LOCUS       NM_207361              16122 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens FRAS1 related extracellular matrix 2 (FREM2), mRNA.
ACCESSION   NM_207361 XM_292193
VERSION     NM_207361.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16122)
  AUTHORS   Mambueni,H.M., Hue,C., Jobart-Malfait,A., Said-Nahal,R., El
            Hafci,H., Petite,H., Nich,C., Breban,M., Costantino,F. and
            Garchon,H.J.
  TITLE     Targeted resequencing of the 13q13 spondyloarthritis-linked locus
            identifies a rare variant in FREM2 possibly associated with
            familial spondyloarthritis
  JOURNAL   Joint Bone Spine 89 (6), 105419 (2022)
   PUBMED   35640836
  REMARK    GeneRIF: Targeted resequencing of the 13q13
            spondyloarthritis-linked locus identifies a rare variant in FREM2
            possibly associated with familial spondyloarthritis.
REFERENCE   2  (bases 1 to 16122)
  AUTHORS   Al-Hamed,M.H., Sayer,J.A., Alsahan,N., Tulbah,M., Kurdi,W.,
            Ambusaidi,Q., Ali,W. and Imtiaz,F.
  TITLE     Novel loss of function variants in FRAS1 AND FREM2 underlie renal
            agenesis in consanguineous families
  JOURNAL   J Nephrol 34 (3), 893-900 (2021)
   PUBMED   32643034
  REMARK    GeneRIF: Novel loss of function variants in FRAS1 AND FREM2
            underlie renal agenesis in consanguineous families.
REFERENCE   3  (bases 1 to 16122)
  AUTHORS   Zhang,X., Wang,D., Dongye,M., Zhu,Y., Chen,C., Wang,R., Long,E.,
            Liu,Z., Wu,X., Lin,D., Chen,J., Lin,Z., Wang,J., Li,W., Li,Y.,
            Li,D. and Lin,H.
  TITLE     Loss-of-function mutations in FREM2 disrupt eye morphogenesis
  JOURNAL   Exp Eye Res 181, 302-312 (2019)
   PUBMED   30802441
  REMARK    GeneRIF: Our findings extend the spectrum of FREM2 mutations, and
            provide insights into opportunities for the prenatal diagnosis of
            isolated cryptophthalmos. Furthermore, our work highlights the
            importance of the FREM2 protein during the development of eyelids
            and the anterior segment of the eyeballs, establishes a suitable
            animal model for studying epithelial reopening during eyelid
            development and serves as a valuable reference
REFERENCE   4  (bases 1 to 16122)
  AUTHORS   Yu,Q., Lin,B., Xie,S., Gao,S., Li,W., Liu,Y., Wang,H., Huang,D. and
            Xie,Z.
  TITLE     A homozygous mutation p.Arg2167Trp in FREM2 causes isolated
            cryptophthalmos
  JOURNAL   Hum Mol Genet 27 (13), 2357-2366 (2018)
   PUBMED   29688405
  REMARK    GeneRIF: Our results showed that p.Arg2167Trp had a weaker effect
            in interrupting interactions between FREM2 and FREM1 than
            FS-associated missense mutation p.Glu1972Lys. Overall, our data
            demonstrate that the homozygous mutation p.Arg2167Trp in FREM2
            causes isolated Cryptophthalmos(CO), which will facilitate our
            better understanding of the molecular mechanisms underlying the
            disease
REFERENCE   5  (bases 1 to 16122)
  AUTHORS   Vidak,M., Jovcevska,I., Samec,N., Zottel,A., Liovic,M., Rozman,D.,
            Dzeroski,S., Juvan,P. and Komel,R.
  TITLE     Meta-Analysis and Experimental Validation Identified FREM2 and
            SPRY1 as New Glioblastoma Marker Candidates
  JOURNAL   Int J Mol Sci 19 (5), 1369 (2018)
   PUBMED   29734672
  REMARK    GeneRIF: FREM2 is thus proposed as a novel GB biomarker and a
            putative biomarker of glioblastoma stem cells. Both FREM2 and SPRY1
            are expressed on the surface of the GB cells, while SPRY1 alone was
            found overexpressed in the cytosol of non-malignant astrocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16122)
  AUTHORS   Kiyozumi,D., Sugimoto,N. and Sekiguchi,K.
  TITLE     Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1,
            and Frem2 at the basement membrane provokes Fraser syndrome-like
            defects
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11981-11986 (2006)
   PUBMED   16880404
REFERENCE   7  (bases 1 to 16122)
  AUTHORS   Jadeja,S., Smyth,I., Pitera,J.E., Taylor,M.S., van Haelst,M.,
            Bentley,E., McGregor,L., Hopkins,J., Chalepakis,G., Philip,N.,
            Perez Aytes,A., Watt,F.M., Darling,S.M., Jackson,I., Woolf,A.S. and
            Scambler,P.J.
