LOCUS       NM_001349343            6497 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens forkhead box P1 (FOXP1), transcript variant 16, mRNA.
ACCESSION   NM_001349343
VERSION     NM_001349343.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6497)
  AUTHORS   Wang,P., Hu,Z., Yu,S., Su,S., Wu,R., Chen,C., Ye,Y., Wang,H.,
            Ye,X., Zhou,Z., Zhou,S. and Ren,N.
  TITLE     A novel protein encoded by circFOXP1 enhances ferroptosis and
            inhibits tumor recurrence in intrahepatic cholangiocarcinoma
  JOURNAL   Cancer Lett 598, 217092 (2024)
   PUBMED   38945202
  REMARK    GeneRIF: A novel protein encoded by circFOXP1 enhances ferroptosis
            and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
REFERENCE   2  (bases 1 to 6497)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   3  (bases 1 to 6497)
  AUTHORS   Wu,M., Tang,W., Chen,Y., Xue,L., Dai,J., Li,Y., Zhu,X., Wu,C.,
            Xiong,J., Zhang,J., Wu,T., Zhou,S., Chen,D., Sun,C., Yu,J., Li,H.,
            Guo,Y., Huang,Y., Zhu,Q., Wei,S., Zhou,Z., Wu,M., Li,Y., Xiang,T.,
            Qiao,H. and Wang,S.
  TITLE     Spatiotemporal transcriptomic changes of human ovarian aging and
            the regulatory role of FOXP1
  JOURNAL   Nat Aging 4 (4), 527-545 (2024)
   PUBMED   38594460
  REMARK    GeneRIF: Spatiotemporal transcriptomic changes of human ovarian
            aging and the regulatory role of FOXP1.
REFERENCE   4  (bases 1 to 6497)
  AUTHORS   Chen,X., Hao,Y., Liu,Y., Zhong,S., You,Y., Ao,K., Chong,T., Luo,X.,
            Yin,M., Ye,M., He,H., Lu,A., Chen,J., Li,X., Zhang,J. and Guo,X.
  TITLE     NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates
            Immunosuppression by Reprogramming Glycolytic Metabolism in
            Cervical Cancer
  JOURNAL   Adv Sci (Weinh) 10 (32), e2302705 (2023)
   PUBMED   37818745
  REMARK    GeneRIF: NAT10/ac4C/FOXP1 Promotes Malignant Progression and
            Facilitates Immunosuppression by Reprogramming Glycolytic
            Metabolism in Cervical Cancer.
REFERENCE   5  (bases 1 to 6497)
  AUTHORS   Park,S.H.E., Kulkarni,A. and Konopka,G.
  TITLE     FOXP1 orchestrates neurogenesis in human cortical basal radial
            glial cells
  JOURNAL   PLoS Biol 21 (8), e3001852 (2023)
   PUBMED   37540706
  REMARK    GeneRIF: FOXP1 orchestrates neurogenesis in human cortical basal
            radial glial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6497)
  AUTHORS   Banham,A.H., Beasley,N., Campo,E., Fernandez,P.L., Fidler,C.,
            Gatter,K., Jones,M., Mason,D.Y., Prime,J.E., Trougouboff,P.,
            Wood,K. and Cordell,J.L.
  TITLE     The FOXP1 winged helix transcription factor is a novel candidate
            tumor suppressor gene on chromosome 3p
  JOURNAL   Cancer Res 61 (24), 8820-8829 (2001)
   PUBMED   11751404
  REMARK    GeneRIF: The FOXP1 winged helix transcription factor is a novel
            candidate tumor suppressor gene on chromosome 3p.
REFERENCE   7  (bases 1 to 6497)
  AUTHORS   Wolska,M.K., Bukowski,K. and Jakubczak,A.
