LOCUS       NM_004118               1302 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens forkhead box S1 (FOXS1), mRNA.
ACCESSION   NM_004118
VERSION     NM_004118.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Ren,R., Wang,H., Xu,Y., Wu,J., Ma,D. and Guan,W.
  TITLE     FOXS1 acts as an oncogene and induces EMT through FAK/PI3K/AKT
            pathway by upregulating HILPDA in prostate cancer
  JOURNAL   FASEB J 38 (10), e23698 (2024)
   PUBMED   38780613
  REMARK    GeneRIF: FOXS1 acts as an oncogene and induces EMT through
            FAK/PI3K/AKT pathway by upregulating HILPDA in prostate cancer.
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Bates,E.A., Kipp,Z.A., Lee,W.H., Martinez,G.J., Weaver,L.,
            Becker,K.N., Pauss,S.N., Creeden,J.F., Anspach,G.B., Helsley,R.N.,
            Xu,M., Bruno,M.E.C., Starr,M.E. and Hinds,T.D. Jr.
  TITLE     FOXS1 is increased in liver fibrosis and regulates TGFbeta
            responsiveness and proliferation pathways in human hepatic stellate
            cells
  JOURNAL   J Biol Chem 300 (3), 105691 (2024)
   PUBMED   38280429
  REMARK    GeneRIF: FOXS1 is increased in liver fibrosis and regulates TGFbeta
            responsiveness and proliferation pathways in human hepatic stellate
            cells.
REFERENCE   3  (bases 1 to 1302)
  AUTHORS   Wang,M. and Huang,W.
  TITLE     FOXS1 promotes prostate cancer progression through the
            Hedgehog/Gli1 pathway
  JOURNAL   Biochem Pharmacol 218, 115893 (2023)
   PUBMED   37890593
  REMARK    GeneRIF: FOXS1 promotes prostate cancer progression through the
            Hedgehog/Gli1 pathway.
            Erratum:[Biochem Pharmacol. 2023 Dec;218:115926. doi:
            10.1016/j.bcp.2023.115926.. PMID: 37992588]
REFERENCE   4  (bases 1 to 1302)
  AUTHORS   Tian,Y., Sun,H., Bao,Y., Feng,H., Pang,J., En,R., Jiang,H. and
            Wang,T.
  TITLE     ERp44 Regulates the Proliferation, Migration, Invasion, and
            Apoptosis of Gastric Cancer Cells Via Activation of ER Stress
  JOURNAL   Biochem Genet 61 (2), 809-822 (2023)
   PUBMED   36178559
  REMARK    GeneRIF: ERp44 Regulates the Proliferation, Migration, Invasion,
            and Apoptosis of Gastric Cancer Cells Via Activation of ER Stress.
REFERENCE   5  (bases 1 to 1302)
  AUTHORS   Wang,F. and Li,S.
  TITLE     Forkhead Box S1 inhibits the progression of lung squamous cell
            carcinoma cells by mediating Wnt/beta-catenin pathway
  JOURNAL   Chin J Physiol 65 (5), 266-275 (2022)
   PUBMED   36308082
  REMARK    GeneRIF: Forkhead Box S1 inhibits the progression of lung squamous
            cell carcinoma cells by mediating Wnt/beta-catenin pathway.
REFERENCE   6  (bases 1 to 1302)
  AUTHORS   Lu,Q., Ma,X., Li,Y., Song,W., Zhang,L., Shu,Y. and Wan,B.
  TITLE     Overexpression of FOXS1 in gastric cancer cell lines inhibits
            proliferation, metastasis, and epithelial-mesenchymal transition of
            tumor through downregulating wnt/beta-catenin pathway
  JOURNAL   J Cell Biochem 120 (3), 2897-2907 (2019)
   PUBMED   30500980
  REMARK    GeneRIF: Study showed that FOXS1 expression is downregulated in
            gastric cancer tumors and cell lines promoting cell proliferation
            and metastasis through upregulation of wnt/beta-catenin pathway.
REFERENCE   7  (bases 1 to 1302)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1302)
  AUTHORS   Wotton,K.R. and Shimeld,S.M.
  TITLE     Comparative genomics of vertebrate Fox cluster loci
  JOURNAL   BMC Genomics 7, 271 (2006)
   PUBMED   17062144
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1302)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 1302)
  AUTHORS   Cederberg,A., Betz,R., Lagercrantz,S., Larsson,C., Hulander,M.,
            Carlsson,P. and Enerback,S.
  TITLE     Chromosome localization, sequence analysis, and expression pattern
            identify FKHL 18 as a novel human forkhead gene
  JOURNAL   Genomics 44 (3), 344-346 (1997)
   PUBMED   9325056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013408.2.
            
            On May 17, 2019 this sequence version replaced NM_004118.3.
