LOCUS       NM_001080446             358 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens Frey regulator of sperm-oocyte fusion 1 (FREY1), mRNA.
ACCESSION   NM_001080446 XM_096472
VERSION     NM_001080446.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Contreras,W., Wiesehofer,C., Schreier,D., Leinung,N., Peche,P.,
            Wennemuth,G., Gentzel,M., Schroder,B. and Mentrup,T.
  TITLE     C11orf94/Frey is a key regulator for male fertility by controlling
            Izumo1 complex assembly
  JOURNAL   Sci Adv 8 (32), eabo6049 (2022)
   PUBMED   35960805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068385.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001080446.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA393247.1, AI652381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449465.2/ ENSP00000401498.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC068385.9         81089-81215         c
            128-201             AC068385.9         80813-80886         c
            202-358             AC068385.9         80478-80634         c
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..358
                     /gene="FREY1"
                     /gene_synonym="C11orf94; Frey"
                     /note="Frey regulator of sperm-oocyte fusion 1"
                     /db_xref="GeneID:143678"
                     /db_xref="HGNC:HGNC:37213"
     exon            1..127
                     /gene="FREY1"
                     /gene_synonym="C11orf94; Frey"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..323
                     /gene="FREY1"
                     /gene_synonym="C11orf94; Frey"
                     /note="uncharacterized protein C11orf94; protein Frey"
                     /codon_start=1
                     /product="protein Frey 1"
                     /protein_id="NP_001073915.2"
                     /db_xref="CCDS:CCDS44577.1"
                     /db_xref="GeneID:143678"
                     /db_xref="HGNC:HGNC:37213"
                     /translation="MVLAMLGALHPRAGLSLFLHLILAVALLRSQPLRSQRSVPEAFS
                     APLELSQPLSGLVDDYGILPKHPRPRGPRPLLSRAQQRKRDGPDLAEYYYDAHL"
     exon            128..201
                     /gene="FREY1"
                     /gene_synonym="C11orf94; Frey"
                     /inference="alignment:Splign:2.1.0"
     exon            202..358
                     /gene="FREY1"
                     /gene_synonym="C11orf94; Frey"
                     /inference="alignment:Splign:2.1.0"
     regulatory      335..340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FREY1"
                     /gene_synonym="C11orf94; Frey"
                     /note="hexamer: CATAAA"
     polyA_site      358
                     /gene="FREY1"
                     /gene_synonym="C11orf94; Frey"
                     /note="major polyA site"
ORIGIN      
        1 gacaggagcc aggacccgtg taggagatgg ttctcgccat gctgggggct ctgcaccccc
       61 gggctgggct cagcctcttc ctccacctca tcctggcagt ggcactgctt cgctcccagc
      121 ctctgaggtc tcagcggtct gttcctgagg cattttccgc ccccctggaa ctctcgcagc
      181 cactttccgg cctggtggat gactatggca tcctccccaa gcacccaagg ccgcgagggc
      241 ctcgacccct cctgtctagg gcccagcagc gcaagcggga cgggcccgac cttgccgagt
      301 attactatga tgcacaccta tgacccaagg ccctcataaa gataccatgt gtgacaaa
//
