LOCUS       NM_002030               2627 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens formyl peptide receptor 3 (FPR3), mRNA.
ACCESSION   NM_002030
VERSION     NM_002030.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2627)
  AUTHORS   Wang,L., Mao,X., Yu,X., Su,J., Li,Z., Chen,Z., Ren,Y., Huang,H.,
            Wang,W., Zhao,C. and Hu,Y.
  TITLE     FPR3 reprograms glycolytic metabolism and stemness in gastric
            cancer via calcium-NFATc1 pathway
  JOURNAL   Cancer Lett 593, 216841 (2024)
   PUBMED   38614385
  REMARK    GeneRIF: FPR3 reprograms glycolytic metabolism and stemness in
            gastric cancer via calcium-NFATc1 pathway.
REFERENCE   2  (bases 1 to 2627)
  AUTHORS   Lee,C., Han,J. and Jung,Y.
  TITLE     Formyl peptide receptor 2 is an emerging modulator of inflammation
            in the liver
  JOURNAL   Exp Mol Med 55 (2), 325-332 (2023)
   PUBMED   36750693
  REMARK    GeneRIF: Formyl peptide receptor 2 is an emerging modulator of
            inflammation in the liver.
            Review article
REFERENCE   3  (bases 1 to 2627)
  AUTHORS   Nawaz,M.I., Rezzola,S., Tobia,C., Coltrini,D., Belleri,M.,
            Mitola,S., Corsini,M., Sandomenico,A., Caporale,A., Ruvo,M. and
            Presta,M.
  TITLE     D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce
            neovascularization via endothelial N-formyl peptide receptor 3
  JOURNAL   Angiogenesis 23 (3), 357-369 (2020)
   PUBMED   32152757
  REMARK    GeneRIF: D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce
            neovascularization via endothelial N-formyl peptide receptor 3.
REFERENCE   4  (bases 1 to 2627)
  AUTHORS   Chen,Y.C., Su,M.C., Chin,C.H., Lin,I.C., Hsu,P.Y., Liou,C.W.,
            Huang,K.T., Wang,T.Y., Lin,Y.Y., Zheng,Y.X., Hsiao,C.C. and
            Lin,M.C.
  TITLE     Formyl peptide receptor 1 up-regulation and formyl peptide receptor
            2/3 down-regulation of blood immune cells along with defective
            lipoxin A4/resolvin D1 production in obstructive sleep apnea
            patients
  JOURNAL   PLoS One 14 (5), e0216607 (2019)
   PUBMED   31116781
  REMARK    GeneRIF: Low FPR3 expression is associated with obstructive sleep
            apnea.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2627)
  AUTHORS   Chen,Y.C., Lin,M.C., Lee,C.H., Liu,S.F., Wang,C.C., Fang,W.F.,
            Chao,T.Y., Wu,C.C., Wei,Y.F., Chang,H.C., Tsen,C.C. and Chen,H.C.
  CONSRTM   Taiwan Clinical Trial Consortium of Respiratory Disease (TCORE)
            group
  TITLE     Defective formyl peptide receptor 2/3 and annexin A1 expressions
            associated with M2a polarization of blood immune cells in patients
            with chronic obstructive pulmonary disease
  JOURNAL   J Transl Med 16 (1), 69 (2018)
   PUBMED   29544524
  REMARK    GeneRIF: These findings provide evidence for defective FPR2/3 and
            annexin A1 expressions that, associated with decreased M2a
            polarization, might be involved in the development of cigarette
            smoking induced persistent airflow limitation in chronic
            obstructive pulmonary disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2627)
  AUTHORS   Christophe,T., Karlsson,A., Rabiet,M.J., Boulay,F. and Dahlgren,C.
  TITLE     Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through
            FPRL1/LXA4R, is not affected by lipoxin A4
  JOURNAL   Scand J Immunol 56 (5), 470-476 (2002)
   PUBMED   12410796
  REMARK    GeneRIF: investigated the direct effect of LXA4 as well as the
            effect on agonist-induced biological responses using transfected
            HL-60 cells expressing FPR, FPRL1 or FPRL2
REFERENCE   7  (bases 1 to 2627)
  AUTHORS   Yang,D., Chen,Q., Gertz,B., He,R., Phulsuksombati,M., Ye,R.D. and
            Oppenheim,J.J.
  TITLE     Human dendritic cells express functional formyl peptide
            receptor-like-2 (FPRL2) throughout maturation
  JOURNAL   J Leukoc Biol 72 (3), 598-607 (2002)
   PUBMED   12223529
  REMARK    GeneRIF: Human dendritic cells express functional FPRL2 throughout
            maturation. FPRL2 & its endogenous ligand may be involved in
            regulating DC trafficking during Ag uptake & processing s well as
            the T-cell-stimulating phase of the immune responses.
