LOCUS       NM_001244812            6510 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens forkhead box P1 (FOXP1), transcript variant 5, mRNA.
ACCESSION   NM_001244812
VERSION     NM_001244812.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6510)
  AUTHORS   Wang,P., Hu,Z., Yu,S., Su,S., Wu,R., Chen,C., Ye,Y., Wang,H.,
            Ye,X., Zhou,Z., Zhou,S. and Ren,N.
  TITLE     A novel protein encoded by circFOXP1 enhances ferroptosis and
            inhibits tumor recurrence in intrahepatic cholangiocarcinoma
  JOURNAL   Cancer Lett 598, 217092 (2024)
   PUBMED   38945202
  REMARK    GeneRIF: A novel protein encoded by circFOXP1 enhances ferroptosis
            and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
REFERENCE   2  (bases 1 to 6510)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   3  (bases 1 to 6510)
  AUTHORS   Wu,M., Tang,W., Chen,Y., Xue,L., Dai,J., Li,Y., Zhu,X., Wu,C.,
            Xiong,J., Zhang,J., Wu,T., Zhou,S., Chen,D., Sun,C., Yu,J., Li,H.,
            Guo,Y., Huang,Y., Zhu,Q., Wei,S., Zhou,Z., Wu,M., Li,Y., Xiang,T.,
            Qiao,H. and Wang,S.
  TITLE     Spatiotemporal transcriptomic changes of human ovarian aging and
            the regulatory role of FOXP1
  JOURNAL   Nat Aging 4 (4), 527-545 (2024)
   PUBMED   38594460
  REMARK    GeneRIF: Spatiotemporal transcriptomic changes of human ovarian
            aging and the regulatory role of FOXP1.
REFERENCE   4  (bases 1 to 6510)
  AUTHORS   Chen,X., Hao,Y., Liu,Y., Zhong,S., You,Y., Ao,K., Chong,T., Luo,X.,
            Yin,M., Ye,M., He,H., Lu,A., Chen,J., Li,X., Zhang,J. and Guo,X.
  TITLE     NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates
            Immunosuppression by Reprogramming Glycolytic Metabolism in
            Cervical Cancer
  JOURNAL   Adv Sci (Weinh) 10 (32), e2302705 (2023)
   PUBMED   37818745
  REMARK    GeneRIF: NAT10/ac4C/FOXP1 Promotes Malignant Progression and
            Facilitates Immunosuppression by Reprogramming Glycolytic
            Metabolism in Cervical Cancer.
REFERENCE   5  (bases 1 to 6510)
  AUTHORS   Park,S.H.E., Kulkarni,A. and Konopka,G.
  TITLE     FOXP1 orchestrates neurogenesis in human cortical basal radial
            glial cells
  JOURNAL   PLoS Biol 21 (8), e3001852 (2023)
   PUBMED   37540706
  REMARK    GeneRIF: FOXP1 orchestrates neurogenesis in human cortical basal
            radial glial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6510)
  AUTHORS   Banham,A.H., Beasley,N., Campo,E., Fernandez,P.L., Fidler,C.,
            Gatter,K., Jones,M., Mason,D.Y., Prime,J.E., Trougouboff,P.,
            Wood,K. and Cordell,J.L.
  TITLE     The FOXP1 winged helix transcription factor is a novel candidate
            tumor suppressor gene on chromosome 3p
  JOURNAL   Cancer Res 61 (24), 8820-8829 (2001)
   PUBMED   11751404
  REMARK    GeneRIF: The FOXP1 winged helix transcription factor is a novel
            candidate tumor suppressor gene on chromosome 3p.
REFERENCE   7  (bases 1 to 6510)
  AUTHORS   Wolska,M.K., Bukowski,K. and Jakubczak,A.
  TITLE     [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas
            aeruginosa rods]
  JOURNAL   Med Dosw Mikrobiol 53 (1), 45-51 (2001)
   PUBMED   11757404
REFERENCE   8  (bases 1 to 6510)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 6510)
  AUTHORS   Li,C. and Tucker,P.W.
  TITLE     DNA-binding properties and secondary structural model of the
            hepatocyte nuclear factor 3/fork head domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11583-11587 (1993)
   PUBMED   8265594
REFERENCE   10 (bases 1 to 6510)
  AUTHORS   Rappold,G., Siper,P., Kostic,A., Braden,R., Morgan,A., Koene,S. and
            Kolevzon,A.
  TITLE     FOXP1 Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37733892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104442.2, AK092383.1,
            AA380962.1, AC103586.3 and GD144178.1.
            
            On May 20, 2020 this sequence version replaced NM_001244812.2.
