaatt gctacactgt cctccacaat ggttgaacta
     3601 atttatactc ccaccaacag agtaaaagtg taaatgtgtt cctatttctc cacatcctct
     3661 ttggcatcca aaacagcatc ctgttgtttc ctgacttttt aatgatcacc attctaactg
     3721 gtgtgagatg gtatctcatt gtggttttga tttggatttc tctaatgatc agatgatgag
     3781 ctttttttca tatgtctgtt ggctgcataa atatcttctt ttgaaatgtg tctgttcaaa
     3841 tccttcgccc actttttgat ggggttgttt gtttttttct tttaaatttg tttatgttcc
     3901 ttgtagattc ttggtattag ccctttgtca gatggatagc ttgcaaaaat tttctcccat
     3961 tctgtaggtt gcctgttcac tctgatgata gtttcttttg ctgtctagaa gctctttagt
     4021 ttaattagat cccatttctc aatttgggct tttgttgcca ttggtttttg tgttttagtc
     4081 atgatgtctt ttccaatgcc tatgtcctga atggtgttgc ctaggttttc ttctagggtt
     4141 tttatggttt taggtcttac atttaagtct ttaatccatc ttgagttaat ttttgtatag
     4201 gtgtaaggaa ggggtccagt ttcagttttc tgcatatggc tagctagttt tcccaacacc
     4261 atttattaaa tagggaatcc tttccccatt ggttgttttt gtaaggtttg tcaaagatca
     4321 gatggttgta gatgtgtggt gttatttctg aggcctctgt tctgttctgt tggtctagat
     4381 atctgttttg gtaccactac catgctgttt tgtttactgt agccttgtag tatagtttga
     4441 agtcaggtag catgatgcct ataactttgt tctttttgct tagaattgtc ttggctatgc
     4501 gggctctttt ttgattccat atgaagttta aagtagtttt ttccaattct gtgaagaaag
     4561 tcaatggtag tttgatgggg atagcactga atatataaat tgccttgggc aatatggcca
     4621 ttttcacgat attgattctt cctatccatg agcatggaat gtttttccat ttatttgtgt
     4681 cctctcttat ttccttgagc agtggtttgt agttctcctt gaagaggtcc tttgcatccc
     4741 ttgtaagttg taatcctaga tatttcattc tctttgtagc aattgtgaat gggagttcac
     4801 tcatgatttg gctctctgtt tgttattggt gtataggaat gtgtgtgatt tttgcacatt
     4861 gattttgtat cctgagactt tgctgaagtt gcttatcagc ttaaggagat tttgggctga
     4921 gatggtgggg ttccctatat atacaattca tatcatctgc aaacagagac aattttactt
     4981 cctgttttcc tatttgaata ccctttattt ctttctcttg cctgattgcc ctggccagaa
     5041 ctttcaatac tattttgaac aggagtggtg agagggggca tccttgtctt gtgccagctt
     5101 tcaaagggaa tgcttccagg tttacccatt cagtatgata ttggctgtgg ttttgtctta
     5161 aatctgtcat tttttttgag ctacgttcca tcaataccta gtttattgag agtttttagt
     5221 atgaaggggt gttgaatttt atcaaatttt ctgcatctat tgagatcatc atgtggtttt
     5281 tgtcattggt tctgtttatg tgatggattg tgtttattga tttgcgtatg ttgaaccagc
     5341 cttgtgtctc agggatgaag ccaacttgat cgtggtggat aagctttttg atgtgctgct
     5401 gcactcagtt tgccagtatt ttattgagga tttttgcatg gatgttcgtc agggatactg
     5461 gcctgaaatt ttctctcttt tttttttttt gttgtgtctc tgccaggttt tggtttcagg
     5521 atgatgctgg cctcataaaa tgagttaggg aggagtccct cttttcctat tgtttggaat
     5581 agtttcagaa agaatagtac tagctttgta cctctttgta cctctggtag aattcggctg
     5641 tgaatctatc tggtcctgga ctttttttgg ttggtaggct attaattact gcctcaattt
     5701 cagaacttgt tattggtcta tttagggatt catcttcttc ctggtttaga cttgggaggg
     5761 tgtatgtttg caggaattta cccatttctt ctagattttc tagtttattt gcttagaggt
     5821 atttatagta atctctgatg gtattttgta tttctgtggg atcagtggtg atctccgctt
     5881 tatcattttt tattgtgtct atttgattct gctctctttt cttctttatt agtctggcta
     5941 gcattctatt ttgttgatct tttcaaaaaa tcagatcctg gattcattga ttttttgaaa