  TITLE     [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas
            aeruginosa rods]
  JOURNAL   Med Dosw Mikrobiol 53 (1), 45-51 (2001)
   PUBMED   11757404
REFERENCE   8  (bases 1 to 6497)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 6497)
  AUTHORS   Li,C. and Tucker,P.W.
  TITLE     DNA-binding properties and secondary structural model of the
            hepatocyte nuclear factor 3/fork head domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11583-11587 (1993)
   PUBMED   8265594
REFERENCE   10 (bases 1 to 6497)
  AUTHORS   Rappold,G., Siper,P., Kostic,A., Braden,R., Morgan,A., Koene,S. and
            Kolevzon,A.
  TITLE     FOXP1 Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37733892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097632.2 and AC103586.3.
            
            On May 20, 2020 this sequence version replaced NM_001349343.2.
            
            Summary: This gene belongs to subfamily P of the forkhead box (FOX)
            transcription factor family. Forkhead box transcription factors
            play important roles in the regulation of tissue- and cell
            type-specific gene transcription during both development and
            adulthood. Forkhead box P1 protein contains both DNA-binding- and
            protein-protein binding-domains. This gene may act as a tumor
            suppressor as it is lost in several tumor types and maps to a
            chromosomal region (3p14.1) reported to contain a tumor suppressor
            gene(s). Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (16), as well as variant 17,
            encodes isoform i.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.95158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC097632.2         91090-91196         c
            108-209             AC097632.2         71535-71636         c
            210-347             AC103586.3         169597-169734       c
            348-434             AC103586.3         168498-168584       c
            435-588             AC103586.3         162903-163056       c
            589-793             AC103586.3         157289-157493       c
            794-898             AC103586.3         131510-131614       c
            899-986             AC103586.3         116933-117020       c
            987-1070            AC103586.3         103955-104038       c
            1071-1272           AC103586.3         93789-93990         c
            1273-1352           AC103586.3         93604-93683         c
            1353-1454           AC103586.3         92902-93003         c
            1455-1576           AC103586.3         88516-88637         c
            1577-1646           AC103586.3         86697-86766         c
            1647-1813           AC103586.3         81851-82017         c
            1814-6497           AC103586.3         70669-75352         c
FEATURES             Location/Qualifiers
     source          1..6497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..6497
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="forkhead box P1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
     exon            1..107
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..209
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..347
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1958
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="isoform i is encoded by transcript variant 16; fork
                     head-related protein like B; glutamine-rich factor 1;
                     mac-1-regulated forkhead"
