LOCUS       NM_001349338            7177 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens forkhead box P1 (FOXP1), transcript variant 11, mRNA.
ACCESSION   NM_001349338 NM_001349339
VERSION     NM_001349338.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7177)
  AUTHORS   Wang,P., Hu,Z., Yu,S., Su,S., Wu,R., Chen,C., Ye,Y., Wang,H.,
            Ye,X., Zhou,Z., Zhou,S. and Ren,N.
  TITLE     A novel protein encoded by circFOXP1 enhances ferroptosis and
            inhibits tumor recurrence in intrahepatic cholangiocarcinoma
  JOURNAL   Cancer Lett 598, 217092 (2024)
   PUBMED   38945202
  REMARK    GeneRIF: A novel protein encoded by circFOXP1 enhances ferroptosis
            and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
REFERENCE   2  (bases 1 to 7177)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   3  (bases 1 to 7177)
  AUTHORS   Wu,M., Tang,W., Chen,Y., Xue,L., Dai,J., Li,Y., Zhu,X., Wu,C.,
            Xiong,J., Zhang,J., Wu,T., Zhou,S., Chen,D., Sun,C., Yu,J., Li,H.,
            Guo,Y., Huang,Y., Zhu,Q., Wei,S., Zhou,Z., Wu,M., Li,Y., Xiang,T.,
            Qiao,H. and Wang,S.
  TITLE     Spatiotemporal transcriptomic changes of human ovarian aging and
            the regulatory role of FOXP1
  JOURNAL   Nat Aging 4 (4), 527-545 (2024)
   PUBMED   38594460
  REMARK    GeneRIF: Spatiotemporal transcriptomic changes of human ovarian
            aging and the regulatory role of FOXP1.
REFERENCE   4  (bases 1 to 7177)
  AUTHORS   Chen,X., Hao,Y., Liu,Y., Zhong,S., You,Y., Ao,K., Chong,T., Luo,X.,
            Yin,M., Ye,M., He,H., Lu,A., Chen,J., Li,X., Zhang,J. and Guo,X.
  TITLE     NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates
            Immunosuppression by Reprogramming Glycolytic Metabolism in
            Cervical Cancer
  JOURNAL   Adv Sci (Weinh) 10 (32), e2302705 (2023)
   PUBMED   37818745
  REMARK    GeneRIF: NAT10/ac4C/FOXP1 Promotes Malignant Progression and
            Facilitates Immunosuppression by Reprogramming Glycolytic
            Metabolism in Cervical Cancer.
REFERENCE   5  (bases 1 to 7177)
  AUTHORS   Park,S.H.E., Kulkarni,A. and Konopka,G.
  TITLE     FOXP1 orchestrates neurogenesis in human cortical basal radial
            glial cells
  JOURNAL   PLoS Biol 21 (8), e3001852 (2023)
   PUBMED   37540706
  REMARK    GeneRIF: FOXP1 orchestrates neurogenesis in human cortical basal
            radial glial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7177)
  AUTHORS   Banham,A.H., Beasley,N., Campo,E., Fernandez,P.L., Fidler,C.,
            Gatter,K., Jones,M., Mason,D.Y., Prime,J.E., Trougouboff,P.,
            Wood,K. and Cordell,J.L.
  TITLE     The FOXP1 winged helix transcription factor is a novel candidate
            tumor suppressor gene on chromosome 3p
  JOURNAL   Cancer Res 61 (24), 8820-8829 (2001)
   PUBMED   11751404
  REMARK    GeneRIF: The FOXP1 winged helix transcription factor is a novel
            candidate tumor suppressor gene on chromosome 3p.
REFERENCE   7  (bases 1 to 7177)
  AUTHORS   Wolska,M.K., Bukowski,K. and Jakubczak,A.
  TITLE     [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas
            aeruginosa rods]
  JOURNAL   Med Dosw Mikrobiol 53 (1), 45-51 (2001)
   PUBMED   11757404
REFERENCE   8  (bases 1 to 7177)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 7177)
  AUTHORS   Li,C. and Tucker,P.W.
  TITLE     DNA-binding properties and secondary structural model of the
            hepatocyte nuclear factor 3/fork head domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11583-11587 (1993)
   PUBMED   8265594
REFERENCE   10 (bases 1 to 7177)
  AUTHORS   Rappold,G., Siper,P., Kostic,A., Braden,R., Morgan,A., Koene,S. and
            Kolevzon,A.
