LOCUS       NP_997244               3169 aa            linear   PRI 28-APR-2025
DEFINITION  FRAS1-related extracellular matrix protein 2 precursor [Homo
            sapiens].
ACCESSION   NP_997244 XP_292193
VERSION     NP_997244.4
DBSOURCE    REFSEQ: accession NM_207361.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 3169)
  AUTHORS   Mambueni,H.M., Hue,C., Jobart-Malfait,A., Said-Nahal,R., El
            Hafci,H., Petite,H., Nich,C., Breban,M., Costantino,F. and
            Garchon,H.J.
  TITLE     Targeted resequencing of the 13q13 spondyloarthritis-linked locus
            identifies a rare variant in FREM2 possibly associated with
            familial spondyloarthritis
  JOURNAL   Joint Bone Spine 89 (6), 105419 (2022)
   PUBMED   35640836
  REMARK    GeneRIF: Targeted resequencing of the 13q13
            spondyloarthritis-linked locus identifies a rare variant in FREM2
            possibly associated with familial spondyloarthritis.
REFERENCE   2  (residues 1 to 3169)
  AUTHORS   Al-Hamed,M.H., Sayer,J.A., Alsahan,N., Tulbah,M., Kurdi,W.,
            Ambusaidi,Q., Ali,W. and Imtiaz,F.
  TITLE     Novel loss of function variants in FRAS1 AND FREM2 underlie renal
            agenesis in consanguineous families
  JOURNAL   J Nephrol 34 (3), 893-900 (2021)
   PUBMED   32643034
  REMARK    GeneRIF: Novel loss of function variants in FRAS1 AND FREM2
            underlie renal agenesis in consanguineous families.
REFERENCE   3  (residues 1 to 3169)
  AUTHORS   Zhang,X., Wang,D., Dongye,M., Zhu,Y., Chen,C., Wang,R., Long,E.,
            Liu,Z., Wu,X., Lin,D., Chen,J., Lin,Z., Wang,J., Li,W., Li,Y.,
            Li,D. and Lin,H.
  TITLE     Loss-of-function mutations in FREM2 disrupt eye morphogenesis
  JOURNAL   Exp Eye Res 181, 302-312 (2019)
   PUBMED   30802441
  REMARK    GeneRIF: Our findings extend the spectrum of FREM2 mutations, and
            provide insights into opportunities for the prenatal diagnosis of
            isolated cryptophthalmos. Furthermore, our work highlights the
            importance of the FREM2 protein during the development of eyelids
            and the anterior segment of the eyeballs, establishes a suitable
            animal model for studying epithelial reopening during eyelid
            development and serves as a valuable reference
REFERENCE   4  (residues 1 to 3169)
  AUTHORS   Yu,Q., Lin,B., Xie,S., Gao,S., Li,W., Liu,Y., Wang,H., Huang,D. and
            Xie,Z.
  TITLE     A homozygous mutation p.Arg2167Trp in FREM2 causes isolated
            cryptophthalmos
  JOURNAL   Hum Mol Genet 27 (13), 2357-2366 (2018)
   PUBMED   29688405
  REMARK    GeneRIF: Our results showed that p.Arg2167Trp had a weaker effect
            in interrupting interactions between FREM2 and FREM1 than
            FS-associated missense mutation p.Glu1972Lys. Overall, our data
            demonstrate that the homozygous mutation p.Arg2167Trp in FREM2
            causes isolated Cryptophthalmos(CO), which will facilitate our
            better understanding of the molecular mechanisms underlying the
            disease
REFERENCE   5  (residues 1 to 3169)
  AUTHORS   Vidak,M., Jovcevska,I., Samec,N., Zottel,A., Liovic,M., Rozman,D.,
            Dzeroski,S., Juvan,P. and Komel,R.
  TITLE     Meta-Analysis and Experimental Validation Identified FREM2 and
            SPRY1 as New Glioblastoma Marker Candidates
  JOURNAL   Int J Mol Sci 19 (5), 1369 (2018)
   PUBMED   29734672
  REMARK    GeneRIF: FREM2 is thus proposed as a novel GB biomarker and a
            putative biomarker of glioblastoma stem cells. Both FREM2 and SPRY1
            are expressed on the surface of the GB cells, while SPRY1 alone was
            found overexpressed in the cytosol of non-malignant astrocytes.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 3169)
  AUTHORS   Kiyozumi,D., Sugimoto,N. and Sekiguchi,K.
  TITLE     Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1,
            and Frem2 at the basement membrane provokes Fraser syndrome-like
            defects
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11981-11986 (2006)
   PUBMED   16880404
REFERENCE   7  (residues 1 to 3169)
  AUTHORS   Jadeja,S., Smyth,I., Pitera,J.E., Taylor,M.S., van Haelst,M.,
            Bentley,E., McGregor,L., Hopkins,J., Chalepakis,G., Philip,N.,
            Perez Aytes,A., Watt,F.M., Darling,S.M., Jackson,I., Woolf,A.S. and
            Scambler,P.J.
