LOCUS       NM_001012426            5994 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens forkhead box P4 (FOXP4), transcript variant 1, mRNA.
ACCESSION   NM_001012426
VERSION     NM_001012426.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5994)
  AUTHORS   Ji,J., Qian,Q., Cheng,W., Ye,X., Jing,A., Ma,S., Ding,Y., Ma,X.,
            Wang,Y., Sun,Q., Wang,X., Chen,Y., Zhu,L., Yuan,Q., Xu,M., Qin,J.,
            Ma,L., Yang,J., Zhang,M., Geng,T., Wang,S., Wang,D., Song,Y.,
            Zhang,B., Xu,Y., Xu,L., Liu,S., Liu,W. and Liu,B.
  TITLE     FOXP4-mediated induction of PTK7 activates the Wnt/beta-catenin
            pathway and promotes ovarian cancer development
  JOURNAL   Cell Death Dis 15 (5), 332 (2024)
   PUBMED   38740744
  REMARK    GeneRIF: FOXP4-mediated induction of PTK7 activates the
            Wnt/beta-catenin pathway and promotes ovarian cancer development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5994)
  AUTHORS   Zhang,F., Zhou,P., Wang,L., Liao,X., Liu,X., Ke,C., Wen,S. and
            Shu,Y.
  TITLE     Polymorphisms of IFN signaling genes and FOXP4 influence the
            severity of COVID-19
  JOURNAL   BMC Infect Dis 24 (1), 270 (2024)
   PUBMED   38429664
  REMARK    GeneRIF: Polymorphisms of IFN signaling genes and FOXP4 influence
            the severity of COVID-19.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5994)
  AUTHORS   Luo,S.W., Tang,L., Zhou,D., Bo,H. and Fan,L.Q.
  TITLE     FOXP4 promotes proliferation of human spermatogonial stem cells
  JOURNAL   Asian J Androl 25 (3), 322-330 (2023)
   PUBMED   36018067
  REMARK    GeneRIF: FOXP4 promotes proliferation of human spermatogonial stem
            cells.
REFERENCE   4  (bases 1 to 5994)
  AUTHORS   Del Viso,F., Zhou,D., Thiffault,I., Lawson,C., Cross,L.,
            Jenkins,J., Rush,E. and Saunders,C.
  TITLE     Recurrent FOXP4 nonsense variant in two unrelated patients:
            Association with neurodevelopmental disease and congenital
            diaphragmatic hernia
  JOURNAL   Am J Med Genet A 191 (1), 259-264 (2023)
   PUBMED   36301021
  REMARK    GeneRIF: Recurrent FOXP4 nonsense variant in two unrelated
            patients: Association with neurodevelopmental disease and
            congenital diaphragmatic hernia.
REFERENCE   5  (bases 1 to 5994)
  AUTHORS   Matsumoto,T., Iizuka,T., Nakamura,M., Suzuki,T., Yamamoto,M.,
            Ono,M., Kagami,K., Kasama,H., Wakae,K., Muramatsu,M., Horike,S.I.,
            Kyo,S., Yamamoto,Y., Mizumoto,Y., Daikoku,T. and Fujiwara,H.
  TITLE     FOXP4 inhibits squamous differentiation of atypical cells in
            cervical intraepithelial neoplasia via an ELF3-dependent pathway
  JOURNAL   Cancer Sci 113 (10), 3376-3389 (2022)
   PUBMED   35838233
  REMARK    GeneRIF: FOXP4 inhibits squamous differentiation of atypical cells
            in cervical intraepithelial neoplasia via an ELF3-dependent
            pathway.
REFERENCE   6  (bases 1 to 5994)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   7  (bases 1 to 5994)
  AUTHORS   Hannenhalli,S., Putt,M.E., Gilmore,J.M., Wang,J., Parmacek,M.S.,
            Epstein,J.A., Morrisey,E.E., Margulies,K.B. and Cappola,T.P.