  TITLE     FOXP1 Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37733892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097634.2, AC104645.8,
            AC104442.2, AC138058.2, AC097632.2 and AC103586.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 20, 2020 this sequence version replaced NM_001349338.2.
            
            Summary: This gene belongs to subfamily P of the forkhead box (FOX)
            transcription factor family. Forkhead box transcription factors
            play important roles in the regulation of tissue- and cell
            type-specific gene transcription during both development and
            adulthood. Forkhead box P1 protein contains both DNA-binding- and
            protein-protein binding-domains. This gene may act as a tumor
            suppressor as it is lost in several tumor types and maps to a
            chromosomal region (3p14.1) reported to contain a tumor suppressor
            gene(s). Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (11), as well as variants 1, 7, 9,
            and 13, encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.4548172.1,
                                           SRR11853567.21247.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649528.3/ ENSP00000497369.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC097634.2         92457-92614         c
            159-307             AC097634.2         90435-90583         c
            308-437             AC104645.8         119854-119983       c
            438-532             AC104442.2         151975-152069       c
            533-593             AC104442.2         92645-92705         c
            594-784             AC138058.2         65636-65826         c
            785-886             AC097632.2         71535-71636         c
            887-1024            AC103586.3         169597-169734       c
            1025-1114           AC103586.3         168498-168587       c
            1115-1268           AC103586.3         162903-163056       c
            1269-1473           AC103586.3         157289-157493       c
            1474-1578           AC103586.3         131510-131614       c
            1579-1666           AC103586.3         116933-117020       c
            1667-1750           AC103586.3         103955-104038       c
            1751-1952           AC103586.3         93789-93990         c
            1953-2032           AC103586.3         93604-93683         c
            2033-2134           AC103586.3         92902-93003         c
            2135-2256           AC103586.3         88516-88637         c
            2257-2326           AC103586.3         86697-86766         c
            2327-2493           AC103586.3         81851-82017         c
            2494-7177           AC103586.3         70669-75352         c
FEATURES             Location/Qualifiers
     source          1..7177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..7177
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="forkhead box P1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
     exon            1..158
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..307
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..437
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..532
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..593
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..784
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..2638
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="isoform a is encoded by transcript variant 11; fork
                     head-related protein like B; glutamine-rich factor 1;
                     mac-1-regulated forkhead"
                     /codon_start=1
                     /product="forkhead box protein P1 isoform a"
                     /protein_id="NP_001336267.1"
