LOCUS       NM_001193306            1950 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens formyl peptide receptor 1 (FPR1), transcript variant
            1, mRNA.
ACCESSION   NM_001193306
VERSION     NM_001193306.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1950)
  AUTHORS   Zhangsun,Z., Dong,Y., Tang,J., Jin,Z., Lei,W., Wang,C., Cheng,Y.,
            Wang,B., Yang,Y. and Zhao,H.
  TITLE     FPR1: A critical gatekeeper of the heart and brain
  JOURNAL   Pharmacol Res 202, 107125 (2024)
   PUBMED   38438091
  REMARK    GeneRIF: FPR1: A critical gatekeeper of the heart and brain.
            Review article
REFERENCE   2  (bases 1 to 1950)
  AUTHORS   Carbonnier,V., Le Naour,J., Bachelot,T., Vacchelli,E., Andre,F.,
            Delaloge,S. and Kroemer,G.
  TITLE     Rs867228 in FPR1 accelerates the manifestation of luminal B breast
            cancer
  JOURNAL   Oncoimmunology 12 (1), 2189823 (2023)
   PUBMED   36970071
  REMARK    GeneRIF: Rs867228 in FPR1 accelerates the manifestation of luminal
            B breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1950)
  AUTHORS   Lee,C., Han,J. and Jung,Y.
  TITLE     Formyl peptide receptor 2 is an emerging modulator of inflammation
            in the liver
  JOURNAL   Exp Mol Med 55 (2), 325-332 (2023)
   PUBMED   36750693
  REMARK    GeneRIF: Formyl peptide receptor 2 is an emerging modulator of
            inflammation in the liver.
            Review article
REFERENCE   4  (bases 1 to 1950)
  AUTHORS   Busch,L., Al Taleb,Z., Tsai,Y.L., Nguyen,V.T.T., Lu,Q.,
            Synatschke,C.V., Endres,K. and Bufe,B.
  TITLE     Amyloid beta and its naturally occurring N-terminal variants are
            potent activators of human and mouse formyl peptide receptor 1
  JOURNAL   J Biol Chem 298 (12), 102642 (2022)
   PUBMED   36309087
  REMARK    GeneRIF: Amyloid beta and its naturally occurring N-terminal
            variants are potent activators of human and mouse formyl peptide
            receptor 1.
            Review article
REFERENCE   5  (bases 1 to 1950)
  AUTHORS   Wang,J. and Ye,R.D.
  TITLE     Agonist concentration-dependent changes in FPR1 conformation lead
            to biased signaling for selective activation of phagocyte functions
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2201249119 (2022)
   PUBMED   35878025
  REMARK    GeneRIF: Agonist concentration-dependent changes in FPR1
            conformation lead to biased signaling for selective activation of
            phagocyte functions.
REFERENCE   6  (bases 1 to 1950)
  AUTHORS   Perez,H.D., Holmes,R., Kelly,E., McClary,J., Chou,Q. and
            Andrews,W.H.
  TITLE     Cloning of the gene coding for a human receptor for formyl
            peptides. Characterization of a promoter region and evidence for
            polymorphic expression
  JOURNAL   Biochemistry 31 (46), 11595-11599 (1992)
   PUBMED   1445895
REFERENCE   7  (bases 1 to 1950)
  AUTHORS   Graves,V., Gabig,T., McCarthy,L., Strour,E.F., Leemhuis,T. and
            English,D.
  TITLE     Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide
            chemoattractant receptors in human neutrophils
  JOURNAL   Blood 80 (3), 776-787 (1992)
   PUBMED   1322204
  REMARK    Erratum:[Blood 1993 Mar 15;81(6):1668]
REFERENCE   8  (bases 1 to 1950)
  AUTHORS   Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C.
  TITLE     Mapping of genes for the human C5a receptor (C5AR), human FMLP
            receptor (FPR), and two FMLP receptor homologue orphan receptors
            (FPRH1, FPRH2) to chromosome 19
  JOURNAL   Genomics 13 (2), 437-440 (1992)
   PUBMED   1612600
REFERENCE   9  (bases 1 to 1950)
  AUTHORS   Murphy,P.M., Ozcelik,T., Kenney,R.T., Tiffany,H.L., McDermott,D.
            and Francke,U.
  TITLE     A structural homologue of the N-formyl peptide receptor.
            Characterization and chromosome mapping of a peptide
            chemoattractant receptor family
  JOURNAL   J Biol Chem 267 (11), 7637-7643 (1992)
   PUBMED   1373134
REFERENCE   10 (bases 1 to 1950)
  AUTHORS   Murphy,P.M. and McDermott,D.
  TITLE     Functional expression of the human formyl peptide receptor in
            Xenopus oocytes requires a complementary human factor
  JOURNAL   J Biol Chem 266 (19), 12560-12567 (1991)
   PUBMED   1712023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018755.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001193306.1.