                     /codon_start=1
                     /product="forkhead box protein P1 isoform i"
                     /protein_id="NP_001336272.1"
                     /db_xref="CCDS:CCDS93310.1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
                     /translation="MMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQLQE
                     FYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQG
                     LLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSS
                     SAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCED
                     FQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPK
                     AAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPI
                     RRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYN
                     WFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISG
                     NPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGA
                     MEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDY
                     EDEPVNEDME"
     exon            348..434
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..588
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..793
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..898
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..986
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1070
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1272
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1352
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1454
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1576
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1646
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1813
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..6497
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2684..2689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: ATTATA"
     polyA_site      2704
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     regulatory      5056..5061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      5085
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     polyA_site      5301
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
     regulatory      6463..6468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      6497
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
ORIGIN      
        1 ctgaccgccc actttcatgg cgcccaggct gtgtgccttt tgatactgca acgcagagca
       61 gctgcagggg atgctaataa aatgcaggat tttggacact gagcaaggca cttcaggtgg
      121 caagacagct ccttcttcag cagcaacagc agcagcaagt tagtggatta aaatctccca
      181 agaggaatga caaacaacca gctcttcagg ttcccgtgtc agtggctatg atgacacctc
      241 aagttatcac tccccagcaa atgcagcaga tcctccagca acaagtgctg agccctcagc
      301 agctccaggt tctcctccag cagcagcagg ccctcatgct tcaacagcag cttcaagagt
      361 tttataaaaa acaacaggaa cagttgcagc ttcaactttt acaacaacaa catgctggaa
      421 aacagcctaa agagcaacag caggtggcta cccagcagtt ggcttttcag cagcagcttt
      481 tacagatgca gcagttacag cagcagcacc tcctgtcttt gcagcgccaa ggccttctga
      541 caattcagcc cgggcagcct gcccttcccc ttcaacctct tgctcaaggc atgattccaa
      601 cagaactgca gcagctctgg aaagaagtga caagtgctca tactgcagaa gaaaccacag
      661 gcaacaatca cagcagtttg gatctgacca cgacatgtgt ctcctcctct gcaccttcca
      721 agacctcctt aataatgaac ccacatgcct ctaccaatgg acagctctca gtccacactc
      781 ccaaaaggga aagtttgtcc catgaggagc acccccatag ccatcctctc tatggacatg
      841 gtgtatgcaa gtggccaggc tgtgaagcag tgtgcgaaga tttccaatca tttctaaaac
