LOCUS       NM_012083               2233 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens FRAT regulator of WNT signaling pathway 2 (FRAT2),
            mRNA.
ACCESSION   NM_012083
VERSION     NM_012083.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Tang,W., Pei,M., Li,J., Xu,N., Xiao,W., Yu,Z., Zhang,J., Hong,L.,
            Guo,Z., Lin,J., Dai,W., Xiao,Y., Wu,X., Liu,G., Zhi,F., Li,G.,
            Xiong,J., Chen,Y., Zhang,H., Xiang,L., Li,A., Liu,S. and Wang,J.
  TITLE     The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the
            metastasis and invasion of gastric cancer cells
  JOURNAL   Oncogene 41 (43), 4823-4838 (2022)
   PUBMED   36153370
  REMARK    GeneRIF: The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop
            modulates the metastasis and invasion of gastric cancer cells.
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Lee,D.Y., Kim,H., Ku,S.Y., Kim,S.H., Choi,Y.M. and Kim,J.G.
  TITLE     Association between polymorphisms in Wnt signaling pathway genes
            and bone mineral density in postmenopausal Korean women
  JOURNAL   Menopause 17 (5), 1064-1070 (2010)
   PUBMED   20613673
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Liu,G.P., Zhang,Y., Yao,X.Q., Zhang,C.E., Fang,J., Wang,Q. and
            Wang,J.Z.
  TITLE     Activation of glycogen synthase kinase-3 inhibits protein
            phosphatase-2A and the underlying mechanisms
  JOURNAL   Neurobiol Aging 29 (9), 1348-1358 (2008)
   PUBMED   17433504
  REMARK    GeneRIF: It suggests that activation of GSK-3 inhibits PP-2A
            through up-regulation of I(2)(PP-2A) with hnRNP A18-involved
            mechanism.
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Stoothoff,W.H., Cho,J.H., McDonald,R.P. and Johnson,G.V.
  TITLE     FRAT-2 preferentially increases glycogen synthase kinase 3
            beta-mediated phosphorylation of primed sites, which results in
            enhanced tau phosphorylation
  JOURNAL   J Biol Chem 280 (1), 270-276 (2005)
   PUBMED   15522877
  REMARK    GeneRIF: FRAT-2 enhances glycogen synthase kinase 3 beta-mediated
            phosphorylation of a primed substrate to a greater extent than an
            unprimed substrate
REFERENCE   5  (bases 1 to 2233)
  AUTHORS   Freemantle,S.J., Portland,H.B., Ewings,K., Dmitrovsky,F.,
            DiPetrillo,K., Spinella,M.J. and Dmitrovsky,E.
  TITLE     Characterization and tissue-specific expression of human
            GSK-3-binding proteins FRAT1 and FRAT2
  JOURNAL   Gene 291 (1-2), 17-27 (2002)
   PUBMED   12095675
REFERENCE   6  (bases 1 to 2233)
  AUTHORS   Bax,B., Carter,P.S., Lewis,C., Guy,A.R., Bridges,A., Tanner,R.,
            Pettman,G., Mannix,C., Culbert,A.A., Brown,M.J., Smith,D.G. and
            Reith,A.D.
  TITLE     The structure of phosphorylated GSK-3beta complexed with a peptide,
            FRATtide, that inhibits beta-catenin phosphorylation
  JOURNAL   Structure 9 (12), 1143-1152 (2001)
   PUBMED   11738041
REFERENCE   7  (bases 1 to 2233)
  AUTHORS   Saitoh,T., Moriwaki,J., Koike,J., Takagi,A., Miwa,T., Shiokawa,K.
            and Katoh,M.
  TITLE     Molecular cloning and characterization of FRAT2, encoding a
            positive regulator of the WNT signaling pathway
  JOURNAL   Biochem Biophys Res Commun 281 (3), 815-820 (2001)
   PUBMED   11237732
REFERENCE   8  (bases 1 to 2233)
  AUTHORS   Yost,C., Farr,G.H. 3rd, Pierce,S.B., Ferkey,D.M., Chen,M.M. and
            Kimelman,D.
  TITLE     GBP, an inhibitor of GSK-3, is implicated in Xenopus development
            and oncogenesis
  JOURNAL   Cell 93 (6), 1031-1041 (1998)
   PUBMED   9635432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355490.24, DR006612.1,
            AB045118.1 and BU675503.1.
            
            On May 17, 2019 this sequence version replaced NM_012083.2.