  TITLE     Identification of a new gene mutated in Fraser syndrome and mouse
            myelencephalic blebs
  JOURNAL   Nat Genet 37 (5), 520-525 (2005)
   PUBMED   15838507
REFERENCE   8  (bases 1 to 16122)
  AUTHORS   Smyth,I., Du,X., Taylor,M.S., Justice,M.J., Beutler,B. and
            Jackson,I.J.
  TITLE     The extracellular matrix gene Frem1 is essential for the normal
            adhesion of the embryonic epidermis
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13560-13565 (2004)
   PUBMED   15345741
REFERENCE   9  (bases 1 to 16122)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   10 (bases 1 to 16122)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN291155.1, BN000687.1,
            KF455770.1, AL354819.15 and BX640686.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_207361.5.
            
            Summary: This gene encodes an integral membrane protein containing
            numerous CSPG (chondroitin sulfate proteoglycan element) repeats
            and Calx-beta domains. The encoded protein localizes to the
            basement membrane, forming a ternary complex that plays a role in
            epidermal-dermal interactions. This protein is important for the
            integrity of skin and renal epithelia. Mutations in this gene are
            associated with Fraser syndrome. [provided by RefSeq, Apr 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280481.9/ ENSP00000280481.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               CN291155.1         42-309
            269-2500            BN000687.1         1-2232
            2501-2501           KF455770.1         192-192
            2502-9778           BN000687.1         2234-9510
            9779-15511          AL354819.15        88732-94464
            15512-16122         BX640686.1         6689-7299
FEATURES             Location/Qualifiers
     source          1..16122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..16122
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /note="FRAS1 related extracellular matrix 2"
                     /db_xref="GeneID:341640"
                     /db_xref="HGNC:HGNC:25396"
                     /db_xref="MIM:608945"
     exon            1..5441
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..9778
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /note="ECM3 homolog; FRAS1 related extracellular matrix
                     protein 2"
                     /codon_start=1
                     /product="FRAS1-related extracellular matrix protein 2
                     precursor"
                     /protein_id="NP_997244.4"
                     /db_xref="CCDS:CCDS31960.1"
                     /db_xref="GeneID:341640"
                     /db_xref="HGNC:HGNC:25396"
                     /db_xref="MIM:608945"
                     /translation="MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRV
                     PAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPG
                     DRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAP
                     GGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRV
                     GILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPN
                     RDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFV
                     LTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLK
                     IAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILY
                     EGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFT
                     VAELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNAN
                     TGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQEL
                     LRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPN
                     QSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRY
                     TVTQPPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATR
                     VAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVND
                     VDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSC
                     SLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGT
                     NEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKAD
                     SFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSV
                     HISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHI
                     NYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGM
                     SLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSS
                     IIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTK
                     IINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRN
                     LIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGK
                     VTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYY
                     IHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLIT
                     PFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTE
                     SSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLR
                     TLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQAD
                     IDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDS
                     KFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRIL
                     SDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGEL
                     FIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDERE
                     KLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVE
                     YSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGV
                     NMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQF
                     KERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITF
                     LPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADK
                     TVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPV
                     SEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIVYIEEMS
                     SMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICA
                     SENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQC
                     AARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAEPFSAKLRYTGPEDADYTN
                     LIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFL
                     TDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGG
                     TIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILW
                     NDGIGSPPEAELQGSLYPTSMRIGDEGRLAVHFKTEAQFHGLFVLSHPASFTSSVIMS
                     ADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTAPSHQEYRL
                     PVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDV
                     AFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNAEYGCLADSP
                     SLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQ
                     VALGREWYIHTIYTVRSKDNANRGIGKRSVEYHSLVSQGKPQSTTKSRKKREIRSTPS
                     LAWEIGAENSRGTNIQHIALDRTKRQIPHGRAPPDGILPWELNSPSSAVSLVTVVGGT
                     TVGLLTICLTVIAVLMCRGKESFRGKDAPKGSSSSEPMVPPQSHHNDSSEV"
     exon            5442..5531
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5532..5678
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5679..5909
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            5910..6035
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6036..6287
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6288..6437
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6438..6647
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6648..6845
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            6846..7010
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7011..7193
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7194..7324
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7325..7483
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7484..7787
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7788..7919
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            7920..8251
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8252..8444
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8445..8549
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8550..8677
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8678..8812