  TITLE     Transcriptional genomics associates FOX transcription factors with
            human heart failure
  JOURNAL   Circulation 114 (12), 1269-1276 (2006)
   PUBMED   16952980
  REMARK    GeneRIF: these data implicate specific members of the FOX family of
            TFs (FOXC1, C2, P1, P4, and O1A) not previously suggested in heart
            failure pathogenesis.
REFERENCE   8  (bases 1 to 5994)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Human FOX gene family (Review)
  JOURNAL   Int J Oncol 25 (5), 1495-1500 (2004)
   PUBMED   15492844
  REMARK    Review article
REFERENCE   9  (bases 1 to 5994)
  AUTHORS   Teufel,A., Wong,E.A., Mukhopadhyay,M., Malik,N. and Westphal,H.
  TITLE     FoxP4, a novel forkhead transcription factor
  JOURNAL   Biochim Biophys Acta 1627 (2-3), 147-152 (2003)
   PUBMED   12818433
REFERENCE   10 (bases 1 to 5994)
  AUTHORS   Lu,M.M., Li,S., Yang,H. and Morrisey,E.E.
  TITLE     Foxp4: a novel member of the Foxp subfamily of winged-helix genes
            co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues
  JOURNAL   Mech Dev 119 Suppl 1, S197-S202 (2002)
   PUBMED   14516685
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139331.19, BC040962.1,
            AB080747.1 and AW450805.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001012426.1.
            
            Summary: This gene belongs to subfamily P of the forkhead box (FOX)
            transcription factor family. Forkhead box transcription factors
            play important roles in the regulation of tissue- and cell
            type-specific gene transcription during both development and
            adulthood. Many members of the forkhead box gene family, including
            members of subfamily P, have roles in mammalian oncogenesis. This
            gene may play a role in the development of tumors of the kidney and
            larynx. Alternative splicing of this gene produces multiple
            transcript variants, some encoding different isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.257709.1,
                                           SRR14038191.2967054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000307972.10/ ENSP00000309823.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL139331.19        117921-117965
            46-491              BC040962.1         1-446
            492-4236            AB080747.1         1-3745
            4237-5973           AL139331.19        172167-173903
            5974-5994           AW450805.1         17-37               c
FEATURES             Location/Qualifiers
     source          1..5994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..5994
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /note="forkhead box P4"
                     /db_xref="GeneID:116113"
                     /db_xref="HGNC:HGNC:20842"
                     /db_xref="MIM:608924"
     exon            1..487
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            488..707
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2546
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     winged-helix repressor FOXP4; fork head-related protein
                     like A; forkhead box protein P4"
                     /codon_start=1
                     /product="forkhead box protein P4 isoform 1"
                     /protein_id="NP_001012426.1"
                     /db_xref="CCDS:CCDS34447.1"