      901 atctcaacag tgagcatgcg ctggacgata gaagtacagc ccaatgtaga gtacaaatgc
      961 aggttgtaca gcagttagag ctacagcttg caaaagacaa agaacgcctg caagccatga
     1021 tgacccacct gcatgtgaag tctacagaac ccaaagccgc ccctcagccc ttgaatctgg
     1081 tatcaagtgt cactctctcc aagtccgcat cggaggcttc tccacagagc ttacctcata
     1141 ctccaacgac cccaaccgcc cccctgactc ccgtcaccca aggcccctct gtcatcacaa
     1201 ccaccagcat gcacacggtg ggacccatcc gcaggcggta ctcagacaaa tacaacgtgc
     1261 ccatttcgtc agcagatatt gcgcagaacc aagaatttta taagaacgca gaagttagac
     1321 caccatttac atatgcatct ttaattaggc aggccattct cgaatctcca gaaaagcagc
     1381 taacactaaa tgagatctat aactggttca cacgaatgtt tgcttacttc cgacgcaacg
     1441 cggccacgtg gaagaatgca gtgcgtcata atcttagtct tcacaagtgt tttgtgcgag
     1501 tagaaaacgt taaaggggca gtatggacag tggatgaagt agaattccaa aaacgaaggc
     1561 cacaaaagat cagtggtaac ccttccctta ttaaaaacat gcagagcagc cacgcctact
     1621 gcacacctct caatgcagct ttacaggctt caatggctga gaatagtata cctctataca
     1681 ctaccgcttc catgggaaat cccactctgg gcaacttagc cagcgcaata cgggaagagc
     1741 tgaacggggc aatggagcat accaacagca acgagagtga cagcagtcca ggcagatctc
     1801 ctatgcaagc cgtgcatcct gtacacgtca aagaagagcc cctcgatcca gaggaagctg
     1861 aagggcccct gtccttagtg acaacagcca accacagtcc agattttgac catgacagag
     1921 attacgaaga tgaaccagta aacgaggaca tggagtgact atcggggcgg gccaaccccg
     1981 agaatgaaga ttggaaaaag gaaaaaaaaa aaaacacgtc aaaagttagc agtgaaattg
     2041 ttctccattt gttgtacagt ctggaggatt ttcactacgt tttgacaact ctgaaatgtg
     2101 ttaactctta gtgccatcaa gaaccccatt tgggagtatt tttgattttt ctactttttg
     2161 ttgaaaaaag gaatttgtac tctgtgcatt ggatggactt gtttggtact tgggattttc
     2221 ctctcttaac cgtcaacatc agtgttgtaa atttgctaaa ctgattcact tttagcagca
     2281 gactttgaac tgcagtcctg ccaacgttgg acactgagga cgcccgacag agcttgtgca
     2341 cctaagctgc agaccaagcc tttgcccaga atttaaggat tccaatggac gacctatttg
     2401 cacagtactg catgttgatt atcactgcct ttactccttt tttttttttt tttttttttt
     2461 tttttttgct tccagttggg atggggaagg cctttgtgtg tgtattgggg ggaggggtta
     2521 aaaaataatt atcccaaact ttttaatgta ttgctttttt tttttttttt tttccttcta
     2581 ctataccatt ttaagttctg acctcaggcc tccatttggg ccgatggcct cttggaggct
     2641 taaagttttc tgtaccttgt gatgaatgtt aataggtgtt tttattatac aaagctgaat
     2701 gtcatttctc gtttgtagct ttctgtcact cattccatct tccttcagac atcaccacgt
     2761 ttctctaaag tcagaaaaca ttccgttttg gtctttttca aaaaggtccc aaatgctgca
     2821 ctctacacat gaaggccctc tcacacagac gtgacgtcct gccagaaaga gaatgaatga
     2881 cagaaaaaaa aaagagagac aaactctagg aacaatgccg attcattcca cgcagcagta
     2941 ttgggggtgg ttcgggggag gggtgtttcg gattttcttt ttttcttttc ttttcttttt
     3001 ttttttttgc agcaaccatt aataaatgcc accacattct accagcacaa ggaaacatag
     3061 gcagcactga aaaaaaaaaa aaagctcata ttaattagac tgacaatatg gccttggaag
     3121 gctctccctt gtggaaccaa gttgccatgg gccttgggtg ctctgcgata acgggtgtgg
     3181 gttggttttg tttgcaaaat ggccaaaaaa aaaaaccggc ttccccgagc agctgccctg
     3241 aaagtagggg tggcggcggc ggcgctgagt ttatacatta gttcagacct acttggtggc
     3301 attaaactgt ttgaatgcaa attcgatttc agattgaact tgttaaggga gttaacgagg
     3361 gctgagttca gcaaatgcta aagtgttaat ttcaaatatg caaatttggt actgcagttt
     3421 gttatgcaat attatatcac caacccagta tcacaaaaac tcatagaaga tatcatgtag
     3481 gccctgggct ttgggggggt cccaaacatg gtatgcagaa atgtgatggt tacaggtcag
     3541 tacaacctca gtccttagaa cccctccaca cttcagctct gcacccactt tcctgtcatt
     3601 tatttatata ggactgtagt tttttttagt tcgagagcct ttcgaagctt aatttatatt
     3661 ctttctttgt accttttttc taaaattacc aaagatatta cacaaaggta aattatgttc
