LOCUS       NM_001005738            1938 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens formyl peptide receptor 2 (FPR2), transcript variant
            2, mRNA.
ACCESSION   NM_001005738
VERSION     NM_001005738.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Cimmino,T.P., Pagano,E., Stornaiuolo,M., Esposito,G., Ammendola,R.
            and Cattaneo,F.
  TITLE     Formyl-peptide receptor 2 signalling triggers aerobic metabolism of
            glucose through Nox2-dependent modulation of pyruvate dehydrogenase
            activity
  JOURNAL   Open Biol 13 (10), 230336 (2023)
   PUBMED   37875162
  REMARK    GeneRIF: Formyl-peptide receptor 2 signalling triggers aerobic
            metabolism of glucose through Nox2-dependent modulation of pyruvate
            dehydrogenase activity.
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Lee,C., Han,J. and Jung,Y.
  TITLE     Formyl peptide receptor 2 is an emerging modulator of inflammation
            in the liver
  JOURNAL   Exp Mol Med 55 (2), 325-332 (2023)
   PUBMED   36750693
  REMARK    GeneRIF: Formyl peptide receptor 2 is an emerging modulator of
            inflammation in the liver.
            Review article
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Lou,X., Liu,S., Shi,J., Chen,H., Wang,Z., Le,Y., Chen,H., Zhu,R.
            and Yu,Y.
  TITLE     The G-Protein-Coupled Formyl Peptide Receptor 2 Promotes
            Endothelial-Mesenchymal Transition in Diabetic Retinopathy
  JOURNAL   Ophthalmic Res 66 (1), 681-691 (2023)
   PUBMED   36805961
  REMARK    GeneRIF: The G-Protein-Coupled Formyl Peptide Receptor 2 Promotes
            Endothelial-Mesenchymal Transition in Diabetic Retinopathy.
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Huang,K., Wang,Z., He,Z., Li,Y., Li,S., Shen,K., Zhu,G., Liu,Z.,
            Lv,S., Zhang,C., Yang,H., Yang,X. and Liu,S.
  TITLE     Downregulated formyl peptide receptor 2 expression in the
            epileptogenic foci of patients with focal cortical dysplasia type
            IIb and tuberous sclerosis complex
  JOURNAL   Immun Inflamm Dis 10 (11), e706 (2022)
   PUBMED   36301030
  REMARK    GeneRIF: Downregulated formyl peptide receptor 2 expression in the
            epileptogenic foci of patients with focal cortical dysplasia type
            IIb and tuberous sclerosis complex.
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Filiberto,A.C., Ladd,Z., Leroy,V., Su,G., Elder,C.T., Pruitt,E.Y.,
            Hensley,S.E., Lu,G., Hartman,J.B., Zarrinpar,A., Sharma,A.K. and
            Upchurch,G.R. Jr.
  TITLE     Resolution of inflammation via RvD1/FPR2 signaling mitigates Nox2
            activation and ferroptosis of macrophages in experimental abdominal
            aortic aneurysms
  JOURNAL   FASEB J 36 (11), e22579 (2022)
   PUBMED   36183323
  REMARK    GeneRIF: Resolution of inflammation via RvD1/FPR2 signaling
            mitigates Nox2 activation and ferroptosis of macrophages in
            experimental abdominal aortic aneurysms.
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Nomura,H., Nielsen,B.W. and Matsushima,K.
  TITLE     Molecular cloning of cDNAs encoding a LD78 receptor and putative
            leukocyte chemotactic peptide receptors
  JOURNAL   Int Immunol 5 (10), 1239-1249 (1993)
   PUBMED   7505609
REFERENCE   7  (bases 1 to 1938)
  AUTHORS   Perez,H.D., Holmes,R., Kelly,E., McClary,J. and Andrews,W.H.
  TITLE     Cloning of a cDNA encoding a receptor related to the formyl peptide
            receptor of human neutrophils
  JOURNAL   Gene 118 (2), 303-304 (1992)
   PUBMED   1511907
REFERENCE   8  (bases 1 to 1938)
  AUTHORS   Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C.
  TITLE     Mapping of genes for the human C5a receptor (C5AR), human FMLP
            receptor (FPR), and two FMLP receptor homologue orphan receptors
            (FPRH1, FPRH2) to chromosome 19
  JOURNAL   Genomics 13 (2), 437-440 (1992)
   PUBMED   1612600
REFERENCE   9  (bases 1 to 1938)
  AUTHORS   Ye,R.D., Cavanagh,S.L., Quehenberger,O., Prossnitz,E.R. and
            Cochrane,C.G.
  TITLE     Isolation of a cDNA that encodes a novel granulocyte N-formyl
            peptide receptor
  JOURNAL   Biochem Biophys Res Commun 184 (2), 582-589 (1992)
   PUBMED   1374236
REFERENCE   10 (bases 1 to 1938)
  AUTHORS   Murphy,P.M., Ozcelik,T., Kenney,R.T., Tiffany,H.L., McDermott,D.
            and Francke,U.
  TITLE     A structural homologue of the N-formyl peptide receptor.