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8813..8939
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            8940..9127
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            9128..9274
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            9275..16122
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14908..14913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /note="hexamer: AATAAA"
     polyA_site      14928
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /note="major polyA site"
     regulatory      16100..16105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /note="hexamer: AATAAA"
     polyA_site      16122
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
ORIGIN      
        1 agaagtggag ggattcaatt ctccgcgcga ttgaggcgct agcggcggag ctggacggcc
       61 tgggaaggct tcggctcctc ggctgcggct ccagcccgga cggcgccgcg caactttgcc
      121 atccttctgg cccagccccg gctacaggag gaccccgcgg gcaacgcgcg gagttcctgg
      181 cacttcccgg cggtgtctct tgttgtctgc ccggggaccg acttcgcatg ctctcaggct
      241 gacctgtcca agcccgaaca ccgggaccat gcactcagcc gggactcccg ggttatcctc
      301 gcgccggaca ggcaactcca ccagctttca accaggaccg ccaccgccgc cccggctgct
      361 gctgctgctg ctgcttctcc tgtcactggt aagccgcgtc ccggcacagc ccgctgcctt
      421 cggcagggcg ttgctgtccc ctggtctcgc gggggctgca ggggtccctg ctgaggaggc
      481 catagtgctg gcgaaccgcg gactccgggt gcctttcggc cgtgaagtct ggctggatcc
      541 cctgcatgac ctggtgttgc aggtgcagcc cggggaccgc tgcgcggttt cggtactaga
      601 caacgacgca ctggcccagc gaccgggccg cctgagtccc aagcgcttcc cgtgcgactt
      661 tggccctggc gaggtgcgct actctcacct gggcgcgcgc agcccgtctc gggaccgcgt
      721 ccggctgcag ctgcgctatg acgcgcccgg aggggcagta gtgctaccac tggtactgga
      781 ggtggaggtg gtcttcaccc agctggaggt tgtgactcgg aacttgcctc tggtcgtgga
      841 agagctgctg gggaccagca atgccctgga cgcgcggagc ctggagttcg ccttccagcc
      901 cgagacagag gagtgccgcg tgggcatcct gtccggcttg ggcgcgctgc ctcgctatgg
      961 agaactcctc cactacccgc aggtccctgg aggagccaga gagggaggcg ccccggagac
     1021 tctcctgatg gactgcaaag ctttccagga actaggcgtg cgctatcgcc acacagccgc
     1081 cagtcgctca ccaaacaggg actggatacc catggtggtg gagctgcgtt cacgaggggc
     1141 tcctgtgggc agccctgctt tgaaacgcga gcacttccag gttctggtga ggatccgagg
     1201 aggggccgag aacactgcac ccaagcccag tttcgtggcc atgatgatga tggaggtgga
     1261 ccagtttgta ctgacggccc tgaccccaga catgctggca gccgaggatg ctgagtctcc
     1321 ctctgacctg ttgatcttca accttacttc tccattccag cctggccagg gctacttggt
     1381 gagcaccgat gatcgcagcc tgcccctttc ctccttcact cagagggatc tgcggctcct
     1441 gaagattgcc taccagcccc cttctgaaga ctctgaccag gagcgcctct ttgaactgga
     1501 attggaggta gtggatctag aaggagcagc ttcagaccct tttgccttca tggtagtggt
     1561 gaagcccatg aacacaatgg ctccggtggt cacccggaat accggtctta ttctctatga
     1621 gggtcagtct cggcccctca caggccctgc aggcagtggt ccgcaaaact tggtcatcag
     1681 cgatgaggat gacctagaag cagtgcggct agaggtggtg gctgggctcc ggcatggtca
     1741 ccttgtcatt ctgggtgctt ccagtggcag ctctgctccc aagagcttta cagtggctga
     1801 gctggcagcc ggccaggtgg tctaccagca tgatgacaga gacggctcgc tgagcgacaa
     1861 cctggtgctt cgcatggtgg atggaggagg caggcaccag gtacagtttc tgttccccat
     1921 caccttagtg cctgtggatg accagccacc tgttctcaat gccaacacgg ggctgacact
     1981 ggcagagggt gaaacagtgc ccatcctgcc cctttccctg agtgcaactg acatggattc
     2041 agatgattct ctgctgcttt ttgtgctgga gtcacccttc ttaactacgg ggcatctgct
     2101 tctccgccaa actcaccctc cccatgagaa gcaggaactt ctcagaggcc tttggaggaa
     2161 ggagggggca ttttatgagc gaacagtgac agagtggcag cagcaggaca taacagaggg
     2221 caggctgttc tatagacact ctgggcccca tagtcctggg ccagtcacag accagttcac
     2281 atttagagtc caggataacc atgaccctcc taatcagtcc gggctacagc ggtttgtgat
     2341 tcgtatccat cctgtggatc gcctccctcc ggagctgggc agtggctgtc cccttcgtat
     2401 ggtggtacag gaatcccagc tcacaccact gaggaagaag tggctgcgct acactgacct
     2461 ggacacagat gaccgagaac tacgttacac agtgactcag ccccccacag acacagacga
     2521 aaatcacctg ccagccccac tgggtacctt ggtcttgact gacaacccct cagtcgtggt
     2581 gacccatttt acccaagccc agatcaacca tcataaaatt gcttacagac ccccgggtca
     2641 agaactgggc gtggctactc gagtggccca gttccagttc caggtggaag accgagctgg
     2701 gaatgtggct ccaggtacct ttacccttta cttgcatccc gtggacaacc agccacctga
