LOCUS       NM_033260               2661 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens forkhead box Q1 (FOXQ1), mRNA.
ACCESSION   NM_033260
VERSION     NM_033260.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Zhao,Q., Zhang,R., Wang,Y., Li,T., Xue,J. and Chen,Z.
  TITLE     FOXQ1, deubiquitinated by USP10, alleviates sepsis-induced acute
            kidney injury by targeting the CREB5/NF-kappaB signaling axis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167331 (2024)
   PUBMED   38960057
  REMARK    GeneRIF: FOXQ1, deubiquitinated by USP10, alleviates sepsis-induced
            acute kidney injury by targeting the CREB5/NF-kappaB signaling
            axis.
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Pizzolato,G., Moparthi,L., Pagella,P., Cantu,C., D'Arcy,P. and
            Koch,S.
  TITLE     The tumor suppressor p53 is a negative regulator of the
            carcinoma-associated transcription factor FOXQ1
  JOURNAL   J Biol Chem 300 (4), 107126 (2024)
   PUBMED   38432629
  REMARK    GeneRIF: The tumor suppressor p53 is a negative regulator of the
            carcinoma-associated transcription factor FOXQ1.
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Wu,J., Wu,Y., Chen,S., Guo,Q., Shao,Y., Liu,C., Lin,K., Wang,S.,
            Zhu,J., Chen,X., Ju,X., Xia,L. and Wu,X.
  TITLE     PARP1-stabilised FOXQ1 promotes ovarian cancer progression by
            activating the LAMB3/WNT/beta-catenin signalling pathway
  JOURNAL   Oncogene 43 (12), 866-883 (2024)
   PUBMED   38297082
  REMARK    GeneRIF: PARP1-stabilised FOXQ1 promotes ovarian cancer progression
            by activating the LAMB3/WNT/beta-catenin signalling pathway.
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   Liu,Q., Cao,Y., Wei,X., Dong,H., Cui,M., Guan,S., Liu,B., Wang,X.
            and Xing,P.
  TITLE     Nuclear isoform of RAPH1 interacts with FOXQ1 to promote
            aggressiveness and radioresistance in breast cancer
  JOURNAL   Cell Death Dis 14 (12), 803 (2023)
   PUBMED   38062011
  REMARK    GeneRIF: Nuclear isoform of RAPH1 interacts with FOXQ1 to promote
            aggressiveness and radioresistance in breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   Leger,B., Senese,R., Al-Khodairy,A.W., Deriaz,O., Gobelet,C.,
            Giacobino,J.P. and Russell,A.P.
  TITLE     Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and
            4E-BP1 are reduced in skeletal muscle of chronic spinal
            cord-injured patients
  JOURNAL   Muscle Nerve 40 (1), 69-78 (2009)
   PUBMED   19533653
  REMARK    GeneRIF: This study demenostrated that the forkhead transcription
            factor is reduced in skeletal muscle of chronic spinal cord-injured
            patients.
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 2661)
  AUTHORS   Samatar,A.A., Wang,L., Mirza,A., Koseoglu,S., Liu,S. and Kumar,C.C.
  TITLE     Transforming growth factor-beta 2 is a transcriptional target for
            Akt/protein kinase B via forkhead transcription factor
  JOURNAL   J Biol Chem 277 (31), 28118-28126 (2002)
   PUBMED   12011061
  REMARK    GeneRIF: Transforming growth factor-beta 2 is a transcriptional
            target for Akt/protein kinase B via this protein
REFERENCE   9  (bases 1 to 2661)
  AUTHORS   Bieller,A., Pasche,B., Frank,S., Glaser,B., Kunz,J., Witt,K. and
            Zoll,B.
  TITLE     Isolation and characterization of the human forkhead gene FOXQ1
  JOURNAL   DNA Cell Biol 20 (9), 555-561 (2001)
   PUBMED   11747606
REFERENCE   10 (bases 1 to 2661)
  AUTHORS   Hong,H.K., Noveroske,J.K., Headon,D.J., Liu,T., Sy,M.S.,
            Justice,M.J. and Chakravarti,A.
