LOCUS       NM_001168235            6729 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens FRAS1 related extracellular matrix 3 (FREM3), mRNA.
ACCESSION   NM_001168235 XM_001127662 XM_001720656 XM_094074
VERSION     NM_001168235.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6729)
  AUTHORS   Nikolova,Y.S., Iruku,S.P., Lin,C.W., Conley,E.D., Puralewski,R.,
            French,B., Hariri,A.R. and Sibille,E.
  TITLE     FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide
            polymorphism effects on gene expression, amygdala reactivity and
            perceptual processing speed: An accelerated aging pathway of
            depression risk
  JOURNAL   Front Psychol 6, 1377 (2015)
   PUBMED   26441752
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6729)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 6729)
  AUTHORS   Shi,C., Zhang,K., Wang,X., Shen,Y. and Xu,Q.
  TITLE     A study of the combined effects of the EHD3 and FREM3 genes in
            patients with major depressive disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 159B (3), 336-342 (2012)
   PUBMED   22337703
  REMARK    GeneRIF: The combined effect of the EHD3 and FREM3 genes may play
            an important role in developing major depressive disorder.
REFERENCE   4  (bases 1 to 6729)
  AUTHORS   Barallobre-Barreiro,J., Didangelos,A., Schoendube,F.A., Drozdov,I.,
            Yin,X., Fernandez-Caggiano,M., Willeit,P., Puntmann,V.O.,
            Aldama-Lopez,G., Shah,A.M., Domenech,N. and Mayr,M.
  TITLE     Proteomics analysis of cardiac extracellular matrix remodeling in a
            porcine model of ischemia/reperfusion injury
  JOURNAL   Circulation 125 (6), 789-802 (2012)
   PUBMED   22261194
REFERENCE   5  (bases 1 to 6729)
  AUTHORS   Petrou,P., Makrygiannis,A.K. and Chalepakis,G.
  TITLE     The Fras1/Frem family of extracellular matrix proteins: structure,
            function, and association with Fraser syndrome and the mouse bleb
            phenotype
  JOURNAL   Connect Tissue Res 49 (3), 277-282 (2008)
   PUBMED   18661360
REFERENCE   6  (bases 1 to 6729)
  AUTHORS   Smyth,I., Du,X., Taylor,M.S., Justice,M.J., Beutler,B. and
            Jackson,I.J.
  TITLE     The extracellular matrix gene Frem1 is essential for the normal
            adhesion of the embryonic epidermis
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13560-13565 (2004)
   PUBMED   15345741
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139713.1, AW953229.1,
            DN831271.1, AI184955.1, DR731220.1, DR007885.1, BE223071.1 and
            R44783.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001168235.1.
            
            Summary: This gene encodes an integral membrane protein containing
            numerous CSPG (chondroitin sulfate proteoglycan element) repeats
            and Calx-beta domains. The protein belongs to the family of
            FRAS1/FREM extracellular matrix proteins and may play a role cell
            adhesion. [provided by RefSeq, Feb 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.105583.1,
                                           SRR1803611.254327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329798.5/ ENSP00000332886.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4867              AC139713.1         154821-159687       c
            4868-5470           AW953229.1         11-613
            5471-5840           DN831271.1         110-479
            5841-6028           AI184955.1         141-328             c
            6029-6124           DR731220.1         1-96                c
            6125-6230           DR007885.1         39-144
            6231-6600           BE223071.1         132-501             c
            6601-6624           R44783.1           20-43               c
            6625-6729           AC139713.1         36314-36418         c
FEATURES             Location/Qualifiers
     source          1..6729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..6729
                     /gene="FREM3"
                     /note="FRAS1 related extracellular matrix 3"
                     /db_xref="GeneID:166752"
                     /db_xref="HGNC:HGNC:25172"
                     /db_xref="MIM:608946"
     CDS             1..6420
                     /gene="FREM3"
