LOCUS       NM_025074              15871 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens Fraser extracellular matrix complex subunit 1 (FRAS1),
            transcript variant 1, mRNA.
ACCESSION   NM_025074
VERSION     NM_025074.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15871)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15871)
  AUTHORS   Wang,V., Geybels,M.S., Jordahl,K.M., Gerke,T., Hamid,A.,
            Penney,K.L., Markt,S.C., Freedman,M., Pomerantz,M., Lee,G.M.,
            Rana,H., Bornigen,D., Rebbeck,T.R., Huttenhower,C., Eeles,R.A.,
            Stanford,J.L., Consortium,P., Berndt,S.I., Claessens,F.,
            Sorensen,K.D., Park,J.Y., Vega,A., Usmani,N., Mucci,L. and
            Sweeney,C.J.
  TITLE     A polymorphism in the promoter of FRAS1 is a candidate SNP
            associated with metastatic prostate cancer
  JOURNAL   Prostate 81 (10), 683-693 (2021)
   PUBMED   33956343
  REMARK    GeneRIF: A polymorphism in the promoter of FRAS1 is a candidate SNP
            associated with metastatic prostate cancer.
REFERENCE   3  (bases 1 to 15871)
  AUTHORS   Al-Hamed,M.H., Sayer,J.A., Alsahan,N., Tulbah,M., Kurdi,W.,
            Ambusaidi,Q., Ali,W. and Imtiaz,F.
  TITLE     Novel loss of function variants in FRAS1 AND FREM2 underlie renal
            agenesis in consanguineous families
  JOURNAL   J Nephrol 34 (3), 893-900 (2021)
   PUBMED   32643034
  REMARK    GeneRIF: Novel loss of function variants in FRAS1 AND FREM2
            underlie renal agenesis in consanguineous families.
REFERENCE   4  (bases 1 to 15871)
  AUTHORS   Umeda,S., Kanda,M., Miwa,T., Tanaka,H., Tanaka,C., Kobayashi,D.,
            Hayashi,M., Yamada,S., Nakayama,G., Koike,M. and Kodera,Y.
  TITLE     Fraser extracellular matrix complex subunit 1 promotes liver
            metastasis of gastric cancer
  JOURNAL   Int J Cancer 146 (10), 2865-2876 (2020)
   PUBMED   31597194
  REMARK    GeneRIF: Fraser extracellular matrix complex subunit 1 promotes
            liver metastasis of gastric cancer.
REFERENCE   5  (bases 1 to 15871)
  AUTHORS   Midro,A.T., Stasiewicz-Jarocka,B., Borys,J., Hubert,E.,
            Skotnicka,B., Hassmann-Poznanska,E., Sierpinska,T., Panasiuk,B.,
            Schanze,D. and Zenker,M.
  TITLE     Two unrelated families with variable expression of Fraser syndrome
            due to the same pathogenic variant in the FRAS1 gene
  JOURNAL   Am J Med Genet A 182 (4), 773-779 (2020)
   PUBMED   31999076
  REMARK    GeneRIF: Two unrelated families with variable expression of Fraser
            syndrome due to the same pathogenic variant in the FRAS1 gene.
REFERENCE   6  (bases 1 to 15871)
  AUTHORS   Short,K., Wiradjaja,F. and Smyth,I.
  TITLE     Let's stick together: the role of the Fras1 and Frem proteins in
            epidermal adhesion
  JOURNAL   IUBMB Life 59 (7), 427-435 (2007)
   PUBMED   17654118
  REMARK    GeneRIF: In this review, recent studies support direct interactions
            between Fras1 and Frem proteins and shed new light on their role in
            the regulation of epidermal-basement membrane adhesion and
            organogenesis during development.
            Review article
REFERENCE   7  (bases 1 to 15871)
  AUTHORS   Vrontou,S., Petrou,P., Meyer,B.I., Galanopoulos,V.K., Imai,K.,
            Yanagi,M., Chowdhury,K., Scambler,P.J. and Chalepakis,G.
  TITLE     Fras1 deficiency results in cryptophthalmos, renal agenesis and
            blebbed phenotype in mice
  JOURNAL   Nat Genet 34 (2), 209-214 (2003)
   PUBMED   12766770
REFERENCE   8  (bases 1 to 15871)
  AUTHORS   McGregor,L., Makela,V., Darling,S.M., Vrontou,S., Chalepakis,G.,
            Roberts,C., Smart,N., Rutland,P., Prescott,N., Hopkins,J.,
            Bentley,E., Shaw,A., Roberts,E., Mueller,R., Jadeja,S., Philip,N.,
            Nelson,J., Francannet,C., Perez-Aytes,A., Megarbane,A., Kerr,B.,
            Wainwright,B., Woolf,A.S., Winter,R.M. and Scambler,P.J.
  TITLE     Fraser syndrome and mouse blebbed phenotype caused by mutations in
            FRAS1/Fras1 encoding a putative extracellular matrix protein
  JOURNAL   Nat Genet 34 (2), 203-208 (2003)
   PUBMED   12766769
  REMARK    GeneRIF: Locus FS1 at chromosome 4q21 is associated with Fraser
            syndrome. Mutation analysis identified five frameshift mutations in
            FRAS1, which encodes one member of a family of novel proteins
            related to an extracellular matrix (ECM) protein found in sea
            urchin.