                     /db_xref="CCDS:CCDS2914.1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
                     /translation="MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAV
                     DIGAADLAHAQQQQQQALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMM
                     TPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQ
                     QQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQP
                     LAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHAS
                     TNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALD
                     DRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLS
                     KSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSA
                     DIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAAT
                     WKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYC
                     TPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGAMEHTNSNESDSSPGR
                     SPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME"
     exon            785..886
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1024
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1114
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1268
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1473
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1578
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1666
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1750
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1952
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2032
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2134
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2256
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2326
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2493
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..7177
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3364..3369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: ATTATA"
     polyA_site      3384
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     regulatory      5736..5741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      5765
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     polyA_site      5981
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
     regulatory      7143..7148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      7177
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
ORIGIN      
        1 gtactcgcgg cggcccggcc ctcgcccggg agtgcgtgtg tgcgcgcgtg tgtgcgcgag
       61 tgagtgtgtg cgcggggtgc gcgcgcgggc gggagtgggc gcgcgcgggg aaaggcccga
      121 aaacacctta gtttgcaccg agagaccatt tgcagcggaa cccgaaagtt tgtaagagga
      181 agagagcgcg cggcgagcga gcgagcgggc cgggggcagc ggcagcggcg ccggggacca
      241 tggtgctgcc ggcgcctcct ccgcgggcgt gaaggcggcg ctcctactcc ctccccggac
      301 tccgcggtgt cccagaagct tttgttgaca attccagttt ccgaacaaaa catttcggca
      361 atggtgaggg cttcgatccc ttctctgatt tgctgtcagc catgaacgga tggatgtgat
      421 gcctgctagc caaaaggctt ccctctgtgt gttgcagtcc tgtggcatta tgcatgcccc
      481 ctcccagtga ccccaggctt tttatggctg tgagacacgt taaaatttca ggggtaagac
      541 gtgacctttt gaggtgacta taactgaaga ttgctttaca gaagccaaaa aaggtttttg
      601 agtcatgatg caagaatctg ggactgagac aaaaagtaac ggttcagcca tccagaatgg
      661 gtcgggcggc agcaaccact tactagagtg cggcggtctt cgggaggggc ggtccaacgg
      721 agagacgccg gccgtggaca tcggggcagc tgacctcgcc cacgcccagc agcagcagca
      781 acaggcactt caggtggcaa gacagctcct tcttcagcag caacagcagc agcaagttag
      841 tggattaaaa tctcccaaga ggaatgacaa acaaccagct cttcaggttc ccgtgtcagt
      901 ggctatgatg acacctcaag ttatcactcc ccagcaaatg cagcagatcc tccagcaaca
      961 agtgctgagc cctcagcagc tccaggttct cctccagcag cagcaggccc tcatgcttca
     1021 acagcagcag cttcaagagt tttataaaaa acaacaggaa cagttgcagc ttcaactttt