            
            Summary: The forkhead family of transcription factors belongs to
            the winged helix class of DNA-binding proteins. The protein encoded
            by this intronless gene contains a forkhead domain and is found
            predominantly in aorta and kidney. The function of the encoded
            protein is unknown. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.946400.1, BC013408.2
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375978.5/ ENSP00000365145.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1302              BC013408.2         14-1315
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1302
                     /gene="FOXS1"
                     /gene_synonym="FKHL18; FREAC10"
                     /note="forkhead box S1"
                     /db_xref="GeneID:2307"
                     /db_xref="HGNC:HGNC:3735"
                     /db_xref="MIM:602939"
     exon            1..1302
                     /gene="FOXS1"
                     /gene_synonym="FKHL18; FREAC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1055
                     /gene="FOXS1"
                     /gene_synonym="FKHL18; FREAC10"
                     /note="forkhead-related transcription factor 10;
                     forkhead-related activator 10; forkhead-related
                     transcription factor FREAC-10; forkhead-like 18 protein"
                     /codon_start=1
                     /product="forkhead box protein S1"
                     /protein_id="NP_004109.1"
                     /db_xref="CCDS:CCDS13192.1"
                     /db_xref="GeneID:2307"
                     /db_xref="HGNC:HGNC:3735"
                     /db_xref="MIM:602939"
                     /translation="MQQQPLPGPGAPTTEPTKPPYSYIALIAMAIQSSPGQRATLSGI
                     YRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMF
                     EHGSFLRRRRRFTRQTGAEGTRGPAKARRGPLRATSQDPGVPNATTGRQCSFPPELPD
                     PKGLSFGGLVGAMPASMCPATTDGRPRPPMEPKEISTPKPACPGELPVATSSSSCPAF
                     GFPAGFSEAESFNKAPTPVLSPESGIGSSYQCRLQALNFCMGADPGLEHLLASAAPSP
                     APPTPPGSLRAPLPLPTDHKEPWVAGGFPVQGGSGYPLGLTPCLYRTPGMFFFE"
     regulatory      1282..1287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXS1"
                     /gene_synonym="FKHL18; FREAC10"
                     /note="hexamer: AATAAA"
     polyA_site      1302
                     /gene="FOXS1"
                     /gene_synonym="FKHL18; FREAC10"
                     /note="major polyA site"
ORIGIN      
        1 acgccagccc tggaagctga gcctgaccca gcaggtccca gcagcctggc agcccggcca
       61 gcatgcagca gcagcctctg cccgggcctg gcgcccccac aactgagcca accaagcctc
      121 cctacagcta catcgccctt attgctatgg ccatccagag ctcaccgggg cagcgggcca
      181 ccctcagtgg catctaccgc tacatcatgg gccgattcgc cttctaccgc cacaaccggc
      241 ccggctggca gaacagcatc cgccacaacc tgtcactcaa cgagtgcttt gtcaaggtgc
      301 cccgcgatga ccgcaagcca ggcaagggca gctactggac gctggaccct gactgccacg
      361 acatgtttga gcacggcagc ttcctacgcc gccgccgccg cttcacccgg cagacaggtg
      421 ctgagggcac ccggggcccc gccaaggcac gccgtggacc cctcagggcg accagccagg
      481 acccaggagt ccccaacgcc acgaccggca ggcagtgctc attcccacca gagctgccag
      541 atcccaaggg cctaagcttt gggggtctgg tgggggccat gccagccagt atgtgcccag
      601 caaccactga tggcaggcct cggccaccca tggagcccaa agagatttcc acgcccaagc
      661 ctgcatgccc aggggagctc cccgtggcca cctcatcttc ctcatgccca gcgtttggct
      721 ttcctgccgg cttctcagag gctgagagtt ttaataaggc ccctacgccc gtcttgtccc
      781 cggaatcagg catcgggagc agctaccagt gtcggctgca ggcactgaat ttttgcatgg
      841 gggctgaccc aggccttgag cacctcttgg cctcagcagc cccctcccct gcaccaccca
      901 cccctccagg ctcactccgg gccccactgc ccctgccaac tgaccacaag gaaccctggg
      961 ttgcaggtgg cttccctgtc cagggaggct ccggctaccc attggggctg accccctgcc
     1021 tataccggac gccaggaatg ttcttctttg agtaaaggca gcctcacctc gggcagtccc
     1081 tgcaggtccc tcaccctccg ggctgagcct ggctctagga cctgaagaac tctcgaagga
     1141 cccagccctg gtgagccaag gacaaccaca cagaaagcca ggattgaagc ggtgctcagc
     1201 caggcccctg gggcctccgg acaaacttgg gggtgagggg aagcagggcc tcttgggatt
     1261 tactctgtgg ctctcagggc caataaagcc atgtgatgat ga
//
