LOCUS       NM_001244815            6482 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens forkhead box P1 (FOXP1), transcript variant 8, mRNA.
ACCESSION   NM_001244815
VERSION     NM_001244815.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6482)
  AUTHORS   Wang,P., Hu,Z., Yu,S., Su,S., Wu,R., Chen,C., Ye,Y., Wang,H.,
            Ye,X., Zhou,Z., Zhou,S. and Ren,N.
  TITLE     A novel protein encoded by circFOXP1 enhances ferroptosis and
            inhibits tumor recurrence in intrahepatic cholangiocarcinoma
  JOURNAL   Cancer Lett 598, 217092 (2024)
   PUBMED   38945202
  REMARK    GeneRIF: A novel protein encoded by circFOXP1 enhances ferroptosis
            and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
REFERENCE   2  (bases 1 to 6482)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   3  (bases 1 to 6482)
  AUTHORS   Wu,M., Tang,W., Chen,Y., Xue,L., Dai,J., Li,Y., Zhu,X., Wu,C.,
            Xiong,J., Zhang,J., Wu,T., Zhou,S., Chen,D., Sun,C., Yu,J., Li,H.,
            Guo,Y., Huang,Y., Zhu,Q., Wei,S., Zhou,Z., Wu,M., Li,Y., Xiang,T.,
            Qiao,H. and Wang,S.
  TITLE     Spatiotemporal transcriptomic changes of human ovarian aging and
            the regulatory role of FOXP1
  JOURNAL   Nat Aging 4 (4), 527-545 (2024)
   PUBMED   38594460
  REMARK    GeneRIF: Spatiotemporal transcriptomic changes of human ovarian
            aging and the regulatory role of FOXP1.
REFERENCE   4  (bases 1 to 6482)
  AUTHORS   Chen,X., Hao,Y., Liu,Y., Zhong,S., You,Y., Ao,K., Chong,T., Luo,X.,
            Yin,M., Ye,M., He,H., Lu,A., Chen,J., Li,X., Zhang,J. and Guo,X.
  TITLE     NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates
            Immunosuppression by Reprogramming Glycolytic Metabolism in
            Cervical Cancer
  JOURNAL   Adv Sci (Weinh) 10 (32), e2302705 (2023)
   PUBMED   37818745
  REMARK    GeneRIF: NAT10/ac4C/FOXP1 Promotes Malignant Progression and
            Facilitates Immunosuppression by Reprogramming Glycolytic
            Metabolism in Cervical Cancer.
REFERENCE   5  (bases 1 to 6482)
  AUTHORS   Park,S.H.E., Kulkarni,A. and Konopka,G.
  TITLE     FOXP1 orchestrates neurogenesis in human cortical basal radial
            glial cells
  JOURNAL   PLoS Biol 21 (8), e3001852 (2023)
   PUBMED   37540706
  REMARK    GeneRIF: FOXP1 orchestrates neurogenesis in human cortical basal
            radial glial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6482)
  AUTHORS   Banham,A.H., Beasley,N., Campo,E., Fernandez,P.L., Fidler,C.,
            Gatter,K., Jones,M., Mason,D.Y., Prime,J.E., Trougouboff,P.,
            Wood,K. and Cordell,J.L.
  TITLE     The FOXP1 winged helix transcription factor is a novel candidate
            tumor suppressor gene on chromosome 3p
  JOURNAL   Cancer Res 61 (24), 8820-8829 (2001)
   PUBMED   11751404
  REMARK    GeneRIF: The FOXP1 winged helix transcription factor is a novel
            candidate tumor suppressor gene on chromosome 3p.
REFERENCE   7  (bases 1 to 6482)
  AUTHORS   Wolska,M.K., Bukowski,K. and Jakubczak,A.
  TITLE     [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas
            aeruginosa rods]
  JOURNAL   Med Dosw Mikrobiol 53 (1), 45-51 (2001)
   PUBMED   11757404
REFERENCE   8  (bases 1 to 6482)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 6482)
  AUTHORS   Li,C. and Tucker,P.W.
  TITLE     DNA-binding properties and secondary structural model of the
            hepatocyte nuclear factor 3/fork head domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11583-11587 (1993)
   PUBMED   8265594
REFERENCE   10 (bases 1 to 6482)
  AUTHORS   Rappold,G., Siper,P., Kostic,A., Braden,R., Morgan,A., Koene,S. and
            Kolevzon,A.
  TITLE     FOXP1 Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37733892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA634017.1, AK027264.1,
            AC103586.3 and GD144178.1.
            
            On Jun 4, 2019 this sequence version replaced NM_001244815.1.