     1081 acaacaacaa catgctggaa aacagcctaa agagcaacag caggtggcta cccagcagtt
     1141 ggcttttcag cagcagcttt tacagatgca gcagttacag cagcagcacc tcctgtcttt
     1201 gcagcgccaa ggccttctga caattcagcc cgggcagcct gcccttcccc ttcaacctct
     1261 tgctcaaggc atgattccaa cagaactgca gcagctctgg aaagaagtga caagtgctca
     1321 tactgcagaa gaaaccacag gcaacaatca cagcagtttg gatctgacca cgacatgtgt
     1381 ctcctcctct gcaccttcca agacctcctt aataatgaac ccacatgcct ctaccaatgg
     1441 acagctctca gtccacactc ccaaaaggga aagtttgtcc catgaggagc acccccatag
     1501 ccatcctctc tatggacatg gtgtatgcaa gtggccaggc tgtgaagcag tgtgcgaaga
     1561 tttccaatca tttctaaaac atctcaacag tgagcatgcg ctggacgata gaagtacagc
     1621 ccaatgtaga gtacaaatgc aggttgtaca gcagttagag ctacagcttg caaaagacaa
     1681 agaacgcctg caagccatga tgacccacct gcatgtgaag tctacagaac ccaaagccgc
     1741 ccctcagccc ttgaatctgg tatcaagtgt cactctctcc aagtccgcat cggaggcttc
     1801 tccacagagc ttacctcata ctccaacgac cccaaccgcc cccctgactc ccgtcaccca
     1861 aggcccctct gtcatcacaa ccaccagcat gcacacggtg ggacccatcc gcaggcggta
     1921 ctcagacaaa tacaacgtgc ccatttcgtc agcagatatt gcgcagaacc aagaatttta
     1981 taagaacgca gaagttagac caccatttac atatgcatct ttaattaggc aggccattct
     2041 cgaatctcca gaaaagcagc taacactaaa tgagatctat aactggttca cacgaatgtt
     2101 tgcttacttc cgacgcaacg cggccacgtg gaagaatgca gtgcgtcata atcttagtct
     2161 tcacaagtgt tttgtgcgag tagaaaacgt taaaggggca gtatggacag tggatgaagt
     2221 agaattccaa aaacgaaggc cacaaaagat cagtggtaac ccttccctta ttaaaaacat
     2281 gcagagcagc cacgcctact gcacacctct caatgcagct ttacaggctt caatggctga
     2341 gaatagtata cctctataca ctaccgcttc catgggaaat cccactctgg gcaacttagc
     2401 cagcgcaata cgggaagagc tgaacggggc aatggagcat accaacagca acgagagtga
     2461 cagcagtcca ggcagatctc ctatgcaagc cgtgcatcct gtacacgtca aagaagagcc
     2521 cctcgatcca gaggaagctg aagggcccct gtccttagtg acaacagcca accacagtcc
     2581 agattttgac catgacagag attacgaaga tgaaccagta aacgaggaca tggagtgact
     2641 atcggggcgg gccaaccccg agaatgaaga ttggaaaaag gaaaaaaaaa aaaacacgtc
     2701 aaaagttagc agtgaaattg ttctccattt gttgtacagt ctggaggatt ttcactacgt
     2761 tttgacaact ctgaaatgtg ttaactctta gtgccatcaa gaaccccatt tgggagtatt
     2821 tttgattttt ctactttttg ttgaaaaaag gaatttgtac tctgtgcatt ggatggactt
     2881 gtttggtact tgggattttc ctctcttaac cgtcaacatc agtgttgtaa atttgctaaa
     2941 ctgattcact tttagcagca gactttgaac tgcagtcctg ccaacgttgg acactgagga
     3001 cgcccgacag agcttgtgca cctaagctgc agaccaagcc tttgcccaga atttaaggat
     3061 tccaatggac gacctatttg cacagtactg catgttgatt atcactgcct ttactccttt
     3121 tttttttttt tttttttttt tttttttgct tccagttggg atggggaagg cctttgtgtg
     3181 tgtattgggg ggaggggtta aaaaataatt atcccaaact ttttaatgta ttgctttttt
     3241 tttttttttt tttccttcta ctataccatt ttaagttctg acctcaggcc tccatttggg
     3301 ccgatggcct cttggaggct taaagttttc tgtaccttgt gatgaatgtt aataggtgtt
     3361 tttattatac aaagctgaat gtcatttctc gtttgtagct ttctgtcact cattccatct
     3421 tccttcagac atcaccacgt ttctctaaag tcagaaaaca ttccgttttg gtctttttca
     3481 aaaaggtccc aaatgctgca ctctacacat gaaggccctc tcacacagac gtgacgtcct
     3541 gccagaaaga gaatgaatga cagaaaaaaa aaagagagac aaactctagg aacaatgccg
     3601 attcattcca cgcagcagta ttgggggtgg ttcgggggag gggtgtttcg gattttcttt
     3661 ttttcttttc ttttcttttt ttttttttgc agcaaccatt aataaatgcc accacattct
     3721 accagcacaa ggaaacatag gcagcactga aaaaaaaaaa aaagctcata ttaattagac
     3781 tgacaatatg gccttggaag gctctccctt gtggaaccaa gttgccatgg gccttgggtg
     3841 ctctgcgata acgggtgtgg gttggttttg tttgcaaaat ggccaaaaaa aaaaaccggc
     3901 ttccccgagc agctgccctg aaagtagggg tggcggcggc ggcgctgagt ttatacatta
     3961 gttcagacct acttggtggc attaaactgt ttgaatgcaa attcgatttc agattgaact
     4021 tgttaaggga gttaacgagg gctgagttca gcaaatgcta aagtgttaat ttcaaatatg
     4081 caaatttggt actgcagttt gttatgcaat attatatcac caacccagta tcacaaaaac
