LOCUS       XM_017014322            7352 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1
            (FREM1), transcript variant X6, mRNA.
ACCESSION   XM_017014322
VERSION     XM_017014322.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017014322.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..7352
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /note="FRAS1 related extracellular matrix 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 16 ESTs, 170 long SRA reads, 3 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 13 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:158326"
                     /db_xref="HGNC:HGNC:23399"
                     /db_xref="MIM:608944"
     CDS             542..7108
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /codon_start=1
                     /product="FRAS1-related extracellular matrix protein 1
                     isoform X1"
                     /protein_id="XP_016869811.1"
                     /db_xref="GeneID:158326"
                     /db_xref="HGNC:HGNC:23399"
                     /db_xref="MIM:608944"
                     /translation="MNSLSWGAANAVLLLLLLAWASPTFISINRGVRVMKGHSAFLSG
                     DDLKFAIPKEKDACKVEVVMNEPITQRVGKLTPQVFDCHFLPNEVKYVHNGCPILDED
                     TVKLRLYRFTERDTFIETFILWVYLLEPDCNIIHMSNNVLEVPEFNGLSQAIDKNLLR
                     FDYDRMASLECTVSLDTARTRLPAHGQMVLGEPRPEEPRGDQPHSFFPESRMMSFNAF
                     LELRAKLKCPGGSCTPGLKKIGSLKVSCEEFLLMGLRYQHLDPPSPNIDYISIQLDLT
                     DTRSKIVYKSESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSLTTSVLDCEED
                     ETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPPNSSHSERRHD
                     EVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQFQVVD
                     NDDIGAVRLVTVGGLQHGWLTLRGGKGFLFTVADLQAGVVRYHHDDSDSTKDFVVFRI
                     FDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYI
                     FFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLW
                     DSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSES
                     YDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKV
                     AYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEAFTNPLKVTE
                     GGQSIISTEHILISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLK
                     VRYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGG
                     EVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVTYKH
                     TGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPVD
                     NQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPS
                     VGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPF
                     SIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGL
                     LIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQL
                     SDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKI
                     YYVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTF
                     YLWDGNNRSPALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPE
                     ELLYVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIIS
                     NGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLT
                     FLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDGTNQ
                     GFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKAS
                     DPDTEDDQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSD
                     TVEFQIMDPTGNSATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFV
                     GIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPV
                     NAVLGTKTKAAVKILDSKGGQCHPSYSSNQSKHSTWEKGIWHLLPPGSSSSTTSGSFH
                     LERRPLPSSMQLAVIRGDTLRGFDSTDLSQRKLRTRGNGKTVRPSSVYRNGTDIIYNY
                     HGIVSLKLEDDSFPTHKRKAKVSIISQPQKTIKVAELPQADKVESTTDSHFPRQDQLP
                     SFPKNCTLELKGLFHFEEGIQKLYQCNGIAWKAWSPQTKDVEDKSCPAGWHQHSGYCH
                     ILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMRWLWDIGGRKSFWIGLNDQVHAGH
                     WEWIGGEPVAFTNGRRGPSQRSKLGKSCVLVQRQGKWQTKDCRRAKPHNYVCSRKL"
ORIGIN      
        1 agtacaaaac tagtagtgag aaaggaagct gggaagagac tgggaagagg caaccgacct
       61 cattaacaaa agctcagttt tgtccctgcg gacccaacca gcagaaggca cggggctagc
      121 ggtggctgtc cgccagggag gtcgggctct gtgtaaacag tagaaggcat ctttatcatg
      181 cccttctcac agggagtcct gaggcttggc gctcaggaag tttgcaaagc tgcagcagct
      241 gccttggaga agaccagcaa agaaagtgga gtgtgattag aaaagcactt gggaagccca
      301 ttaatcttgc cggcgttgtc aggagtgatc agcgagtttt attaaaagcc ctgggattgc
      361 ctgaaaggcc cccttgtctg actttgaaat gaaaggggca tgttaagatc tcggggcaca
      421 ttgtcaggac ccctcaccct gccccttgga ctatgagctg accctccagg aggaagcaca
      481 gaagccctcc tttgttaaag ggatttcgcc ggtggacaga gaagagttgg gccctgtcag
      541 catgaactct ctgagttggg gggctgcgaa tgccgtgctg ctgctgctcc tcctggcctg
      601 ggccagcccc accttcatca gcatcaaccg cggggtgagg gtgatgaagg gccactctgc
      661 cttcctgtca ggagatgacc tgaagtttgc catccctaaa gagaaagatg cctgcaaagt
      721 ggaagttgtg atgaatgagc caataaccca gagggttggg aaactcactc cacaggtctt
      781 tgactgccat ttccttccca acgaagtcaa gtatgttcac aatggttgtc caattcttga
      841 tgaagacaca gtgaagctca gactttacag atttactgaa agagatacct tcatagaaac
      901 ttttatcctg tgggtctatc tcctggaacc agactgtaac atcatccata tgagtaacaa
      961 tgtgctggag gtgcctgaat tcaatggctt gtcccaagcg attgataaaa atctgctcag
     1021 attcgattat gataggatgg ctagcctgga atgtaccgtc agcctggaca ctgcgagaac
     1081 tcggctgcca gcccatggcc agatggttct cggggagcct cgaccagaag aacctcgtgg
     1141 agatcagcca cacagttttt tcccagagtc ccgtatgatg tcttttaatg cctttctgga
     1201 actgagagca aaactgaagt gtccaggtgg gagctgtacc ccaggattaa agaaaatagg
     1261 aagcctcaaa gtgagctgtg aggagttcct gctgatgggc cttcgttatc agcatctgga
     1321 tcccccttca cccaacattg attatatctc catccaactg gacctcacag ataccaggag
     1381 caaaattgtg tacaagtcag agagtgcgtg gctgcctgtc tatatcagag ctggaattcc
     1441 gaatcagatt ccaaaggctg cattcatggc cgtgtttatt ctggaagtgg atcagttcat
     1501 cctgacctcc ttgactacat cagttctgga ctgtgaagaa gatgagaccc ctaaaccctt
     1561 gctggtgttc aacattacta aagccccgct ccagggctat gtgactcacc tgttggatca
     1621 caccagacca atctcctcat tcacctggaa agatctcagt gacatgcaga tcgcctatca
     1681 gccaccaaac agcagccatt ctgagaggag acatgatgag gtagaattgg aggtatacga
     1741 cttcttcttt gaaaggagtg cacctatgac agtccacatc tccatcagaa cagcagatac
     1801 aaatgccccc cgtgtatcct ggaatacagg tctgagtctc cttgaggggc agtctcgagc
     1861 catcacttgg gaacagtttc aggttgtcga caatgacgac attggtgctg tccggctagt
     1921 caccgttggt ggcctgcagc atggatggct gactttaaga ggggggaaag ggtttctctt