            
            Summary: This gene belongs to subfamily P of the forkhead box (FOX)
            transcription factor family. Forkhead box transcription factors
            play important roles in the regulation of tissue- and cell
            type-specific gene transcription during both development and
            adulthood. Forkhead box P1 protein contains both DNA-binding- and
            protein-protein binding-domains. This gene may act as a tumor
            suppressor as it is lost in several tumor types and maps to a
            chromosomal region (3p14.1) reported to contain a tumor suppressor
            gene(s). Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2406008.1, AK027264.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA634017.1         356-368
            14-426              AK027264.1         1-413
            427-427             AC103586.3         163049-163049       c
            428-521             AK027264.1         415-508
            522-522             AC103586.3         162954-162954       c
            523-1986            AK027264.1         510-1973
            1987-6378           AC103586.3         70773-75164         c
            6379-6476           GD144178.1         9-106
            6477-6482           AC103586.3         70669-70674         c
FEATURES             Location/Qualifiers
     source          1..6482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..6482
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="forkhead box P1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
     exon            1..89
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..191
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..329
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1943
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="isoform f is encoded by transcript variant 8; fork
                     head-related protein like B; glutamine-rich factor 1;
                     mac-1-regulated forkhead"
                     /codon_start=1
                     /product="forkhead box protein P1 isoform f"
                     /protein_id="NP_001231744.2"
                     /db_xref="CCDS:CCDS74963.1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
                     /translation="MMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQ
                     EFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQ
                     GLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVS
                     SSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCE
                     DFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEP
                     KAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGP
                     IRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIY
                     NWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKIS
                     GNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNG
                     AMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRD
                     YEDEPVNEDME"
     exon            330..419
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..573
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..778
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..883
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..971
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1055
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1257
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1337
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1439
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1561
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1631
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1798
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..6482
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2669..2674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: ATTATA"
     polyA_site      2689
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     regulatory      5041..5046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      5070
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     polyA_site      5286