REFERENCE   9  (bases 1 to 15871)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   10 (bases 1 to 15871)
  AUTHORS   Gattuso,J., Patton,M.A. and Baraitser,M.
  TITLE     The clinical spectrum of the Fraser syndrome: report of three new
            cases and review
  JOURNAL   J Med Genet 24 (9), 549-555 (1987)
   PUBMED   3118036
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093652.5, DA725113.1,
            DA881824.1, BC131820.1, AC093886.2, AB040933.2, AC104808.4,
            BX647949.1 and BX647420.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_025074.6.
            
            Summary: This gene encodes an extracellular matrix protein that
            appears to function in the regulation of epidermal-basement
            membrane adhesion and organogenesis during development. Mutations
            in this gene cause Fraser syndrome, a multisystem malformation that
            can include craniofacial, urogenital and respiratory system
            abnormalities. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142853,
                              SAMEA2144120 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000512123.4/ ENSP00000422834.2
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AC093652.5         48267-48513
            248-553             DA725113.1         1-306
            554-657             DA881824.1         274-377
            658-3692            BC131820.1         1-3035
            3693-3693           AC093886.2         81662-81662
            3694-4781           BC131820.1         3037-4124
            4782-4782           AC093886.2         109661-109661
            4783-6002           BC131820.1         4126-5345
            6003-7154           AB040933.2         1-1152
            7155-7155           AC093886.2         160584-160584
            7156-7697           AB040933.2         1154-1695
            7698-7698           AC104808.4         1041-1041
            7699-7818           AB040933.2         1697-1816
            7819-7819           AC104808.4         2786-2786
            7820-9125           AB040933.2         1818-3123
            9126-9358           BX647949.1         1159-1391
            9359-13007          AB040933.2         3357-7005
            13008-13008         BX647949.1         5041-5041
            13009-15855         AB040933.2         7007-9853
            15856-15871         BX647420.1         7003-7018
FEATURES             Location/Qualifiers
     source          1..15871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..15871
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /note="Fraser extracellular matrix complex subunit 1"
                     /db_xref="GeneID:80144"
                     /db_xref="HGNC:HGNC:19185"
                     /db_xref="MIM:607830"
     exon            1..763
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             688..12726
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; extracellular matrix protein FRAS1; Fraser
                     syndrome 1; fraser syndrome 1 protein; extracellular
                     matrix organizing protein FRAS1"
                     /codon_start=1
                     /product="extracellular matrix organizing protein FRAS1
                     isoform 1 precursor"
                     /protein_id="NP_079350.5"
                     /db_xref="CCDS:CCDS54771.1"
                     /db_xref="GeneID:80144"
                     /db_xref="HGNC:HGNC:19185"
                     /db_xref="MIM:607830"
                     /translation="MGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLADATIWKPD
                     SCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIH
                     EHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCS
                     YEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSA
                     RSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCE
                     ECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHL
                     DGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCY
                     EPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWC
                     VHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRH
                     SCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCD
                     SCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCT
                     ACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQV
                     EQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLD
                     GQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQ
                     FLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGA
                     CKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHVCQPCNTHCG
                     SCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTD
                     CLQCMDGYVLQDGACVEQCLSSFYQDSGLCKNCDSYCLQCQGPHECTRCKGPFLLLEA
                     QCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVYNCVPGFS
                     VHTSNETCSGKIHTPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTP
                     TNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHSKEKLRKGYLFLKISDQQFFSE
                     PQLINIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVIEIIDPPLH
                     GQLLQTLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSDVAVLQANDGHSFHNILFQV
                     KTVPQNDRGLQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQDYPQFGE
                     VVLLVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFE
                     VSSASNAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINS
                     EKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQE
                     LMAFSFAGLPESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGG
                     STSVGLQVVVRDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKN
                     ALQYIHDGSSTREDSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASK
                     STAIITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDIN
                     NKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLI
                     TVDEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDL
                     EASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEP
                     PRMTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPL
                     ENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELP
                     ASDTPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKH
                     GNLEQISIKGPIRSFTQADISQGHVEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFS
                     ISILEDKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHL
                     EHAASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLH
                     PVDDSLPVVQNLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTS
                     NGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFIIEEGGKEIMT
                     AAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTMDPDTEDAQLV
                     YEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDS
                     KPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTA
                     SSSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELSMPAY
                     ALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAICYT
                     VPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFE
                     IALADASDNARIGRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPVIRHGTDL
                     STFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQYPVIEGL
                     ETFVVFLSSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITRS
                     GDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFEP
                     EEQFRVYLGLPLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPAGPDAI
                     AILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILS
                     NEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYD
                     HVEEVTKEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAA
                     PTDGNGARSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRS
                     NIVTIGTDSAICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDG
                     MLPLISTMPLHNLHFLLSESIYRHQHVCSNLVTTYDLRGISEAGFLDDVVYDSTALGP
                     GYDRPFQFDPSVREPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRD
                     SAQSFLTVHVPLYVSYIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSAR
                     LQIIRIYIREDGRLVIEFKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDLQLL
                     WSAQTFDSPHQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWVDPGEKPLACTAHAP
                     ERFLIPIAFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKG
                     QILYGRVLWNPEQNLNSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPN
                     KHLKHRFLLLDRNQPEVTDKYFHDVPFEAHFASELPDFHVVSNMPGVDGFTLKVDALY
                     KVEAGHQWYLQVIYIIGPDTISGPRVQRSLTAPLRRNRRDLVEPDGQLILDDSLIYDN
                     EGDQVKNGTNMKSLNLEMQELAVAASLSQTGASIGSALAAIMLLLLVFLVACFINRKC
                     QKQRKKKPAEDILEEYPLNTKVEVPKRHPDRVEKNVNRHYCTVRNVNILSEPEAAYTF
                     KGAKVKRLNLEVRVHNNLQDGTEV"
     exon            764..795
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..903
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..996
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1156
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1290
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1374
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1476
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1668
