LOCUS       NM_001379081            7566 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens FRAS1 related extracellular matrix 1 (FREM1),
            transcript variant 13, mRNA.
ACCESSION   NM_001379081 XM_005251382
VERSION     NM_001379081.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7566)
  AUTHORS   Chen,X., Yu,B., Wang,Z., Li,Q., Dai,C. and Wei,J.
  TITLE     Two novel mutations within FREM1 gene in patients with bifid nose
  JOURNAL   BMC Pediatr 23 (1), 631 (2023)
   PUBMED   38097983
  REMARK    GeneRIF: Two novel mutations within FREM1 gene in patients with
            bifid nose.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7566)
  AUTHORS   Kashem,M.A., Lischynski,J., Stojak,B., Li,L., Yuan,X.Y., Liang,B.,
            Kimani,J., Plummer,F.A. and Luo,M.
  TITLE     High level of plasma TILRR protein is associated with faster HIV
            seroconversion
  JOURNAL   EBioMedicine 78, 103955 (2022)
   PUBMED   35339895
  REMARK    GeneRIF: High level of plasma TILRR protein is associated with
            faster HIV seroconversion.
REFERENCE   3  (bases 1 to 7566)
  AUTHORS   Dawson,A.J., Hovanes,K., Liu,J., Marles,S., Greenberg,C.,
            Mhanni,A., Chudley,A., Frosk,P., Sahoo,T., Schanze,D. and Zenker,M.
  TITLE     Heterozygous intragenic deletions of FREM1 are not associated with
            trigonocephaly
  JOURNAL   Clin Dysmorphol 30 (2), 83-88 (2021)
   PUBMED   33038106
  REMARK    GeneRIF: Heterozygous intragenic deletions of FREM1 are not
            associated with trigonocephaly.
REFERENCE   4  (bases 1 to 7566)
  AUTHORS   Li,H.N., Li,X.R., Lv,Z.T., Cai,M.M., Wang,G. and Yang,Z.F.
  TITLE     Elevated expression of FREM1 in breast cancer indicates favorable
            prognosis and high-level immune infiltration status
  JOURNAL   Cancer Med 9 (24), 9554-9570 (2020)
   PUBMED   33058542
  REMARK    GeneRIF: Elevated expression of FREM1 in breast cancer indicates
            favorable prognosis and high-level immune infiltration status.
REFERENCE   5  (bases 1 to 7566)
  AUTHORS   Brischoux-Boucher,E., Dahlen,E., Gronier,C., Nobili,F., Marcoux,E.,
            Alkuraya,F.S. and Van Maldergem,L.
  TITLE     Bifid nose as the sole manifestation of BNAR syndrome, a
            FREM1-related condition
  JOURNAL   Clin Genet 98 (5), 515-516 (2020)
   PUBMED   32926405
  REMARK    GeneRIF: Bifid nose as the sole manifestation of BNAR syndrome, a
            FREM1-related condition.
REFERENCE   6  (bases 1 to 7566)
  AUTHORS   Zhang,X., Shephard,F., Kim,H.B., Palmer,I.R., McHarg,S.,
            Fowler,G.J., O'Neill,L.A., Kiss-Toth,E. and Qwarnstrom,E.E.
  TITLE     TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to
            control Ras-dependent amplification of NF-kappaB
  JOURNAL   J Biol Chem 285 (10), 7222-7232 (2010)
   PUBMED   19940113
  REMARK    GeneRIF: TILRR, an isoform encoded by an alternatively spliced
            FREM1 mRNA, is an IL-1RI co-receptor that associates with the
            signaling receptor complex to enhance recruitment of MyD88 and
            control Ras-dependent amplification of NF-kappaB and inflammatory
            responses.