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
     regulatory      6448..6453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      6482
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
ORIGIN      
        1 agaaacagcc agaacccatc tacagcaaga agacggaaat ccaaaggcag acagtacggg
       61 ctcccttcgc caaactcttc attttctctg cacttcaggt ggcaagacag ctccttcttc
      121 agcagcaaca gcagcagcaa gttagtggat taaaatctcc caagaggaat gacaaacaac
      181 cagctcttca ggttcccgtg tcagtggcta tgatgacacc tcaagttatc actccccagc
      241 aaatgcagca gatcctccag caacaagtgc tgagccctca gcagctccag gttctcctcc
      301 agcagcagca ggccctcatg cttcaacagc agcagcttca agagttttat aaaaaacaac
      361 aggaacagtt gcagcttcaa cttttacaac aacaacatgc tggaaaacag cctaaagagc
      421 aacagcaggt ggctacccag cagttggctt ttcagcagca gcttttacag atgcagcagt
      481 tacagcagca gcacctcctg tctttgcagc gccaaggcct tctgacaatt cagcccgggc
      541 agcctgccct tccccttcaa cctcttgctc aaggcatgat tccaacagaa ctgcagcagc
      601 tctggaaaga agtgacaagt gctcatactg cagaagaaac cacaggcaac aatcacagca
      661 gtttggatct gaccacgaca tgtgtctcct cctctgcacc ttccaagacc tccttaataa
      721 tgaacccaca tgcctctacc aatggacagc tctcagtcca cactcccaaa agggaaagtt
      781 tgtcccatga ggagcacccc catagccatc ctctctatgg acatggtgta tgcaagtggc
      841 caggctgtga agcagtgtgc gaagatttcc aatcatttct aaaacatctc aacagtgagc
      901 atgcgctgga cgatagaagt acagcccaat gtagagtaca aatgcaggtt gtacagcagt
      961 tagagctaca gcttgcaaaa gacaaagaac gcctgcaagc catgatgacc cacctgcatg
     1021 tgaagtctac agaacccaaa gccgcccctc agcccttgaa tctggtatca agtgtcactc
     1081 tctccaagtc cgcatcggag gcttctccac agagcttacc tcatactcca acgaccccaa
     1141 ccgcccccct gactcccgtc acccaaggcc cctctgtcat cacaaccacc agcatgcaca
     1201 cggtgggacc catccgcagg cggtactcag acaaatacaa cgtgcccatt tcgtcagcag
     1261 atattgcgca gaaccaagaa ttttataaga acgcagaagt tagaccacca tttacatatg
     1321 catctttaat taggcaggcc attctcgaat ctccagaaaa gcagctaaca ctaaatgaga
     1381 tctataactg gttcacacga atgtttgctt acttccgacg caacgcggcc acgtggaaga
     1441 atgcagtgcg tcataatctt agtcttcaca agtgttttgt gcgagtagaa aacgttaaag
     1501 gggcagtatg gacagtggat gaagtagaat tccaaaaacg aaggccacaa aagatcagtg
     1561 gtaacccttc ccttattaaa aacatgcaga gcagccacgc ctactgcaca cctctcaatg
     1621 cagctttaca ggcttcaatg gctgagaata gtatacctct atacactacc gcttccatgg
     1681 gaaatcccac tctgggcaac ttagccagcg caatacggga agagctgaac ggggcaatgg
     1741 agcataccaa cagcaacgag agtgacagca gtccaggcag atctcctatg caagccgtgc
     1801 atcctgtaca cgtcaaagaa gagcccctcg atccagagga agctgaaggg cccctgtcct
     1861 tagtgacaac agccaaccac agtccagatt ttgaccatga cagagattac gaagatgaac
     1921 cagtaaacga ggacatggag tgactatcgg ggcgggccaa ccccgagaat gaagattgga
     1981 aaaaggaaaa aaaaaaaaac acgtcaaaag ttagcagtga aattgttctc catttgttgt
     2041 acagtctgga ggattttcac tacgttttga caactctgaa atgtgttaac tcttagtgcc
     2101 atcaagaacc ccatttggga gtatttttga tttttctact ttttgttgaa aaaaggaatt
     2161 tgtactctgt gcattggatg gacttgtttg gtacttggga ttttcctctc ttaaccgtca
     2221 acatcagtgt tgtaaatttg ctaaactgat tcacttttag cagcagactt tgaactgcag
     2281 tcctgccaac gttggacact gaggacgccc gacagagctt gtgcacctaa gctgcagacc
     2341 aagcctttgc ccagaattta aggattccaa tggacgacct atttgcacag tactgcatgt
     2401 tgattatcac tgcctttact cctttttttt tttttttttt tttttttttt ttgcttccag
     2461 ttgggatggg gaaggccttt gtgtgtgtat tggggggagg ggttaaaaaa taattatccc
     2521 aaacttttta atgtattgct tttttttttt ttttttttcc ttctactata ccattttaag
     2581 ttctgacctc aggcctccat ttgggccgat ggcctcttgg aggcttaaag ttttctgtac
     2641 cttgtgatga atgttaatag gtgtttttat tatacaaagc tgaatgtcat ttctcgtttg
     2701 tagctttctg tcactcattc catcttcctt cagacatcac cacgtttctc taaagtcaga
     2761 aaacattccg ttttggtctt tttcaaaaag gtcccaaatg ctgcactcta cacatgaagg
     2821 ccctctcaca cagacgtgac gtcctgccag aaagagaatg aatgacagaa aaaaaaaaga
     2881 gagacaaact ctaggaacaa tgccgattca ttccacgcag cagtattggg ggtggttcgg
     2941 gggaggggtg tttcggattt tctttttttc ttttcttttc tttttttttt tttgcagcaa
     3001 ccattaataa atgccaccac attctaccag cacaaggaaa cataggcagc actgaaaaaa
     3061 aaaaaaaagc tcatattaat tagactgaca atatggcctt ggaaggctct cccttgtgga
     3121 accaagttgc catgggcctt gggtgctctg cgataacggg tgtgggttgg ttttgtttgc