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1758
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1794
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1942
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2086
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2221
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2365
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2506
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2647
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2824
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2965
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3109
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3262
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3409
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3556
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3697
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3838
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3979
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4250
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4335
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4336..4662
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4816
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4995
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4996..5112
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5113..5227
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5228..5365
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5398
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5399..5530
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5531..5656
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5657..5904
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5905..6053
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6054..6216
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6217..6352
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6353..6543
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6544..6697
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6698..6961
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6962..7150
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7151..7270
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7271..7450
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7451..7575
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7576..7716
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7717..7944
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7945..8058
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8059..8209
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8210..8369
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8370..8538
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8539..8785
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8786..9130
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9131..9291
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9292..9439
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9440..9645
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9646..9802
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9803..10003
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10004..10191
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10192..10467
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10468..10700
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10701..10861
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10862..11076
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11077..11227
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11228..11335
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11336..11495
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11496..11612
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11613..11779
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11780..11985
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11986..12132
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12133..15871
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15834..15839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /note="hexamer: TATAAA"
     regulatory      15848..15853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /note="hexamer: AATAAA"
     polyA_site      15856
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
     polyA_site      15871
                     /gene="FRAS1"
                     /gene_synonym="FRASRS1"
                     /note="major polyA site"
ORIGIN      
        1 ctttcctctg aagcttccga acagtctgct tcagggagcg cagcctgagg cggtgtggtg
       61 cggtgcggct gcagggcggg cgagtccccg gagctgccct cagcgctgca cagtttccag
      121 cgagcggacc ccggcagatg aggtctgccg agccgggtgg ctcgaccaag gagtgggtgt
      181 gggtgggtct ttcggggctc ccggcgaccc gcggtgccga cgcaacgccg acgtatggtg
      241 ccaagcgaac tttaaaaagc tgcttcggac aaaccagagc caggatttcc actgtcgggg
