LOCUS       NM_198451               2793 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens forkhead box R2 (FOXR2), mRNA.
ACCESSION   NM_198451 XM_066802
VERSION     NM_198451.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Gharbaran,R.
  TITLE     Insights into the molecular roles of FOXR2 in the pathology of
            primary pediatric brain tumors
  JOURNAL   Crit Rev Oncol Hematol 192, 104188 (2023)
   PUBMED   37879492
  REMARK    GeneRIF: Insights into the molecular roles of FOXR2 in the
            pathology of primary pediatric brain tumors.
            Review article
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Tsai,J.W., Cejas,P., Wang,D.K., Patel,S., Wu,D.W., Arounleut,P.,
            Wei,X., Zhou,N., Syamala,S., Dubois,F.P.B., Crane,A., Pelton,K.,
            Vogelzang,J., Sousa,C., Baguette,A., Chen,X., Condurat,A.L.,
            Dixon-Clarke,S.E., Zhou,K.N., Lu,S.D., Gonzalez,E.M., Chacon,M.S.,
            Digiacomo,J.J., Kumbhani,R., Novikov,D., Hunter,J., Tsoli,M.,
            Ziegler,D.S., Dirksen,U., Jager,N., Balasubramanian,G.P.,
            Kramm,C.M., Nathrath,M., Bielack,S., Baker,S.J., Zhang,J.,
            McFarland,J.M., Getz,G., Aguet,F., Jabado,N., Witt,O.,
            Pfister,S.M., Ligon,K.L., Hovestadt,V., Kleinman,C.L., Long,H.,
            Jones,D.T.W., Bandopadhayay,P. and Phoenix,T.N.
  TITLE     FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That
            Activates ETS Transcriptional Circuits
  JOURNAL   Cancer Res 82 (17), 2980-3001 (2022)
   PUBMED   35802025
  REMARK    GeneRIF: FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene
            That Activates ETS Transcriptional Circuits.
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Luo,Z., Ye,X., Cheng,Y., Li,F., Shou,F. and Wang,G.
  TITLE     E3 ubiquitin ligase PJA1 regulates lung adenocarcinoma apoptosis
            and invasion through promoting FOXR2 degradation
  JOURNAL   Biochem Biophys Res Commun 556, 106-113 (2021)
   PUBMED   33839405
  REMARK    GeneRIF: E3 ubiquitin ligase PJA1 regulates lung adenocarcinoma
            apoptosis and invasion through promoting FOXR2 degradation.
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Chen,X., Chen,H., Liu,M., Xiong,J. and Song,Z.
  TITLE     Long noncoding RNA LINC00520 accelerates lung adenocarcinoma
            progression via miR-1252-5p/FOXR2 pathway
  JOURNAL   Hum Cell 34 (2), 478-490 (2021)
   PUBMED   33464477
  REMARK    GeneRIF: Long noncoding RNA LINC00520 accelerates lung
            adenocarcinoma progression via miR-1252-5p/FOXR2 pathway.
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Korshunov,A., Okonechnikov,K., Schmitt-Hoffner,F., Ryzhova,M.,
            Sahm,F., Stichel,D., Schrimpf,D., Reuss,D.E., Sievers,P.,
            Suwala,A.K., Kumirova,E., Zheludkova,O., Golanov,A., Jones,D.T.W.,
            Pfister,S.M., Kool,M. and von Deimling,A.
  TITLE     Molecular analysis of pediatric CNS-PNET revealed nosologic
            heterogeneity and potent diagnostic markers for CNS neuroblastoma
            with FOXR2-activation
  JOURNAL   Acta Neuropathol Commun 9 (1), 20 (2021)
   PUBMED   33536079
  REMARK    GeneRIF: Molecular analysis of pediatric CNS-PNET revealed
            nosologic heterogeneity and potent diagnostic markers for CNS
            neuroblastoma with FOXR2-activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Wang,X., He,B., Gao,Y. and Li,Y.
  TITLE     FOXR2 contributes to cell proliferation and malignancy in human
            hepatocellular carcinoma
  JOURNAL   Tumour Biol 37 (8), 10459-10467 (2016)
   PUBMED   26846213
  REMARK    GeneRIF: FOXR2 is frequently upregulated in hepatocellular
            carcinoma specimens compared with neighboring non-cancerous tissues
            in both messenger RNA and protein. It promoted cell growth and
            colony formation, and it facilitated tumor xenograft growth.
            beta-catenin, Skp2, c-Myc, and Gli-1 are the potential downstream
            effectors of FOXR2.