  TITLE     Identification of a new gene mutated in Fraser syndrome and mouse
            myelencephalic blebs
  JOURNAL   Nat Genet 37 (5), 520-525 (2005)
   PUBMED   15838507
REFERENCE   8  (residues 1 to 3169)
  AUTHORS   Smyth,I., Du,X., Taylor,M.S., Justice,M.J., Beutler,B. and
            Jackson,I.J.
  TITLE     The extracellular matrix gene Frem1 is essential for the normal
            adhesion of the embryonic epidermis
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13560-13565 (2004)
   PUBMED   15345741
REFERENCE   9  (residues 1 to 3169)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   10 (residues 1 to 3169)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN291155.1, BN000687.1,
            KF455770.1, AL354819.15 and BX640686.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 19, 2014 this sequence version replaced NP_997244.3.
            
            Summary: This gene encodes an integral membrane protein containing
            numerous CSPG (chondroitin sulfate proteoglycan element) repeats
            and Calx-beta domains. The encoded protein localizes to the
            basement membrane, forming a ternary complex that plays a role in
            epidermal-dermal interactions. This protein is important for the
            integrity of skin and renal epithelia. Mutations in this gene are
            associated with Fraser syndrome. [provided by RefSeq, Apr 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280481.9/ ENSP00000280481.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3169
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     Protein         1..3169
                     /product="FRAS1-related extracellular matrix protein 2
                     precursor"
                     /note="ECM3 homolog; FRAS1 related extracellular matrix
                     protein 2"
                     /calculated_mol_wt=346383
     sig_peptide     1..46
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4804
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     mat_peptide     47..3169
                     /product="FRAS1-related extracellular matrix protein 2.
                     /id=PRO_0000010124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
                     /calculated_mol_wt=346383
     Region          72..284
                     /region_name="Frem_N"
                     /note="Frem protein N-terminal domain; pfam19309"
                     /db_xref="CDD:466034"
     Region          319..413
                     /region_name="CSPG 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          <336..396
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Site            358
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          422..539
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          438..537
                     /region_name="CSPG 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          543..676
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          560..675
                     /region_name="CSPG 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          683..808
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          700..807
                     /region_name="CSPG 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          815..920
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          828..919
                     /region_name="CSPG 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          923..1038
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          945..1037
                     /region_name="CSPG 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          1053..1170
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1066..1168
                     /region_name="CSPG 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          1174..1284
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1189..1282
                     /region_name="CSPG 8.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Site            1244
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          1286..1401
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1303..1399
                     /region_name="CSPG 9.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Site            1369
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          1406..1514
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1420..1512
                     /region_name="CSPG 10.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          1516..1623
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1532..1621
                     /region_name="CSPG 11.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Site            1584
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          1641..1754
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1655..1752
                     /region_name="CSPG 12.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01201"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Site            1741