  TITLE     The winged helix/forkhead transcription factor Foxq1 regulates
            differentiation of hair in satin mice
  JOURNAL   Genesis 29 (4), 163-171 (2001)
   PUBMED   11309849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL499606.19, BC053850.1 and BU566731.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033260.3.
            
            Summary: FOXQ1 is a member of the FOX gene family, which is
            characterized by a conserved 110-amino acid DNA-binding motif
            called the forkhead or winged helix domain. FOX genes are involved
            in embryonic development, cell cycle regulation, tissue-specific
            gene expression, cell signaling, and tumorigenesis (Bieller et al.,
            2001 [PubMed 11747606]).[supplied by OMIM, May 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC053850.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296839.5/ ENSP00000296839.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AL499606.19        16338-16679
            343-411             BC053850.1         1-69
            412-789             AL499606.19        16749-17126
            790-2651            BC053850.1         448-2309
            2652-2661           BU566731.1         251-260
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.3"
     gene            1..2661
                     /gene="FOXQ1"
                     /gene_synonym="HFH1"
                     /note="forkhead box Q1"
                     /db_xref="GeneID:94234"
                     /db_xref="HGNC:HGNC:20951"
                     /db_xref="MIM:612788"
     exon            1..2661
                     /gene="FOXQ1"
                     /gene_synonym="HFH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             608..1819
                     /gene="FOXQ1"
                     /gene_synonym="HFH1"
                     /note="winged helix/forkhead transcription factor; HFH-1;
                     HNF-3/forkhead-like protein 1; hepatocyte nuclear factor 3
                     forkhead homolog 1"
                     /codon_start=1
                     /product="forkhead box protein Q1"
                     /protein_id="NP_150285.3"
                     /db_xref="CCDS:CCDS4471.1"
                     /db_xref="GeneID:94234"
                     /db_xref="HGNC:HGNC:20951"
                     /db_xref="MIM:612788"
                     /translation="MKLEVFVPRAAHGDKQGSDLEGAGGSDAPSPLSAAGDDSLGSDG
                     DCAANSPAAGGGARDTQGDGEQSAGGGPGAEEAIPAAAAAAVVAEGAEAGAAGPGAGG
                     AGSGEGARSKPYTRRPKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSY
                     TGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRLSH
                     RAPVPAPGLRPEEAPGLPAAPPPAPAAPASPRMRSPARQEERASPAGKFSSSFAIDSI
                     LRKPFRSRRLRDTAPGTTLQWGAAPCPPLPAFPALLPAAPCRALLPLCAYGAGEPARL
                     GAREAEVPPTAPPLLLAPLPAAAPAKPLRGPAAGGAHLYCPLRLPAALQAASVRRPGP
                     HLPYPVETLLA"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXQ1"
                     /gene_synonym="HFH1"
                     /note="hexamer: TATAAA"
     polyA_site      2614
                     /gene="FOXQ1"
                     /gene_synonym="HFH1"
                     /note="major polyA site"
     regulatory      2633..2638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXQ1"
                     /gene_synonym="HFH1"
                     /note="hexamer: AATAAA"
     polyA_site      2661