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Song,H., He,W., Huang,X., Zhang,H. and Huang,T.
  TITLE     High expression of FOXR2 in breast cancer correlates with poor
            prognosis
  JOURNAL   Tumour Biol 37 (5), 5991-5997 (2016)
   PUBMED   26596836
  REMARK    GeneRIF: we observed that the highly expressed FOXR2 in breast and
            overexpression of FOXR2 was positively associated with the
            progression and poor prognosis in patients with breast cancer,
            which indicated that FOXR2 might serve as a valuable prognosis
            biomarker for breast cancer individuals.
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FOXK1 gene in silico
  JOURNAL   Int J Mol Med 14 (1), 127-132 (2004)
   PUBMED   15202027
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FOXN6, mouse Foxn6,
            and rat Foxn6 genes in silico
  JOURNAL   Int J Oncol 25 (1), 219-223 (2004)
   PUBMED   15202009
  REMARK    GeneRIF: Human FOXN6 gene was identified within human genome
            sequence RP11-167P23 (
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012934.2 and AL159987.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_198451.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC012934.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339140.5/ ENSP00000427329.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1926              BC012934.2         15-1940
            1927-2793           AL159987.19        7795-8661
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..2793
                     /gene="FOXR2"
                     /gene_synonym="FOXN6"
                     /note="forkhead box R2"
                     /db_xref="GeneID:139628"
                     /db_xref="HGNC:HGNC:30469"
                     /db_xref="MIM:300949"
     exon            1..2793
                     /gene="FOXR2"
                     /gene_synonym="FOXN6"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1248
                     /gene="FOXR2"
                     /gene_synonym="FOXN6"
                     /note="forkhead box protein N6"
                     /codon_start=1
                     /product="forkhead box protein R2"
                     /protein_id="NP_940853.1"
                     /db_xref="CCDS:CCDS35308.1"
                     /db_xref="GeneID:139628"
                     /db_xref="HGNC:HGNC:30469"
                     /db_xref="MIM:300949"
                     /translation="MDLKLKDCEFWYSLHGQVPGLLDWDMRNELFLPCTTDQCSLAEQ
                     ILAKYRVGVMKPPEMPQKRRPSPDGDGPPCEPNLWMWVDPNILCPLGSQEAPKPSGKE
                     DLTNISPFPQPPQKDEGSNCSEDKVVESLPSSSSEQSPLQKQGIHSPSDFELTEEEAE
                     EPDDNSLQSPEMKCYQSQKLWQINNQEKSWQRPPLNCSHLIALALRNNPHCGLSVQEI
                     YNFTRQHFPFFWTAPDGWKSTIHYNLCFLDSFEKVPDSLKDEDNARPRSCLWKLTKEG
                     HRRFWEETRVLAFAQRERIQECMSQPELLTSLFDL"
     regulatory      2436..2441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXR2"
                     /gene_synonym="FOXN6"
                     /note="hexamer: AATAAA"
     polyA_site      2456
                     /gene="FOXR2"
                     /gene_synonym="FOXN6"
                     /note="major polyA site"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXR2"
                     /gene_synonym="FOXN6"
                     /note="hexamer: AATAAA"
     polyA_site      2793
                     /gene="FOXR2"
                     /gene_synonym="FOXN6"
                     /note="major polyA site"
ORIGIN      