     4141 tcatagaaga tatcatgtag gccctgggct ttgggggggt cccaaacatg gtatgcagaa
     4201 atgtgatggt tacaggtcag tacaacctca gtccttagaa cccctccaca cttcagctct
     4261 gcacccactt tcctgtcatt tatttatata ggactgtagt tttttttagt tcgagagcct
     4321 ttcgaagctt aatttatatt ctttctttgt accttttttc taaaattacc aaagatatta
     4381 cacaaaggta aattatgttc tctgttttat gctttatctg atgaagccaa atatcctctt
     4441 attgttgatc aaaggaggca aaagaattta gaggcaaatg acaagcgata ggctattgca
     4501 acctgagaaa gagaactgct ccttcatcgt aaatttagaa gaccaagtag ataatggaac
     4561 caaagttgtt acttttttct agtagttatt tttccttttt ctttttgtgt acctctacag
     4621 agaccaaaac tcattctctt aaagagattt tatggggcta ctgcagataa aaataggaca
     4681 caatattaaa ggagctacag aaggaaggga gtcccatctc aaaaaaaaaa tgaatgtatg
     4741 ccactgcaat tagagtatcc aataaaggag acagtttaga gtcaggacag aaaagcttcc
     4801 ataattgaac tagattacat aatagtattt ctagaaaaag agatattttt agattgtatg
     4861 ccacttttgt ttaagaactg tgctgtgatc actgtattaa ttttggttta tcttggcata
     4921 tatccttcag tttgttttta tttttaattt ttcctttttt tccgattagg ctttggtcag
     4981 catttttcat ttaaagaaaa gtaacactcc catccactca taagcttggt acaaaaactt
     5041 ctctggcagt tacttttgaa gcttcactct gctttctgta taaagggcag tctgtggtca
     5101 cgcaagactt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aacttttcca
     5161 ggcagcttca tgatgtgcag gcagtagcca gacagggtca tgggaagggg gccctgtgct
     5221 tctaaactga gtggttgctg gttagtttgg tattcaaaag aggataaaaa tctggtagat
     5281 tagttcattc tcagcatgtg tagctagaca tgagtaaaga taacagcatg agaaactgtt
     5341 agtacgcata cctcagttca aacctttagg gaatgattaa aatttaaaaa aaaaacattt
     5401 cactcagttg cacttagtcg tatgtcttgc atgcttagtc taaagactgt agcaaaaaaa
     5461 aaaaaaaaag aaaaattaga ttttacatat ctttgcaggt atcacagcct tgcagaagaa
     5521 ccaactgaaa aaaaaattct caggctttac agcaagcaaa cttcactatg atttttacaa
     5581 ttctgattct gtatcccctg ggggttatcc cagttgcttc tttaggatgg ggtttattac
     5641 gttgtacata tatcccgatg tgtctgtgtg aatctttgtc ttttttgggg gagggcagag
     5701 ggcggttctt tttttagata ttgttcctaa aaaggaataa atgcatacac ctgtttgtca
     5761 aaacaccttt gctttttgtg caactgcttt atattaacga tactaaaaaa aaatagcttt
     5821 ggaaaaaaaa ctactgtatg taacggaatt gcagaatatg ctgcacatgt attttattta
     5881 gttatccttg ctttaagaat attggatgac atttcctgac atgtgggagg gagaaactcc
     5941 ctaacttttt ttttctgctt ttaaactgta acatagttga agatttcttt tttctgttct
     6001 cattgattgg agcattttgt acaggttttg tgtgtgtgtg tgtgtgtgtg tgcgcgcgtg
     6061 cgtgtgtgtt aatctgtttt ttgatacatt cctatccctt gtgtttatcc taccactgcc
     6121 ttcctggcta tcttaaacaa gttcatacat ttgaaaagaa aaaaaaatgt tgtttaaaaa
     6181 atgttttctc ctgctgcagt aaatattttg catgatgaaa ttccagggtc acacttttcc
     6241 aagtttatca gtgaagtagt gattaacaat ggggagtgtc aaaactattg aacttttgta
     6301 taaaaaaaaa aaaactttac aaggtgccaa gatgtaaaga aaatctgtta cttttttttt
     6361 ctcaaagaaa agcatacatt agggaggtag tcccgtgtgt cagacaaatg cactgtcagg
     6421 aatgaggatc caacctacct gtccctagag tccgtcttgt aagatgagtt aggctgcccc
     6481 ttggaccagc cacaaaatgg aatatcaagg cttatgtaca tacgtgaaga gttaccacca
     6541 gtcctgccac ctttggacag ctctaacacc atccccagca tccagtcaga cctagtaaag
     6601 aaaaccttgg attcttaacc caagataggc tgtaaatcac tagctttttt ttcctcatga
     6661 aaaaaaatag agttaaaaaa tatttcctct cttttccata ttccagctga actccgtttc
     6721 caaaggcaca aagaagagtg tgcttattca gattttgaat ctttttggta ccttttggtt
     6781 aatgacatag cctcctgaaa ttctggatgt cttcaaagtc agttttgctt ctttatcctg
     6841 aaaatcagat ttacaatgct gaaggcattt cttgggccca gtgtagctca cgcaatctct
     6901 gctacccata agccttgatg aagatgatac agtccggact gtgagcatgg tgcttcatgt
     6961 atatgtgctg ccagtaacaa gaattttttt gttttgtttt gttttgtttt gataaggcat
     7021 aaaagaaact cattccttga catcaactgt aattccatca ttccatgtct gcggatacag
     7081 acaataaaaa aaatgttgtg tagtcagtac taattactga cattataagc attctcaaat
     7141 gcaataaaaa tgctggttgt tcacgctggt agtaaaa
//
