LOCUS       NM_005479               2645 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FRAT regulator of WNT signaling pathway 1 (FRAT1),
            mRNA.
ACCESSION   NM_005479 XM_001714291
VERSION     NM_005479.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Tang,W., Pei,M., Li,J., Xu,N., Xiao,W., Yu,Z., Zhang,J., Hong,L.,
            Guo,Z., Lin,J., Dai,W., Xiao,Y., Wu,X., Liu,G., Zhi,F., Li,G.,
            Xiong,J., Chen,Y., Zhang,H., Xiang,L., Li,A., Liu,S. and Wang,J.
  TITLE     The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the
            metastasis and invasion of gastric cancer cells
  JOURNAL   Oncogene 41 (43), 4823-4838 (2022)
   PUBMED   36153370
  REMARK    GeneRIF: The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop
            modulates the metastasis and invasion of gastric cancer cells.
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Yang,B., Liu,D., Ren,Y.Q., Sun,Y.Q., Zhang,J.P., Wang,X.G.,
            Wu,Y.Q., Wang,S.L., Guo,S.H. and Guo,G.
  TITLE     FRAT1 promotes the angiogenic properties of human glioblastoma
            cells via VEGFA
  JOURNAL   Mol Med Rep 25 (3) (2022)
   PUBMED   35059733
  REMARK    GeneRIF: FRAT1 promotes the angiogenic properties of human
            glioblastoma cells via VEGFA.
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Cai,X., Dai,Y., Gao,P., Ren,G., Cheng,D., Wang,B., Wang,Y., Yu,J.,
            Du,Y., Wang,X. and Xue,B.
  TITLE     LncRNA CCAT1 promotes prostate cancer cells proliferation,
            migration, and invasion through regulation of miR-490-3p/FRAT1 axis
  JOURNAL   Aging (Albany NY) 13 (14), 18527-18544 (2021)
   PUBMED   34319909
  REMARK    GeneRIF: LncRNA CCAT1 promotes prostate cancer cells proliferation,
            migration, and invasion through regulation of miR-490-3p/FRAT1
            axis.
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Bax,B., Carter,P.S., Lewis,C., Guy,A.R., Bridges,A., Tanner,R.,
            Pettman,G., Mannix,C., Culbert,A.A., Brown,M.J., Smith,D.G. and
            Reith,A.D.
  TITLE     The structure of phosphorylated GSK-3beta complexed with a peptide,
            FRATtide, that inhibits beta-catenin phosphorylation
  JOURNAL   Structure 9 (12), 1143-1152 (2001)
   PUBMED   11738041
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Saitoh,T. and Katoh,M.
  TITLE     FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are
            up-regulated in gastric cancer
  JOURNAL   Int J Oncol 19 (2), 311-315 (2001)
   PUBMED   11445844
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Thomas,G.M., Frame,S., Goedert,M., Nathke,I., Polakis,P. and
            Cohen,P.
  TITLE     A GSK3-binding peptide from FRAT1 selectively inhibits the
            GSK3-catalysed phosphorylation of axin and beta-catenin
  JOURNAL   FEBS Lett 458 (2), 247-251 (1999)
   PUBMED   10481074
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Li,L., Yuan,H., Weaver,C.D., Mao,J., Farr,G.H. 3rd, Sussman,D.J.,
            Jonkers,J., Kimelman,D. and Wu,D.
  TITLE     Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in
            Wnt-mediated regulation of LEF-1
  JOURNAL   EMBO J 18 (15), 4233-4240 (1999)
   PUBMED   10428961
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Jonkers,J., Korswagen,H.C., Acton,D., Breuer,M. and Berns,A.
  TITLE     Activation of a novel proto-oncogene, Frat1, contributes to
            progression of mouse T-cell lymphomas
  JOURNAL   EMBO J 16 (3), 441-450 (1997)
   PUBMED   9034327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355490.24.
            
            On May 17, 2019 this sequence version replaced NM_005479.3.