     2761 gatcctcaac accggcttca ctattcagga gaagggtcac cacatcctga gtgagacaga
     2821 gttgcacgtg aatgatgtag acactgatgt tgcccatatc tctttcactc tcactcaggc
     2881 acccaaacat ggccacatga gagtgtctgg acagatcctg catgtagggg gtctcttcca
     2941 cttggaggac ataaaacagg gccgagtttc ctatgcccat aatggggaca agtccctgac
     3001 tgatagctgc tccttggaag tcagtgacag acatcatgtg gtgcccatca ctctcagagt
     3061 aaatgtccgg ccagtggatg atgaagtgcc catactgagc catcctactg gcactctgga
     3121 gtcctatcta gatgtcttag aaaatggggc tactgaaatc actgccaatg ttattaaggg
     3181 gaccaatgag gaaactgatg acttgatgtt gactttcctc ttggaagatc cacctttgta
     3241 tggggaaatc ttggtcaatg gcattccagc agagcagttt actcaaaggg acatcttgga
     3301 gggctctgtt gtatataccc acaccagtgg tgagataggc ctattgccta aagcggattc
     3361 ttttaacctg agtctgtcag atatgtctca agaatggaga attggtggca atactatcca
     3421 aggagttact atatgggtga ccatcctgcc tgttgatagc caggccccag aaatctttgt
     3481 aggtgaacag ttgatagtaa tggaaggtga taaaagtgtt ataacatcag tgcatataag
     3541 tgctgaagat gtcgactccc tgaatgatga catcttgtgc actatagtta ttcagcctac
     3601 ttcaggttat gttgaaaaca tttctccagc accaggctct gagaaatcaa gagcagggat
     3661 tgccataagt gctttcaact tgaaagatct caggcagggc cacataaact atgtccagag
     3721 tgtccataaa ggggtggaac ctgtggagga ccgatttgta tttcgttgtt ctgatggcat
     3781 taacttttca gagagacagt tcttccccat tgtaatcatt cccaccaatg atgaacagcc
     3841 agagatgttt atgagagaat ttatggtgat ggaaggcatg agtctggtaa ttgatacacc
     3901 cattctcaat gctgctgatg ctgatgttcc cctggatgat ttaactttca ctattaccca
     3961 attccccact catggtcaca tcatgaatca gctgataaat ggcacggttt tggtcgaaag
     4021 cttcaccttg gatcagatca tagagagttc cagcattatt tatgagcatg atgactccga
     4081 gacccaggaa gacagttttg tgattaaact aacagatggg aagcactctg tggaaaagac
     4141 ggtcctcatt atagttatcc ctgttgatga tgagacgccc agaatgacta tcaataatgg
     4201 actagaaata gaaattgggg ataccaagat tatcaacaac aaaatattaa tggcaacaga
     4261 tttagattca gaagacaaat ctttggttta tattattcgt tatgggccag gacatggctt
     4321 attacagaga cgaaaaccta ctggtgcctt tgaaaatatc acactgggca tgaattttac
     4381 ccaggatgaa gtagacagaa acttaattca gtatgtccat ttggggcaag agggcattcg
     4441 ggacctaatt aaatttgatg tgactgatgg aataaatccc ctcatagatc gttactttta
     4501 tgtgtccatc gggagcattg acattgtctt ccctgatgtg ataagtaagg gagtgtcctt
     4561 gaaagaaggt ggcaaagtca ctcttacaac agacctacta agcactagtg acttgaacag
     4621 tcctgatgaa aacttggttt ttaccatcac cagggctccc atgcgaggtc acctggaatg
     4681 cacggatcag cctggtgtgt ccatcacgtc tttcactcag ctgcaactgg ctggaaacaa
     4741 aatctactac atccacacag ctgatgatga agtgaaaatg gacagttttg agtttcaagt
     4801 caccgatgga cgtaaccctg tctttcggac attccgtatc tccattagcg atgtggacaa
     4861 taaaaagcca gtggtcacca tccacaagct ggttgtcagt gaaagtgaaa acaagctgat
     4921 tactcctttt gagctcactg tcgaagacag agatactcct gacaagctcc tgaaattcac
     4981 tatcacccag gtgcctattc atggccatct cctattcaac aataccagac ctgtcatggt
     5041 ttttaccaag caagacttga atgaaaactt aatcagctac aaacatgatg gcactgagtc
     5101 aagtgaagat agcttctcct tcacagtgac tgatggcacc catacagact tctatgtttt
     5161 tcctgatacg gtgtttgaaa caaggagacc ccaagtgatg aagatccagg tcttggctgt
     5221 tgacaacagt gtcccccaaa tcgcagtgaa taagggggcc tctacacttc gcactctagc
     5281 cactggccac ttggggttca tgatcacaag caaaatattg aaagtggagg acagagacag
     5341 cttacacatt tctcttagat ttatcgtgac agaggcccct caacatggat atcttctcaa
     5401 cctggacaaa ggcaaccaca gcatcactca gttcacacaa gctgacattg atgacatgaa
     5461 aatatgctat gtcttaagag aaggggctaa tgccacaagt gatatgttct attttgcagt
     5521 tgaagatggt ggtggaaaca agttaacgta ccagaatttt cgtctgaatt gggcatggat
     5581 ctcctttgaa aaggaatatt acctggtcaa tgaggactcc aaatttctag atgttgttct
     5641 taaacgtaga ggttacttgg gagaaacttc ttttataagt attggcacaa gagacagaac
     5701 tgcagaaaaa gacaaagact tcaagggcaa agcacagaaa caagtgcagt tcaacccagg
     5761 ccagaccagg gccacatggc gagtgcggat cctgagtgat ggggagcatg agcagtctga
     5821 aacctttcag gtggtactct cagagcccgt gctggctgcc ttggaattcc ccacagtcgc
     5881 cactgttgag atcgttgatc caggagatga gccaactgtg tttattcccc agtccaaata
     5941 ctccgttgaa gaagatgttg gtgagctgtt cattcccatc aggaggagcg gagatgtgag
     6001 ccaggagttg atggtggtct gttataccca acaaggaaca gcaactggaa ctgtgccgac
     6061 ttccgtgttg tcttactctg attacatatc caggcctgag gaccacacca gtgttgtccg