            Characterization and chromosome mapping of a peptide
            chemoattractant receptor family
  JOURNAL   J Biol Chem 267 (11), 7637-7643 (1992)
   PUBMED   1373134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018755.3, BM922150.1, BC071722.1 and D10922.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001005738.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA674465.1, SRR1803612.48234.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340023.7/ ENSP00000340191.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC018755.3         188329-188348
            21-65               BM922150.1         37-81
            66-1906             BC071722.1         316-2156
            1907-1933           D10922.1           1876-1902
            1934-1938           AC018755.3         197676-197680
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1938
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
                     /note="formyl peptide receptor 2"
                     /db_xref="GeneID:2358"
                     /db_xref="HGNC:HGNC:3827"
                     /db_xref="MIM:136538"
     exon            1..51
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
                     /inference="alignment:Splign:2.1.0"
     exon            52..1938
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1121
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
                     /note="formyl peptide receptor-like 1; lipoxin A4 receptor
                     (formyl peptide receptor related); RFP; FMLP-R-I; LXA4
                     receptor; FMLP-related receptor I"
                     /codon_start=1
                     /product="N-formyl peptide receptor 2"
                     /protein_id="NP_001005738.1"
                     /db_xref="CCDS:CCDS12840.1"
                     /db_xref="GeneID:2358"
                     /db_xref="HGNC:HGNC:3827"
                     /db_xref="MIM:136538"
                     /translation="METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGN
                     GLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIH
                     IVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPV
                     FLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVA
                     ICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGK
                     YKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTND
                     TAANSASPPAETELQAM"
     regulatory      1687..1692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
                     /note="hexamer: AATAAA"
     polyA_site      1708
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
                     /note="hexamer: ATTAAA"
     polyA_site      1938
                     /gene="FPR2"
                     /gene_synonym="ALX; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1;
                     FPRH2; FPRL1; HM63; LXA4R"
                     /note="major polyA site"
ORIGIN      
        1 gttgctccac aggaagccaa gaagcacaca ggaaaaggag cttagctgct ggtgctgctg
       61 gcaagatgga aaccaacttc tccactcctc tgaatgaata tgaagaagtg tcctatgagt
      121 ctgctggcta cactgttctg cggatcctcc cattggtggt gcttggggtc acctttgtcc
      181 tcggggtcct gggcaatggg cttgtgatct gggtggctgg attccggatg acacgcacag
      241 tcaccaccat ctgttacctg aacctggccc tggctgactt ttctttcacg gccacattac
      301 cattcctcat tgtctccatg gccatgggag aaaaatggcc ttttggctgg ttcctgtgta
      361 agttaattca catcgtggtg gacatcaacc tctttggaag tgtcttcttg attggtttca
      421 ttgcactgga ccgctgcatt tgtgtcctgc atccagtctg ggcccagaac caccgcactg
      481 tgagtctggc catgaaggtg atcgtcggac cttggattct tgctctagtc cttaccttgc
      541 cagttttcct ctttttgact acagtaacta ttccaaatgg ggacacatac tgtactttca
      601 actttgcatc ctggggtggc acccctgagg agaggctgaa ggtggccatt accatgctga
      661 cagccagagg gattatccgg tttgtcattg gctttagctt gccgatgtcc attgttgcca
      721 tctgctatgg gctcattgca gccaagatcc acaaaaaggg catgattaaa tccagccgtc
      781 ccttacgggt cctcactgct gtggtggctt ctttcttcat ctgttggttt ccctttcaac
      841 tggttgccct tctgggcacc gtctggctca aagagatgtt gttctatggc aagtacaaaa
      901 tcattgacat cctggttaac ccaacgagct ccctggcctt cttcaacagc tgcctcaacc
      961 ccatgcttta cgtctttgtg ggccaagact tccgagagag actgatccac tccctgccca
     1021 ccagtctgga gagggccctg tctgaggact cagccccaac taatgacacg gctgccaatt
     1081 ctgcttcacc tcctgcagag actgagttac aggcaatgtg aggatggggt cagggatatt
     1141 ttgagttctg ttcatcctac cctaatgcca gttccagctt catctaccct tgagtcatat
     1201 tgaggcattc aaggatgcac agctcaagta tttattcagg aaaaatgctt ttgtgtccct
     1261 gatttggggc taagaaatag acagtcaggc tactaaaata ttagtgttat tttttgtttt
     1321 ttgacttctg cctataccct ggggtaagtg gagttgggaa atacaagaag agaaagacca
     1381 gtggggattt gtaagactta gatgagatag cgcataataa ggggaagact ttaaagtata
     1441 aagtaaaatg tttgctgtag gttttttata gctattaaaa aaaatcagat tatggaagtt
     1501 ttcttctatt tttagtttgc taagagtttt ctgtttcttt ttcttacatc atgagtggac
     1561 tttgcatttt atcaaatgca ttttctacat gtattaagat ggtcatatta ttcttcttct
     1621 tttatgtaaa tcattataaa taatgttcat taagttctga atgttaaact actcttgaat
     1681 tcctggaata aaccacactt agtcctgatg tactttaaat atttatatct cacaggagtt
     1741 ggttagaatt tctgtgttta tgtttatata ctgttatttc actttttcta ctatccttgc
     1801 taagttttca tagaaaataa ggaacaaaga gaaacttgta atggtctctg aaaaggaatt
     1861 gagaagtaat tcctctgatt ctgttttctg gtgttatatc tttattaaat attcagaaaa
     1921 attcaccagt gaagccaa
//