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952; propagated from
                     UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          <1771..>1984
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     Region          <1990..>2223
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     Region          <2108..>2364
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     Region          3036..3057
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Site            3114..3134
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     Region          3141..3169
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SZK8.3)"
     CDS             1..3169
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /coded_by="NM_207361.6:269..9778"
                     /db_xref="CCDS:CCDS31960.1"
                     /db_xref="GeneID:341640"
                     /db_xref="HGNC:HGNC:25396"
                     /db_xref="MIM:608945"
ORIGIN      
        1 mhsagtpgls srrtgnstsf qpgppppprl llllllllsl vsrvpaqpaa fgrallspgl
       61 agaagvpaee aivlanrglr vpfgrevwld plhdlvlqvq pgdrcavsvl dndalaqrpg
      121 rlspkrfpcd fgpgevrysh lgarspsrdr vrlqlrydap ggavvlplvl evevvftqle
      181 vvtrnlplvv eellgtsnal darslefafq peteecrvgi lsglgalpry gellhypqvp
      241 ggareggape tllmdckafq elgvryrhta asrspnrdwi pmvvelrsrg apvgspalkr
      301 ehfqvlvrir ggaentapkp sfvammmmev dqfvltaltp dmlaaedaes psdllifnlt
      361 spfqpgqgyl vstddrslpl ssftqrdlrl lkiayqppse dsdqerlfel elevvdlega
      421 asdpfafmvv vkpmntmapv vtrntglily egqsrpltgp agsgpqnlvi sdeddleavr
      481 levvaglrhg hlvilgassg ssapksftva elaagqvvyq hddrdgslsd nlvlrmvdgg
      541 grhqvqflfp itlvpvddqp pvlnantglt laegetvpil plslsatdmd sddslllfvl
      601 espflttghl llrqthpphe kqellrglwr kegafyertv tewqqqdite grlfyrhsgp
      661 hspgpvtdqf tfrvqdnhdp pnqsglqrfv irihpvdrlp pelgsgcplr mvvqesqltp
      721 lrkkwlrytd ldtddrelry tvtqpptdtd enhlpaplgt lvltdnpsvv vthftqaqin
      781 hhkiayrppg qelgvatrva qfqfqvedra gnvapgtftl ylhpvdnqpp eilntgftiq
      841 ekghhilset elhvndvdtd vahisftltq apkhghmrvs gqilhvgglf hledikqgrv
      901 syahngdksl tdscslevsd rhhvvpitlr vnvrpvddev pilshptgtl esyldvleng
      961 ateitanvik gtneetddlm ltflledppl ygeilvngip aeqftqrdil egsvvythts
     1021 geigllpkad sfnlslsdms qewriggnti qgvtiwvtil pvdsqapeif vgeqlivmeg
     1081 dksvitsvhi saedvdslnd dilctiviqp tsgyvenisp apgseksrag iaisafnlkd
     1141 lrqghinyvq svhkgvepve drfvfrcsdg infserqffp iviiptndeq pemfmrefmv
     1201 megmslvidt pilnaadadv plddltftit qfpthghimn qlingtvlve sftldqiies
     1261 ssiiyehdds etqedsfvik ltdgkhsvek tvliivipvd detprmtinn gleieigdtk
     1321 iinnkilmat dldsedkslv yiirygpghg llqrrkptga fenitlgmnf tqdevdrnli
     1381 qyvhlgqegi rdlikfdvtd ginplidryf yvsigsidiv fpdviskgvs lkeggkvtlt
     1441 tdllstsdln spdenlvfti trapmrghle ctdqpgvsit sftqlqlagn kiyyihtadd
     1501 evkmdsfefq vtdgrnpvfr tfrisisdvd nkkpvvtihk lvvsesenkl itpfeltved
     1561 rdtpdkllkf titqvpihgh llfnntrpvm vftkqdlnen lisykhdgte ssedsfsftv
     1621 tdgthtdfyv fpdtvfetrr pqvmkiqvla vdnsvpqiav nkgastlrtl atghlgfmit
     1681 skilkvedrd slhislrfiv teapqhgyll nldkgnhsit qftqadiddm kicyvlrega
     1741 natsdmfyfa vedgggnklt yqnfrlnwaw isfekeyylv nedskfldvv lkrrgylget
     1801 sfisigtrdr taekdkdfkg kaqkqvqfnp gqtratwrvr ilsdgeheqs etfqvvlsep
     1861 vlaalefptv atveivdpgd eptvfipqsk ysveedvgel fipirrsgdv sqelmvvcyt
     1921 qqgtatgtvp tsvlsysdyi srpedhtsvv rfdkderekl criviiddsl yeeeetfhvl
     1981 lsmpmggrig sefpgaqvti vpdkddepif yfgdveysvd esagyvevqv wrtgtdlsks
     2041 ssvtvrsrkt dppsadagtd yvgisrnldf apgvnmqpvr vvilddlgqp alegiekfel
     2101 vlrmpmnaal gepskatvsi ndsvsdlpkm qfkeriytgs esdgqivtmi hrtgdvqyrs
     2161 svrcytrqgs aqvmmdfeer pntdtsiitf lpgetekpci lelmddvlye eveelrlvlg
     2221 tpqsnspfga avgeqnetli rirddadktv ikfgetkfsv tepkepgesv viripvirqg
     2281 dtskvsivrv htkdgsatsg edyhpvseei efkegetqhv veievtfdgv remreaftvh
     2341 lkpdenmiae mqltkaivyi eemssmadvt fpsvpqivsl lmyddtskak esaepmsgyp
     2401 vicitacnpk ysdydktgsi casenindtl tryrwlisap agpdgvtspm revdfdtfft
     2461 sskmvtldsi yfqpgsrvqc aaravntngd eglelmspiv tisreeglcq prvpgvvgae
     2521 pfsaklrytg pedadytnli kltvtmphid gmlpvistre lsnfeltlsp dgtrvgnhkc
     2581 snlldytevk thygfltdat knpeiigety pyqyslsirg sttlrfyrnl nleaclwefv
     2641 syydmsella dcggtigtdg qvlnlvqsyv tlrvplyvsy vfhspvgvgg wqhfdlksel
     2701 rltfvydtai lwndgigspp eaelqgslyp tsmrigdegr lavhfkteaq fhglfvlshp
     2761 asftssvims adhpgltfsl rlirseptyn qpvqqwsfvs dfavrdysgt ytvklvpcta
     2821 pshqeyrlpv tcnprepvtf dldirfqqvs dpvaaefsln tqmyllskks lwlsdgsmgf
     2881 gqesdvafae gdiiygrvmv dpvqnlgdsf ycsiekvflc tgadgyvpky spmnaeygcl
     2941 adspsllyrf kivdkaqpet qatsfgnvlf naklavddpe aillvnqpgs dgfkvdstpl
     3001 fqvalgrewy ihtiytvrsk dnanrgigkr sveyhslvsq gkpqsttksr kkreirstps
     3061 laweigaens rgtniqhial drtkrqiphg rappdgilpw elnspssavs lvtvvggttv
     3121 gllticltvi avlmcrgkes frgkdapkgs sssepmvppq shhndssev
//