     6121 ctttgacaaa gatgaacggg agaaactgtg tcggatagtc ataattgatg actctttgta
     6181 cgaggaggag gaaaccttcc atgtccttct gagcatgccc atggggggaa gaatcggatc
     6241 agagttccca ggggctcaag ttacaatcgt tcctgacaaa gatgatgaac ccatctttta
     6301 cttcggtgat gtggaatact ctgtggatga gagtgctggc tatgtggaag tgcaggtgtg
     6361 gagaacgggc actgacctgt ccaagtcttc tagtgtcaca gtgaggtctc ggaaaacaga
     6421 tcctccctct gcagatgctg gaacagacta tgtgggcatc agccgtaatt tagattttgc
     6481 acctggagtc aacatgcagc ctgttcgtgt tgtcattctg gatgaccttg gacaaccagc
     6541 gctggaggga attgagaaat ttgaactggt gcttcgcatg cctatgaacg cagcccttgg
     6601 cgagcccagc aaagccacag tgtccataaa tgactctgtc tccgatttgc ctaagatgca
     6661 attcaaagaa cgaatatata ctggcagcga aagtgatggg cagatagtta caatgatcca
     6721 taggactggg gatgtccagt acagatcttc agtgagatgc tacacccggc aggggtctgc
     6781 acaggtgatg atggactttg aagaacgccc aaacactgat acctccatca tcacattcct
     6841 ccctggtgag acagaaaagc cctgcattct tgagctgatg gacgatgtgc tctatgagga
     6901 ggtagaggag ctccgcctgg tactcggcac tccacaaagc aactctccct ttggggctgc
     6961 agttggtgaa caaaatgaaa ctctcataag gatccgagat gatgctgata agactgttat
     7021 taaatttgga gaaaccaaat ttagtgtcac tgaacccaaa gaacctggag agtcggtggt
     7081 tataagaatt ccagtgattc gccaaggaga cacttcaaag gtttccattg tgagagtcca
     7141 caccaaggat ggctcggcca cctctggaga agactaccac cctgtgtcag aagaaattga
     7201 gtttaaggaa ggggaaaccc agcacgtggt tgaaatcgaa gttacctttg acggggtgag
     7261 agagatgaga gaggccttca ctgttcacct aaaacctgat gaaaatatga tagcagagat
     7321 gcagttgacg aaagccattg tgtacataga agaaatgagc agcatggcag atgtcacttt
     7381 tccttctgtc cctcaaattg tatccctgtt gatgtatgac gacacttcca aagctaagga
     7441 gagtgctgaa cccatgtctg gctatcctgt catctgtatc acagcttgca accccaaata
     7501 ttcagactac gataaaacag gctctatctg tgcaagtgag aacatcaatg acactttgac
     7561 gcggtaccgg tggctgatta gtgcacctgc gggccctgac ggtgtgacca gccctatgag
     7621 agaagtggac ttcgacacct tttttacgtc atccaagatg gtcacactgg actccatata
     7681 ctttcagcct ggctcccggg tacagtgcgc agctcgtgct gtgaacacca atggggatga
     7741 aggcctggag ctcatgagcc ctattgtaac catcagcaga gaagaaggtc tttgtcagcc
     7801 ccgtgtacct ggggttgttg gagcagagcc gttctcagct aaattgcgct acacaggccc
     7861 tgaggatgca gactacacaa accttatcaa gctcactgtc acaatgccac acatagatgg
     7921 catgctcccc gtgatctcca ctagagagct ttccaacttt gagctcaccc tcagccctga
     7981 tggcacaaga gttggaaacc acaagtgctc caacctcctg gattatactg aagtgaagac
     8041 tcattatggt ttcttgactg atgctaccaa aaatccagaa ataattggag agacatatcc
     8101 ttaccagtac agcttgtcca tcagaggttc cactaccttg cgcttctacc ggaacctgaa
     8161 cctagaggcc tgtttatggg agttcgttag ctactatgac atgtcagaac tccttgctga
     8221 ctgtggtggc accattggaa cagatggaca ggtcctaaac ctagtgcagt cctatgtgac
     8281 ccttcgagtc cctctgtatg tttcctacgt gttccattcc cccgtggggg taggaggctg
     8341 gcagcatttt gacttgaagt cagagcttcg tctaactttt gtgtacgaca ccgccatctt
     8401 gtggaatgat ggaattggca gccccccaga ggctgaactt caaggttctc tctatccaac
     8461 cagcatgcgc atcggtgatg aggggcgctt ggccgtgcac ttcaagacag aggctcagtt
     8521 ccatggctta tttgtgctgt cacatcccgc atcctttaca agctcagtga tcatgtcagc
     8581 tgatcatcca ggcctgacat tttccctccg cctcataagg agtgaaccaa cctataacca
     8641 gccagtacag cagtggagct ttgtctctga ctttgccgta cgtgactact cagggaccta
     8701 tactgtgaag ctggtgccat gcactgcccc atcacatcag gaataccgcc tgccagtcac
     8761 ctgcaacccc agagaacctg tcacctttga ccttgacatc cgattccaac aggtcagtga
     8821 tccagtggct gctgagttta gcttgaacac ccaaatgtac ctgctctcta agaagagtct
     8881 ctggttgtct gatggatcca tgggattcgg gcaagagagt gatgttgctt ttgcagaagg
     8941 tgatataatt tatggtcgtg tcatggtgga tcctgtccag aatctgggtg actcctttta
     9001 ctgcagcatt gagaaggtgt ttctatgcac tggagctgat ggctatgttc ccaagtatag
     9061 tccaatgaat gcagaatatg gctgcttagc cgactctcct tcactcttat atagatttaa
     9121 aattgtggac aaagctcagc cagagacaca agcgaccagt tttggaaatg tcctatttaa
     9181 tgccaaacta gcagtggatg accctgaagc cattctctta gtgaatcagc ctggatctga
     9241 tggatttaaa gtcgactcaa caccactctt tcaggtcgct ctaggccgag aatggtatat
     9301 acatacgatc tatacagtga gatcgaaaga caatgccaat cgaggtattg gcaaaagaag
     9361 tgtggagtac cattctctgg tgagtcaagg aaagccccaa tccaccacca agagccggaa