                     /note="FRAS1-related extracellular matrix protein 3"
                     /codon_start=1
                     /product="FRAS1-related extracellular matrix protein 3
                     precursor"
                     /protein_id="NP_001161707.1"
                     /db_xref="CCDS:CCDS54808.1"
                     /db_xref="GeneID:166752"
                     /db_xref="HGNC:HGNC:25172"
                     /db_xref="MIM:608946"
                     /translation="MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPAL
                     YLPARGALDGTRPDGPSVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDA
                     LPRLKGALSPRRFPCTFGPRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAV
                     DLVFSQLELVTRNRPLVVEKLRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDG
                     PLPKYGRLVDAVGAPLPRGKGVDCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEG
                     QDAGSAGVLVREHFQLLVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTPDALAAED
                     VESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPP
                     AENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRP
                     LSSTHSIPISDKDNLEEVKMAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQHD
                     GSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFV
                     LSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLST
                     EDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDP
                     PNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNL
                     WYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPR
                     VVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTD
                     PDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDT
                     FHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVI
                     HGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQK
                     QHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIVYEGEKNSL
                     TLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQV
                     RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVL
                     EGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQE
                     ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG
                     HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQD
                     EINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITL
                     IEGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASN
                     KISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDS
                     QLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKH
                     DGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGA
                     PALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVF
                     TQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIV
                     DEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWR
                     VRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEED
                     IGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKN
                     ETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFG
                     DAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA
                     PGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITDCKQ
                     SACSSFD"
     exon            1..5185
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5186..5275
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5422
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5423..5653
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5654..5779
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5780..6028
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     exon            6029..6178
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     exon            6179..6729
                     /gene="FREM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6703..6708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FREM3"
                     /note="hexamer: ATTAAA"
     polyA_site      6729