     3721 tctgttttat gctttatctg atgaagccaa atatcctctt attgttgatc aaaggaggca
     3781 aaagaattta gaggcaaatg acaagcgata ggctattgca acctgagaaa gagaactgct
     3841 ccttcatcgt aaatttagaa gaccaagtag ataatggaac caaagttgtt acttttttct
     3901 agtagttatt tttccttttt ctttttgtgt acctctacag agaccaaaac tcattctctt
     3961 aaagagattt tatggggcta ctgcagataa aaataggaca caatattaaa ggagctacag
     4021 aaggaaggga gtcccatctc aaaaaaaaaa tgaatgtatg ccactgcaat tagagtatcc
     4081 aataaaggag acagtttaga gtcaggacag aaaagcttcc ataattgaac tagattacat
     4141 aatagtattt ctagaaaaag agatattttt agattgtatg ccacttttgt ttaagaactg
     4201 tgctgtgatc actgtattaa ttttggttta tcttggcata tatccttcag tttgttttta
     4261 tttttaattt ttcctttttt tccgattagg ctttggtcag catttttcat ttaaagaaaa
     4321 gtaacactcc catccactca taagcttggt acaaaaactt ctctggcagt tacttttgaa
     4381 gcttcactct gctttctgta taaagggcag tctgtggtca cgcaagactt taaaaaaaaa
     4441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aacttttcca ggcagcttca tgatgtgcag
     4501 gcagtagcca gacagggtca tgggaagggg gccctgtgct tctaaactga gtggttgctg
     4561 gttagtttgg tattcaaaag aggataaaaa tctggtagat tagttcattc tcagcatgtg
     4621 tagctagaca tgagtaaaga taacagcatg agaaactgtt agtacgcata cctcagttca
     4681 aacctttagg gaatgattaa aatttaaaaa aaaaacattt cactcagttg cacttagtcg
     4741 tatgtcttgc atgcttagtc taaagactgt agcaaaaaaa aaaaaaaaag aaaaattaga
     4801 ttttacatat ctttgcaggt atcacagcct tgcagaagaa ccaactgaaa aaaaaattct
     4861 caggctttac agcaagcaaa cttcactatg atttttacaa ttctgattct gtatcccctg
     4921 ggggttatcc cagttgcttc tttaggatgg ggtttattac gttgtacata tatcccgatg
     4981 tgtctgtgtg aatctttgtc ttttttgggg gagggcagag ggcggttctt tttttagata
     5041 ttgttcctaa aaaggaataa atgcatacac ctgtttgtca aaacaccttt gctttttgtg
     5101 caactgcttt atattaacga tactaaaaaa aaatagcttt ggaaaaaaaa ctactgtatg
     5161 taacggaatt gcagaatatg ctgcacatgt attttattta gttatccttg ctttaagaat
     5221 attggatgac atttcctgac atgtgggagg gagaaactcc ctaacttttt ttttctgctt
     5281 ttaaactgta acatagttga agatttcttt tttctgttct cattgattgg agcattttgt
     5341 acaggttttg tgtgtgtgtg tgtgtgtgtg tgcgcgcgtg cgtgtgtgtt aatctgtttt
     5401 ttgatacatt cctatccctt gtgtttatcc taccactgcc ttcctggcta tcttaaacaa
     5461 gttcatacat ttgaaaagaa aaaaaaatgt tgtttaaaaa atgttttctc ctgctgcagt
     5521 aaatattttg catgatgaaa ttccagggtc acacttttcc aagtttatca gtgaagtagt
     5581 gattaacaat ggggagtgtc aaaactattg aacttttgta taaaaaaaaa aaaactttac
     5641 aaggtgccaa gatgtaaaga aaatctgtta cttttttttt ctcaaagaaa agcatacatt
     5701 agggaggtag tcccgtgtgt cagacaaatg cactgtcagg aatgaggatc caacctacct
     5761 gtccctagag tccgtcttgt aagatgagtt aggctgcccc ttggaccagc cacaaaatgg
     5821 aatatcaagg cttatgtaca tacgtgaaga gttaccacca gtcctgccac ctttggacag
     5881 ctctaacacc atccccagca tccagtcaga cctagtaaag aaaaccttgg attcttaacc
     5941 caagataggc tgtaaatcac tagctttttt ttcctcatga aaaaaaatag agttaaaaaa
     6001 tatttcctct cttttccata ttccagctga actccgtttc caaaggcaca aagaagagtg
     6061 tgcttattca gattttgaat ctttttggta ccttttggtt aatgacatag cctcctgaaa
     6121 ttctggatgt cttcaaagtc agttttgctt ctttatcctg aaaatcagat ttacaatgct
     6181 gaaggcattt cttgggccca gtgtagctca cgcaatctct gctacccata agccttgatg
     6241 aagatgatac agtccggact gtgagcatgg tgcttcatgt atatgtgctg ccagtaacaa
     6301 gaattttttt gttttgtttt gttttgtttt gataaggcat aaaagaaact cattccttga
     6361 catcaactgt aattccatca ttccatgtct gcggatacag acaataaaaa aaatgttgtg
     6421 tagtcagtac taattactga cattataagc attctcaaat gcaataaaaa tgctggttgt
     6481 tcacgctggt agtaaaa
//