      301 acccgggatc ggaagggtct agcccgaggg aaatgctgga agatcccatc ggccagtgac
      361 cagcaacttt ccggcgagat tttgacgcgg agaactgtgc tctgcctcct cttattctcc
      421 caaagctcac gttggcgtcc tgccttgcgg gggaactcgg cgcgctctct gcctgagcag
      481 cgagtgaatt gaaccccagc ccgctccggc gcctccgggc tgatgagtgt cgctctccgc
      541 ccgtccatct ctttttcccg gaggtaaagg cccgcggtcc cccaccttca gtgcgcccgg
      601 gttccaagcg ccggagccag cgttttggcg gagccgcttc ttggatgctg aaggctgggc
      661 tcctccatcg tgggtgccga ggcggcgatg ggtgtcctca aagtgtggct cgggctggcc
      721 ctagcgttgg cggaatttgc agtattgcct catcattccg aaggtgcttg tgtctatcag
      781 gattccttgt tggcggatgc cacaatttgg aagcccgatt catgccagag ctgccgttgc
      841 catggtgata ttgttatctg caaacctgct gtttgcagaa accctcaatg tgcctttgag
      901 aagggagaag tgcttcaaat agctgccaac caatgctgtc ctgagtgtgt tttgaggact
      961 ccaggatctt gccatcatga aaagaaaatc catgagcatg ggacagaatg ggcctcttct
     1021 ccatgtagtg tgtgctcttg caatcatggg gaagtccgat gtacccccca accatgccca
     1081 ccgctgtcat gtggacacca ggagctggca ttcatccctg aaggaagctg ctgcccagtt
     1141 tgtgtgggcc ttgggaaacc ctgttcctat gaaggccatg tgtttcagga tggggaggac
     1201 tggcggctga gccggtgtgc caaatgtctg tgtagaaatg gggttgccca gtgcttcaca
     1261 gctcagtgtc agcctctatt ttgtaaccag gatgagactg tagtccgagt ccctggaaaa
     1321 tgttgcccgc agtgctctgc aagatcctgc tctgcagctg gccaagtata cgagcatggt
     1381 gagcagtgga gcgaaaatgc ctgcaccacg tgtatatgtg accggggtga ggtcaggtgt
     1441 cacaagcagg cctgcctgcc cctgagatgc ggaaagggtc agagcagggc tcggcgtcat
     1501 gggcaatgct gtgaggaatg tgtgtctcct gccgggagct gctcctatga tggagttgtg
     1561 cggtaccagg acgaaatgtg gaagggctcg gcctgtgagt tctgcatgtg tgatcatggc
     1621 caagtgacct gccagactgg agagtgtgcc aaagtggagt gtgcccggga tgaagaatta
     1681 attcacttag atggaaagtg ttgtcctgaa tgcatttcaa ggaatggtta ttgtgtttat
     1741 gaagaaactg gagaatttat gtcatcaaat gctagtgaag ttaaacgtat tccagaggga
     1801 gagaagtggg aagatggccc ttgcaaggtg tgtgagtgcc gaggggctca ggtaacttgc
     1861 tacgagccct cttgcccacc atgtccagtg ggcacactgg ccttagaggt gaagggacag
     1921 tgctgtccag actgcacatc agttcattgc catccagatt gtttgacatg ctctcagtct
     1981 ccagaccact gtgacctctg ccaagatcct accaagttac tgcagaatgg atggtgtgtg
     2041 cacagctgtg gactgggttt ttaccaagct ggcagtctct gtttagcctg ccagccccag
     2101 tgctccacgt gtaccagtgg gctggagtgc tcatcctgcc agcctcccct gctgatgcgg
     2161 cacgggcagt gtgtgcctac ctgtggggac ggcttctacc aagatcgcca ttcctgtgca
     2221 gtctgccatg agtcctgtgc aggttgctgg ggcccaacgg agaagcactg cttggcctgc
     2281 agagatcccc tccacgtgct gagagatggc ggctgtgaga gcagctgtgg aaaaggcttc
     2341 tacaacaggc agggcacctg tagcgcttgt gaccaatcct gtgacagttg tggccccagt
     2401 agccccaggt gtcttacctg tactgagaag acagtgctgc atgatgggaa atgcatgtct
     2461 gaatgccctg gcgggtacta tgctgatgcc actggcaggt gcaaagtttg tcataactca
     2521 tgtgccagct gctctgggcc cacaccctct cactgtacag cctgcagccc ccccaaggct
     2581 ctgcgtcaag gccactgtct gccccgctgt ggagagggtt tctactctga ccatggagtc
     2641 tgcaaagcct gtcactcctc ctgcctggct tgtatgggtc ccgcaccctc tcactgtact
     2701 gggtgtaaga agccagagga aggactgcaa gtggagcagc tgtctgacgt gggcatcccc
     2761 tctggcgagt gtctagccca gtgtagagcc catttttact tggagagcac tggcatatgt
     2821 gaagcttgcc accagtcctg tttcagatgt gcagggaaaa gcccacataa ctgcacagac
     2881 tgtgggcctt cccatgtgct gttggatggg cagtgcctct cccagtgccc agatggctac
     2941 tttcaccagg aaggtagttg cacagagtgt cacccaacct gcaggcagtg tcatgggccg
     3001 ttggagtctg actgcatctc ctgttaccct cacatctctc ttaccaatgg taactgcagg
     3061 accagctgca gggaagagca gttcctcaac ctcgtgggat actgtgctga ctgccatcac
     3121 ctgtgccagc actgtgcagc tgatctccac aacactggga gcatctgcct caggtgccag
     3181 aatgcccact acctgctgct cggggaccac tgtgttcctg actgcccttc aggatactat
     3241 gcagagagag gagcttgtaa aaaatgccac tcctcctgca gaacctgcca gggcagagga
     3301 cctttctcct gctcctcatg tgacaccaac ctcgtgctgt cccacactgg cacctgcagc
     3361 accacctgct tccctgggca ctatcttgat gacaatcatg tttgccagcc atgcaacaca
     3421 cactgtggaa gctgtgattc acaggccagc tgtacctcct gccgagatcc aaacaaggtt
     3481 ctgctctttg gggaatgtca atacgagagc tgcgccccac agtactatct tgacttctcc
     3541 accaacacgt gcaaagagtg tgattggagc tgcagtgcat gcagtgggcc cctgaaaaca
     3601 gactgcctgc agtgcatgga tggctatgtt ctccaggatg gggcctgcgt ggagcagtgc
     3661 ttgtcatcat tttaccagga ctcgggcctc tgcaagaact gtgacagcta ctgtctccag
     3721 tgccaaggtc cccatgagtg tacccgctgc aaagggccat ttctcctctt ggaagcccag
     3781 tgtgtccagg aatgtgggaa ggggtacttt gcagatcatg caaagcacaa atgcacagcc
     3841 tgccctcagg ggtgcttgca gtgcagccac agggaccgtt gtcacctctg tgaccatggg
     3901 ttctttctga agagtggcct ctgtgtttac aactgtgttc ctggcttttc tgtccacacc
     3961 tctaatgaaa catgttctgg caaaatacac acccctagtc ttcatgtgaa tggttccctg
     4021 atcctcccaa ttggttcaat aaagccactg gatttttccc tcctgaatgt ccaagaccag
     4081 gagggtaggg tcgaagatct cctatttcat gttgtgagca ctcccaccaa tggtcagcta
     4141 gtgctctcaa gaaatggaaa agaggttcag ctggacaagg ctggccgttt tagctggaaa