     1981 caccgtggct gacctccagg ctggagttgt tcgctatcat catgatgaca gcgactccac
     2041 caaagacttc gtggtcttcc ggatatttga tggccatcac agcatccgtc acaaattccc
     2101 catcaacgtc ttgcccaaag atgatagtcc cccgttcctc ataaccaatg ttgtgattga
     2161 actggaggag gggcagacca tcctgatcca gggatccatg ctgcgagctt cagatgtgga
     2221 cgccagtgat gactacatct tcttcaatat cacaaagcct ccacaggctg gggagatcat
     2281 gaagaagcca gggccaggac tgataggcta tcctgtccat ggcttccttc agagggattt
     2341 gtttaatgga atcatttatt atcgtcattt tggtggagaa atctttgaag attcttttca
     2401 atttgtcctg tgggacagcc atgaacctcc aaatctttca gtgccacagg tggcaacaat
     2461 ccatataact ccagtggatg accagcttcc aaaagaggct cctggagttt ctcggcattt
     2521 ggttgtcaag gaaactgagg tggcctatat aactaagaaa cagctacatt ttatagattc
     2581 agaatcatat gacagggagc tggtctacac aataactact cctccatttt tctccttcag
     2641 ccacagacac ttggatgctg ggaaattatt tatggtggac agcataccaa aagtagttaa
     2701 gaatcctacg gccctggagc tgaggtcatt cactcagcat gctgtgaact atatgaaagt
     2761 ggcctacatg ccccccatgc aagacattgg tccccattgc agagatgtcc agttcacatt
     2821 ttctgtcagt aaccaacatg gcggtacttt gcatgggatc tgctttaaca ttacaatcct
     2881 cccagtggac aatcaagttc ctgaggcgtt caccaaccct ctgaaagtga ctgagggagg
     2941 tcaaagcatc atcagcacag agcacattct aatttctgat gcagatacca agctggacaa
     3001 tattgacctc tccctgcggg aattgcctct gcacggaagg gtggagctga atggatttcc
     3061 tctaaattca gggggcacat tttcttgggg cgatctccat accttaaaag ttaggtatca
     3121 acatgatgga actgaagttc ttcaggatga cctactcttg gaggtcaccg atggcacaaa
     3181 ttcagcagaa tttgtactac atgttgaggt attccctgtc aacgatgagc caccagtctt
     3241 aaaggctgac ctcatgcctg tcatgaattg ctcagaggga ggagaggtgg tcatcacctc
     3301 tgaatacatt tttgctactg atgtggacag cgataacttg aagttgatgt ttgtgattgc
     3361 tcgcgaacct cagcatgggg tggtgaggag agctggagtc acagtggatc agttctctca
     3421 gagagatgtt atctcagagg ccgtgacata caaacacaca ggtggcgaga ttggcctgat
     3481 gccttgtttt gacaccatta cattggtggt ttcggatgga gaggctggcc cttttgtgaa
     3541 tggctgttgc tacaatggac ccaatccatc tgttccactt catgcgtcct ttccagtgta
     3601 tgatctcaac atcacggtat acccagtaga caaccagcca ccttccattg caataggtcc
     3661 cgtgtttgtt gtagatgagg gctgctcaac agcccttact gttaaccatt tgtccgccac
     3721 tgaccctgac actgcagcag atgacttgga atttgttttg gtttctcctc ctcagtttgg
     3781 ctacctcgaa aatatactcc cttctgtggg ttttgaaaaa agcaatattg gcataagtat
     3841 agattcattt cagtggaaag acatgaacgc ttttcacatt aactatgtgc agtccaggca
     3901 tctgaggata gaaccaactg ccgaccagtt cacggtgtac gtcacagatg ggaagcatca
     3961 ctccttggag ataccatttt ctattataat caaccccaca aatgatgaag ctcctgactt
     4021 tgtagtgcag aatattactg tgtgtgaggg tcagatgaaa gagctggact cttccatcat
     4081 cagcgctgtg gacctggaca ttccccagga tgccctgctg ttcagcatca ctcaaaagcc
     4141 acgccatggc ctcctcatcg atagggggtt tagcaaagac ttctctgaga ataagcagcc
     4201 agccaaccct caccagaaac atgcacctgt tcacagcttt tccatggaac tcctcaagac
     4261 tggaatgagg ttgacgtaca tgcatgatga ctcagagagc cttgctgatg attttacaat
     4321 ccaattgtca gatgggaaac ataagatact taaaaccatt tcagtagagg tcatcccagt
     4381 taatgatgaa aaaccaatgc tgagcaagaa ggctgaaatt gcaatgaata tgggtgaaac
     4441 tcgtattatt tccagtgcta ttctttcagc catagatgaa gactcaccca gggagaagat
     4501 ttactatgta tttgaaaggc ttccccaaaa tgggcaactt cagcttaaga tagggaggga
     4561 ctgggttcct ctctcccctg gcatgaaatg cactcaggag gaagtggatc tgaacttgct
     4621 gagatacaca cacaccgggg caatggattc ccagaatcaa gatagcttca ccttctacct