            
            Summary: The protein encoded by this gene belongs to the
            GSK-3-binding protein family. The protein inhibits GSK-3-mediated
            phosphorylation of beta-catenin and positively regulates the Wnt
            signaling pathway. It may function in tumor progression and in
            lymphomagenesis. [provided by RefSeq, Oct 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U58975.2, AB074890.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371021.5/ ENSP00000360060.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2645              AL355490.24        21148-23792
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..2645
                     /gene="FRAT1"
                     /note="FRAT regulator of WNT signaling pathway 1"
                     /db_xref="GeneID:10023"
                     /db_xref="HGNC:HGNC:3944"
                     /db_xref="MIM:602503"
     exon            1..2645
                     /gene="FRAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1023
                     /gene="FRAT1"
                     /note="FRAT-1; frequently rearranged in advanced T-cell
                     lymphomas 1; FRAT1, WNT signaling pathway regulator"
                     /codon_start=1
                     /product="proto-oncogene FRAT1"
                     /protein_id="NP_005470.2"
                     /db_xref="CCDS:CCDS7455.1"
                     /db_xref="GeneID:10023"
                     /db_xref="HGNC:HGNC:3944"
                     /db_xref="MIM:602503"
                     /translation="MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLV
                     AQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAET
                     VGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGI
                     PQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVR
                     RLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLV
                     PGS"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRAT1"
                     /note="hexamer: AATAAA"
     polyA_site      2553
                     /gene="FRAT1"
                     /note="major polyA site"
     regulatory      2619..2624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRAT1"
                     /note="hexamer: CATAAA"
     polyA_site      2645
                     /gene="FRAT1"
                     /note="major polyA site"
ORIGIN      
        1 cggctcccgc ggctgcaggc gcgcggctag agtgcctggc gggctccggc ttccgcgtcc
       61 gccccggccc cggtccagac ttagtcttca gctccgcgcc cgctccgccg cggcccaccg
      121 cgcccgccgg cagccgagcc cccagcgacg cccgcacagc tccgggtgcc cagacagggg
      181 gccatgccgt gccggaggga ggaggaagag gaagccggcg aggaggcgga gggggaggaa
      241 gaggaggagg acagcttcct cctactgcag cagtcagtgg cgctgggcag ctcgggcgag
      301 gtggaccggc tggtggccca gatcggcgag acgctgcagc tggacgcggc gcagcacagc
      361 ccggcctcgc cgtgcgggcc cccgggggcg ccgctgcggg ccccggggcc cctggctgcg
      421 gcggtgccgg cggacaaggc caggtccccg gcggtgccgc tgctgctgcc gcccgcgttg
      481 gcggagactg tgggcccggc gccccctggg gtcctgcgct gcgccctggg ggaccgcggc
      541 cgcgtgcggg gccgcgctgc gccctactgc gtggccgagc tcgccacagg ccccagcgcg
      601 ctgtccccac tgccccctca ggccgacctt gatgggcctc cgggagctgg caagcagggc
      661 atcccgcagc cgctgtcggg tccgtgccgg cgaggatggc tccggggcgc cgccgcctcc
      721 cgccgcctgc agcagcgacg cgggtcccaa ccagaaaccc gcacaggcga cgacgacccg
      781 caccggcttc tgcagcagct agtgctctct ggaaacctca tcaaggaggc cgtgcgaagg
      841 cttcattcgc gacggctgca gttacgtgca aagcttcccc aacgcccgct cctgggacct
      901 ctgtcggccc cggtgcatga acccccttcg cctcgcagcc ctcgcgcggc ctgcagtgac
      961 cctggcgcct ccgggagggc gcagctcaga actggcgacg gcgttcttgt gcctggcagc
     1021 taacacgccc ggggtggcca cagcgccagc ctcagactgg agggcaaggg gttcccttga
     1081 gggctgcagt tctactcagg ctggtggaga actctggctt ttggaagcga gagtaaaaag
     1141 ctaatgacga ggaaccgaaa aatcgcgagt gtttcgcggg taactggggt tgagggccaa
     1201 aatatttgga atgaaggact ttggccctat ttaaggcaga ttttacagag cgcacctcaa
     1261 acgtacaagt cagtaggact ccttatttgg cgtgacccga cctggccgcg gagcctgcat
     1321 ttcctcgcag cctctcagtg ccctccagcc ccgcgaccat gtggccacaa tccacgcttc
     1381 tccggatcgc ggtgcgccgg aaccacggag gatgatgcca gttacttgct ttaccttttc
     1441 agggctggct cctgatccac tttgggggag gagaacatga gtagataatt tcagggtgca
     1501 gcccaatctg ccagacttaa aaaaaccatc ttgtgtcttt ggaggtgctg cttaatacca
     1561 aacatgcggt gccatgaagg gaccctttgg gggttgaata ggagttaacc cctgcgctct
     1621 ctttgcaact gtctctcttc tcagagtggt gggggaaggc tgtacgacac gggtggggaa
     1681 aggaggtggg ggcggggagt attgaatggt ggtggaaggg tagagaggcg cggagtgaac
     1741 cccacgccct gtctaaagtg tattttcaga gccggcccgc ctctcctcgg ttcaaggtca
     1801 ctgtttcctg ggcacgcact gggttgcggg acagagtagc caggttctgc cggtgctcgg
     1861 agaagagcgc agtgttttgc aagtgctgga gtctcctgag gacacgcgcg tcgccgccac
     1921 cgcgggtgtg ggaaagcgcg gacgtgctgg gcggctgtgc ttcggtaggc gaccaccgcc
     1981 cctggccgcg ctccgggctt tcacggaaac tcccgagacc gggccctggg ttcctcctct
     2041 cctactcggc tctgcagtcc tactcaagcg ggtggctctg ggatcctggg ggcctgggtt
     2101 gggggctagg gagacgccat gtgatggaca ctccagggac acacagccta gcacagcagc
     2161 ttataatggg ctctccgggg ccatttgcaa taacagctgc aattccctgg atagacgagt
     2221 tgatttcctc cctctgcccc tcccccagcc atgccagctg gcctttgtaa gtgcaggaaa
     2281 ccgagtagaa aatgtgaccc tccaaatgga gaagctgcag gctttgccat tgtgaaccat
     2341 ggtgaagtgc ttggaacata ctgttcactc actctaaagg cgctgagact gtgctgttgt
     2401 tctcgttttt atagtcaatg gcttgttcat catccagatg tggctactga catatctaca
     2461 cttcgcaccg gagtgtctgg aattgtggct atcctgatta taggatttta acttaactga
     2521 aatgcctgct ttgaataaat gtgttgggtt ttttgtttgg ttttatttta tacttgccat
     2581 cagtgaaaaa gatgtacaga acacatttct ctgatctcca taaacatgaa aacacttgaa
     2641 atctc
//