     4201 gatgtgaacg agaagaaagt gcgttttgtg cacagcaaag aaaaactcag gaaaggttac
     4261 cttttcctga aaattagtga ccagcagttc ttctctgagc cacagctgat caacatacaa
     4321 gcattttcaa cacaggcccc ctatgtgctg agaaatgaag ttctccacat tagcagagga
     4381 gagagggcaa ccatcaccac ccagatgctt gacatccgag atgatgacaa cccacaggat
     4441 gtggtcattg aaataatcga tcctccactt catggccaat tgcttcagac acttcagtcc
     4501 ccggcaaccc ctatctatca attccagctg gatgaactct ctagaggcct tctccactat
     4561 gctcatgatg gttcagacag cacatccgat gttgcagtct tgcaggccaa tgatggacac
     4621 tccttccata atatactgtt ccaagtgaag accgtgcctc agaatgacag gggtcttcag
     4681 cttgtggcta attcgatggt gtgggttcca gaagggggga tgctgcagat caccaacaga
     4741 atcttacagg ccgaggctcc tggtgccagt gctgaagaaa tcatctacaa gattacacaa
     4801 gactaccccc agtttgggga ggtggtcctt ctagtgaata tgcctgcaga cagccctgca
     4861 gatgaagggc agcacctgcc tgatgggagg acagctaccc ccaccagcac cttcacccag
     4921 caggacatca atgaaggcat cgtatggtac aggcactcag gagccccagc ccagagcgac
     4981 tccttccgct tcgaggtgtc cagtgcctcc aatgcccaga cccgcctgga gagccacatg
     5041 ttcaacatcg cgatcttacc acagacacct gaagcaccta aagtgtctct ggaagcatct
     5101 ctccatatga ctgctagaga agatggcctg actgttattc agcctcattc cctctccttc
     5161 ataaactctg agaagccaag tggaaagatt gtctacaaca tcactctacc tctgcatcca
     5221 aatcaaggta tcatcgagca ccgggaccac cctcactctc ctatccggta tttcacgcaa
     5281 gaggatatta accagggcaa agtcatgtac cgccctcccc cggcagcacc ccacctccag
     5341 gagctcatgg ccttctcgtt cgctggtctc ccagaatcag tgaaattcca cttcacagtt
     5401 tcagatggag aacacacaag tccggagatg gtcctcacca ttcacttact tcccagtgat
     5461 cagcaactgc cagtgttcca ggtcacagct ccacggctgg cggtcagccc aggaggcagc
     5521 acttctgtag gacttcaggt ggtagtaaga gatgctgaga cagcgcccaa agaactcttc
     5581 tttgagcttc ggagacctcc acagcatggt gtgcttctta agcatacagc tgagttccga
     5641 aggccgatgg ccacaggtga cactttcacc tatgaggatg ttgagaaaaa tgctctacag
     5701 tatatacatg atggttcctc tacccgggaa gacagcatgg agatctcagt cacagatggc
     5761 ctcacagtga caatgctgga ggtgagagta gaggtgtccc tgtcagaaga ccgagggcct
     5821 cgactggctg ctggctcctc tctgagcatt actgttgcca gtaaaagcac agccataatc
     5881 actaggtcac accttgctta cgtggatgat tcttcccccg acccagagat ctggattcag
     5941 ttaaattatc tgccctcata tggtactctc ttaagaatct caggatctga ggtggaagag
     6001 ctctcagaag tttccaattt cacaatggaa gacatcaata acaagaaaat cagatactca
     6061 gctgtgtttg aaactgatgg tcatctggtt actgatagct tctatttctc tgtctctgac
     6121 atggaccaca accatctgga taatcagata tttaccatca tgatcactcc tgctgaaaat
     6181 ccacctccag tcattgcttt tgctgacctt atcacggttg atgagggagg gagagcacca
     6241 ctctcatttc accatttttt tgctactgat gatgatgaca acctccagag agatgccatc
     6301 attaaactaa gtgctctgcc caaatatggc tgcattgaga acacaggaac aggtgatcgt
     6361 tttggccctg aaactgccag tgacctagag gcatcatttc ctattcaaga cgtcctggaa
     6421 aactacattt actactttca gagtgttcat gaaagcattg agccaaccca tgatattttt
     6481 agtttttatg tgagtgatgg aaccagtcgt tcagaaattc acagcatcaa tatcaccatt
     6541 gagaggaaga acgatgagcc tcccaggatg accttgcagc ccctcagagt gcagctgagc
     6601 tcgggagtgg tgataagcaa ttcttctttg agcctgcaag acctggacac cccagataat
     6661 gagctcattt ttgtattgac aaaaaagcct gaccacggtc atgtactctg gaggcaaact
     6721 gcttctgagc ctctggagaa tgggagagtt ttagtccagg gctcaacctt cacctaccag
     6781 gatatcctag ctgggctggt tgggtatgtg cctagtgtcc ctggcatggt cgtggatgag
     6841 ttccagttct ccctcactga tggcctccac gtggacacag ggaggatgaa gatctacaca
     6901 gaactgcctg caagtgacac acctcacttg gctataaacc aaggcctaca gctctcagca
     6961 gggtctgtag cacgcatcac agaacagcac ttgaaagtga cagatattga ctcagatgac
     7021 catcaggtta tgtacatcat gaaggaagat cctggtgcag ggcgcctgca gatgatgaag
     7081 catggcaacc tggagcaaat ttctattaaa ggccccatcc gaagtttcac ccaggcagac
     7141 attagccaag gccacgtaga atatagtcat ggaacaggag aacctggagg gagctttgct
     7201 tttaaatttg atgtggttga tggagaaggc aacagattga ttgacaagtc attttccatc
     7261 agcattctag aagacaaatc cccaccagtc atcaccacca ataaaggact ggtcttggat
     7321 gaaaactcag tgaagaaaat caccaccctg cagctgtctg ccactgacca ggacagtggg
     7381 cctacagaat tgatctacag aatcaccaga cagccccagc tgggccactt ggaacatgca
     7441 gcatcaccag gtatccagat tagttccttt actcaagctg atctgacttc acgaaatgtt
     7501 cagtatgtcc attctagtga ggctgagaaa cattcagatg ccttcagctt tacactgtct
     7561 gatggagtca gtgaggtgac tcagactttc catatcactc ttcaccctgt cgatgattcg
     7621 ctgcccgtcg tacagaactt aggaatgcgg gtgcaggagg gcatgaggaa gaccatcaca
     7681 gagtttgagc ttaaggcggt ggatgctgac acagaggccg agtctgtcac attcaccatc
     7741 gtgcagcctc cacgccatgg caccatcgag cgaaccagca atgggcagca tttccacctc
     7801 acctccacct tcaccatgaa agatatctac cagaaccggg tcagctacag ccatgacggc
     7861 agtaactccc tcaaggaccg gttcaccttc actgtttctg atgggacaaa ccccttcttt
     7921 atcattgagg aagggggaaa agagattatg acagcagcac ctcagccgtt ccgagtagac
     7981 atcctcccgg tagatgatgg cacgcctaga attgtcacca acctgggact ccagtggctg
     8041 gaatacatgg atggcaaggc aaccaacctg atcaccaaga aggaactgct gaccatggac