     6001 ggtttttcat gtctctatca ccttcagttc tgttctgatc ttagttattt cttgtcttct
     6061 gctagctttt gaatttgttt gctcttgctt ctctagtact tttaattgtg atattagggt
     6121 atagatttta gttctttcct gattcctctt gtgggcagtt ggtgctataa atttccctct
     6181 acacactgct ttaaatgtgt cccagagatt ctggtatgtt gtgtttttgt tctcattggt
     6241 ttcaatgaac aactttattt ctaccttaat tttattattt acccagtagt cattcaggag
     6301 caggttgttc agtttccaag tagttgttag gttttctgtc agttttaatc ctgagttcta
     6361 atttgattgc actgtggtct tagagactgt ttgttatgac ttccgttctt ttgcatttgc
     6421 tgaggagtgt tttacttcca attatgtgat cacttttaga ataagtgcga tgaggtgctg
     6481 agaagaatgt atattctgtt gatttggggt agagaattct gtagatgtct gttaggtcca
     6541 cttggtccag agctgagttc aagttctgaa tatctttgtt aattttctgt ctcatttatc
     6601 tgtctaatat tgacagcagg ctgttaaaat ttcccactat tattgtgtgg gagtctaagt
     6661 ctctttgtag ttctctaaga acttgcttta tgaatctggg tgcttctgta ttgggtgtat
     6721 atatatttag gatagttagc tattcttgtt gcattgatct gtttaccatt atgtaatgcc
     6781 cttctttgtc tcttttgatc tttgttgatt taaagtctgt tttatcagag actaggattg
     6841 caacccctgc tttttttttc tgctttccgt ttgcttcgta aatattcctc catcccttta
     6901 tcttgagcct gtgtgtctct ttgcatgtga gatgggtctc ctgaatacag cacactgatg
     6961 ggtcttgagt ctttatccaa tttgccattc tgtcttttac ttggggcatt cagcctgttt
     7021 acatttaagg ttagtattgt tatgtgtgaa tttgattctg tcatatgatg ctagctggtt
     7081 attttgcccg aaagttgatg caggttcttc gtatcctcga tgatctttac aatttggtat
     7141 gtttttgcag tggctggtat tgattgttcc tctctatgtt tagtgcttcc ttcaggagct
     7201 cttttagggc aggcctggtg gtaacaaaat ctctcagcat ttgcttgtct gtaaaggatt
     7261 ttatttctcc ttcgcttatg aaactgagtt tggttggata tgaaattctg ggttgaaaat
     7321 tcttttcttt aagaatgttg aatattggcc cctactctat tctggcttgt aaggtgtctg
     7381 cagagagatc ctctgttagt ctgatgggct tccctttgtg gctaacctga cctttctctc
     7441 tggctgccct taacattttt tccttcattt caaccttggt gaatatgacg attatatgtc
     7501 ttggggttgc tctgctcgag gagtatcttt gtggcgttct ctgtatttcc ttaatttgaa
     7561 tgttgacctg tcttgctagg ttggggatgt tctcctggat aatatcctga ggagtgtttt
     7621 ccaacttggt tccattctcc ccgtcacttt caggtacacc aatcaaacgt agacttggtg
     7681 ttttcacata atcccatatt tcttggaggc tttgttagtt ccttttcact cttttttctc
     7741 taatcttgtc ttctccttta tttcattaag ttgatcttca atctttgata tcctttcttg
     7801 tgctttatcg acttggctat tgataattgt gtatgcttca tgaagttctc atgctgtatt
     7861 tttcagctcc atcaggtcat ttatgtgctt ctctatactt gttattctag ttagcaattc
     7921 ctctaatctt tttacagtgt tcttaacttc cttgcattgg gttagaacat gctcctttag
     7981 cttggaggag tttgttatta cccaccttct gaggcctact tctatccatc cgtcaaactc
     8041 attctccatc cagttttatt cccttgctgg caaggagttg tgatcctttg gaggagaaga
     8101 ggcattctgt ttttttgaat tttcagctgt tttgcgctgg tttctcctca tcttcctgga
     8161 tttatctact tttggtcttt gatcctgctg atgttcggat ggggtctctg agtggacata
     8221 ctattccttt ctgtttgtta gttttccttc taagagttag tgccctctgc tgcaggtctg
     8281 ctggagtttg ctggaggtcc actccagatg ctgtttgcct tggtgtcacg agtggaggct
     8341 gcagaacagc aaagattgct gcctgttctt tcctctggaa gcttcgtccc agaggggcac
     8401 ccactggatg ccagccagag ctctcctgta tgaggtgtct gttggcccct actgggagat
