LOCUS       NM_001349344            6389 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens forkhead box P1 (FOXP1), transcript variant 17, mRNA.
ACCESSION   NM_001349344 XM_005264742
VERSION     NM_001349344.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6389)
  AUTHORS   Wang,P., Hu,Z., Yu,S., Su,S., Wu,R., Chen,C., Ye,Y., Wang,H.,
            Ye,X., Zhou,Z., Zhou,S. and Ren,N.
  TITLE     A novel protein encoded by circFOXP1 enhances ferroptosis and
            inhibits tumor recurrence in intrahepatic cholangiocarcinoma
  JOURNAL   Cancer Lett 598, 217092 (2024)
   PUBMED   38945202
  REMARK    GeneRIF: A novel protein encoded by circFOXP1 enhances ferroptosis
            and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
REFERENCE   2  (bases 1 to 6389)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   3  (bases 1 to 6389)
  AUTHORS   Wu,M., Tang,W., Chen,Y., Xue,L., Dai,J., Li,Y., Zhu,X., Wu,C.,
            Xiong,J., Zhang,J., Wu,T., Zhou,S., Chen,D., Sun,C., Yu,J., Li,H.,
            Guo,Y., Huang,Y., Zhu,Q., Wei,S., Zhou,Z., Wu,M., Li,Y., Xiang,T.,
            Qiao,H. and Wang,S.
  TITLE     Spatiotemporal transcriptomic changes of human ovarian aging and
            the regulatory role of FOXP1
  JOURNAL   Nat Aging 4 (4), 527-545 (2024)
   PUBMED   38594460
  REMARK    GeneRIF: Spatiotemporal transcriptomic changes of human ovarian
            aging and the regulatory role of FOXP1.
REFERENCE   4  (bases 1 to 6389)
  AUTHORS   Chen,X., Hao,Y., Liu,Y., Zhong,S., You,Y., Ao,K., Chong,T., Luo,X.,
            Yin,M., Ye,M., He,H., Lu,A., Chen,J., Li,X., Zhang,J. and Guo,X.
  TITLE     NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates
            Immunosuppression by Reprogramming Glycolytic Metabolism in
            Cervical Cancer
  JOURNAL   Adv Sci (Weinh) 10 (32), e2302705 (2023)
   PUBMED   37818745
  REMARK    GeneRIF: NAT10/ac4C/FOXP1 Promotes Malignant Progression and
            Facilitates Immunosuppression by Reprogramming Glycolytic
            Metabolism in Cervical Cancer.
REFERENCE   5  (bases 1 to 6389)
  AUTHORS   Park,S.H.E., Kulkarni,A. and Konopka,G.
  TITLE     FOXP1 orchestrates neurogenesis in human cortical basal radial
            glial cells
  JOURNAL   PLoS Biol 21 (8), e3001852 (2023)
   PUBMED   37540706
  REMARK    GeneRIF: FOXP1 orchestrates neurogenesis in human cortical basal
            radial glial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6389)
  AUTHORS   Banham,A.H., Beasley,N., Campo,E., Fernandez,P.L., Fidler,C.,
            Gatter,K., Jones,M., Mason,D.Y., Prime,J.E., Trougouboff,P.,
            Wood,K. and Cordell,J.L.
  TITLE     The FOXP1 winged helix transcription factor is a novel candidate
            tumor suppressor gene on chromosome 3p
  JOURNAL   Cancer Res 61 (24), 8820-8829 (2001)
   PUBMED   11751404
  REMARK    GeneRIF: The FOXP1 winged helix transcription factor is a novel
            candidate tumor suppressor gene on chromosome 3p.
REFERENCE   7  (bases 1 to 6389)
  AUTHORS   Wolska,M.K., Bukowski,K. and Jakubczak,A.
  TITLE     [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas
            aeruginosa rods]
  JOURNAL   Med Dosw Mikrobiol 53 (1), 45-51 (2001)
   PUBMED   11757404
REFERENCE   8  (bases 1 to 6389)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 6389)
  AUTHORS   Li,C. and Tucker,P.W.
  TITLE     DNA-binding properties and secondary structural model of the
            hepatocyte nuclear factor 3/fork head domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11583-11587 (1993)
   PUBMED   8265594
REFERENCE   10 (bases 1 to 6389)
  AUTHORS   Rappold,G., Siper,P., Kostic,A., Braden,R., Morgan,A., Koene,S. and
            Kolevzon,A.
  TITLE     FOXP1 Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37733892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097632.2 and AC103586.3.
            
            On May 20, 2020 this sequence version replaced NM_001349344.2.