     9421 gaagagagag atcaggagca caccctcact ggcatgggag attggtgctg aaaacagtcg
     9481 aggaacaaac atccagcaca ttgccctgga ccgcaccaag aggcagatcc cccatgggag
     9541 agcacctcca gatggcatcc tcccctggga gctcaacagc cccagctctg cagtcagcct
     9601 ggtcactgtg gtgggaggca ccacggtagg gttactcacc atctgcctca ctgtcattgc
     9661 agtgctgatg tgcaggggca aggaaagttt cagggggaag gatgccccga aaggctccag
     9721 cagcagtgag cccatggtgc ccccacagag ccatcacaat gacagctcag aagtttgatg
     9781 actgcaggta gaattcaacc ttttccgtaa gtgcctcgga aaagatcaca atggaacctt
     9841 aaatacttct ggtaaaccat agagaatgga ggatggctgt gatgaagctg cttagagaat
     9901 atgactgtac taatggagtt tgatttgaat tctccatact cttttttgca tcaaaggaca
     9961 aattaaggca tctttcctct tgccccaaag gcagcaacaa cgtactcata tgtacacaga
    10021 gccatgatgt gaggaatgta ctcctcattt tagacatatt ctctatgcag tggagataaa
    10081 tctattaaaa ggtgctaaca gactctctta caagtgtaag aggaatctac tgttgctatg
    10141 ttagtgtgaa tgttgaaggt gcaattatca cattgtttat taattgtata acagattatt
    10201 actagaaagg tttttgttgc tagtctggaa aactggtgaa cacactgttt attatgacaa
    10261 gttttcaaat aggtgaagac agcatagaat tatgaccagg gtggctcaac ccacaaatca
    10321 actgatctac tacttgggag acagtggaag gaaagataga gggaaggaag ttcactcact
    10381 tgaatttgaa ttgcttctca ttctcatcag actctccttg ttttgtttgc atatttaatt
    10441 ttaaattaaa ccaaagaata tgttaattct gaaagagatt tttaagagat gctgctctgt
    10501 tttggcatat agtgagtaat ggtagagctc ttgcatggta atatacctta ttggtgctca
    10561 acatttgtgg gaaattagag ggttggtgag attttggtga tgaataaatg ccatagagtt
    10621 agagtcacta caagacaatg ttctctaaga actgagccta gatgtttgca gtattgaacc
    10681 cataaatgat aataagaaac attgttacag atggtgaagg gagaaagtgg tatttattaa
    10741 tataatgtgt ataatcagag tgcctcttat acatacttta tagaataaag gaacattttg
    10801 acagatgagg ttatccctcg gagtagcgta atcacacaat aacatttaga acttaaattg
    10861 gctacaggac attttattag ctttctatcc agcatctggt ccaaacgatg ggactctctg
    10921 caactatcat tccagaaatg gtcttggagg tggccagaat cattgaccat atttttattt
    10981 ggttcaagaa gacatcgctc tggcatcccc agttcagtga actggtacaa tgtggtccct
    11041 ctcaatattt aaaaatataa tttgtaacag tgcttaccat tcacctccca aagccaagga
    11101 acttgagtga gcttccttgg caagcctccc attgcctttc tgcatcaatg tgtttgttac
    11161 caaatagcag aaatttcgct tagaagggga aaacttcagc tttccaaaag ctagtaaaca
    11221 tgtttcaaag aaaaataagg tcaggagaaa aagaataatg cctacagatt atccttcaga
    11281 tgctggctag aatccccttt gacttctagc cataagctgg ccacattgga catcttggtc
    11341 actgcagaat tttaaaaggc aaacttctca gaacagatgt gcacatctta atttggtgtc
    11401 tgtaagtatc aaccatttct tgatcaagat aaggaagcaa cactgatact gagagagagg
    11461 tcatatgtcc aatagttgcc tttcttctct taggcagctc tgcacttcat gttcagtttt
    11521 ttaaaaatag actgtagtat cctttcattg gagaatttac aaaaatatca tctacagctc
    11581 aaaagtccca ctaacggctt atatgaacag aaagtactgt gtagcccagg agtttattta
    11641 gcaagataaa tagtggtaat ttcttaatca ttcccctttc ctttgcttta ccttctggca
    11701 gatgcttagc tacttctttg gctacctcat aatttgtatg ggaatgaaca tgaattaggg
    11761 aacttcaaat agtgcgtaga cttttcccta cttaccattg ggttcaattg atgtagactg
    11821 ttagagcaag tatactcaat caacttgctg atattttagt agttaacagc ttccgagcct
    11881 atcatgcaat ttggagtctg tcaatgaata tagcaatcgg tgaagcatta ctgtacgaag
    11941 tctgttttca ggctttgggt caagctggtt ttataccaaa tttcactcta caatgcatat
    12001 tctaatgaag ctactttata taaattggag agcttataaa atgcagaaca tttctatcct
    12061 atcctaccaa atatttatcc ttctctgtcc tctattctct tactctcctc tctccctttt
    12121 tccttccctt tattcccttg aaaaaagaga atctgtggga aataggcaga tatagctttt
    12181 taaaatataa agtacttggg attttgcatt atttttctta atatctattt actaagtatg
    12241 taatttaata tacattaatt attttttgaa actcttgtta gtgggaagaa tatggtaaat
    12301 tttttgttaa ataaaataga cccttatgtt tagcattttg tttttagaga actattctgg
    12361 tactatcaga acaaatacat aaaataactt cccatagaga acaggatata gcaataatag
    12421 ctccttagat actcagtggc ttctgactcc aatcaaggtc ttgttgatat tatatagtaa
    12481 aaataaaacc aaaaataaat attattcaag tggctcttct aagcatgtga atcatgaagc
    12541 actgaaatat gtattttaat gatgatctta tttattccca tttttgccct tagttaacat
    12601 ttactggtgc tcacctagga ttggctattc tgagggattg catagaaacc aagctccact
    12661 tgctgtcctt gggaaggtta taactgaatg cagctcttta tttggactaa agtgtcagga
    12721 tatgcattag attctctcct gaaccaaaaa cacaacagtc attatctgtg aaccataatt
