LOCUS       NM_002029               1298 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens formyl peptide receptor 1 (FPR1), transcript variant
            2, mRNA.
ACCESSION   NM_002029
VERSION     NM_002029.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1298)
  AUTHORS   Zhangsun,Z., Dong,Y., Tang,J., Jin,Z., Lei,W., Wang,C., Cheng,Y.,
            Wang,B., Yang,Y. and Zhao,H.
  TITLE     FPR1: A critical gatekeeper of the heart and brain
  JOURNAL   Pharmacol Res 202, 107125 (2024)
   PUBMED   38438091
  REMARK    GeneRIF: FPR1: A critical gatekeeper of the heart and brain.
            Review article
REFERENCE   2  (bases 1 to 1298)
  AUTHORS   Carbonnier,V., Le Naour,J., Bachelot,T., Vacchelli,E., Andre,F.,
            Delaloge,S. and Kroemer,G.
  TITLE     Rs867228 in FPR1 accelerates the manifestation of luminal B breast
            cancer
  JOURNAL   Oncoimmunology 12 (1), 2189823 (2023)
   PUBMED   36970071
  REMARK    GeneRIF: Rs867228 in FPR1 accelerates the manifestation of luminal
            B breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1298)
  AUTHORS   Lee,C., Han,J. and Jung,Y.
  TITLE     Formyl peptide receptor 2 is an emerging modulator of inflammation
            in the liver
  JOURNAL   Exp Mol Med 55 (2), 325-332 (2023)
   PUBMED   36750693
  REMARK    GeneRIF: Formyl peptide receptor 2 is an emerging modulator of
            inflammation in the liver.
            Review article
REFERENCE   4  (bases 1 to 1298)
  AUTHORS   Busch,L., Al Taleb,Z., Tsai,Y.L., Nguyen,V.T.T., Lu,Q.,
            Synatschke,C.V., Endres,K. and Bufe,B.
  TITLE     Amyloid beta and its naturally occurring N-terminal variants are
            potent activators of human and mouse formyl peptide receptor 1
  JOURNAL   J Biol Chem 298 (12), 102642 (2022)
   PUBMED   36309087
  REMARK    GeneRIF: Amyloid beta and its naturally occurring N-terminal
            variants are potent activators of human and mouse formyl peptide
            receptor 1.
            Review article
REFERENCE   5  (bases 1 to 1298)
  AUTHORS   Wang,J. and Ye,R.D.
  TITLE     Agonist concentration-dependent changes in FPR1 conformation lead
            to biased signaling for selective activation of phagocyte functions
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2201249119 (2022)
   PUBMED   35878025
  REMARK    GeneRIF: Agonist concentration-dependent changes in FPR1
            conformation lead to biased signaling for selective activation of
            phagocyte functions.
REFERENCE   6  (bases 1 to 1298)
  AUTHORS   Perez,H.D., Holmes,R., Kelly,E., McClary,J., Chou,Q. and
            Andrews,W.H.
  TITLE     Cloning of the gene coding for a human receptor for formyl
            peptides. Characterization of a promoter region and evidence for
            polymorphic expression
  JOURNAL   Biochemistry 31 (46), 11595-11599 (1992)
   PUBMED   1445895
REFERENCE   7  (bases 1 to 1298)
  AUTHORS   Graves,V., Gabig,T., McCarthy,L., Strour,E.F., Leemhuis,T. and
            English,D.
  TITLE     Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide
            chemoattractant receptors in human neutrophils
  JOURNAL   Blood 80 (3), 776-787 (1992)
   PUBMED   1322204
  REMARK    Erratum:[Blood 1993 Mar 15;81(6):1668]
REFERENCE   8  (bases 1 to 1298)
  AUTHORS   Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C.
  TITLE     Mapping of genes for the human C5a receptor (C5AR), human FMLP
            receptor (FPR), and two FMLP receptor homologue orphan receptors
            (FPRH1, FPRH2) to chromosome 19
  JOURNAL   Genomics 13 (2), 437-440 (1992)
   PUBMED   1612600
REFERENCE   9  (bases 1 to 1298)
  AUTHORS   Murphy,P.M., Ozcelik,T., Kenney,R.T., Tiffany,H.L., McDermott,D.
            and Francke,U.
  TITLE     A structural homologue of the N-formyl peptide receptor.
            Characterization and chromosome mapping of a peptide
            chemoattractant receptor family
  JOURNAL   J Biol Chem 267 (11), 7637-7643 (1992)
   PUBMED   1373134
REFERENCE   10 (bases 1 to 1298)
  AUTHORS   Murphy,P.M. and McDermott,D.
