LOCUS       XM_017014316            7593 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens FRAS1 related extracellular matrix 1
            (FREM1), transcript variant X1, mRNA.
ACCESSION   XM_017014316
VERSION     XM_017014316.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017014316.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..7593
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /note="FRAS1 related extracellular matrix 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 18 ESTs, 180 long SRA reads, 3 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 16 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:158326"
                     /db_xref="HGNC:HGNC:23399"
                     /db_xref="MIM:608944"
     CDS             783..7349
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /codon_start=1
                     /product="FRAS1-related extracellular matrix protein 1
                     isoform X1"
                     /protein_id="XP_016869805.1"
                     /db_xref="GeneID:158326"
                     /db_xref="HGNC:HGNC:23399"
                     /db_xref="MIM:608944"
                     /translation="MNSLSWGAANAVLLLLLLAWASPTFISINRGVRVMKGHSAFLSG
                     DDLKFAIPKEKDACKVEVVMNEPITQRVGKLTPQVFDCHFLPNEVKYVHNGCPILDED
                     TVKLRLYRFTERDTFIETFILWVYLLEPDCNIIHMSNNVLEVPEFNGLSQAIDKNLLR
                     FDYDRMASLECTVSLDTARTRLPAHGQMVLGEPRPEEPRGDQPHSFFPESRMMSFNAF
                     LELRAKLKCPGGSCTPGLKKIGSLKVSCEEFLLMGLRYQHLDPPSPNIDYISIQLDLT
                     DTRSKIVYKSESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSLTTSVLDCEED
                     ETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPPNSSHSERRHD
                     EVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQFQVVD
                     NDDIGAVRLVTVGGLQHGWLTLRGGKGFLFTVADLQAGVVRYHHDDSDSTKDFVVFRI
                     FDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYI
                     FFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLW
                     DSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSES
                     YDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKV
                     AYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEAFTNPLKVTE
                     GGQSIISTEHILISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLK
                     VRYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGG
                     EVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVTYKH
                     TGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPVD
                     NQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPS
                     VGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPF
                     SIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGL
                     LIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQL
                     SDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKI
                     YYVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTF
                     YLWDGNNRSPALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPE
                     ELLYVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIIS
                     NGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLT
                     FLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDGTNQ
                     GFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKAS
                     DPDTEDDQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSD
                     TVEFQIMDPTGNSATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFV
                     GIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPV
                     NAVLGTKTKAAVKILDSKGGQCHPSYSSNQSKHSTWEKGIWHLLPPGSSSSTTSGSFH
                     LERRPLPSSMQLAVIRGDTLRGFDSTDLSQRKLRTRGNGKTVRPSSVYRNGTDIIYNY
                     HGIVSLKLEDDSFPTHKRKAKVSIISQPQKTIKVAELPQADKVESTTDSHFPRQDQLP
                     SFPKNCTLELKGLFHFEEGIQKLYQCNGIAWKAWSPQTKDVEDKSCPAGWHQHSGYCH
                     ILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMRWLWDIGGRKSFWIGLNDQVHAGH
                     WEWIGGEPVAFTNGRRGPSQRSKLGKSCVLVQRQGKWQTKDCRRAKPHNYVCSRKL"
ORIGIN      
        1 agtacaaaac tagtagtgag aaaggaagct gggaagagac tgggaagagg caaccgacct
       61 cattaacaaa agctcagttt tgtccctgcg gacccaacca gcagaaggca cggggctagc
      121 ggtggctgtc cgccagggag gtcgggctct gtgtaaacag tagaaggcat ctttatcatg
      181 cccttctcac agggagtcct gaggcttggc gctcaggaag tttgcaaagc tgcagcagct
      241 gccttggaga agaccagcaa agaaagtgga gtgtgtatgt gaacttcaat tctgtatttt
      301 ctgtgaggtg ggttaatgga tttttagtaa aaagaaatct caaacacagc tgacctgaaa
      361 gactggaatt tcagctctct tccttcccgg ggttcttttt cctccccctt cctctcaaag
      421 ccctttaaac cagattgctg tgtcagtgac tcttatcctg cccgccagtt ccaagggttt
      481 ctaacttttt gtcttggaaa ggaaaaccac tacctgatta gaaaagcact tgggaagccc
      541 attaatcttg ccggcgttgt caggagtgat cagcgagttt tattaaaagc cctgggattg
      601 cctgaaaggc ccccttgtct gactttgaaa tgaaaggggc atgttaagat ctcggggcac
      661 attgtcagga cccctcaccc tgccccttgg actatgagct gaccctccag gaggaagcac
      721 agaagccctc ctttgttaaa gggatttcgc cggtggacag agaagagttg ggccctgtca
      781 gcatgaactc tctgagttgg ggggctgcga atgccgtgct gctgctgctc ctcctggcct
      841 gggccagccc caccttcatc agcatcaacc gcggggtgag ggtgatgaag ggccactctg
      901 ccttcctgtc aggagatgac ctgaagtttg ccatccctaa agagaaagat gcctgcaaag
      961 tggaagttgt gatgaatgag ccaataaccc agagggttgg gaaactcact ccacaggtct
     1021 ttgactgcca tttccttccc aacgaagtca agtatgttca caatggttgt ccaattcttg
     1081 atgaagacac agtgaagctc agactttaca gatttactga aagagatacc ttcatagaaa
     1141 cttttatcct gtgggtctat ctcctggaac cagactgtaa catcatccat atgagtaaca
     1201 atgtgctgga ggtgcctgaa ttcaatggct tgtcccaagc gattgataaa aatctgctca
     1261 gattcgatta tgataggatg gctagcctgg aatgtaccgt cagcctggac actgcgagaa
     1321 ctcggctgcc agcccatggc cagatggttc tcggggagcc tcgaccagaa gaacctcgtg
     1381 gagatcagcc acacagtttt ttcccagagt cccgtatgat gtcttttaat gcctttctgg
     1441 aactgagagc aaaactgaag tgtccaggtg ggagctgtac cccaggatta aagaaaatag
     1501 gaagcctcaa agtgagctgt gaggagttcc tgctgatggg ccttcgttat cagcatctgg
     1561 atcccccttc acccaacatt gattatatct ccatccaact ggacctcaca gataccagga
     1621 gcaaaattgt gtacaagtca gagagtgcgt ggctgcctgt ctatatcaga gctggaattc
     1681 cgaatcagat tccaaaggct gcattcatgg ccgtgtttat tctggaagtg gatcagttca
     1741 tcctgacctc cttgactaca tcagttctgg actgtgaaga agatgagacc cctaaaccct
     1801 tgctggtgtt caacattact aaagccccgc tccagggcta tgtgactcac ctgttggatc
     1861 acaccagacc aatctcctca ttcacctgga aagatctcag tgacatgcag atcgcctatc
     1921 agccaccaaa cagcagccat tctgagagga gacatgatga ggtagaattg gaggtatacg
     1981 acttcttctt tgaaaggagt gcacctatga cagtccacat ctccatcaga acagcagata
     2041 caaatgcccc ccgtgtatcc tggaatacag gtctgagtct ccttgagggg cagtctcgag