     8101 ccagacaccg aggacgcgca gcttgtctat gagataacga cgggccctaa gcatggcttt
     8161 gtggagaaca agctgcagcc tggcagagct gctgccactt tcacccagga ggatgtgaac
     8221 ttggggttga ttcgttatgt gttgcacaag gagaagatcc gtgagatgat ggatagtttt
     8281 cagtttctgg tgaaagacag taaacccaat gtggtcagcg acaatgtctt ccatatccag
     8341 tggtcactca tcagctttaa atataccagc tacaatgtca gtgagaaggc agggtctgtc
     8401 agtgtcacgg tgcagaggac tgggaacctg aaccaatatg ccatcgtcct gtgtcgcacc
     8461 gagcaaggca ccgccagctc cagctccagg gtcagctccc aacctgggca acaggactat
     8521 gtagagtatg ctggccaggt ccagtttgat gagcgagagg acaccaagtc ctgcaccatt
     8581 gtcatcaacg atgatgacgt gtttgaaaat gttgagagtt tcactgtgga gctcagcatg
     8641 ccagcttatg ccctgttagg ggaattcacc caggcgaagg tcattatcaa cgataccgag
     8701 gatgaaccca cattagagtt tgacaagaag atctactggg ttaacgagag cgctggtttt
     8761 ctgtttgcac ctattgaaag aaaaggagat gcaagcagca ttgtatctgc aatttgctac
     8821 acagtcccta agtcagctat gggaagtagc ctctatgctc tagaatcagg ctctgatttt
     8881 aaatctagag ggatgtctgc cgcgagtcgt gtgatattcg ggcctggtgt gaccatgtcc
     8941 acctgtgatg tcatgcttat tgatgacagc gagtatgaag aggaagaaga gtttgagatt
     9001 gccttggcag atgcctctga caatgcccgc attggaaggg tggcgacagc caaggtgctc
     9061 attagtggtc ccaacgatgc ctcgactgtg tccctgggca acacggcttt cactgtcagt
     9121 gaggacgcag gcacagtaaa gattccagtt atccgccatg gtactgacct ctctactttc
     9181 gcatctgtct ggtgtgcaac gcggccctca gacccagctt ctgccacacc aggagttgac
     9241 tacgttccca gctctcggaa ggtggaattt gggcctggtg tcattgaaca gtattgcacc
     9301 ttgactatct tggatgacac tcagtatccg gtaattgaag gactggagac atttgtggtt
     9361 ttcctcagct cagcacaagg agccgaactg accaaaccct tccaggcagt cattgcaatt
     9421 aatgacacat tccaagatgt gcccagcatg cagtttgcca aggatttgct cctagtgaag
     9481 gagaaggagg gtgtcctgca tgtccctatc actcggagcg gagacctgag ctatgagtca
     9541 tcagtgaggt gctatactca gagccattcc gctcaggtca tggaggactt tgaggagaga
     9601 caaaatgcag actcttcacg gattacattt ctcaaagggg acaaagtgaa gaactgtacg
     9661 gtctatatcc acgatgactc catgtttgag ccagaggaac agttcagggt ctacctcggc
     9721 cttcctcttg gaaaccactg gagtggagct agaattggaa agaataacat ggccaccatc
     9781 accatatcca atgatgaaga tgcccccacc attgagtttg aagaagctgc ataccaagtc
     9841 cgggaacccg caggcccaga tgccattgcg attctgaaca tcaaggtgat ccgcagaggg
     9901 gatcagaaca ggacctccaa ggttcgctgc agcacgcggg atggctctgc ccagtctggt
     9961 gtggattatt acccaaagag ccgagtcttg aagttcagtc ccggtgtgga tcatatcttt
    10021 tttaaagttg agatcctgtc caatgaagac cgggaatggc atgaatcttt ctcactagtc
    10081 cttggcccag atgacccagt ggaagcagtt cttggggatg tgactactgc cacggtgaca
    10141 attctagacc aggaggcagc agggagcctc atattgccag caccacccat tgtggtcaca
    10201 cttgctgact atgaccatgt ggaagaagtt accaaggaag gagtcaagaa atccccctcc
    10261 ccaggctacc cactggtctg tgtcaccccc tgcgaccctc atttccccag atacgctgtc
    10321 atgaaggagc gctgcagtga ggccggcatc aaccagacat ctgtgcagtt cagctgggaa
    10381 gtggctgccc ccactgatgg caatggggcc cggtctccct ttgaaaccat cactgacaac
    10441 acaccattca ccagtgtcaa ccacatggtc ctggacagca tttacttcag ccggaggttc
    10501 catgtgcgtt gtgtggccaa ggctgtggac aaggtgggcc atgtggggac ccccttaagg
    10561 agcaacattg ttaccattgg aacagacagt gctatctgcc acacaccagt ggtggctggg
    10621 acatccagag gcttccaggc tcagtccttc atcgcaacct tgaaatacct ggatgtcaaa
    10681 cataaggagc atccgaacag aatccacatt tcggtgcaga tcccacacca ggatggaatg
    10741 ctgcccctta tctccaccat gccgttgcac aacttacatt ttctactgtc tgagtccatc
    10801 tacagacacc agcacgtctg ctccaattta gttaccacct atgacctgag aggcatctca
    10861 gaggcagggt tcctggatga tgtggtctat gatagcactg ccctggggcc tggctacgat
    10921 cgccccttcc agtttgaccc cagcgtgcga gagccgaaga ccatccagct ctacaaacac
    10981 ctgaacctga agagctgcgt gtggaccttt gatgcttatt atgacatgac tgagctgatt
    11041 gacgtctgtg ggggctctgt aaccgctgac ttccaggtga gggactctgc ccagtccttc
    11101 ttgacagtgc acgtgcctct atatgtgtcc tacatctatg tgacagcccc caggggctgg
    11161 gcctccttgg agcaccacac cgagatggag ttttctttct tctatgacac tgttctctgg
    11221 agaacaggaa tccagacaga cagcgtgctc tctgcaaggc ttcagataat aagaatctac
    11281 attcgagagg atggccgtct tgtcattgaa ttcaagaccc atgccaaatt cagaggacag
    11341 tttgtgatgg agcatcacac tctcccagaa gtgaaatctt tcgtattgac tccagaccac
    11401 ctaggaggaa ttgaatttga cttgcagcta ttatggagcg ctcagacttt tgattctcca
    11461 catcaactct ggagagccac aagctcttat aacaggaagg actactcagg agagtacacc
    11521 atctacctga tcccttgcac agtgcagccc acacagccat gggttgaccc aggagagaag
    11581 cctttggcct gcactgcaca tgccccagaa agattcctga tacccattgc attccagcag
    11641 accaaccgcc ctgtgccagt tgtgtattca cttaacactg aatttcagct ctgcaataat
    11701 gagaaggtgt tcctaatgga tcccaataca tctgatatgt cactagcaga aatggattac
    11761 aaaggagcct tttcaaaagg tcaaatcctt tatggccgag tactttggaa tccagaacaa
    11821 aatcttaatt ctgcttacaa actccagctg gagaaagtct atctttgtac gggcaaggat
    11881 ggttatgtgc ctttctttga tcccacgggg acaatctaca atgaagggcc ccagtatgga
    11941 tgcattcagc caaacaaaca cctaaaacac agattcctgc tgttggaccg caatcagcca