                     /db_xref="GeneID:116113"
                     /db_xref="HGNC:HGNC:20842"
                     /db_xref="MIM:608924"
                     /translation="MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGR
                     EVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNNDSKQSASAVQVP
                     VSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLHLQLLTQ
                     QQAGKPQPKEALGNKQLAFQQQLLQMQQLQQQHLLNLQRQGLVSLQPNQASGPLQTLP
                     QAAVCPTDLPQLWKGEGAPGQPAEDSVKQEGLDLTGTAATATSFAAPPKVSPPLSHHT
                     LPNGQPTVLTSRRDSSSHEETPGSHPLYGHGECKWPGCETLCEDLGQFIKHLNTEHAL
                     DDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHLHMRPSEPKPFSQPLNPVPGSSS
                     FSKVTVSAADSFPDGLVHPPTSAAAPVTPLRPPGLGSASLHGGGPARRRSSDKFCSPI
                     SSELAQNHEFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNT
                     ATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEREYQKRRPPKMTGSPTLVKNMISGLS
                     YGALNASYQAALAESSFPLLNSPGMLNPGSASSLLPLSHDDVGAPVEPLPSNGSSSPP
                     RLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPSASGPPEDRDLEEELPGEELS"
     exon            708..803
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            804..926
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1013
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1161
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1375
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1480
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1568
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1652
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1860
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1937
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2039
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2161
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2228
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2398
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..5994
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3573
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /note="major polyA site"
     regulatory      4213..4218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /note="hexamer: ATTAAA"
     polyA_site      4236
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /note="major polyA site"
     regulatory      5974..5979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
                     /note="hexamer: AATAAA"
     polyA_site      5994
                     /gene="FOXP4"
                     /gene_synonym="hFKHLA"
ORIGIN      
        1 actcgcagcc caggctcagt cgcagcccct cggagtccgg agcccgccgt ccctgcggac
       61 cggacagtgc ggccggcggc cggcggccgg gacggagccc ccagcccgcg aggagggcgc
      121 ggcgcaggcg gcggcggcgc ggcggggagg agcccgggcc ggaaccaggg ctgggccggg
      181 ggcggggacg ccggggtccg ggagcccggg agccggagcg agctgacgag cgtcgcggaa
      241 ggaccgggaa ggaagagcgg agccggagcg agccaagcag cccacaaagt gccatgcccc
      301 ggcggggttg aggcgcgcgg cggtcggccc ggcgcgctgg gaggacgccc gggagctgcg
      361 cgacgcgggg cggcgcggaa gggcagcccc ggcgggcggc ggcgggcccg ggctgcgacc
      421 ggagcgagcc ccatgccccg cgcgggctga cgggccggag cccgcacgga gcggccgggc
      481 gggacaggta ccgctagagc gacatgatgg tggaatctgc ctcggagaca atcaggtcgg
      541 ctccatctgg tcagaatggc gtgggcagcc tctctgggca agccgatggc agcagcggcg