     2101 ccatcacttg ggaacagttt caggttgtcg acaatgacga cattggtgct gtccggctag
     2161 tcaccgttgg tggcctgcag catggatggc tgactttaag aggggggaaa gggtttctct
     2221 tcaccgtggc tgacctccag gctggagttg ttcgctatca tcatgatgac agcgactcca
     2281 ccaaagactt cgtggtcttc cggatatttg atggccatca cagcatccgt cacaaattcc
     2341 ccatcaacgt cttgcccaaa gatgatagtc ccccgttcct cataaccaat gttgtgattg
     2401 aactggagga ggggcagacc atcctgatcc agggatccat gctgcgagct tcagatgtgg
     2461 acgccagtga tgactacatc ttcttcaata tcacaaagcc tccacaggct ggggagatca
     2521 tgaagaagcc agggccagga ctgataggct atcctgtcca tggcttcctt cagagggatt
     2581 tgtttaatgg aatcatttat tatcgtcatt ttggtggaga aatctttgaa gattcttttc
     2641 aatttgtcct gtgggacagc catgaacctc caaatctttc agtgccacag gtggcaacaa
     2701 tccatataac tccagtggat gaccagcttc caaaagaggc tcctggagtt tctcggcatt
     2761 tggttgtcaa ggaaactgag gtggcctata taactaagaa acagctacat tttatagatt
     2821 cagaatcata tgacagggag ctggtctaca caataactac tcctccattt ttctccttca
     2881 gccacagaca cttggatgct gggaaattat ttatggtgga cagcatacca aaagtagtta
     2941 agaatcctac ggccctggag ctgaggtcat tcactcagca tgctgtgaac tatatgaaag
     3001 tggcctacat gccccccatg caagacattg gtccccattg cagagatgtc cagttcacat
     3061 tttctgtcag taaccaacat ggcggtactt tgcatgggat ctgctttaac attacaatcc
     3121 tcccagtgga caatcaagtt cctgaggcgt tcaccaaccc tctgaaagtg actgagggag
     3181 gtcaaagcat catcagcaca gagcacattc taatttctga tgcagatacc aagctggaca
     3241 atattgacct ctccctgcgg gaattgcctc tgcacggaag ggtggagctg aatggatttc
     3301 ctctaaattc agggggcaca ttttcttggg gcgatctcca taccttaaaa gttaggtatc
     3361 aacatgatgg aactgaagtt cttcaggatg acctactctt ggaggtcacc gatggcacaa
     3421 attcagcaga atttgtacta catgttgagg tattccctgt caacgatgag ccaccagtct
     3481 taaaggctga cctcatgcct gtcatgaatt gctcagaggg aggagaggtg gtcatcacct
     3541 ctgaatacat ttttgctact gatgtggaca gcgataactt gaagttgatg tttgtgattg
     3601 ctcgcgaacc tcagcatggg gtggtgagga gagctggagt cacagtggat cagttctctc
     3661 agagagatgt tatctcagag gccgtgacat acaaacacac aggtggcgag attggcctga
     3721 tgccttgttt tgacaccatt acattggtgg tttcggatgg agaggctggc ccttttgtga
     3781 atggctgttg ctacaatgga cccaatccat ctgttccact tcatgcgtcc tttccagtgt
     3841 atgatctcaa catcacggta tacccagtag acaaccagcc accttccatt gcaataggtc
     3901 ccgtgtttgt tgtagatgag ggctgctcaa cagcccttac tgttaaccat ttgtccgcca
     3961 ctgaccctga cactgcagca gatgacttgg aatttgtttt ggtttctcct cctcagtttg
     4021 gctacctcga aaatatactc ccttctgtgg gttttgaaaa aagcaatatt ggcataagta
     4081 tagattcatt tcagtggaaa gacatgaacg cttttcacat taactatgtg cagtccaggc
     4141 atctgaggat agaaccaact gccgaccagt tcacggtgta cgtcacagat gggaagcatc
     4201 actccttgga gataccattt tctattataa tcaaccccac aaatgatgaa gctcctgact
     4261 ttgtagtgca gaatattact gtgtgtgagg gtcagatgaa agagctggac tcttccatca
     4321 tcagcgctgt ggacctggac attccccagg atgccctgct gttcagcatc actcaaaagc
     4381 cacgccatgg cctcctcatc gatagggggt ttagcaaaga cttctctgag aataagcagc
     4441 cagccaaccc tcaccagaaa catgcacctg ttcacagctt ttccatggaa ctcctcaaga
     4501 ctggaatgag gttgacgtac atgcatgatg actcagagag ccttgctgat gattttacaa
     4561 tccaattgtc agatgggaaa cataagatac ttaaaaccat ttcagtagag gtcatcccag
     4621 ttaatgatga aaaaccaatg ctgagcaaga aggctgaaat tgcaatgaat atgggtgaaa
     4681 ctcgtattat ttccagtgct attctttcag ccatagatga agactcaccc agggagaaga
     4741 tttactatgt atttgaaagg cttccccaaa atgggcaact tcagcttaag atagggaggg
     4801 actgggttcc tctctcccct ggcatgaaat gcactcagga ggaagtggat ctgaacttgc