                     /gene="FREM3"
                     /note="major polyA site"
ORIGIN      
        1 atggcggggg cttctcggca cccgactggg acgccccggc agctccttgt ggcgctcgcc
       61 tgcctgctct tgagtcgccc cgcgctgcag ggacgggcat cctcacttgg gaccgagccc
      121 gacccggcgc tttacctgcc cgcccggggt gcgcttgacg gcactcgccc cgacggcccc
      181 agcgtgctga ttgccaaccc tggactccgg gtgcccctgg gtcgttccct ttggctcgac
      241 ccgctccggg atctggtgat tggagtgcag ccgggggacc ggtgcgaagt cacggtactg
      301 gacgccctgc cgcggctcaa gggcgcgctc tccccgcgcc gcttcccctg caccttcggg
      361 ccccgccaag tccagtacac tcacttcggc tcccacagcc ccggacgcgc ccgggtgctg
      421 ctgcagctgc gctacgacgc cccgactcac actctggtgc tgcccttcac gctggcggtg
      481 gacttggtct tctcccagct ggagctggtg acgcgtaaca ggcctttggt agtggagaag
      541 ctgcgaagct ggagccgcgc catagacagg agagtgctgg acttcgcctc cctgaagtct
      601 ggagccacgg ccacccgcag gtgccggctt accccacttc ctcacgagga cggccccctg
      661 cccaagtacg ggcgcttggt ggacgcggtg ggggcccctc tccccagggg caagggcgta
      721 gactgtgagg ctttcctccg tgctggggtg cgctatcagc acacagccac ctcctcgccc
      781 aaccgtgact acgtgcccat gatggtggag ctgctggggc ctgagggcca agacgctggg
      841 tccgcgggtg tgctggtccg cgagcacttc cagctgctcg tgaggatccg cggcggagcc
      901 gagaacacac cgcccaggcc cagcttcatg gccacgatga tgatggaggt ggatccactg
      961 gtgctgacag ccctgacgcc tgacgcactg gccgcggagg acgtcgagtc agaccctggt
     1021 gacctggtgt tcaacattct gaacgccccc actcacccac cagggcaccc ggggcaacag
     1081 ggctacgtgg tcagcaccga cgaccctcta gggcttccag tctccttctt cacccagcag
     1141 gagctgaggg agctgaagat tgcctatcag ccccctgcag agaactccca tggggagcgc
     1201 ctctttcagc tggagctgga ggtggtggac ggagacggcg ccgcctcaga cccctttgcc
     1261 ttcatggtga cagtgaaatc catgaatact ctggtcccag tggctagcca taacagggga
     1321 cttgtgcttt ttgaaggtca gtcaaggccc ttgtccagca cccacagcat tcctatcagt
     1381 gataaagata acctggaaga ggtgaaaatg gctgcagtca ggggcttgag acatgggcag
     1441 ctggtggtgt ttggggcacc tgctgggtgc aagtatttca caccagcgga cctggcagca
     1501 gggcgagtgg tgtatcagca tgatggcagc aacacctaca gtgacaatat catcttccgg
     1561 atggaggacg ggcaccacca agtggacttc ctctttcccc tcaccatcct acctgtggat
     1621 gatgaaccac caatggtcaa tactaacaca ggactctcac tcactgaagg gcaggtggtc
     1681 cagatctctc cctttgtact gagtgctact gatattgact ctgaggactc aaccatccac
     1741 tttgtgctgg agaaccagcc cctaaaagga aatgaggaag agcctcagtg ggagttggcc
     1801 cctggttcct cccactcagg ccactacctg ggggacctgt tgctgcagca ggctgaacta
     1861 cctctctcaa ctgaagatga agactggcac tacatggaaa aggaagggct ttatgagaaa
     1921 gtggtgactg agtggctaca gagagacata atggaaggga gactcttcta ccgccatctt
     1981 ggaccacaca gccctcaatc tgtaatggtc cagctggctt tccatgtgca ggatgaccat
     2041 gacccaccca atctctccaa acagcacatt ttcaccatca aggtccaacc agtggatata
     2101 ctgagtccac agctgtatcc aggaactaca ctagaaatga ctgtacaaga ataccaactc
     2161 actcacttcc agaagaattt cctccgatac attgaccagg actctgatga ccagaaccta
     2221 tggtacaccc tactgacact cccgactgac acagatggca accaccaagt ccgggctgga
     2281 gaaattgtgc tcactgattc accagacaca ctcatcatgc actttaccca agcccaggta
     2341 aatcagcata aagttgccta ccagcctcca cagaaattgg gtattgcacc acgggttgtg
     2401 cagtttactt accaggtgga agatgctgca ggcaatagcg tgccaggcac attcacatta
     2461 ttcctgcaac ctgtggacaa ccagccccca gaagtcacca acagaggctt tgctatctta
     2521 gagggaggca gctttaacct cagcagtaat gagctgcatg ttacagaccc agacacagac
     2581 attgaccaaa ttgtcttcat attagtccgg ggtccccaac atggacactt gcagtacttt
     2641 aaaagatgta tggtcccagg ggaatctttc atgcaagctg atgttattaa cgggagtgtc
     2701 tcttaccagc atggcagaga ccagacgact accagtgaca ctttccatct ggaagtaagt
     2761 gatggggtgc accatatacc catcaccatc ccaatttctg tgcatcccaa tgtggctaac
     2821 agaagtccta ggatctctct cagaagtagt tcattattgg atgtttctat agacgtacta
     2881 gagaataaag ccactgaaat taccatgggt gtcatccatg gcaaaaggaa ggatgtaggt
     2941 gacttgatgc tgtctttcat tgtaaaggac agccccaaac tgggcactat tctggtaaat
     3001 ggtttgccca cagaacgatt cacccaagag gatctcatca atgggagagt agcctatgcc
     3061 cacactgcag gtgaagttgg ttttcaaaag cagcacgatg ccttcagcct catcctctcc
     3121 aaagattctt accaatgggt agtggggaat agcataatag agaaagtaca ggtacaagta
     3181 actgtgctgc ctgtggacaa tgtgggaccc aaggtcttcg tcggggagtc cttcattgtc
     3241 tatgaaggtg agaagaactc cttgacctta caacatctcc atgttgaaga tgtggacact
     3301 catcaagatg aactcctctg cacagtgact agtcagccag cctctggcta cctggaaaag