            
            Summary: This gene belongs to subfamily P of the forkhead box (FOX)
            transcription factor family. Forkhead box transcription factors
            play important roles in the regulation of tissue- and cell
            type-specific gene transcription during both development and
            adulthood. Forkhead box P1 protein contains both DNA-binding- and
            protein-protein binding-domains. This gene may act as a tumor
            suppressor as it is lost in several tumor types and maps to a
            chromosomal region (3p14.1) reported to contain a tumor suppressor
            gene(s). Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (17), as well as variant 16,
            encodes isoform i.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.563772.1,
                                           SRR14038192.1293255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC097632.2         23823-23923         c
            102-239             AC103586.3         169597-169734       c
            240-326             AC103586.3         168498-168584       c
            327-480             AC103586.3         162903-163056       c
            481-685             AC103586.3         157289-157493       c
            686-790             AC103586.3         131510-131614       c
            791-878             AC103586.3         116933-117020       c
            879-962             AC103586.3         103955-104038       c
            963-1164            AC103586.3         93789-93990         c
            1165-1244           AC103586.3         93604-93683         c
            1245-1346           AC103586.3         92902-93003         c
            1347-1468           AC103586.3         88516-88637         c
            1469-1538           AC103586.3         86697-86766         c
            1539-1705           AC103586.3         81851-82017         c
            1706-6389           AC103586.3         70669-75352         c
FEATURES             Location/Qualifiers
     source          1..6389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..6389
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="forkhead box P1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
     exon            1..101
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..239
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1850
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="isoform i is encoded by transcript variant 17; fork
                     head-related protein like B; glutamine-rich factor 1;
                     mac-1-regulated forkhead"
                     /codon_start=1
                     /product="forkhead box protein P1 isoform i"
                     /protein_id="NP_001336273.1"
                     /db_xref="CCDS:CCDS93310.1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
                     /translation="MMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQLQE
                     FYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQG
                     LLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSS
                     SAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCED
                     FQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPK
                     AAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPI
                     RRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYN
                     WFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISG
                     NPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGA
                     MEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDY
                     EDEPVNEDME"
     exon            240..326
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..480
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..685
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..790
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..878
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..962
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1164
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1244
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1346
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1468
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1538
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1705