            Erratum:[J Biol Chem. 2010 Jun 4;285(23):18122]
REFERENCE   7  (bases 1 to 7566)
  AUTHORS   Alazami,A.M., Shaheen,R., Alzahrani,F., Snape,K., Saggar,A.,
            Brinkmann,B., Bavi,P., Al-Gazali,L.I. and Alkuraya,F.S.
  TITLE     FREM1 mutations cause bifid nose, renal agenesis, and anorectal
            malformations syndrome
  JOURNAL   Am J Hum Genet 85 (3), 414-418 (2009)
   PUBMED   19732862
  REMARK    GeneRIF: The phenotypic variability reported for different Frem1
            mouse mutants suggests that the apparently distinct phenotype of
            bifid nose and anorectal and renal anomalies syndrome in humans may
            represent a previously unrecognized variant of Fraser syndrome.
            Erratum:[Am J Hum Genet. 2009 Nov;85(5):756]
REFERENCE   8  (bases 1 to 7566)
  AUTHORS   Kiyozumi,D., Osada,A., Sugimoto,N., Weber,C.N., Ono,Y., Imai,T.,
            Okada,A. and Sekiguchi,K.
  TITLE     Identification of a novel cell-adhesive protein spatiotemporally
            expressed in the basement membrane of mouse developing hair
            follicle
  JOURNAL   Exp Cell Res 306 (1), 9-23 (2005)
   PUBMED   15878328
REFERENCE   9  (bases 1 to 7566)
  AUTHORS   Smyth,I., Du,X., Taylor,M.S., Justice,M.J., Beutler,B. and
            Jackson,I.J.
  TITLE     The extracellular matrix gene Frem1 is essential for the normal
            adhesion of the embryonic epidermis
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13560-13565 (2004)
   PUBMED   15345741
REFERENCE   10 (bases 1 to 7566)
  AUTHORS   Li,C. and Slavotinek,A.
  TITLE     FREM1 Autosomal Recessive Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354672.27, AL512643.9 and
            AL390732.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 8, 2020 this sequence version replaced NM_001379081.1.
            
            Summary: This gene encodes a basement membrane protein that may
            play a role in craniofacial and renal development. Mutations in
            this gene have been associated with bifid nose with or without
            anorectal and renal anomalies. Alternatively spliced transcript
            variants encoding different isoforms have been described. PubMed ID
            19940113 describes one such variant that initiates transcription
            within a distinct, internal exon; the resulting shorter isoform
            (named Toll-like/interleukin-1 receptor regulator, TILRR) is
            suggested to be a co-receptor of the interleukin 1 receptor family
            and may regulate receptor function and Toll-like
            receptor/interleukin 1 receptor signal transduction, contributing
            to the control of inflammatory response activation. [provided by
            RefSeq, Apr 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB160987.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380880.4/ ENSP00000370262.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               AL354672.27        57204-57718         c
            516-1016            AL354672.27        16034-16534         c
            1017-1111           AL354672.27        11099-11193         c
            1112-1413           AL354672.27        6473-6774           c
            1414-1610           AL354672.27        4843-5039           c
            1611-1934           AL512643.9         113380-113703       c
            1935-2043           AL512643.9         110761-110869       c
            2044-2175           AL512643.9         108056-108187       c
            2176-2520           AL512643.9         104412-104756       c
            2521-2663           AL512643.9         103543-103685       c