      601 gggccacagg gacaactgca agtggcacgg gcagggaagt gaccacgggt gcagacagca
      661 atggtgagat gagtcccgca gagctgctgc acttccagca gcaacaggct ctccaagtgg
      721 cccggcagtt cctgctgcag caggcctcag gcctgagctc cccagggaac aatgacagca
      781 aacagtctgc ctctgctgtg caggtgcctg tgtcggtggc catgatgtcg ccgcagatgc
      841 ttaccccgca acagatgcag cagatcctgt cgcccccgca gctgcaggcc ttgctccagc
      901 agcagcaagc cctcatgctc cagcagctac aggagtacta caagaagcag caggagcagc
      961 tccacctgca gctcctcacc cagcagcagg ctgggaaacc gcagcccaaa gaggcactgg
     1021 ggaacaagca gctggccttc cagcagcagc tcctgcaaat gcaacagttg cagcagcagc
     1081 acctgctcaa cctgcagagg caggggctgg tcagcctgca gcccaaccaa gcctcggggc
     1141 ccctccagac ccttccgcaa gcagctgttt gcccaacaga cctgccccag ctgtggaagg
     1201 gcgagggtgc ccccgggcag cctgccgagg acagcgtcaa gcaggagggg ctggacctca
     1261 ctggcacggc cgccaccgct acctcgtttg ccgctccccc caaggtctca ccccccctct
     1321 cccaccatac cctgcccaac ggacagccta ctgtgctcac atctcggaga gacagctctt
     1381 cccacgagga gacccccggc tcccaccccc tgtacggaca cggagagtgc aagtggccag
     1441 gctgtgagac cctgtgtgaa gacctgggcc agtttatcaa acacctcaac acagagcacg
     1501 ccctggatga ccggagtaca gcccagtgcc gggtacagat gcaggtggtg cagcagctgg
     1561 agatccagct cgccaaggag agcgagcggc tgcaggccat gatggcccac ctgcacatgc
     1621 ggccctcgga gcccaagccc ttcagccagc cactgaaccc ggtccccggc tcctcctcat
     1681 tctccaaggt gaccgtctct gcagcagact cattcccaga tggtctcgtg caccccccga
     1741 cctcggccgc agcccctgtc acccctctac ggccccctgg cctgggctct gcctccctgc
     1801 atggtggggg cccagcccgt cggagaagca gtgacaagtt ctgctccccc atctcctcag
     1861 agctggccca gaatcatgag ttctacaaga acgccgacgt ccggcccccc ttcacctacg
     1921 cctccctcat ccgccaggcc atcctggaaa cccctgacag gcagctgacc ctgaatgaga
     1981 tctataactg gttcaccagg atgttcgcct atttccgcag aaacactgcc acctggaaga
     2041 acgccgtgcg ccacaacctc agcctgcaca agtgcttcgt ccgcgtggag aacgtcaagg
     2101 gtgccgtgtg gactgtggac gagcgggagt atcagaagcg gagaccgcca aagatgacag
     2161 ggagccccac cctggtgaag aacatgatct ctggcctcag ctatggagca cttaatgcca
     2221 gctaccaggc cgccctggcc gagagcagct tccccctcct caacagccct ggcatgctga
     2281 accctggctc cgccagcagc ctgctgcccc tcagccacga tgacgtgggt gcccccgtgg
     2341 agccgctgcc cagcaacggc agcagcagcc ctcctcgcct ctccccgccc cagtacagcc
     2401 accaggtgca ggtgaaggag gagccagcag aggcagagga agacaggcag cccgggcctc
     2461 ccctgggcgc ccctaacccc agcgcctcgg ggcctccgga agacagggac ctggaggagg
     2521 agctgccggg agaagaactg tcctaagggc ctgtagtgac cggcagggct ggggtgagac
     2581 ccctcccttc cagaatccag gccccatctc ccccaactcc acagcccctc ccgagcctca
     2641 aggcaagtcc aggactcaga ccggggaggc ccgggccagc agctcccagt gtgacctgac
     2701 aaaaacacgt aggggcaggg acggtcccca cccccaggga cacaacccct ggtcttggac
     2761 cagtagagga cacggagggt tcagacccct cctcagaccc tccccacatc tgaaactgcc
     2821 tccccccaac caccagcagc agcagggccc tcctccccca ccagctctcc ccacagggcc
     2881 cctcagcatc atggagaccc gcaggcgggg cttagccacc cctcaaaccc agggccccct
     2941 ggcacctggc tctggccgtg ttttctggcc agaggccccc actttcctaa ctcgtgctcc
     3001 cttccgcctt cttttccgta ctgtgaagaa agaactctcc accccagctc ccaccctgcc
     3061 ctggcctggg tggaggaact gtgcctccat ccccagaaga aacagccccc tctgctgctg
     3121 gggtgggact gtctgtgtgc cctgtggggg tccgtgtgag caggcccacc tggctccaga
     3181 cccgccccca acctgagaca gaaccaggct gagccaggcc tccaccccca cccccgtttg
     3241 ctgggggctc ctccagccgc ccccatggga agaggcctgg taccgcctca cccacagagg