    12001 gaggtaactg ataagtactt ccatgatgtg ccttttgagg ctcactttgc ctctgagttg
    12061 cctgatttcc atgtggtcag taacatgcca ggtgtggatg gatttactct aaaagtagat
    12121 gcactctata aggtggaagc aggacaccag tggtatctcc aggtcatcta catcattggc
    12181 cctgacacca tctcagggcc ccgggtccag cgctctctca cagctccact cagacgcaac
    12241 cgaagggacc tggtagagcc cgatggccag ctgatccttg atgattccct catctatgac
    12301 aatgaaggag accaagtcaa gaatggcacc aatatgaagt ccctgaatct ggagatgcaa
    12361 gagttggcgg tagctgcgtc cctgtcacag actggggcgt ccattggcag tgccctggct
    12421 gcaatcatgc ttctacttct ggtgtttttg gtggcttgtt ttatcaacag gaaatgccag
    12481 aaacagagga agaagaagcc cgcagaggac attttggaag aatatcctct gaataccaag
    12541 gtagaagtgc ccaagaggca cccggaccgg gtggagaaga acgtgaatag acactactgc
    12601 actgtgcgga acgtcaacat cctgagtgag cctgaggcgg cttacacgtt caaaggtgct
    12661 aaagtcaaaa gactgaatct agaagtcaga gttcacaaca atttacaaga tggaacagaa
    12721 gtttaatgga ggagacctat gtgtattttt ttctaaaatc atttttataa aatgggggga
    12781 aatactggta tttttataat ctcgcagata aaaaagggaa aactatagct ttgagtggca
    12841 gacagcacac atcacatgca tcaactcaca actgagctac ctcattcagc aaagaaccac
    12901 tgagaacccc agagtattac agttatttcc gtagatccct ttaatagtgt caacaactgt
    12961 acacagctcc ttctgtaagg ctggtcttag aaaacaagta ctttagtatc aggacaggag
    13021 ttgaacaatt aggttagcag atggagatga gaggactggg tagagtacca tggcagatct
    13081 cagagagaag aagtaggtac gggcctttgg ttccctcccc cagccccagc tttctcctac
    13141 agggcttttc ctgagtcccc agacagcaga gtatgaactg ctgacaccca gattccatta
    13201 aaaattctgc taatcgacac aacacatata tttgctcatg atttcacttg acagcgtatg
    13261 ctccttggcc tctaattgta ctttgctttt ccagagccct ttttacctgg ggatttcagt
    13321 gtgcttaagt aaaatcctct gaaaaccacg ggagcctctg cctcctcagc cacagagaac
    13381 tccctcctac aaagggggag actgaaaccc gagttaagga ggggcctggc aggcgtatca
    13441 gagcacatta gtgatgccct tcaccccagg gaggtgtctg ttcccaacta gtttatgtgg
    13501 cactgagaca tccatccctg accaaggatg ctgcgaaaca ggatcaatgt actacggcct
    13561 tttaattcaa cattgccata aatgctttaa agaaaaccca ccacactttc ctcctactcc
    13621 ggtctttgcc cgttcctgta acagacaatc ccatgtccta ggtatggttt tttattctgt
    13681 tagtgcttcg ggaaagtaag tgattcattt gaataaggca aattaggaga aagcccaggt
    13741 tggggtgaaa tcagacttaa cagatacatg ctggttctcc ttgctgtgtg tgacacagca
    13801 gacagaggca ctattcctgg tgcagtattt cagggatttc tctttgaggg gttcttttct
    13861 ggtagctcag gcaattattt ttaccatatc agcacatgac aaggccatga acacatggct
    13921 ctaaaataat ttagtgttca agtatcagct taactatttt gtgtaggcta cacacagctt
    13981 gcttttgttt ctcttctgtt tctgccttat tggcggaaac ataagcgtgc atgccatgtt
    14041 gttttgaatt ggaggcacaa tttcattatt cgagagtaaa agacatgtcc tcttctgatg
    14101 catggcacac catagtcacc aagcaaataa cagagccttc acattgtgta atatttgtat
    14161 gagaatgact caagctcttt gagaacattc caaactagta acatttcgct actaaaagct
    14221 agaaaggatg aactgtgaaa ggttctaggc agctctgtga gactccaagc tccttgaaag
    14281 taggaccttt gtgagccacg cctttcattc ttcaacagtg ccttgcatgt aacaagcact
    14341 ccagaaatgt ttgttgaatg aatgaatggt gtcatgggtg aatgatgggg agtaaattta
    14401 ggaaggggaa gtgagagagt atggtggcaa tatcacaagg gaggagagag gaaaacaatt
    14461 atcttctcta cttggattat gagataacct tttcttggag gaaagaaaca ccgctttaca
    14521 aaggcatgac tctggcggtg gtcctaagga agcatgagca gaaaattcat aaaaatgtat
    14581 catcagcagg agatgagact atgaattggc atccagaaca ggagatttag agcaaaatct
    14641 aatttagcat tctgagatga gtgtcaggtt ttcaggagag aatgagttgg ggtgagccca
    14701 gagtctgaaa ctcctgactg gtcaggtgct acttaagacc agcttgggca attcagggca
    14761 gaactcctgt atcagcctca tggacaccca gaattggtat ctcatggctg gagagctgat
    14821 cagccaggca cagaatctcc agaacaacct agagagtgaa tgctaatttg tagagcgaac
    14881 ttccatttgg cccattattt gtaactgtgt aactgctcca agtgccagaa tgcttacacg
    14941 ttaaagcagc acctttccat ttgcccacat attcttcttg cacacccctt ccattactgc
    15001 tgaataggac attgcatggg aagagtacag aggtggcaga atgaagctag agtgggaagg
    15061 actaaagact gagccccaga gtgctcccag caaccgccac gtacaaggtc tgaaatgaca
    15121 agggcaagag tgagatagga aactgtgtgt gaaaggaaag cccttgcagt atttctgcct
    15181 ccctttcttt ctgcctttca ccccactaaa tgtatgttat tgaatgccag tacttctcta
    15241 gtggatgcac acttgttaaa tagtgttaag agatgtggag atgagatata cccctttgat
    15301 gtagaattat tcatttggtt tgtttcatac ttcattatag gaatcaagta atttgatgac
    15361 taatgtggat tatatttcag tcaaagctct gctttcaatt tctctgattt gctcactaat
    15421 gccttgtgtg tgttttacta accttttata tcttgccttc aagtgagaag gaacaaacaa
    15481 ctctcagtgg ttactacttg cttttatatg ctggctgtga aggttaaaag aaagaatggt
    15541 ctgtaccatt ctgctttgct gcccttttat tgtaccccag gcctcctaga ggactcctgc
    15601 agattctatt gttgggtggg aaatagtgtt ggaatgtgtt tgcacagtct tatgatattc
    15661 agtctcagtc tgctataggt atttgttatt cttggatact acacacctgc tcagactgag
    15721 taaacatttg tggtgctgtc aacctgattt cttgactctc aaatgatttt tgtatttcca
    15781 atatgaattt gtgtgttatg aatttctgat ttctccaata gtatatgcca ctatataaat
    15841 ttgtattaat aaatgacagt cttgttggtt t
//