     8461 atctcccaat caggataaac gagggtcagg gacccacttg aggaggcagt ctgactctta
     8521 ccagagctcg agcactgtgc tgggaaatcc actactctct tcagagctgt ccggcagaga
     8581 tatttaagtc tgctgaagct gctcccatat ccaccccttc ccacaggtgc tctgtcccag
     8641 ggagatgggg ttttatctat tagtccctga ctgccttttt tttagagttg ccctgcccag
     8701 agaggaggaa tctagagagg cagtctggcc agagtggcct tgctgagctg aggtggtggg
     8761 ctctacccaa ttcgaactcc caggcagctt tgtttagact gtgagggtaa aatgcctact
     8821 caagcttcag caatggcaga cggccctcct ccctccaagc tcgagtgtcc caggtcgacc
     8881 tcagactgct gtgcttgcaa tgaggatttc aagccagtga atcttagctt gctgggctcc
     8941 gtgggggtgg gacccgccaa gctagaccac ttggctccct ggcttcagcc ccccttccag
     9001 gggagtgaat ggttctgcct tgctggcatt ccaggcacca ctggggtatg gaaaataaaa
     9061 ctcctgcagc tagttcagtg tctgcccaaa tggctgccca gttttgtgct tgacacccag
     9121 ggccccagtg gcgtaggcac cggagggaat ctcctggtct gcaggtttca aagaccatgg
     9181 gaaaagtgca gtatctgggc tggagtgcac cgttcctcag gtacagtccc tcatggcttc
     9241 ccttgggtag aggaggtagt tccctgaccc cttgtgcttc ctgggtgagg tgacacccca
     9301 ccctgtttca gctggccctc catgggctgc acccactgtc caaccagtcc cactgatatg
     9361 aactgggtac ctcagttgga aatgcagaaa tcacccgcct tctgcgttga tctcactggg
     9421 agctgcagac cagagctgtt cctatttggc catcttgcca gcaatcagac cagagtttta
     9481 aatggactac aaaataggtc aaactctatt tcagaactag aggctaggaa taatgtccaa
     9541 acttggttat gaaagttttt tttttttttt ggtctggtag gataagaggg tttttactca
     9601 tcttaagttt gaattaaact ttgtaacaaa gttattgttt ttttaaacaa tgcatgtatc
     9661 aaattatctg tctcattaga taactaggta gacttttcca agatggtttc aaaatcaaat
     9721 atatattcaa agatcttcca gtgtaaagca ataggaatga aacaagccat gagaaagcag
     9781 aatattttga gtatattctc atgcctttct ttaaaggaga agcgcctatc taaacagtta
     9841 cagaaaccca aattcaaagt agattaaaca agaagtaaat ttgtaaactc ttttaactgg
     9901 gagacaggaa gtagggaggg ctccaggcac aatatcatta gcagttcaat gtgaacgaag
     9961 acccatgtcc tttccaagcc tccctctgcc atcagcattg ccctccttcc cagggtcaca
    10021 gatggctatc aatggcaaaa ctggggttcc gcgttctctt ctcctcatct ggcaagagaa
    10081 aatgggaaat ctctatccca agcttggatt aaaaattatt ttcatttttg tgttccagca
    10141 aacttgggtc ctatgcccag ccatggacca aaaataggct taatgtgaat gttatgtgct
    10201 gattggatta aaataagttc tgactctgaa tctgggaatg tggtcacctt cctcagagac
    10261 aagttgagag gttggcttat ctgaataaaa gcagagaata tgagatgctg gagaggtgtt
    10321 cattaaggag aacattccct gaggtgaatt aacggttaga attatctatc tctgtattta
    10381 tctatccacc catctatcat catcatcacc tcatctccct cctttctctc tctctaaata
    10441 tatacatgcg ggtatgttga gtgtgtatat atttattttt ttgtgtgttt atatggtgtg
    10501 tgtgtgtgtg tattccaggc agatgtgtgc atatataccc aaactttcct gatgaccttg
    10561 aaattaaatg ggtcatgtga agctaaagat tatagaaccc cttgattcct ttataaacag
    10621 tatttctaag ataagatcaa cactaatctt tcaaattagt tgactgtgta tagaacaact
    10681 tgtttattta aagtcatcta gtctaatgca atcaaggagt aaattataaa taaccagtta
    10741 gcataaatgg aaagaaaata gttccttttc tttgaattca tttcatgttt aatttttctt
    10801 gcgcacatat agaaatgaat agaaatattc ccatttcaat atgcaaattc agccactata
    10861 tagtttgttt ctttttggta gctaataata ataaattttt aagtaagatc tgattttgaa