REFERENCE   8  (bases 1 to 2627)
  AUTHORS   Christophe,T., Karlsson,A., Dugave,C., Rabiet,M.J., Boulay,F. and
            Dahlgren,C.
  TITLE     The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically
            activates neutrophils through FPRL1/lipoxin A4 receptors and is an
            agonist for the orphan monocyte-expressed chemoattractant receptor
            FPRL2
  JOURNAL   J Biol Chem 276 (24), 21585-21593 (2001)
   PUBMED   11285256
REFERENCE   9  (bases 1 to 2627)
  AUTHORS   Durstin,M., Gao,J.L., Tiffany,H.L., McDermott,D. and Murphy,P.M.
  TITLE     Differential expression of members of the N-formylpeptide receptor
            gene cluster in human phagocytes
  JOURNAL   Biochem Biophys Res Commun 201 (1), 174-179 (1994)
   PUBMED   8198572
REFERENCE   10 (bases 1 to 2627)
  AUTHORS   Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C.
  TITLE     Mapping of genes for the human C5a receptor (C5AR), human FMLP
            receptor (FPR), and two FMLP receptor homologue orphan receptors
            (FPRH1, FPRH2) to chromosome 19
  JOURNAL   Genomics 13 (2), 437-440 (1992)
   PUBMED   1612600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA844883.1, AK123030.1, CB996360.1, BC059388.1 and AI301735.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002030.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059388.1, AK292541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339223.5/ ENSP00000341821.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA844883.1         12-12
            2-175               AK123030.1         4-177
            176-743             CB996360.1         197-764
            744-1549            AK123030.1         698-1503
            1550-1550           BC059388.1         1544-1544
            1551-2518           AK123030.1         1505-2472
            2519-2627           AI301735.1         6-114               c
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2627
                     /gene="FPR3"
                     /gene_synonym="FML2_HUMAN; FMLP-R-II; FMLPY; FPRH1; FPRH2;
                     FPRL2; RMLP-R-I"
                     /note="formyl peptide receptor 3"
                     /db_xref="GeneID:2359"
                     /db_xref="HGNC:HGNC:3828"
                     /db_xref="MIM:136539"
     exon            1..175
                     /gene="FPR3"
                     /gene_synonym="FML2_HUMAN; FMLP-R-II; FMLPY; FPRH1; FPRH2;
                     FPRL2; RMLP-R-I"
                     /inference="alignment:Splign:2.1.0"
     exon            176..2627
                     /gene="FPR3"
                     /gene_synonym="FML2_HUMAN; FMLP-R-II; FMLPY; FPRH1; FPRH2;
                     FPRL2; RMLP-R-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1247
                     /gene="FPR3"
                     /gene_synonym="FML2_HUMAN; FMLP-R-II; FMLPY; FPRH1; FPRH2;
                     FPRL2; RMLP-R-I"
                     /note="formyl peptide receptor-like 2; FMLP-related
                     receptor II"
                     /codon_start=1
                     /product="N-formyl peptide receptor 3"
                     /protein_id="NP_002021.3"
                     /db_xref="CCDS:CCDS12841.1"
                     /db_xref="GeneID:2359"
                     /db_xref="HGNC:HGNC:3828"
                     /db_xref="MIM:136539"
                     /translation="METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGN
                     GLVIWVAGFRMTRTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVH
                     VMIDINLFVSVYLITIIALDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPN
                     FIFWTTISTTNGDTYCIFNFAFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIIT
                     VCYGIIAAKIHRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGK
                     YKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSAQT
                     SNTDTTSASPPEETELQAM"
     regulatory      2606..2611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FPR3"
                     /gene_synonym="FML2_HUMAN; FMLP-R-II; FMLPY; FPRH1; FPRH2;
                     FPRL2; RMLP-R-I"
                     /note="hexamer: AATAAA"
     polyA_site      2627
                     /gene="FPR3"
                     /gene_synonym="FML2_HUMAN; FMLP-R-II; FMLPY; FPRH1; FPRH2;
                     FPRL2; RMLP-R-I"
                     /note="major polyA site"
ORIGIN      
        1 caaaacactc attttgtttt atagcatgac aggctgtctg attccatctt tataaccaaa
       61 gccaattaag atcttaaaac caaacatata acttcatctt tttacaagta cttagagcct
      121 gagttgctcc acaggaatcc aggaactggg cacaggaaaa ggatctaagc tggtggtgtg
      181 ggaagatgga aaccaacttc tccattcctc tgaatgaaac tgaggaggtg ctccctgagc
      241 ctgctggcca caccgttctg tggatcttct cattgctagt ccacggagtc acctttgtct
      301 tcggggtcct gggcaatggg cttgtgatct gggtggctgg attccggatg acacgcacag
      361 tcaacaccat ctgttacctg aacctggccc tagctgactt ctctttcagt gccatcctac
      421 cattccgaat ggtctcagtc gccatgagag aaaaatggcc ttttggctca ttcctatgta
      481 agttagttca tgttatgata gacatcaacc tgtttgtcag tgtctacctg atcaccatca
      541 ttgctctgga ccgctgtatt tgtgtcctgc atccagcctg ggcccagaac catcgcacca
      601 tgagtctggc caagagggtg atgacgggac tctggatttt caccatagtc cttaccttac
      661 caaatttcat cttctggact acaataagta ctacgaatgg ggacacatac tgtattttca
      721 actttgcatt ctggggtgac actgctgtag agaggttgaa cgtgttcatt accatggcca
      781 aggtctttct gatcctccac ttcattattg gcttcagcgt gcctatgtcc atcatcacag
      841 tctgctatgg gatcatcgct gccaaaattc acagaaacca catgattaaa tccagccgtc
      901 ccttacgtgt cttcgctgct gtggtggctt ctttcttcat ctgttggttc ccttatgaac
      961 taattggcat tctaatggca gtctggctca aagagatgtt gttaaatggc aaatacaaaa
     1021 tcattcttgt cctgattaac ccaacaagct ccttggcctt ttttaacagc tgcctcaacc
     1081 caattctcta cgtctttatg ggtcgtaact tccaagaaag actgattcgc tctttgccca
     1141 ctagtttgga gagggccctg actgaggtcc ctgactcagc ccagaccagc aacacagaca
     1201 ccacttctgc ttcacctcct gaggagacgg agttacaagc aatgtgaggt cggggatatt
     1261 tttgggctct gtctctttct accctgcgtt aagcggaaaa aaaaaattct gacagtgttt
     1321 ttcttcctct ttcataccac caccaccaca atcatcaaca taaaggaagt ctgtaccaaa
     1381 tctgtagggg gtttttccca caaccaagca atagacacca gctgggtgtc ctacaattaa
     1441 attccaacac tatctacctg gagctactgt cagatcccac aggtttaagg gctcattccc
     1501 caagtctgct cctccagttg agacacaagt cacaaatcca ggcttctgaa acttcggacc
     1561 aaccagcttc aatcagggtt cccactaccc cctctttggg ggtagagtgg ctcatggaac
     1621 tcagagaaac atttatttcg gcttgctggt ttattataaa agcaaggttt attataaaag
     1681 atactacaaa ggatacagat gaagaggcac atagggcaag gtacggggtt ccacgccctc
     1741 cctgagtgca tcaccctctg ggaacctccg tgtgttcacg tctcatgaag ctctccaaat
     1801 ccagtcctct tgggttttta tggaagcttc atgatgtcag cattctttcc tccagtgtat
     1861 aggatgggat cctctctggg gagggtctta agacccacaa ttagaaaggc aagggaagat
     1921 tagagtcctg ctttggggta gatgaaagga aaggagagag attctgtttc ctgaggctta
     1981 atacacccaa cattataaca aaggactgta gcaagggcta tgggagttct gaagcagaaa
     2041 ccatgggcta aaaccaacat acatcttaat accagatacc ctaatcccag tcctaacttc
     2101 atttaacctt ggtcacattg agtcattcca ggatgagtgg ctcaagtatt tcctcaggga
     2161 aaatacttct gtgccccctg atttgagggt aagaagtaga taatgaggcc actgtgggtg
     2221 ttattttttc atgtctggac ctcagcctat atcctgagac taagtggaag tgggaaaaga
     2281 gtacaagaga agagacaaag tggggatatt tgtaaggctt agatgagata gtgttttttt
     2341 agaaaaaaac tttatcttac cattaagtaa aatgtttgcc ataggctttc tggggctttc
     2401 tctttttaaa gtcagactgt tgaaggtttc ttctattctt atttgttaag agttttcttt
     2461 tattgtttaa atcatgaatg aatgttgaat tttattaaat gcagtttctg taaatattaa
     2521 cgtgatcata ttatttttat tctttcattt acataattat aaattagatt aagttttcaa
     2581 tgttaagcta cccttgcatt tatgaaataa accacgcttg ctcatga
//