     3301 tctgtgccag gtgcgcttct gcaggtggag ccaagctctc cctgaggcca gaggcggggc
     3361 ctgggccggg agcccagggg aaggccaggc tggaccccgg ctccacaccc acatccagcc
     3421 tgcaggcctc tctgcagtcc tctcaccctc cctcagctcc ccttcctctg cagtcaccct
     3481 cagctcccct tccttgcccg cctctccccc cgccgcccca ccagttaaac ggatgaccaa
     3541 agacctttct tatgccggaa gcaaaaacca aaactttttg ttggcttttt cctttgtcgc
     3601 ctccccagca cctgccctcc cagtctccca ccccggcccc aggctggaag ccctccctcc
     3661 acttaagtta ttgttttaaa ccaaagttta cagtgtctgt tggtggccaa gaccttctct
     3721 ctccacccct cctccatcca ccctgaggac cctggggctc agtggaggca gggccctgcc
     3781 cccctccctt ccgctcctgc ccagcctggg ggaaggagaa aggaggggag aaagcgggct
     3841 ctcaccccct caggagtggg cacgggagcc cttctccctg accctgggct gcttcctggg
     3901 ggctctccag acccctctct aggaccaagt cacccgtcgt gctgggagtg tggattctag
     3961 caaaagagct ggaaaaaagt cagactctcc acagaccccc tatgggggac ccccaactca
     4021 aggccaagga ctgggcgtat cggatgctca taacacccct ggcctggccc ctttactgag
     4081 aagactcctt ggatatttcc caagaacccc ccacatacac ccctcacaag ccacccctcc
     4141 tgagaggcag ggggccctcc gccccctccc catgtattcc ccacctgtgt tccgtttgac
     4201 cagcacagaa atattaaacg tcctctattc accgggccct gtgtgtgtca ccgaggtgcg
     4261 ggaggggagg agcattaaag ctgaaagatc gctctgctcg gggagcctgg gcagagcagc
     4321 agcaacgtga gggtcgctgt ggtggtggtt tctgtgagtg gatggaatga gcagccctgc
     4381 aggggcgctg ggcatgtgcc ctcactgtgg acagggccca cccacctccg gttcccctgt
     4441 gcctcctgtc ccttccacgc ttaaacaggg ttctctgtca ttttcctgtt ttcttccaga
     4501 gtcccaatcc tttgccctag ttctttcact agtttgaaat ccaagttctt gccagagtgt
     4561 tggagcaagg cagctgattt gctgcaggga tggagaggac caccgccgca gggttctttt
     4621 acctgtgcca ccagctctgg agacatccac acccattccc aggtgtcctt ccaggcccat
     4681 tgtccacgtc ttcaaggggg ctgcctggat aggcgtgtgt gtgtgtagtg cccaggtgtg
     4741 gtggtggcat cctgaagcag taggaccatt agtgtgcgtg cacacccacg tggcacactg
     4801 tgtggtgacc atggtcatca tagtgggctc acggcggaaa cgggatcatt caacctatac
     4861 aaaggggacc ctggataggc tgcaaggaaa gaggccaagg gccaagctgc taagccaaag
     4921 atggcccctg acacctcccc cagccccagc acaccagcct gcacctctta tcccgtgtta
     4981 agtcctggtt ccccacctgc tgcccctcct caacacagag cccctcccgc cgcctcagac
     5041 ccctgtgcac atccccaggg cctcagccgt ctcattggtc tttatttttt atttttttta
     5101 agatggagtt tcgctcttat tgcccagact ggagtgcagt gatgctatct cggctcactg
     5161 caacctttgc ctcccaggtt caagtgattc tcctgcctca gcctcccaag tagctgggat
     5221 tacaggcgtg caccaccacg ccgggctaaa tttttttgta tttttagtag agacggggtt
     5281 tctctatgtt ggtcaggctg atctcgaact cccgacctca ggtgatccgc cagcctcagc
     5341 ctcccaaagt gctgggatta caggcgtgag ccactgcacc cggctctcac tggtcttacg
     5401 ccaccttctg gacactccct ccttgagggc agaaaggagt cccaggcctg tccctaggga
     5461 caaggcccag ggaagagtgt atttggggag caggggaggg gagggtgttg agaaagctga
     5521 actggagtca atcacccttc ccacaaatca ccaaactgct ggaactctcc agccaaatgc
     5581 tgggagaagg acctggaggg tgagtctttg ctgacctctc tctactctca ggcatgtctt
     5641 ttgtcctttt cgtccatcta tttctgtctg tcgctcactc gccccgcttt ctctgtctca
     5701 ccttcatcca ctctgcaggc ctgctccacc acagccctaa tcctctggac gcttgtgtag
     5761 ggcctggggt gaattccctg tcccccatgg tacctcgaga ggggctgggg agctcagctt
     5821 ggtctcagag tctccccacc agatactgtt taaaaaagta gcactgatgt gttttgtaat
     5881 ctgcccctcc cagccctccg tggaggctgc cagggccttg tacggtaaac ctagctgcat
     5941 gtaatctgtg gacaatggca ttctctacaa tgcaataaaa acaattaccc atga
//