            2664-2860           AL512643.9         86892-87088         c
            2861-2951           AL512643.9         86121-86211         c
            2952-3119           AL512643.9         85256-85423         c
            3120-3328           AL512643.9         81330-81538         c
            3329-3422           AL512643.9         78874-78967         c
            3423-3675           AL512643.9         74908-75160         c
            3676-3870           AL512643.9         70036-70230         c
            3871-4056           AL512643.9         68757-68942         c
            4057-4253           AL512643.9         67052-67248         c
            4254-4476           AL512643.9         63748-63970         c
            4477-4621           AL512643.9         59594-59738         c
            4622-4763           AL512643.9         54839-54980         c
            4764-4959           AL512643.9         51015-51210         c
            4960-5224           AL512643.9         46466-46730         c
            5225-5639           AL512643.9         37885-38299         c
            5640-5841           AL512643.9         32701-32902         c
            5842-5986           AL512643.9         31820-31964         c
            5987-6116           AL512643.9         21868-21997         c
            6117-6189           AL512643.9         18470-18542         c
            6190-6339           AL512643.9         12223-12372         c
            6340-6578           AL512643.9         10497-10735         c
            6579-6626           AL512643.9         9777-9824           c
            6627-6791           AL512643.9         9360-9524           c
            6792-6920           AL512643.9         9019-9147           c
            6921-7036           AL512643.9         8449-8564           c
            7037-7122           AL512643.9         2245-2330           c
            7123-7566           AL390732.10        140494-140937       c
FEATURES             Location/Qualifiers
     source          1..7566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.3"
     gene            1..7566
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /note="FRAS1 related extracellular matrix 1"
                     /db_xref="GeneID:158326"
                     /db_xref="HGNC:HGNC:23399"
                     /db_xref="MIM:608944"
     exon            1..515
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..1016
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             783..7322
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 13; FRAS1-related extracellular matrix protein 1;
                     extracellular matrix protein QBRICK"
                     /codon_start=1
                     /product="FRAS1-related extracellular matrix protein 1
                     isoform 1 precursor"
                     /protein_id="NP_001366010.1"
                     /db_xref="CCDS:CCDS47952.1"
                     /db_xref="GeneID:158326"
                     /db_xref="HGNC:HGNC:23399"
                     /db_xref="MIM:608944"
                     /translation="MNSLSWGAANAVLLLLLLAWASPTFISINRGVRVMKGHSAFLSG
                     DDLKFAIPKEKDACKVEVVMNEPITQRVGKLTPQVFDCHFLPNEVKYVHNGCPILDED
                     TVKLRLYRFTERDTFIETFILWVYLLEPDCNIIHMSNNVLEVPEFNGLSQAIDKNLLR
                     FDYDRMASLECTVSLDTARTRLPAHGQMVLGEPRPEEPRGDQPHSFFPESQLRAKLKC
                     PGGSCTPGLKKIGSLKVSCEEFLLMGLRYQHLDPPSPNIDYISIQLDLTDTRSKIVYK
                     SESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSLTTSVLDCEEDETPKPLLVF
                     NITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPPNSSHSERRHDEVELEVYDF
                     FFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQFQVVDNDDIGAVRL
                     VTVGGLQHGWLTLRGGKGFLFTVADLQAGVVRYHHDDSDSTKDFVVFRIFDGHHSIRH
                     KFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYIFFNITKPPQ
                     AGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPPNLS
                     VPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTI
                     TTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDI
                     GPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEAFTNPLKVTEGGQSIISTE
                     HILISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLKVRYQHDGTE
                     VLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGGEVVITSEYI
                     FATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVTYKHTGGEIGLMP
                     CFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPVDNQPPSIAIG
                     PVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSVGFEKSNIG
                     ISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSIIINPTND
                     EAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRGFSKD
                     FSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDGKHKILK
                     TISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQ
                     NGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNNRS
                     PALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSP
                     PRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRTEHGV
                     FEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQH
                     GQLYLWGTGLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGRVW
                     EEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQI
                     IFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDP
                     TGNSATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSA
                     AVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTK
                     AAVKILDSKGGQCHPSYSSNQSKHSTWEKGIWHLLPPGSSSSTTSGSFHLERRPLPSS
                     MQLAVIRGDTLRGFDSTDLSQRKLRTRGNGKTVRPSSVYRNGTDIIYNYHGIVSLKLE
                     DDSFPTHKRKAKVSIISQPQKTIKVAELPQADKVESTTDSHFPRQDQLPSFPKNCTLE
                     LKGLFHFEEGIQKLYQCNGIAWKAWSPQTKDVEDKSCPAGWHQHSGYCHILITEQKGT
                     WNAAAQACREQYLGNLVTVFSRQHMRWLWDIGGRKSFWIGLNDQVHAGHWEWIGGEPV
                     AFTNGRRGPSQRSKLGKSCVLVQRQGKWQTKDCRRAKPHNYVCSRKL"
     exon            1017..1111
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1413
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1610
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1934
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2043
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2175
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2520
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2663
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2860
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2951
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3119
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3328
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3422
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3675
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3870
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4056
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4253
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4476
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4477..4621
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4763
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..4959