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..6389
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: ATTATA"
     polyA_site      2596
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     regulatory      4948..4953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      4977
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     polyA_site      5193
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
     regulatory      6355..6360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      6389
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
ORIGIN      
        1 gcagtccgcc tgcacgccga ggccgccgga ccccacgccc ggcccgcgcg ggcgccccga
       61 gcccggctcc gcgcgcctgg cggctacatg gagagtgtca ggttcccgtg tcagtggcta
      121 tgatgacacc tcaagttatc actccccagc aaatgcagca gatcctccag caacaagtgc
      181 tgagccctca gcagctccag gttctcctcc agcagcagca ggccctcatg cttcaacagc
      241 agcttcaaga gttttataaa aaacaacagg aacagttgca gcttcaactt ttacaacaac
      301 aacatgctgg aaaacagcct aaagagcaac agcaggtggc tacccagcag ttggcttttc
      361 agcagcagct tttacagatg cagcagttac agcagcagca cctcctgtct ttgcagcgcc
      421 aaggccttct gacaattcag cccgggcagc ctgcccttcc ccttcaacct cttgctcaag
      481 gcatgattcc aacagaactg cagcagctct ggaaagaagt gacaagtgct catactgcag
      541 aagaaaccac aggcaacaat cacagcagtt tggatctgac cacgacatgt gtctcctcct
      601 ctgcaccttc caagacctcc ttaataatga acccacatgc ctctaccaat ggacagctct
      661 cagtccacac tcccaaaagg gaaagtttgt cccatgagga gcacccccat agccatcctc
      721 tctatggaca tggtgtatgc aagtggccag gctgtgaagc agtgtgcgaa gatttccaat
      781 catttctaaa acatctcaac agtgagcatg cgctggacga tagaagtaca gcccaatgta
      841 gagtacaaat gcaggttgta cagcagttag agctacagct tgcaaaagac aaagaacgcc
      901 tgcaagccat gatgacccac ctgcatgtga agtctacaga acccaaagcc gcccctcagc
      961 ccttgaatct ggtatcaagt gtcactctct ccaagtccgc atcggaggct tctccacaga
     1021 gcttacctca tactccaacg accccaaccg cccccctgac tcccgtcacc caaggcccct
     1081 ctgtcatcac aaccaccagc atgcacacgg tgggacccat ccgcaggcgg tactcagaca
     1141 aatacaacgt gcccatttcg tcagcagata ttgcgcagaa ccaagaattt tataagaacg
     1201 cagaagttag accaccattt acatatgcat ctttaattag gcaggccatt ctcgaatctc
     1261 cagaaaagca gctaacacta aatgagatct ataactggtt cacacgaatg tttgcttact
     1321 tccgacgcaa cgcggccacg tggaagaatg cagtgcgtca taatcttagt cttcacaagt
     1381 gttttgtgcg agtagaaaac gttaaagggg cagtatggac agtggatgaa gtagaattcc
     1441 aaaaacgaag gccacaaaag atcagtggta acccttccct tattaaaaac atgcagagca
     1501 gccacgccta ctgcacacct ctcaatgcag ctttacaggc ttcaatggct gagaatagta
     1561 tacctctata cactaccgct tccatgggaa atcccactct gggcaactta gccagcgcaa
     1621 tacgggaaga gctgaacggg gcaatggagc ataccaacag caacgagagt gacagcagtc
     1681 caggcagatc tcctatgcaa gccgtgcatc ctgtacacgt caaagaagag cccctcgatc
     1741 cagaggaagc tgaagggccc ctgtccttag tgacaacagc caaccacagt ccagattttg
     1801 accatgacag agattacgaa gatgaaccag taaacgagga catggagtga ctatcggggc
     1861 gggccaaccc cgagaatgaa gattggaaaa aggaaaaaaa aaaaaacacg tcaaaagtta
     1921 gcagtgaaat tgttctccat ttgttgtaca gtctggagga ttttcactac gttttgacaa
     1981 ctctgaaatg tgttaactct tagtgccatc aagaacccca tttgggagta tttttgattt
     2041 ttctactttt tgttgaaaaa aggaatttgt actctgtgca ttggatggac ttgtttggta
     2101 cttgggattt tcctctctta accgtcaaca tcagtgttgt aaatttgcta aactgattca
     2161 cttttagcag cagactttga actgcagtcc tgccaacgtt ggacactgag gacgcccgac
     2221 agagcttgtg cacctaagct gcagaccaag cctttgccca gaatttaagg attccaatgg
     2281 acgacctatt tgcacagtac tgcatgttga ttatcactgc ctttactcct tttttttttt
     2341 tttttttttt tttttttttg cttccagttg ggatggggaa ggcctttgtg tgtgtattgg
     2401 ggggaggggt taaaaaataa ttatcccaaa ctttttaatg tattgctttt tttttttttt
     2461 tttttccttc tactatacca ttttaagttc tgacctcagg cctccatttg ggccgatggc
     2521 ctcttggagg cttaaagttt tctgtacctt gtgatgaatg ttaataggtg tttttattat
     2581 acaaagctga atgtcatttc tcgtttgtag ctttctgtca ctcattccat cttccttcag
     2641 acatcaccac gtttctctaa agtcagaaaa cattccgttt tggtcttttt caaaaaggtc
     2701 ccaaatgctg cactctacac atgaaggccc tctcacacag acgtgacgtc ctgccagaaa
     2761 gagaatgaat gacagaaaaa aaaaagagag acaaactcta ggaacaatgc cgattcattc
     2821 cacgcagcag tattgggggt ggttcggggg aggggtgttt cggattttct ttttttcttt
     2881 tcttttcttt tttttttttt gcagcaacca ttaataaatg ccaccacatt ctaccagcac