     3361 attgcatcag ctcctggttc aaaaatgtcc cagtctggta gccctatcag tgctttctcc
     3421 ctcagagata tccaagtgag gcatatcaat tatgtacaga gtattcacaa gggagtagag
     3481 ccacaagagg accaattcac cttttattgc tctgatggca tcaacttctc cccaaatgtc
     3541 ttcttcccta taatcatcct acccaccaat gatgagcagc ctaaactttt tgcccatgag
     3601 tttaaggtac tagaggggat gagcctggtc atagacaccc agctgcttaa tggagcagat
     3661 gctgacctgc caccaaatga gctccacttt caactcacag ccctccctcg gcatggacga
     3721 atcatacagc agctggctac aggcagccag cccatccaca gcttcaccct caaggagatc
     3781 caggaggcct ccaccattgt gtatgagcat gatgactcag agacaaaaga ggacagtttt
     3841 gaggtctggc tgagtgacgg caagcacaca acccacagga aggtacccat tgtagtgacc
     3901 ctagtggatg atgaaactcc tcacctgact gtcaacaatg ggctgaaggt agagaaagga
     3961 cactctgaga tcatcacaaa tcggatcctc aaggccacag atcttgactc agatgataaa
     4021 agcctcagtt ttgtcctcca ttctgggcct caacaagggc ttctacagag gctgagaaaa
     4081 cccagaggag aagtgaggaa caatcttact ctgggaatga actttaccca ggatgagatt
     4141 aacagaggcc tcatctgcta tatccacaca ggccaagaag ggattgttga cattatcaag
     4201 tttgatgtta ctgatggggt taacactttg acagaccact acttctatgt caccattggc
     4261 aacttagaca gcgtcttccc tgaggtaatc agcaaaagga tcaccttgat agaaggtgcc
     4321 agagtgaccc ttaccaacaa tctgcttacc aacagtgaca tcaacagctc tgatgaacat
     4381 cactttagca ttacacgggc tccaagcctg ggtcacttag aaagttctga ctatgctggg
     4441 gaacccattg cctctttcac tcaacttcaa ttggctagca acaaaatatc ctatgtccat
     4501 acttcaaatg atgagaaaaa gatggacagc ttcgaatttc aagtgatcgg cgaactctac
     4561 cctgtgttca gaaccttcag gatcttcatc actgatgtgg ataataagaa acctatcttg
     4621 accatccata gactaacact acagaaagag gatagccaac tgatcactct ccttgagttg
     4681 acagtggaag acagtgatac cccagatgac cttattctct ttaccatcac ccaggtcccc
     4741 atgcatggca agattttgta caatggtagc cgtcccgtga ccactttcac caagcaagac
     4801 ctgaacaaga acctgattag ctacaagcat gacggcagtg agaccactga agatagtttc
     4861 tccttgactg tgacagacgg cactcacact gatttctatg tcctaccaga cactgccctg
     4921 gcgacacaca aacctcaagt aatgagggtc cagataagat cattagacaa taggcttccc
     4981 cagattacta ccaacagggg tgccccagcc ttgaagcgcc ttcacactgg acacatgggc
     5041 ttcctgatta ccagcaagtc tctgaaggca gaagatcagg acagtcccca caggcttctg
     5101 aagtataaag tgaccagagg accagagcat ggcttcatta tcaaaactgg ccttggaaac
     5161 cagagcactc gagtgtttac acaagctgac attgatgaga tgaagatatc ctatgtcttg
     5221 aatgagggca gcaacgcatc aaaggacatc ttctatttct ctgttgaaga caatggagga
     5281 aataaactaa caaatcagcc tttccatcta aactgggctt ggatttgttt ggagaaagag
     5341 tactacattg tggatgaaga ttccacattc ttagaagtga cccttacacg cagaggatac
     5401 cttggagaaa catcatttat cagcattggt accaaagatg aaactgcaaa aaaagacaaa
     5461 gatttcaaat ggaagaccaa taaacagatc cagttcaatc ctggacagac tacagccaca
     5521 tggagggtga gaattatacc tgacaatgaa tatgagactt cagagacctt ccagatcatt
     5581 ctgtctgaac ctctcatggc tgtactggag tttccagaaa tggcaacggt tgaaattgta
     5641 gaccctggag atgaatcaac agtttatatt ccagaggcgg aatacaaaat agaagaggac
     5701 attggggaac ttttgattcc agtaagacga tctggagatg caagccagga actaatcgtc
     5761 atttgctcca cacgtcaagg ttctgccaca ggcacgattt cttccacagt gttattctct
     5821 gattacatct cacgtccaga agaccacacc agcatcctcc actttgacaa gaatgagaca
     5881 cagaagacct gccaggtcct gatcattgat gactcccttt atgaagagga ggaatccttc
     5941 agcgtttcac ttaggctgcc agtgggagga cagctgggag ccagattccc caccactaag
     6001 gtgactattc tggctgatcg ttatgatgaa cctgtcctgc actttgggga tgctgaatat
     6061 cacgtcaatg aaagtgctcg ctacgtggag gtttgtgttt ggagaagagg cactgatctt
     6121 tcccaaccat catccatcgc cgtgcgctcc agaaagtcag agcaggagtc agcagaagct
     6181 ggaacagatt atgttggtat cagccgaaac ctggactttg ctccaggcgt gcgcatgcag
     6241 acattccaag tgaccatcct tgatgacctg ggacagccta ccttggaagg cccagagaag
     6301 tttgaattac ttcttcagat gcctatgggt gcagtgcttg gagaaccaaa taaaactacc
     6361 attttcatcg aggacaccat cacggactgt aagcagagtg cttgtagttc ctttgattga
     6421 aagactttaa gagggaaaaa aacagccaag atatgtctcc taacaacaga atgaaactct
     6481 actgtttata gatcttagca attctgggat atcagtgata ttgtactgtc attggtgtta
     6541 tattctggtg atatgtggaa atgtaattta tatgactgca tggagataga aatatatata
     6601 cctagaaaac attgagccca caaataatta gactgtgttc atgttctttt tctattttgt
     6661 tttactttgt ttctgaggca agtaagaaat ccactgtgat caattaaatc aaaagttaag
     6721 atcaaagaa
//