     4681 ttgggatggc aacaacaggt cccctgctct tgactgtcaa atcaccatca aggacatgga
     4741 aaaaggtgat attgtcatcc ttacaaaacc actcgtggtg tctaaaggtg atagaggttt
     4801 cttaacaacc accacgctcc tggctgtgga cggaacagac aagcctgagg aactgctcta
     4861 tgtcatcacc tcccctccgc gatatggcca gatcgaatat gttcactatc ctggagttcc
     4921 cattacaaac ttcagccaaa tggatgtagt ggggcagaca gtttgctatg tacacaagag
     4981 caaggtgact gtctccagtg acagattcag attcatcatc agcaatggac tgcggaccga
     5041 gcacggggtg tttgagatca cactggagac tgtggacaga gccctgcctg tggtaaccag
     5101 gaacaagggg ttgagactgg cccaaggggc cgtgggcctg ctttcccctg acctccttca
     5161 gctgaccgac cctgatacac ctgcggagaa cctcaccttc ctcttggttc agctccccca
     5221 gcatggccag ctctacctgt gggggacagg gctacttcaa cacaatttca cccagcagga
     5281 tgtggacagc aagaatgtgg cctatcggca ctcaggaggg gactcccaga ctgactgctt
     5341 tactttcatg gccacagatg ggacaaacca aggctttatt gtgaatggga gagtgtggga
     5401 agaacctgtt ttattcacca ttcaggtaga ccaattggac aaaacagctc ctcgtatcac
     5461 actcttgcat tccccttctc aagtggggct cctgaaaaat ggctgctacg ggatttacat
     5521 cacttcccgc gtgttgaagg catcagaccc tgacactgag gacgatcaga tcatctttaa
     5581 aattctacaa ggcccaaaac atggacatct ggagaacaca acaacaggtg aatttatcca
     5641 tgagaaattt agccaaaagg acttaaacag taagactatt ctttacatca taaacccatc
     5701 tttggaagta aattcagata ccgtggaatt tcaaatcatg gaccccacag ggaactcggc
     5761 cactcctcaa attttggaac tgaagtggtc tcatattgaa tggtcacaga ccgaatatga
     5821 agtctgtgag aatgtgggtt tgttgccctt ggaaattatc agaaggggat attccatgga
     5881 ctcggccttt gtgggtataa aggtcaacca agtgtcagct gcagttggaa aagatttcac
     5941 cgtgattcca tctaaactga ttcagtttga cccaggaatg tcaactaaga tgtggaatat
     6001 agcaattacc tatgacggat tagaggaaga tgatgaggtc tttgaagtaa ttctgaactc
     6061 ccctgtgaat gcagttcttg gcacaaagac aaaagctgca gtgaaaattt tggactcaaa
     6121 aggaggacaa tgccatcctt catattcctc caaccaaagc aagcacagca catgggagaa
     6181 gggcatttgg catctgctgc ccccagggtc ttcctcatcc accacttctg gttcctttca
     6241 tctggaaaga agacctcttc catcttccat gcagctagca gtcatcaggg gagacaccct
     6301 gcggggcttt gattctacag atctttctca aaggaagctt aggacccgtg ggaatggcaa
     6361 aacagttcgt ccatcctctg tttatagaaa tggaacagac atcatctata attatcatgg
     6421 gatagtttcc ttgaaactgg aggatgacag tttcccaact cacaaaagga aggccaaagt
     6481 atccatcatt agtcagccac aaaagacaat caaagtggca gaactgcctc aagcagataa
     6541 ggtggaatcc acaactgact cacacttccc cagacaggac cagttgccct catttccaaa
     6601 gaactgcact ctggaattaa agggactctt ccattttgaa gaaggcatcc agaagctgta
     6661 tcagtgcaat gggatcgcct ggaaagcctg gagtccccaa accaaggatg tggaagacaa
     6721 atcctgtcca gccgggtggc accagcactc aggctactgt cacatcttga tcacagagca
     6781 gaaaggcacc tggaatgcgg ctgcccaagc ttgcagggaa caatacctgg gcaaccttgt
     6841 aactgtattc tccaggcagc acatgcggtg gctctgggac attggtggga gaaagtcctt
     6901 ttggataggt ttgaacgacc aagtgcatgc tggccactgg gagtggatcg gtggtgaacc
     6961 tgttgccttc accaatggga gaagagggcc ctctcaacgc tccaagcttg gaaagagctg
     7021 tgttttggtt caaagacaag ggaaatggca aacaaaagac tgtaggagag ccaaacctca
     7081 taattatgtg tgttccagaa aactctaaat ataacagacc ctacaggggg ccacctggag
     7141 tttgtcacct atttattcac aggatctgtg aatattgctc catagaaaac aaattgttat
     7201 gattgagtgg gtataccttt gtgattctgt ctagtgaaaa tgggacattt ttaatagtgc
     7261 cagaaagatt gataaataaa tattttttac aagataagat acaatttttg tatctcaata
     7321 ccttttaaaa taaatgccag cagtattata aa
//