     2941 aaggaaacat aggcagcact gaaaaaaaaa aaaaagctca tattaattag actgacaata
     3001 tggccttgga aggctctccc ttgtggaacc aagttgccat gggccttggg tgctctgcga
     3061 taacgggtgt gggttggttt tgtttgcaaa atggccaaaa aaaaaaaccg gcttccccga
     3121 gcagctgccc tgaaagtagg ggtggcggcg gcggcgctga gtttatacat tagttcagac
     3181 ctacttggtg gcattaaact gtttgaatgc aaattcgatt tcagattgaa cttgttaagg
     3241 gagttaacga gggctgagtt cagcaaatgc taaagtgtta atttcaaata tgcaaatttg
     3301 gtactgcagt ttgttatgca atattatatc accaacccag tatcacaaaa actcatagaa
     3361 gatatcatgt aggccctggg ctttgggggg gtcccaaaca tggtatgcag aaatgtgatg
     3421 gttacaggtc agtacaacct cagtccttag aacccctcca cacttcagct ctgcacccac
     3481 tttcctgtca tttatttata taggactgta gtttttttta gttcgagagc ctttcgaagc
     3541 ttaatttata ttctttcttt gtaccttttt tctaaaatta ccaaagatat tacacaaagg
     3601 taaattatgt tctctgtttt atgctttatc tgatgaagcc aaatatcctc ttattgttga
     3661 tcaaaggagg caaaagaatt tagaggcaaa tgacaagcga taggctattg caacctgaga
     3721 aagagaactg ctccttcatc gtaaatttag aagaccaagt agataatgga accaaagttg
     3781 ttactttttt ctagtagtta tttttccttt ttctttttgt gtacctctac agagaccaaa
     3841 actcattctc ttaaagagat tttatggggc tactgcagat aaaaatagga cacaatatta
     3901 aaggagctac agaaggaagg gagtcccatc tcaaaaaaaa aatgaatgta tgccactgca
     3961 attagagtat ccaataaagg agacagttta gagtcaggac agaaaagctt ccataattga
     4021 actagattac ataatagtat ttctagaaaa agagatattt ttagattgta tgccactttt
     4081 gtttaagaac tgtgctgtga tcactgtatt aattttggtt tatcttggca tatatccttc
     4141 agtttgtttt tatttttaat ttttcctttt tttccgatta ggctttggtc agcatttttc
     4201 atttaaagaa aagtaacact cccatccact cataagcttg gtacaaaaac ttctctggca
     4261 gttacttttg aagcttcact ctgctttctg tataaagggc agtctgtggt cacgcaagac
     4321 tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaacttttc caggcagctt
     4381 catgatgtgc aggcagtagc cagacagggt catgggaagg gggccctgtg cttctaaact
     4441 gagtggttgc tggttagttt ggtattcaaa agaggataaa aatctggtag attagttcat
     4501 tctcagcatg tgtagctaga catgagtaaa gataacagca tgagaaactg ttagtacgca
     4561 tacctcagtt caaaccttta gggaatgatt aaaatttaaa aaaaaaacat ttcactcagt
     4621 tgcacttagt cgtatgtctt gcatgcttag tctaaagact gtagcaaaaa aaaaaaaaaa
     4681 agaaaaatta gattttacat atctttgcag gtatcacagc cttgcagaag aaccaactga
     4741 aaaaaaaatt ctcaggcttt acagcaagca aacttcacta tgatttttac aattctgatt
     4801 ctgtatcccc tgggggttat cccagttgct tctttaggat ggggtttatt acgttgtaca
     4861 tatatcccga tgtgtctgtg tgaatctttg tcttttttgg gggagggcag agggcggttc
     4921 tttttttaga tattgttcct aaaaaggaat aaatgcatac acctgtttgt caaaacacct
     4981 ttgctttttg tgcaactgct ttatattaac gatactaaaa aaaaatagct ttggaaaaaa
     5041 aactactgta tgtaacggaa ttgcagaata tgctgcacat gtattttatt tagttatcct
     5101 tgctttaaga atattggatg acatttcctg acatgtggga gggagaaact ccctaacttt
     5161 ttttttctgc ttttaaactg taacatagtt gaagatttct tttttctgtt ctcattgatt
     5221 ggagcatttt gtacaggttt tgtgtgtgtg tgtgtgtgtg tgtgcgcgcg tgcgtgtgtg
     5281 ttaatctgtt ttttgataca ttcctatccc ttgtgtttat cctaccactg ccttcctggc
     5341 tatcttaaac aagttcatac atttgaaaag aaaaaaaaat gttgtttaaa aaatgttttc
     5401 tcctgctgca gtaaatattt tgcatgatga aattccaggg tcacactttt ccaagtttat
     5461 cagtgaagta gtgattaaca atggggagtg tcaaaactat tgaacttttg tataaaaaaa
     5521 aaaaaacttt acaaggtgcc aagatgtaaa gaaaatctgt tacttttttt ttctcaaaga
     5581 aaagcataca ttagggaggt agtcccgtgt gtcagacaaa tgcactgtca ggaatgagga
     5641 tccaacctac ctgtccctag agtccgtctt gtaagatgag ttaggctgcc ccttggacca
     5701 gccacaaaat ggaatatcaa ggcttatgta catacgtgaa gagttaccac cagtcctgcc
     5761 acctttggac agctctaaca ccatccccag catccagtca gacctagtaa agaaaacctt
     5821 ggattcttaa cccaagatag gctgtaaatc actagctttt ttttcctcat gaaaaaaaat
     5881 agagttaaaa aatatttcct ctcttttcca tattccagct gaactccgtt tccaaaggca
     5941 caaagaagag tgtgcttatt cagattttga atctttttgg taccttttgg ttaatgacat
     6001 agcctcctga aattctggat gtcttcaaag tcagttttgc ttctttatcc tgaaaatcag
     6061 atttacaatg ctgaaggcat ttcttgggcc cagtgtagct cacgcaatct ctgctaccca
     6121 taagccttga tgaagatgat acagtccgga ctgtgagcat ggtgcttcat gtatatgtgc
     6181 tgccagtaac aagaattttt ttgttttgtt ttgttttgtt ttgataaggc ataaaagaaa
     6241 ctcattcctt gacatcaact gtaattccat cattccatgt ctgcggatac agacaataaa
     6301 aaaaatgttg tgtagtcagt actaattact gacattataa gcattctcaa atgcaataaa
     6361 aatgctggtt gttcacgctg gtagtaaaa
//