        1 ttcctcttga agtgactttc tgcttccaat caaagctcaa gaattccacc taaaaatgtt
       61 tttctgctca aaagctcttt tttattactt ccatgttttg agccttgttc cagaaagctg
      121 aggtttctcc aggtctgacc actaatcagt gagacattgg tgcctctttc ttcagtgctt
      181 ctagcaggcc tactgataag ctccctagat gagatacact gcataaaaaa atgatgccca
      241 aaggacagct ttaagtgcct gctagatatc tgttctttca gaagtctctc tccacctatc
      301 tctccagtaa agatggactt aaaactaaaa gactgtgaat tttggtatag tctccatggc
      361 caggtcccag ggctgctgga ctgggacatg aggaatgagt tatttctgcc ttgtaccaca
      421 gaccagtgct ctttagctga gcaaatcctt gccaaataca gagtcggagt aatgaagccc
      481 ccagaaatgc ctcagaagag gagacccagt cctgatggag atggtcctcc ctgtgaaccc
      541 aatctgtgga tgtgggtgga ccccaatatc ctgtgccccc ttggcagcca ggaggcccca
      601 aagcccagtg gaaaagagga tctgacaaac atttctcctt tccctcagcc cccacaaaaa
      661 gacgaagggt ctaactgctc agaggacaaa gtggtagagt ctctgccatc ttcctccagt
      721 gagcagtctc ctttacagaa gcagggtatc cattccccca gtgactttga gctcacagaa
      781 gaggaggctg aggaaccaga cgacaactcc ctccagtccc ctgaaatgaa atgttaccag
      841 agccagaaac tatggcaaat caacaaccaa gagaagtcct ggcaaaggcc ccctctcaat
      901 tgtagccacc ttattgccct agcattaaga aacaaccccc actgtggcct cagtgtgcag
      961 gagatctaca atttcacccg acagcatttc ccctttttct ggacagctcc ggatggctgg
     1021 aagagcacca ttcattacaa cctctgcttc ctggacagct ttgagaaggt gccagacagc
     1081 cttaaggatg aagataatgc aagacctcgc tcttgccttt ggaagctcac taaggagggg
     1141 caccgccgct tttgggagga gactcgtgtc ttagcctttg ctcaaaggga gagaatccaa
     1201 gagtgcatga gtcagccaga gttgttgacc tctctctttg atctttgaaa tgccattgct
     1261 cccttttgga acactgcctt ccttactgtg cctacttatc ccctgacatt cattaatctc
     1321 taaacttacc cagcctggtt ggtgccaagt ctgtctttag ctactgttac aataatggtg
     1381 ttaagtaaag ttagaggtgg gtacagggga gacagaactt aaatccaggt ggagagtcat
     1441 ggaaagtcgc acgaggagag tggctgttgt tccaaatttt gagcaaagga aaagaaatcc
     1501 tagaaacaat ggcatagaaa ctaaggaaag aagggtgtgt tttgtgaaag aaaggaattt
     1561 tgtttataga gagtattttc acacatgaaa gtgaacagtg gaatataaag cataaaaggc
     1621 aggatggagc cgagccatgg agaacctcga gtgccatgtg aagagaattt gacttgtgat
     1681 gaagaatcaa gtttcccctt ctaccattca tcagctacat ctccttttta agtaacccat
     1741 tttatccttc agaacctcac ttttctattt ctggccctgg acttctaagc cttgtttctt
     1801 tgtcatccaa ttccaatatt gacaaataat tctaaacagc tacttttagt ttgtatgttt
     1861 aacgtcctgt gaaatattcc tgtattaacc ccaagccttt tgatgataaa gctttatttt
     1921 ctattatttt tagttctcaa gattttattg aggatatgct aatgtgtcaa ggtccatctt
     1981 agatgctgag gataaaaagc tgagggatac tagtgggaga catatttata atgtaaatat
     2041 gatgaaacag atgtgagaaa ttgacatgga aatggggaga cattcttcct gggaaagaca
     2101 tgaaagggca ttggaaaaaa tacattttga gctagttttg aagaataaat ggcaaactgg
     2161 agtagaggca ttacagagac aacaatgtga acaaagtgga tggagtgttt gggggaatgg
     2221 catgaagttc agtgtgactt aactacatga ggaccgtgag tgactaagag aaaactatta
     2281 ggtgtttgga cttcatcttg tgggttttta ggagccaaga gacatcagtg gagttttgct
     2341 aaaaaacaaa aaaagaaaca agccagcagc aacaacaaac actacagcat ttgtttttct
     2401 aatttcaaaa ttatctttaa catcttttct atgcaaataa acttttgttt atcagattta
     2461 agcatagctt tttgcttcaa tgatattaac atatatccag gagaaaatag atttttaggt
     2521 ataaatttag ttgcaaaacc ttcataatgg gggtacaaaa acgcctgtaa gctacaaaag
     2581 caattaattc aatataattg taactatttt caaagttcac atttttataa tgatgtatta
     2641 tacctcatac aaaattgtat atttaggtta aatcacaaaa caacatatgc aaacagtatt
     2701 ttttgaaaaa aattgtaaat gctacttctg tatcataagg caaagaccaa gttaacagaa
     2761 taccttggaa ttaataaaat attctgcata taa
//