     4861 tgagatacac acacaccggg gcaatggatt cccagaatca agatagcttc accttctacc
     4921 tttgggatgg caacaacagg tcccctgctc ttgactgtca aatcaccatc aaggacatgg
     4981 aaaaaggtga tattgtcatc cttacaaaac cactcgtggt gtctaaaggt gatagaggtt
     5041 tcttaacaac caccacgctc ctggctgtgg acggaacaga caagcctgag gaactgctct
     5101 atgtcatcac ctcccctccg cgatatggcc agatcgaata tgttcactat cctggagttc
     5161 ccattacaaa cttcagccaa atggatgtag tggggcagac agtttgctat gtacacaaga
     5221 gcaaggtgac tgtctccagt gacagattca gattcatcat cagcaatgga ctgcggaccg
     5281 agcacggggt gtttgagatc acactggaga ctgtggacag agccctgcct gtggtaacca
     5341 ggaacaaggg gttgagactg gcccaagggg ccgtgggcct gctttcccct gacctccttc
     5401 agctgaccga ccctgataca cctgcggaga acctcacctt cctcttggtt cagctccccc
     5461 agcatggcca gctctacctg tgggggacag ggctacttca acacaatttc acccagcagg
     5521 atgtggacag caagaatgtg gcctatcggc actcaggagg ggactcccag actgactgct
     5581 ttactttcat ggccacagat gggacaaacc aaggctttat tgtgaatggg agagtgtggg
     5641 aagaacctgt tttattcacc attcaggtag accaattgga caaaacagct cctcgtatca
     5701 cactcttgca ttccccttct caagtggggc tcctgaaaaa tggctgctac gggatttaca
     5761 tcacttcccg cgtgttgaag gcatcagacc ctgacactga ggacgatcag atcatcttta
     5821 aaattctaca aggcccaaaa catggacatc tggagaacac aacaacaggt gaatttatcc
     5881 atgagaaatt tagccaaaag gacttaaaca gtaagactat tctttacatc ataaacccat
     5941 ctttggaagt aaattcagat accgtggaat ttcaaatcat ggaccccaca gggaactcgg
     6001 ccactcctca aattttggaa ctgaagtggt ctcatattga atggtcacag accgaatatg
     6061 aagtctgtga gaatgtgggt ttgttgccct tggaaattat cagaagggga tattccatgg
     6121 actcggcctt tgtgggtata aaggtcaacc aagtgtcagc tgcagttgga aaagatttca
     6181 ccgtgattcc atctaaactg attcagtttg acccaggaat gtcaactaag atgtggaata
     6241 tagcaattac ctatgacgga ttagaggaag atgatgaggt ctttgaagta attctgaact
     6301 cccctgtgaa tgcagttctt ggcacaaaga caaaagctgc agtgaaaatt ttggactcaa
     6361 aaggaggaca atgccatcct tcatattcct ccaaccaaag caagcacagc acatgggaga
     6421 agggcatttg gcatctgctg cccccagggt cttcctcatc caccacttct ggttcctttc
     6481 atctggaaag aagacctctt ccatcttcca tgcagctagc agtcatcagg ggagacaccc
     6541 tgcggggctt tgattctaca gatctttctc aaaggaagct taggacccgt gggaatggca
     6601 aaacagttcg tccatcctct gtttatagaa atggaacaga catcatctat aattatcatg
     6661 ggatagtttc cttgaaactg gaggatgaca gtttcccaac tcacaaaagg aaggccaaag
     6721 tatccatcat tagtcagcca caaaagacaa tcaaagtggc agaactgcct caagcagata
     6781 aggtggaatc cacaactgac tcacacttcc ccagacagga ccagttgccc tcatttccaa
     6841 agaactgcac tctggaatta aagggactct tccattttga agaaggcatc cagaagctgt
     6901 atcagtgcaa tgggatcgcc tggaaagcct ggagtcccca aaccaaggat gtggaagaca
     6961 aatcctgtcc agccgggtgg caccagcact caggctactg tcacatcttg atcacagagc
     7021 agaaaggcac ctggaatgcg gctgcccaag cttgcaggga acaatacctg ggcaaccttg
     7081 taactgtatt ctccaggcag cacatgcggt ggctctggga cattggtggg agaaagtcct
     7141 tttggatagg tttgaacgac caagtgcatg ctggccactg ggagtggatc ggtggtgaac
     7201 ctgttgcctt caccaatggg agaagagggc cctctcaacg ctccaagctt ggaaagagct
     7261 gtgttttggt tcaaagacaa gggaaatggc aaacaaaaga ctgtaggaga gccaaacctc
     7321 ataattatgt gtgttccaga aaactctaaa tataacagac cctacagggg gccacctgga
     7381 gtttgtcacc tatttattca caggatctgt gaatattgct ccatagaaaa caaattgtta
     7441 tgattgagtg ggtatacctt tgtgattctg tctagtgaaa atgggacatt tttaatagtg
     7501 ccagaaagat tgataaataa atatttttta caagataaga tacaattttt gtatctcaat
     7561 accttttaaa ataaatgcca gcagtattat aaa
//