    12781 taaaaatctt tctagaataa caacagcaga ctccactctt gtttgtctaa aagagcccta
    12841 ctgggtatgg atcattctga tgacagattt atacaaaatg attcaaacca gtaacttagt
    12901 aaaattgacc ttcgcaaaac ctcactgggg gagtgccttg tagagctgtg ggtgggactg
    12961 cacattcttt tcctcttagt aaaagatagg cccactttat tccaagaata acacttagca
    13021 cataaactct tcttccagct cgttagcagc attagcacct tctgaattcc accctctcag
    13081 aagaatccac agtgtttgaa caatttgcat aaaggtcagc tagcatcctg ctgccaagcc
    13141 actgcatagc atttgtgata agaaggacca actctaggct caatatgaag ggatttagtt
    13201 ctgtaagcag caaaaaagct tctttatcaa gtcatcttac ctctaattct tttccagtgt
    13261 gccaactcca aagtcaacat taaaaatgta aatggacctg tgtaaatatc acagagagct
    13321 tttccttata catctcaatg ctgagagtta aaatattccc aggttaaaat ttttttaaag
    13381 taccaataat agagctaaat acaatgacat ttgcttttaa aaggtggata ttttatttct
    13441 gctttttgaa aatacttatt tagtattgac ttggaagcca atttggtcct ttaataagta
    13501 aagaaaataa tatgtttaaa aatgtaaatg ttttacaaat ttgaaacttt cataattgta
    13561 ttaatcagaa aacaagcaca ttgccattct ttgaaactca tgtttctaga catgacagca
    13621 gtaataaaag gatgaaaaca agtgtcttca ctaagcgtat ggccaataaa tgggacccaa
    13681 acgttcaatc tgttcagttt accaaggttc agaaatacgt aatttagcag gaaactataa
    13741 ataccagtgc tatcacagcc acacatacac acacacagac ataaaataac caaacatctc
    13801 atttctagga aagagataac actaaaggca tcataggttt aactgaaata cgttatatga
    13861 agttttacaa aaaggtcaac agaaagctca tttgtgaaaa catactctca tgggagcttc
    13921 tttaacatta gttcagaggt taatatattt cctggaggtg ttttcctaga attgattgca
    13981 ctattgcatg gtaataacat ttaattgtta aggaaacatt atatataggt tcaaattatc
    14041 ccttaatgtt gatttctccc cttttccatg gattttgata ctaagaaaca aaatgctttg
    14101 agattttggt aactattttg attttgataa aacatgttaa aatagaagga catgatattt
    14161 ttctatagtt tccatcagga agagtacatc agaaacttct ccataaggaa agaaaactga
    14221 ctctctcttg aactagtgtt gacaaaatac actaatgtct ttcttaattt tattttatta
    14281 ggagaaaaat cagaatatta aatttgcaaa cttttgaaca gcagtaatag ctccttagac
    14341 actcagtatc tttcttccct atctttcaag cacatttaat ttctttcccc tggtatttgt
    14401 ttgctttgtg ttttttcaat attttgtttg ctaaagaaca ataacaacaa caaagctggt
    14461 ccagccctga cacctacttt tgcttttttt ctttctttct tttaatttgt tgaactatag
    14521 gtttctttct gagatgtatt tttcattctt ccaataatgc tctctttttc atttcaaaac
    14581 cattaccact ttcaatatgt aattaacatc ctcattcatc agaaagctgg taagtccaca
    14641 cagcatttgt gcagtatccc ttctgtgtaa aatgttaagg ctttcagatg aaagaaaaaa
    14701 gaacttcctg caaaagatca aaagcatcat actaaataaa atgatgacaa tatgtgcctt
    14761 gatttttctc tcaatggagg ttcaacattg acatttaaga tgtaaaaaaa attactttga
    14821 tggtttaatt aagaataata agtcaaatat cacatgtatg tagttctttt ggatgaccga
    14881 ataccttaaa atgaactaaa taactgaaat aaagtgttaa aatgttaaca gcgttgaagt
    14941 ttttaaaatt ataattatca aatgcacaat gttcttttac tatgccaaat gttgcctaca
    15001 ctgattacat gattgtcaca gtttaagtga atttctacta tggatcttta ttttccccaa
    15061 tgtttggatc atcctctcag ataagaattg tcagtattgc acctcaagaa agaagaaaaa
    15121 ataagaatgt aaatttttaa aagctagcat taaaagtaaa gagcagtaca ataaaaatca
    15181 cttaaaatag agaaaggcaa ctactgagta agaagaaaag ataatttctg taaaagctaa
    15241 atttatgcac attacaaaaa gtagtcaagt cagtcttcca ttgtgacttc aggaattcaa
    15301 atgcaagttg ttggcaaaat atatatatac acacacacac acatacacac acatatatgt
    15361 acatacatat atatatagag agagagagat agattttttt tttttgagac agagtttcgc
    15421 tcttgttgcc caggctggag tgcaatggaa tgatcttggc tcaccgcaac ctccgcctcc
    15481 agggttcaag tgattctcct gcctcaacct cctgagtagc tggaattaca ggtgcccact
    15541 accatgcctg gctagttttt gtatttttag tagagacagg gtttctccat gttggtcagg
    15601 ctgatctcga actcccaacc tcagatgatc ctcccgcctc cacctcccaa agtactggaa
    15661 ttacaatggc gtgagccacc acaagatatt tttaaagccc atttgtctat aaaagaaaac
    15721 tcttggacaa ggagctttgt gttttataat tgtattacgt gcctgcttcc ttaccaagtg
    15781 ccctccataa cactaagtaa atttatattt atctagcctc tgagtgacat atctgtgtgt
    15841 aatggaatta tttgcagaat ttaatagcct tttttatttt cgcatgagaa tttttcaaaa
    15901 actatcaggg tctagtttta tcatacattt actaagttac tacatattgg tggatattga
    15961 cgtttattcc tgggaatcta attttgcaaa caatttggag ccattcagtc ataaattcat
    16021 gtcaacaata agtcttgctg ccgcttgtgt ttcataacta cgcttgcttt ccttcaaaat
    16081 ataccaagtg tgtaatataa ataaagccca tatcaatata aa
//