                     /gene="FOXQ1"
                     /gene_synonym="HFH1"
ORIGIN      
        1 gagacgcagc cgcggcaggc cagcggggag atgctgcccc ggaggctggg agcgggaagg
       61 cggctgcggg cgcagcggcc tcggggactc gcctccgcgg gtgctcaagg ctgaaggcgc
      121 cggaccttcc cccacggtgg cacgcacatc atccggcacc atttccgtgc cccgaagacg
      181 cccgcgcggg acctgggacc gccagtgaag aacccctcct gggctcttta acgagcagca
      241 gatgcgcatg ctgcttctct ccggcaggaa agccttctaa gcccggcgtg ctcgggcacc
      301 cgagggtgga accgcggccc ctgcacacac tcaccccaaa gtctcaacgt cgaaccgaag
      361 gcgacaccca cccaactcct ccctctccgc cccatagtcc acccaacact tgcagcccct
      421 ccagagaaaa agcccagcgg aagaggactc cggaaaagtg actatctcgg aagaccaggg
      481 tagagctccc gggagaaaaa ggcgaagatc cccggccccg gatcgccatc cccttccctg
      541 gcaccagctt ctctaggctg cgcgaaggaa gagggtacga cgccggggag ggactgggtg
      601 cgcgggcatg aagttggagg tgttcgtccc tcgcgcggcc cacggggaca agcagggcag
      661 tgacctggag ggcgcgggcg gcagcgacgc gccgtccccg ctgtcggcgg cgggagacga
      721 ctccctgggc tcagatgggg actgcgcggc caacagcccg gccgcgggcg gcggcgccag
      781 agatacgcag ggcgacggcg aacagagtgc gggaggcggg ccgggcgcgg aggaggcgat
      841 cccggcagca gctgctgcag cggtggtggc ggagggcgcg gaggccgggg cggcggggcc
      901 aggcgcgggc ggcgcgggga gcggcgaggg tgcacgcagc aagccatata cgcggcggcc
      961 caagcccccc tactcgtaca tcgcgctcat cgccatggcc atccgcgact cggcgggcgg
     1021 gcgcttgacg ctggcggaga tcaacgagta cctcatgggc aagttcccct ttttccgcgg
     1081 cagctacacg ggctggcgca actccgtgcg ccacaacctt tcgctcaacg actgcttcgt
     1141 caaggtgctg cgcgacccct cgcggccctg gggcaaggac aactactgga tgctcaaccc
     1201 caacagcgag tacaccttcg ccgacggggt cttccgccgc cgccgcaagc gcctcagcca
     1261 ccgcgcgccg gtccccgcgc ccgggctgcg gcccgaggag gccccgggcc tccccgccgc
     1321 cccgccgccc gcgcccgccg ccccggcctc gccccgcatg cgctcgcccg cccgccagga
     1381 ggagcgcgcc agccccgcgg gcaagttctc cagctccttc gccatcgaca gcatcctgcg
     1441 caagcccttc cgcagccgcc gcctcaggga cacggccccc gggacgacgc ttcagtgggg
     1501 cgccgcgccc tgcccgccgc tgcccgcgtt ccccgcgctc ctccccgcgg cgccctgcag
     1561 ggccctgctg ccgctctgcg cgtacggcgc gggcgagccg gcgcggctgg gcgcgcgcga
     1621 ggccgaggtg ccaccgaccg cgccgcccct cctgcttgca cctctcccgg cggcggcccc
     1681 cgccaagcca ctccgaggcc cggcggccgg cggcgcgcac ctgtactgcc ccctgcggct
     1741 gcccgcagcc ctgcaggcgg cctcagtccg ccgccctggc ccgcacctgc cgtacccggt
     1801 ggagacgctc ctagcctgag tagcgccgcg gggcccggga acgccgagtg cgcgccgtcg
     1861 gggaggcggg aacgcgggcc cgcgcgcgga ctttgcactt tgaatccaga ggaagatgaa
     1921 tttttaaaat ctccatcaaa cgtgccttaa agctaaagca ttttgacagg agtatttaaa
     1981 cttagtccag gatattttcc tttgtgtttt ataactttac agaggaccaa agcaattctt
     2041 gttttagttt ctttgcgaag cctgctcctc cttcccttca taaggacttt ttttgtcttt
     2101 ctttaacgcc caggcttcgt cttatttcta ctgtttttgt cgcaacttcc attgatttat
     2161 gtcccttccc tcccccctaa gtacatcagg gaacctttcc acactataaa tgatatgact
     2221 actgtttggg gtttctgggc ccccatccgt gtacgtatgt ggcatttcca ggtatgactg
     2281 agtgtgagag acatgtcaga ggctcttcag tgatttcttg ctattgaccg atgcttcact
     2341 gtgccaaaag agaaaaaaaa tgttgggttt tgtaattaaa ttatttatat atttttgaaa
     2401 cccgaattga aaatgttgca ggcaacgggc tacagcttta ttagtggttc tctaactgtg
     2461 gtctccttgg gccaagcaat ttctttaaag gaaaagttga ttatgtatgt ggggtgccag
     2521 gaccactgcc ttgaaagcaa gtgtgatttt tatttttaat attattttat ttgtgtctgt
     2581 gtacatattc atgtataaat tttatgaaac ccaagcatag tgcttatttt ttaataaaac
     2641 aactgactta acacattgtg a
//