    10921 atatgaaaag aagtttatcc tttcctgttt taataccacc tgatacccgt ttaacttact
    10981 gtgtttgatt cttggggaca tttatgttca aggttctgtc aaagcaatct attattcttg
    11041 tttttacctg atggatcatg gagaaaaata atggattcag ttatgagaaa cagtaataga
    11101 tttttttaac tgccataaat ttctctccct gtattaaata aaaggatcag gaaaagataa
    11161 gttgaatttt cctacaatga gccagctctt cttaaattta cctcccataa attgtagcaa
    11221 agcacttttc atataatgtt ttatttatgt aattcagtta tttggagatg gtggtgaggg
    11281 atgtgagtac atcatttcat gttgtatttc aaatctcttt tgacagaaac cctaagaatt
    11341 tgcaataaag aaaattcaat gttccattaa gtttttcttt ttcttttttt ttaaaaagag
    11401 ggtaaggaag gaaataaggg aatagattta agttacctaa ggtcaaaaga ggcacagggt
    11461 agactctgaa tagttgtgga acctgaatat tttgtcatca aaaacaaagt taaagtcaga
    11521 gtgaccagga atctgcaaac tggctgtggg aatgggttga cttaaaagac agacaaagaa
    11581 ctagcctgtg gggtaacatc aggctaggct caccctcagc ttctacccac aatatctgta
    11641 tgatgaccat gtggatctaa tgaaccagga ggggcccaaa ctcttccgac tctgtggagg
    11701 cctaaaggaa actgttgcca ttggaaggat gccataccac tacccagctg gagcttcctg
    11761 aaggaagcag agcccagctg gtgttccatg gtttgttaag catatgccat acctacaatc
    11821 acttttttca tggtctggtt gagcatatga tttctgaacc aaatagcctt tctggtattg
    11881 tgtcattggt gactcattat gattctttaa aaagacacat tatgtgagct agaatggtga
    11941 tgatttgggt accttattca aattgcatca tcatttaatt caagagaaag gccattctta
    12001 aagtaaaagt aaatgaggtt tgtacacctg ggtattggaa ttgccagtgg gctgatctga
    12061 caatgtttga ttcttgtttt ttctggaatt attatgtaga agattcagtc tataatcttc
    12121 aacatgatgc aaatattcag tgtcatagga tcaaaaaaat gctggaaagt atctaaaaat
    12181 cttttaaatt catatcttaa ttttcagtgt tatcctctta ctgcctacat tcccccacta
    12241 aactcttaga tttttctctg cttttgttaa gaaagtgatg ttagtaggcc tctcaagtta
    12301 tttatgaaat ttagaaatat actggagaac aaagtagtat ataaaccctg aatttcaaaa
    12361 gccttaacaa gtttagcttc aatctacatt cagatgacac tatctacaga gatgttataa
    12421 gattaaatta caagaaaaga gatgcccaat tatttccatt tactcttctt gcctaggtag
    12481 ttaatttatc tattattcat ttgaagcaac agacgtcaat gtaacatctt tttcattttc
    12541 atggagaata atcagctttt ccagaaaagg gtgctatatc tcaaacacac ctcaagtgtc
    12601 cagttggaag tattaccatg cagaggattc aagtcatatt acctaataac cagaagttgt
    12661 atgttgggaa aaagtggtta aaagcaacta aaactgccct gtttggaaga aactaaatat
    12721 tgctttataa tgattttctg atattttaga atagaggctt caattatact atttgtgaaa
    12781 aagaaaactg cttggtatta accaagttac atttaatttt tatggtccac aaaatttcag
    12841 agtagaaata tatcatagct tttaatcaat tttcaaaatc tatatttaat tattgattca
    12901 aaaaataaga aataaaatca attagccaga tttgtatact ttaaagctac cacagtgaga
    12961 tttttctctt aaaaacatgc atgtttttat attgtattct ttaatattta tattgtacag
    13021 ttacatgtga cacatattac atatgactaa tttatatgta gcaacaggga ttaaagaaga
    13081 cctcttttaa ttgtaccact tgttataatg ctattattta cccagattca aatgtaacta
    13141 cttacaattt ttaaacattt ttatttctgt attctttaaa atattaaggc aatggttttt
    13201 cttgaaatta tattttgccc tatgtattct atttttattc acactggatt tattatgata
    13261 attatatcaa agtgattatt tttaccctga cttttaaaag tcaactgttt cagaagtcaa
    13321 gttgattgtg gatctaaaat ataaattcaa tgtgttcata gca
//