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4960..5224
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5639
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5640..5841
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5842..5986
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5987..6116
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6117..6189
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6190..6339
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6340..6578
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6579..6626
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6627..6791
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6792..6920
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6921..7036
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            7037..7122
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     exon            7123..7566
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7489..7494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /note="hexamer: AATAAA"
     polyA_site      7511
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
     regulatory      7543..7548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /note="hexamer: AATAAA"
     polyA_site      7566
                     /gene="FREM1"
                     /gene_synonym="BNAR; C9orf143; C9orf145; C9orf154; MOTA;
                     TILRR; TRIGNO2"
                     /note="major polyA site"
ORIGIN      
        1 agtacaaaac tagtagtgag aaaggaagct gggaagagac tgggaagagg caaccgacct
       61 cattaacaaa agctcagttt tgtccctgcg gacccaacca gcagaaggca cggggctagc
      121 ggtggctgtc cgccagggag gtcgggctct gtgtaaacag tagaaggcat ctttatcatg
      181 cccttctcac agggagtcct gaggcttggc gctcaggaag tttgcaaagc tgcagcagct
      241 gccttggaga agaccagcaa agaaagtgga gtgtgtatgt gaacttcaat tctgtatttt
      301 ctgtgaggtg ggttaatgga tttttagtaa aaagaaatct caaacacagc tgacctgaaa
      361 gactggaatt tcagctctct tccttcccgg ggttcttttt cctccccctt cctctcaaag
      421 ccctttaaac cagattgctg tgtcagtgac tcttatcctg cccgccagtt ccaagggttt
      481 ctaacttttt gtcttggaaa ggaaaaccac tacctgatta gaaaagcact tgggaagccc
      541 attaatcttg ccggcgttgt caggagtgat cagcgagttt tattaaaagc cctgggattg
      601 cctgaaaggc ccccttgtct gactttgaaa tgaaaggggc atgttaagat ctcggggcac
      661 attgtcagga cccctcaccc tgccccttgg actatgagct gaccctccag gaggaagcac
      721 agaagccctc ctttgttaaa gggatttcgc cggtggacag agaagagttg ggccctgtca
      781 gcatgaactc tctgagttgg ggggctgcga atgccgtgct gctgctgctc ctcctggcct
      841 gggccagccc caccttcatc agcatcaacc gcggggtgag ggtgatgaag ggccactctg
      901 ccttcctgtc aggagatgac ctgaagtttg ccatccctaa agagaaagat gcctgcaaag
      961 tggaagttgt gatgaatgag ccaataaccc agagggttgg gaaactcact ccacaggtct
     1021 ttgactgcca tttccttccc aacgaagtca agtatgttca caatggttgt ccaattcttg
     1081 atgaagacac agtgaagctc agactttaca gatttactga aagagatacc ttcatagaaa
     1141 cttttatcct gtgggtctat ctcctggaac cagactgtaa catcatccat atgagtaaca
     1201 atgtgctgga ggtgcctgaa ttcaatggct tgtcccaagc gattgataaa aatctgctca
     1261 gattcgatta tgataggatg gctagcctgg aatgtaccgt cagcctggac actgcgagaa
     1321 ctcggctgcc agcccatggc cagatggttc tcggggagcc tcgaccagaa gaacctcgtg
     1381 gagatcagcc acacagtttt ttcccagagt cccaactgag agcaaaactg aagtgtccag
     1441 gtgggagctg taccccagga ttaaagaaaa taggaagcct caaagtgagc tgtgaggagt
     1501 tcctgctgat gggccttcgt tatcagcatc tggatccccc ttcacccaac attgattata
     1561 tctccatcca actggacctc acagatacca ggagcaaaat tgtgtacaag tcagagagtg
     1621 cgtggctgcc tgtctatatc agagctggaa ttccgaatca gattccaaag gctgcattca
     1681 tggccgtgtt tattctggaa gtggatcagt tcatcctgac ctccttgact acatcagttc