            
            Summary: The protein encoded by this intronless gene belongs to the
            GSK-3-binding protein family. Studies show that this protein plays
            a role as a positive regulator of the WNT signaling pathway. It may
            be upregulated in tumor progression. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC020165.1, AB045118.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371019.4/ ENSP00000360058.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL355490.24        36579-36606         c
            29-51               DR006612.1         9-31
            52-1900             AB045118.1         24-1872
            1901-1901           AL355490.24        34706-34706         c
            1902-2233           BU675503.1         18-349              c
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..2233
                     /gene="FRAT2"
                     /gene_synonym="FRAT-2"
                     /note="FRAT regulator of WNT signaling pathway 2"
                     /db_xref="GeneID:23401"
                     /db_xref="HGNC:HGNC:16048"
                     /db_xref="MIM:605006"
     exon            1..2233
                     /gene="FRAT2"
                     /gene_synonym="FRAT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..859
                     /gene="FRAT2"
                     /gene_synonym="FRAT-2"
                     /note="frequently rearranged in advanced T-cell lymphomas
                     2; FRAT2, WNT signaling pathway regulator"
                     /codon_start=1
                     /product="GSK-3-binding protein FRAT2"
                     /protein_id="NP_036215.1"
                     /db_xref="CCDS:CCDS7456.1"
                     /db_xref="GeneID:23401"
                     /db_xref="HGNC:HGNC:16048"
                     /db_xref="MIM:605006"
                     /translation="MPCRREEEEEAGEEAEGEEEEDDSFLLLQQSVTLGSSGEVDRLV
                     AQIGETLQLDAAQDSPASPCAPPGVPLRAPGPLAAAVPADKARPPAVPLLLPPASAET
                     VGPAPSGALRCALGDRGRVRGRAAPYCVAEVAAGPSALPGPCRRGWLRDAVTSRRLQQ
                     RRWTQAGARAGDDDPHRLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASAPGPGGGR
                     SGPDRIALQPSGSLL"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRAT2"
                     /gene_synonym="FRAT-2"
                     /note="hexamer: AATAAA"
     polyA_site      2233
                     /gene="FRAT2"
                     /gene_synonym="FRAT-2"
                     /note="major polyA site"
ORIGIN      
        1 attccggctc cagcggctgc aggcgcgtgg ctcgagtgcc tggcgggctc cggcttccgc
       61 gtccgcccct gctccggctt cgcccgcagc tccgcgcccg cgggcaacca agcccccagc
      121 gaagcccgca cagctccggg tgccaggacg gggggccatg ccgtgccgga gggaggagga
      181 agaggaagcc ggcgaggagg cggaggggga ggaagaggag gacgacagct tcctcctgct
      241 gcagcagtcg gtgacgctgg gcagctcggg cgaggtggac cggctggtgg cccagatcgg
      301 cgagacgctg cagctggacg cggcgcagga cagcccggcc tcgccgtgcg cgcccccggg
      361 ggtgccgctg cgggccccgg ggcccctggc tgcggcggtg ccggcggaca aggcccggcc
      421 cccggcggtg ccgctgctgc tgccgcccgc ttcggctgag acggtgggcc cggcgccctc
      481 tggggccctg cgctgcgccc taggggaccg cggccgcgtg cgcggacgcg ctgcgcccta
      541 ctgcgtggcg gaggtcgccg caggccccag cgcgctgccg gggccgtgcc ggcgaggatg
      601 gctcagggac gcggtcacct cccgccgctt gcagcagcgc cgatggaccc aagccggggc
      661 acgcgccggc gacgacgacc cgcatcggct cctccagcag ctcgtgctct cgggaaacct
      721 catcaaggaa gccgtgcgga gactccaacg agccgtcgcc gcggttgcag ccacgggccc
      781 cgcaagcgcc cctgggcccg ggggaggccg cagcggacct gaccgcattg ccctgcagcc
      841 ctcaggctcc ttgctctgac gcaggcctcc tggaggagga agtggaggcc gctgcgtaga
      901 cccaacagcg tccagttcct actaactctg agctgaagcc gacgtcgcca gcctgggagc
      961 gaccactttg gctgcgggga ggcgcgtggg gagagatctc aaccagagaa gttaccagcc
     1021 gcggcgaggc cgtcggagaa aacttaagcg tggagaaatg tatgcgccag ggtgcttccg
     1081 tggggcatga gaatttcccg ggccatccaa gcccaaggac ctgggataaa ctgggagaac
     1141 tatggcagct acttgcatcg acttgtacct cacttagccc ttgggggcgt cgtgagcttg
     1201 gattgtttaa ggagggctca ggggtaggaa tcgcgatggc tttataacaa tacttgaaaa
     1261 ctaacgacac gcatacattt tcttattttc tggtggagga gcttagtaag tggtgctaca
     1321 attgctgtgc aaagaaattc cagaggggag aagaatgtaa aagtttggtg gtgggtggct
     1381 tggcattgcc cctttttccc accgattcgg tggctggtga aggtgggaga tgtgaactcc
     1441 aattaaggga ctggagagag gtgaagaatt ttgcaggtgg gagatttgga tttgaatgtg
     1501 gacttgtaaa tgacttgacc ttgccatctg tgttcaaggt cacggtttgc tgtggggttc
     1561 ctgggagagc ttactcaccc cggagtcttt tctttctctt gctccaagaa gagccctgtt
     1621 ggtgctttac caccgcttgg agtctcccga ggacacaaac aggcagagag ggacgtgtag
     1681 ggagagttct ttcctgtttt ctgtgctttc ctttttacag gactcccgga aggccactca
     1741 tggccatgcc aggagctttc tcagaaacag tcataaacga tctcttgagt ctctttcttg
     1801 tcctcccagc tgagctttct tattccaccc tttctggtgt ctataggaat gcatgagaga
     1861 ccctggacgt ttttctgctc tcttctggcc ctccatggag tcatgggcct cggcctcggc
     1921 ggctcctcac cctcacaatt tatttcctcc tcccgtgcca gcccttcttt tgtgtctgaa
     1981 accggtttta aaatgtgact ctcccagaga agaagccgct ggctgtatga aacttgacgg
     2041 cgcttttgta aggtgccacc cccaaacttt aaggtagcta aaccaatttt taaaagattc
     2101 aatggcttgt tcatcctcca gatgtagcta ttgatgtaca cttcgcaacg gagtgtctga
     2161 aattgtggtg gtcctgattt ataggatttc ataattaaaa tgtctgctga ataaatttgg
     2221 cttttgtttt gga
//