     3181 aaaatggcca aaaaaaaaaa ccggcttccc cgagcagctg ccctgaaagt aggggtggcg
     3241 gcggcggcgc tgagtttata cattagttca gacctacttg gtggcattaa actgtttgaa
     3301 tgcaaattcg atttcagatt gaacttgtta agggagttaa cgagggctga gttcagcaaa
     3361 tgctaaagtg ttaatttcaa atatgcaaat ttggtactgc agtttgttat gcaatattat
     3421 atcaccaacc cagtatcaca aaaactcata gaagatatca tgtaggccct gggctttggg
     3481 ggggtcccaa acatggtatg cagaaatgtg atggttacag gtcagtacaa cctcagtcct
     3541 tagaacccct ccacacttca gctctgcacc cactttcctg tcatttattt atataggact
     3601 gtagtttttt ttagttcgag agcctttcga agcttaattt atattctttc tttgtacctt
     3661 ttttctaaaa ttaccaaaga tattacacaa aggtaaatta tgttctctgt tttatgcttt
     3721 atctgatgaa gccaaatatc ctcttattgt tgatcaaagg aggcaaaaga atttagaggc
     3781 aaatgacaag cgataggcta ttgcaacctg agaaagagaa ctgctccttc atcgtaaatt
     3841 tagaagacca agtagataat ggaaccaaag ttgttacttt tttctagtag ttatttttcc
     3901 tttttctttt tgtgtacctc tacagagacc aaaactcatt ctcttaaaga gattttatgg
     3961 ggctactgca gataaaaata ggacacaata ttaaaggagc tacagaagga agggagtccc
     4021 atctcaaaaa aaaaatgaat gtatgccact gcaattagag tatccaataa aggagacagt
     4081 ttagagtcag gacagaaaag cttccataat tgaactagat tacataatag tatttctaga
     4141 aaaagagata tttttagatt gtatgccact tttgtttaag aactgtgctg tgatcactgt
     4201 attaattttg gtttatcttg gcatatatcc ttcagtttgt ttttattttt aatttttcct
     4261 ttttttccga ttaggctttg gtcagcattt ttcatttaaa gaaaagtaac actcccatcc
     4321 actcataagc ttggtacaaa aacttctctg gcagttactt ttgaagcttc actctgcttt
     4381 ctgtataaag ggcagtctgt ggtcacgcaa gactttaaaa aaaaaaaaaa aaaaaaaaaa
     4441 aaaaaaaaaa aaaaaaactt ttccaggcag cttcatgatg tgcaggcagt agccagacag
     4501 ggtcatggga agggggccct gtgcttctaa actgagtggt tgctggttag tttggtattc
     4561 aaaagaggat aaaaatctgg tagattagtt cattctcagc atgtgtagct agacatgagt
     4621 aaagataaca gcatgagaaa ctgttagtac gcatacctca gttcaaacct ttagggaatg
     4681 attaaaattt aaaaaaaaaa catttcactc agttgcactt agtcgtatgt cttgcatgct
     4741 tagtctaaag actgtagcaa aaaaaaaaaa aaaagaaaaa ttagatttta catatctttg
     4801 caggtatcac agccttgcag aagaaccaac tgaaaaaaaa attctcaggc tttacagcaa
     4861 gcaaacttca ctatgatttt tacaattctg attctgtatc ccctgggggt tatcccagtt
     4921 gcttctttag gatggggttt attacgttgt acatatatcc cgatgtgtct gtgtgaatct
     4981 ttgtcttttt tgggggaggg cagagggcgg ttcttttttt agatattgtt cctaaaaagg
     5041 aataaatgca tacacctgtt tgtcaaaaca cctttgcttt ttgtgcaact gctttatatt
     5101 aacgatacta aaaaaaaata gctttggaaa aaaaactact gtatgtaacg gaattgcaga
     5161 atatgctgca catgtatttt atttagttat ccttgcttta agaatattgg atgacatttc
     5221 ctgacatgtg ggagggagaa actccctaac tttttttttc tgcttttaaa ctgtaacata
     5281 gttgaagatt tcttttttct gttctcattg attggagcat tttgtacagg ttttgtgtgt
     5341 gtgtgtgtgt gtgtgtgcgc gcgtgcgtgt gtgttaatct gttttttgat acattcctat
     5401 cccttgtgtt tatcctacca ctgccttcct ggctatctta aacaagttca tacatttgaa
     5461 aagaaaaaaa aatgttgttt aaaaaatgtt ttctcctgct gcagtaaata ttttgcatga
     5521 tgaaattcca gggtcacact tttccaagtt tatcagtgaa gtagtgatta acaatgggga
     5581 gtgtcaaaac tattgaactt ttgtataaaa aaaaaaaaac tttacaaggt gccaagatgt
     5641 aaagaaaatc tgttactttt tttttctcaa agaaaagcat acattaggga ggtagtcccg
     5701 tgtgtcagac aaatgcactg tcaggaatga ggatccaacc tacctgtccc tagagtccgt
     5761 cttgtaagat gagttaggct gccccttgga ccagccacaa aatggaatat caaggcttat
     5821 gtacatacgt gaagagttac caccagtcct gccacctttg gacagctcta acaccatccc
     5881 cagcatccag tcagacctag taaagaaaac cttggattct taacccaaga taggctgtaa
     5941 atcactagct tttttttcct catgaaaaaa aatagagtta aaaaatattt cctctctttt
     6001 ccatattcca gctgaactcc gtttccaaag gcacaaagaa gagtgtgctt attcagattt
     6061 tgaatctttt tggtaccttt tggttaatga catagcctcc tgaaattctg gatgtcttca
     6121 aagtcagttt tgcttcttta tcctgaaaat cagatttaca atgctgaagg catttcttgg
     6181 gcccagtgta gctcacgcaa tctctgctac ccataagcct tgatgaagat gatacagtcc
     6241 ggactgtgag catggtgctt catgtatatg tgctgccagt aacaagaatt tttttgtttt
     6301 gttttgtttt gttttgataa ggcataaaag aaactcattc cttgacatca actgtaattc
     6361 catcattcca tgtctgcgga tacagacaat aaaaaaaatg ttgtgtagtc agtactaatt
     6421 actgacatta taagcattct caaatgcaat aaaaatgctg gttgttcacg ctggtagtaa
     6481 aa
//