     1741 tggactgtga agaagatgag acccctaaac ccttgctggt gttcaacatt actaaagccc
     1801 cgctccaggg ctatgtgact cacctgttgg atcacaccag accaatctcc tcattcacct
     1861 ggaaagatct cagtgacatg cagatcgcct atcagccacc aaacagcagc cattctgaga
     1921 ggagacatga tgaggtagaa ttggaggtat acgacttctt ctttgaaagg agtgcaccta
     1981 tgacagtcca catctccatc agaacagcag atacaaatgc cccccgtgta tcctggaata
     2041 caggtctgag tctccttgag gggcagtctc gagccatcac ttgggaacag tttcaggttg
     2101 tcgacaatga cgacattggt gctgtccggc tagtcaccgt tggtggcctg cagcatggat
     2161 ggctgacttt aagagggggg aaagggtttc tcttcaccgt ggctgacctc caggctggag
     2221 ttgttcgcta tcatcatgat gacagcgact ccaccaaaga cttcgtggtc ttccggatat
     2281 ttgatggcca tcacagcatc cgtcacaaat tccccatcaa cgtcttgccc aaagatgata
     2341 gtcccccgtt cctcataacc aatgttgtga ttgaactgga ggaggggcag accatcctga
     2401 tccagggatc catgctgcga gcttcagatg tggacgccag tgatgactac atcttcttca
     2461 atatcacaaa gcctccacag gctggggaga tcatgaagaa gccagggcca ggactgatag
     2521 gctatcctgt ccatggcttc cttcagaggg atttgtttaa tggaatcatt tattatcgtc
     2581 attttggtgg agaaatcttt gaagattctt ttcaatttgt cctgtgggac agccatgaac
     2641 ctccaaatct ttcagtgcca caggtggcaa caatccatat aactccagtg gatgaccagc
     2701 ttccaaaaga ggctcctgga gtttctcggc atttggttgt caaggaaact gaggtggcct
     2761 atataactaa gaaacagcta cattttatag attcagaatc atatgacagg gagctggtct
     2821 acacaataac tactcctcca tttttctcct tcagccacag acacttggat gctgggaaat
     2881 tatttatggt ggacagcata ccaaaagtag ttaagaatcc tacggccctg gagctgaggt
     2941 cattcactca gcatgctgtg aactatatga aagtggccta catgcccccc atgcaagaca
     3001 ttggtcccca ttgcagagat gtccagttca cattttctgt cagtaaccaa catggcggta
     3061 ctttgcatgg gatctgcttt aacattacaa tcctcccagt ggacaatcaa gttcctgagg
     3121 cgttcaccaa ccctctgaaa gtgactgagg gaggtcaaag catcatcagc acagagcaca
     3181 ttctaatttc tgatgcagat accaagctgg acaatattga cctctccctg cgggaattgc
     3241 ctctgcacgg aagggtggag ctgaatggat ttcctctaaa ttcagggggc acattttctt
     3301 ggggcgatct ccatacctta aaagttaggt atcaacatga tggaactgaa gttcttcagg
     3361 atgacctact cttggaggtc accgatggca caaattcagc agaatttgta ctacatgttg
     3421 aggtattccc tgtcaacgat gagccaccag tcttaaaggc tgacctcatg cctgtcatga
     3481 attgctcaga gggaggagag gtggtcatca cctctgaata catttttgct actgatgtgg
     3541 acagcgataa cttgaagttg atgtttgtga ttgctcgcga acctcagcat ggggtggtga
     3601 ggagagctgg agtcacagtg gatcagttct ctcagagaga tgttatctca gaggccgtga
     3661 catacaaaca cacaggtggc gagattggcc tgatgccttg ttttgacacc attacattgg
     3721 tggtttcgga tggagaggct ggcccttttg tgaatggctg ttgctacaat ggacccaatc
     3781 catctgttcc acttcatgcg tcctttccag tgtatgatct caacatcacg gtatacccag
     3841 tagacaacca gccaccttcc attgcaatag gtcccgtgtt tgttgtagat gagggctgct
     3901 caacagccct tactgttaac catttgtccg ccactgaccc tgacactgca gcagatgact
     3961 tggaatttgt tttggtttct cctcctcagt ttggctacct cgaaaatata ctcccttctg
     4021 tgggttttga aaaaagcaat attggcataa gtatagattc atttcagtgg aaagacatga
     4081 acgcttttca cattaactat gtgcagtcca ggcatctgag gatagaacca actgccgacc
     4141 agttcacggt gtacgtcaca gatgggaagc atcactcctt ggagatacca ttttctatta
     4201 taatcaaccc cacaaatgat gaagctcctg actttgtagt gcagaatatt actgtgtgtg
     4261 agggtcagat gaaagagctg gactcttcca tcatcagcgc tgtggacctg gacattcccc
     4321 aggatgccct gctgttcagc atcactcaaa agccacgcca tggcctcctc atcgataggg
     4381 ggtttagcaa agacttctct gagaataagc agccagccaa ccctcaccag aaacatgcac
     4441 ctgttcacag cttttccatg gaactcctca agactggaat gaggttgacg tacatgcatg
     4501 atgactcaga gagccttgct gatgatttta caatccaatt gtcagatggg aaacataaga
     4561 tacttaaaac catttcagta gaggtcatcc cagttaatga tgaaaaacca atgctgagca
     4621 agaaggctga aattgcaatg aatatgggtg aaactcgtat tatttccagt gctattcttt