  TITLE     Functional expression of the human formyl peptide receptor in
            Xenopus oocytes requires a complementary human factor
  JOURNAL   J Biol Chem 266 (19), 12560-12567 (1991)
   PUBMED   1712023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005315.1, M60627.1 and
            BQ016000.1.
            
            On Feb 12, 2020 this sequence version replaced NM_002029.3.
            
            Summary: This gene encodes a G protein-coupled receptor of
            mammalian phagocytic cells that is a member of the G-protein
            coupled receptor 1 family. The protein mediates the response of
            phagocytic cells to invasion of the host by microorganisms and is
            important in host defense and inflammation.[provided by RefSeq, Jul
            2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005315.1, M60627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304748.5/ ENSP00000302707.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1068              BC005315.1         13-1080
            1069-1195           M60627.1           1054-1180
            1196-1295           BC005315.1         1208-1307
            1296-1298           BQ016000.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1298
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="formyl peptide receptor 1"
                     /db_xref="GeneID:2357"
                     /db_xref="HGNC:HGNC:3826"
                     /db_xref="MIM:136537"
     exon            1..65
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="alignment:Splign:2.1.0"
     exon            66..1298
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1129
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="fMLP receptor; N-formylpeptide chemoattractant
                     receptor"
                     /codon_start=1
                     /product="fMet-Leu-Phe receptor"
                     /protein_id="NP_002020.1"
                     /db_xref="CCDS:CCDS12839.1"
                     /db_xref="GeneID:2357"
                     /db_xref="HGNC:HGNC:3826"
                     /db_xref="MIM:136537"
                     /translation="METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGN
                     GLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVF
                     TIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPV
                     IIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVA
                     VSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMY
                     KEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDT
                     ATNSTLPSAEVELQAK"
     regulatory      1279..1284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="hexamer: AATAAA"
     polyA_site      1298
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="major polyA site"
ORIGIN      
        1 actctcccca ggagacccag acctagaact acccagagca agaccacagc tggtgaacag
       61 tccaggagca gacaagatgg agacaaattc ctctctcccc acgaacatct ctggagggac
      121 acctgctgta tctgctggct atctcttcct ggatatcatc acttatctgg tatttgcagt
      181 cacctttgtc ctcggggtcc tgggcaacgg gcttgtgatc tgggtggctg gattccggat
      241 gacacacaca gtcaccacca tcagttacct gaacctggcc gtggctgact tctgtttcac
      301 ctccactttg ccattcttca tggtcaggaa ggccatggga ggacattggc ctttcggctg
      361 gttcctgtgc aaattcgtct ttaccatagt ggacatcaac ttgttcggaa gtgtcttcct
      421 gatcgccctc attgctctgg accgctgtgt ttgcgtcctg catccagtct ggacccagaa
      481 ccaccgcacc gtgagcctgg ccaagaaggt gatcattggg ccctgggtga tggctctgct
      541 cctcacattg ccagttatca ttcgtgtgac tacagtacct ggtaaaacgg ggacagtagc
      601 ctgcactttt aacttttcgc cctggaccaa cgaccctaaa gagaggataa atgtggccgt
      661 tgccatgttg acggtgagag gcatcatccg gttcatcatt ggcttcagcg cacccatgtc
      721 catcgttgct gtcagttatg ggcttattgc caccaagatc cacaagcaag gcttgattaa
      781 gtccagtcgt cccttacggg tcctctcctt tgtcgcagca gccttttttc tctgctggtc
      841 cccatatcag gtggtggccc ttatagccac agtcagaatc cgtgagttat tgcaaggcat
      901 gtacaaagaa attggtattg cagtggatgt gacaagtgcc ctggccttct tcaacagctg
      961 cctcaacccc atgctctatg tcttcatggg ccaggacttc cgggagaggc tgatccacgc
     1021 ccttcccgcc agtctggaga gggccctgac cgaggactca acccaaacca gtgacacagc
     1081 taccaattct actttacctt ctgcagaggt ggagttacag gcaaagtgag gagggagctg
     1141 ggggacactt tcgagctccc agctccagct tcgtctcacc ttgagttagg ctgagccaca
     1201 ggcatttcct gcttatttta ggattaccca ctcatcagaa aaaaaaaaaa aagcctttgt
     1261 gtcccctgat ttggggagaa taaacagata tgagttta
//