            
            Summary: This gene encodes a G protein-coupled receptor of
            mammalian phagocytic cells that is a member of the G-protein
            coupled receptor 1 family. The protein mediates the response of
            phagocytic cells to invasion of the host by microorganisms and is
            important in host defense and inflammation.[provided by RefSeq, Jul
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138517.1036365.1,
                                           SRR5189664.167613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC018755.3         178963-179027       c
            66-116              AC018755.3         177352-177402       c
            117-1950            AC018755.3         172321-174154       c
FEATURES             Location/Qualifiers
     source          1..1950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1950
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="formyl peptide receptor 1"
                     /db_xref="GeneID:2357"
                     /db_xref="HGNC:HGNC:3826"
                     /db_xref="MIM:136537"
     exon            1..65
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="alignment:Splign:2.1.0"
     exon            66..116
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="alignment:Splign:2.1.0"
     exon            117..1950
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1180
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="fMLP receptor; N-formylpeptide chemoattractant
                     receptor"
                     /codon_start=1
                     /product="fMet-Leu-Phe receptor"
                     /protein_id="NP_001180235.1"
                     /db_xref="CCDS:CCDS12839.1"
                     /db_xref="GeneID:2357"
                     /db_xref="HGNC:HGNC:3826"
                     /db_xref="MIM:136537"
                     /translation="METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGN
                     GLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVF
                     TIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPV
                     IIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVA
                     VSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMY
                     KEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDT
                     ATNSTLPSAEVELQAK"
     regulatory      1330..1335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="FPR1"
                     /gene_synonym="FMLP; FPR"
                     /note="major polyA site"
ORIGIN      
        1 actctcccca ggagacccag acctagaact acccagagca agaccacagc tggtgaacag
       61 tccagcctgt ctccagttgg actagccaca attcaagtgc ttgaaaacca catgtggagc
      121 agacaagatg gagacaaatt cctctctccc cacgaacatc tctggaggga cacctgctgt
      181 atctgctggc tatctcttcc tggatatcat cacttatctg gtatttgcag tcacctttgt
      241 cctcggggtc ctgggcaacg ggcttgtgat ctgggtggct ggattccgga tgacacacac
      301 agtcaccacc atcagttacc tgaacctggc cgtggctgac ttctgtttca cctccacttt
      361 gccattcttc atggtcagga aggccatggg aggacattgg cctttcggct ggttcctgtg
      421 caaattcgtc tttaccatag tggacatcaa cttgttcgga agtgtcttcc tgatcgccct
      481 cattgctctg gaccgctgtg tttgcgtcct gcatccagtc tggacccaga accaccgcac
      541 cgtgagcctg gccaagaagg tgatcattgg gccctgggtg atggctctgc tcctcacatt
      601 gccagttatc attcgtgtga ctacagtacc tggtaaaacg gggacagtag cctgcacttt
      661 taacttttcg ccctggacca acgaccctaa agagaggata aatgtggccg ttgccatgtt
      721 gacggtgaga ggcatcatcc ggttcatcat tggcttcagc gcacccatgt ccatcgttgc
      781 tgtcagttat gggcttattg ccaccaagat ccacaagcaa ggcttgatta agtccagtcg
      841 tcccttacgg gtcctctcct ttgtcgcagc agcctttttt ctctgctggt ccccatatca
      901 ggtggtggcc cttatagcca cagtcagaat ccgtgagtta ttgcaaggca tgtacaaaga
      961 aattggtatt gcagtggatg tgacaagtgc cctggccttc ttcaacagct gcctcaaccc
     1021 catgctctat gtcttcatgg gccaggactt ccgggagagg ctgatccacg cccttcccgc
     1081 cagtctggag agggccctga ccgaggactc aacccaaacc agtgacacag ctaccaattc
     1141 tactttacct tctgcagagg tggagttaca ggcaaagtga ggagggagct gggggacact
     1201 ttcgagctcc cagctccagc ttcgtctcac cttgagttag gctgagccac aggcatttcc
     1261 tgcttatttt aggattaccc actcatcaga aaaaaaaaaa aaagcctttg tgtcccctga
     1321 tttggggaga ataaacagat atgagtttat tattgacttc ttttttgatt ttggacctca
     1381 gccttgggtg gtcagggtgg gaaatgatag gaagaagctg tcatctgcat cctagtttgc
     1441 ctgaaatgaa cccaaataat acccattatt attagtcctg aattatgagt agtgaatgat
     1501 acccatcatt ctggcatcat gatgagtagt gtccacttcc attctgaaaa gtgccctgct
     1561 gtgaaaaata aattatatag tcatcctagg taaatgaagg aggagggaga agtgtgaaag
     1621 agtatggctt aaatcagaca agatatacaa gaagatactt tatatagggc aggagcggtg
     1681 gctcatgcct gtaatcccag cactttggga ggccgaggca ggcggatcac caggggtcag
     1741 gaattcgaga acagcctggc caacatggtg aaaccctgtc tctactaaaa atacaaaaat
     1801 tagctgggcg tagtggcagg ctcccgtaat cccagctact caggagaccg aggcaggaga
     1861 atcgcttgaa cctggaaggc ggaggttgta gtgagccaag aaaacgccac tacactccag
     1921 cctgggtgac agagagagac tccggctcag
//