     4681 cagccataga tgaagactca cccagggaga agatttacta tgtatttgaa aggcttcccc
     4741 aaaatgggca acttcagctt aagataggga gggactgggt tcctctctcc cctggcatga
     4801 aatgcactca ggaggaagtg gatctgaact tgctgagata cacacacacc ggggcaatgg
     4861 attcccagaa tcaagatagc ttcaccttct acctttggga tggcaacaac aggtcccctg
     4921 ctcttgactg tcaaatcacc atcaaggaca tggaaaaagg tgatattgtc atccttacaa
     4981 aaccactcgt ggtgtctaaa ggtgatagag gtttcttaac aaccaccacg ctcctggctg
     5041 tggacggaac agacaagcct gaggaactgc tctatgtcat cacctcccct ccgcgatatg
     5101 gccagatcga atatgttcac tatcctggag ttcccattac aaacttcagc caaatggatg
     5161 tagtggggca gacagtttgc tatgtacaca agagcaaggt gactgtctcc agtgacagat
     5221 tcagattcat catcagcaat ggactgcgga ccgagcacgg ggtgtttgag atcacactgg
     5281 agactgtgga cagagccctg cctgtggtaa ccaggaacaa ggggttgaga ctggcccaag
     5341 gggccgtggg cctgctttcc cctgacctcc ttcagctgac cgaccctgat acacctgcgg
     5401 agaacctcac cttcctcttg gttcagctcc cccagcatgg ccagctctac ctgtggggga
     5461 cagggctact tcaacacaat ttcacccagc aggatgtgga cagcaagaat gtggcctatc
     5521 ggcactcagg aggggactcc cagactgact gctttacttt catggccaca gatgggacaa
     5581 accaaggctt tattgtgaat gggagagtgt gggaagaacc tgttttattc accattcagg
     5641 tagaccaatt ggacaaaaca gctcctcgta tcacactctt gcattcccct tctcaagtgg
     5701 ggctcctgaa aaatggctgc tacgggattt acatcacttc ccgcgtgttg aaggcatcag
     5761 accctgacac tgaggacgat cagatcatct ttaaaattct acaaggccca aaacatggac
     5821 atctggagaa cacaacaaca ggtgaattta tccatgagaa atttagccaa aaggacttaa
     5881 acagtaagac tattctttac atcataaacc catctttgga agtaaattca gataccgtgg
     5941 aatttcaaat catggacccc acagggaact cggccactcc tcaaattttg gaactgaagt
     6001 ggtctcatat tgaatggtca cagaccgaat atgaagtctg tgagaatgtg ggtttgttgc
     6061 ccttggaaat tatcagaagg ggatattcca tggactcggc ctttgtgggt ataaaggtca
     6121 accaagtgtc agctgcagtt ggaaaagatt tcaccgtgat tccatctaaa ctgattcagt
     6181 ttgacccagg aatgtcaact aagatgtgga atatagcaat tacctatgac ggattagagg
     6241 aagatgatga ggtctttgaa gtaattctga actcccctgt gaatgcagtt cttggcacaa
     6301 agacaaaagc tgcagtgaaa attttggact caaaaggagg acaatgccat ccttcatatt
     6361 cctccaacca aagcaagcac agcacatggg agaagggcat ttggcatctg ctgcccccag
     6421 ggtcttcctc atccaccact tctggttcct ttcatctgga aagaagacct cttccatctt
     6481 ccatgcagct agcagtcatc aggggagaca ccctgcgggg ctttgattct acagatcttt
     6541 ctcaaaggaa gcttaggacc cgtgggaatg gcaaaacagt tcgtccatcc tctgtttata
     6601 gaaatggaac agacatcatc tataattatc atgggatagt ttccttgaaa ctggaggatg
     6661 acagtttccc aactcacaaa aggaaggcca aagtatccat cattagtcag ccacaaaaga
     6721 caatcaaagt ggcagaactg cctcaagcag ataaggtgga atccacaact gactcacact
     6781 tccccagaca ggaccagttg ccctcatttc caaagaactg cactctggaa ttaaagggac
     6841 tcttccattt tgaagaaggc atccagaagc tgtatcagtg caatgggatc gcctggaaag
     6901 cctggagtcc ccaaaccaag gatgtggaag acaaatcctg tccagccggg tggcaccagc
     6961 actcaggcta ctgtcacatc ttgatcacag agcagaaagg cacctggaat gcggctgccc
     7021 aagcttgcag ggaacaatac ctgggcaacc ttgtaactgt attctccagg cagcacatgc
     7081 ggtggctctg ggacattggt gggagaaagt ccttttggat aggtttgaac gaccaagtgc
     7141 atgctggcca ctgggagtgg atcggtggtg aacctgttgc cttcaccaat gggagaagag
     7201 ggccctctca acgctccaag cttggaaaga gctgtgtttt ggttcaaaga caagggaaat
     7261 ggcaaacaaa agactgtagg agagccaaac ctcataatta tgtgtgttcc agaaaactct
     7321 aaatataaca gaccctacag ggggccacct ggagtttgtc acctatttat tcacaggatc
     7381 tgtgaatatt gctccataga aaacaaattg ttatgattga gtgggtatac ctttgtgatt
     7441 ctgtctagtg aaaatgggac atttttaata gtgccagaaa gattgataaa taaatatttt
     7501 ttacaagata agatacaatt tttgtatctc aatacctttt aaaataaatg ccagcagtat
     7561 tataaa
//