            
            Summary: This gene belongs to subfamily P of the forkhead box (FOX)
            transcription factor family. Forkhead box transcription factors
            play important roles in the regulation of tissue- and cell
            type-specific gene transcription during both development and
            adulthood. Forkhead box P1 protein contains both DNA-binding- and
            protein-protein binding-domains. This gene may act as a tumor
            suppressor as it is lost in several tumor types and maps to a
            chromosomal region (3p14.1) reported to contain a tumor suppressor
            gene(s). Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (5) differs in the 5' UTR and
            lacks an alternate in-frame segment compared to variant 1. The
            resulting isoform (e, previously called 5) has the same N- and
            C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092383.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC104442.2         97586-97596         c
            12-102              AK092383.1         1-91
            103-160             AA380962.1         116-173
            161-1133            AK092383.1         150-1122
            1134-1134           AC103586.3         93940-93940         c
            1135-2007           AK092383.1         1124-1996
            2008-6406           AC103586.3         70773-75171         c
            6407-6504           GD144178.1         9-106
            6505-6510           AC103586.3         70669-70674         c
FEATURES             Location/Qualifiers
     source          1..6510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..6510
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="forkhead box P1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
     exon            1..93
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..154
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            155..345
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1971
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="isoform e is encoded by transcript variant 5; fork
                     head-related protein like B; glutamine-rich factor 1;
                     mac-1-regulated forkhead"
                     /codon_start=1
                     /product="forkhead box protein P1 isoform e"
                     /protein_id="NP_001231741.1"
                     /db_xref="CCDS:CCDS58838.1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
                     /translation="MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAV
                     DIGAADLAHAQQQQQQALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQQQQVATQQ
                     LAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVT
                     SAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHE
                     EHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLE
                     LQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTP
                     TAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPF
                     TYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRV
                     ENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPL
                     YTTASMGNPTLGNLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDP
                     EEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME"
     exon            346..447
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..601
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..806
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..911
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..999
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1083
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1285
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1365
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1467
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1589
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1659
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1826
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..6510
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: ATTATA"
     polyA_site      2717
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     regulatory      5069..5074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      5098
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     polyA_site      5314
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
     regulatory      6476..6481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      6510
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
ORIGIN      
        1 gggtacaaat cagtctagag acttagaagc atttattaac agtgaggctg ctgaaggttt
       61 ttaataacaa aattacaaat actctatcta attggtaaga cgtgaccttt tgaggtgact
      121 ataactgaag attgctttac agaagccaaa aaaggttttt gagtcatgat gcaagaatct
      181 gggactgaga caaaaagtaa cggttcagcc atccagaatg ggtcgggcgg cagcaaccac
      241 ttactagagt gcggcggtct tcgggagggg cggtccaacg gagagacgcc ggccgtggac
      301 atcggggcag ctgacctcgc ccacgcccag cagcagcagc aacaggcact tcaggtggca
      361 agacagctcc ttcttcagca gcaacagcag cagcaagtta gtggattaaa atctcccaag
      421 aggaatgaca aacaaccagc tcttcagcaa cagcaggtgg ctacccagca gttggctttt
      481 cagcagcagc ttttacagat gcagcagtta cagcagcagc acctcctgtc tttgcagcgc
      541 caaggccttc tgacaattca gcccgggcag cctgcccttc cccttcaacc tcttgctcaa
      601 ggcatgattc caacagaact gcagcagctc tggaaagaag tgacaagtgc tcatactgca
      661 gaagaaacca caggcaacaa tcacagcagt ttggatctga ccacgacatg tgtctcctcc
      721 tctgcacctt ccaagacctc cttaataatg aacccacatg cctctaccaa tggacagctc
      781 tcagtccaca ctcccaaaag ggaaagtttg tcccatgagg agcaccccca tagccatcct
      841 ctctatggac atggtgtatg caagtggcca ggctgtgaag cagtgtgcga agatttccaa
      901 tcatttctaa aacatctcaa cagtgagcat gcgctggacg atagaagtac agcccaatgt
      961 agagtacaaa tgcaggttgt acagcagtta gagctacagc ttgcaaaaga caaagaacgc
     1021 ctgcaagcca tgatgaccca cctgcatgtg aagtctacag aacccaaagc cgcccctcag
     1081 cccttgaatc tggtatcaag tgtcactctc tccaagtccg catcggaggc ttctccacag
     1141 agcttacctc atactccaac gaccccaacc gcccccctga ctcccgtcac ccaaggcccc
     1201 tctgtcatca caaccaccag catgcacacg gtgggaccca tccgcaggcg gtactcagac
     1261 aaatacaacg tgcccatttc gtcagcagat attgcgcaga accaagaatt ttataagaac
     1321 gcagaagtta gaccaccatt tacatatgca tctttaatta ggcaggccat tctcgaatct
     1381 ccagaaaagc agctaacact aaatgagatc tataactggt tcacacgaat gtttgcttac
     1441 ttccgacgca acgcggccac gtggaagaat gcagtgcgtc ataatcttag tcttcacaag
     1501 tgttttgtgc gagtagaaaa cgttaaaggg gcagtatgga cagtggatga agtagaattc
     1561 caaaaacgaa ggccacaaaa gatcagtggt aacccttccc ttattaaaaa catgcagagc
     1621 agccacgcct actgcacacc tctcaatgca gctttacagg cttcaatggc tgagaatagt
     1681 atacctctat acactaccgc ttccatggga aatcccactc tgggcaactt agccagcgca
     1741 atacgggaag agctgaacgg ggcaatggag cataccaaca gcaacgagag tgacagcagt
     1801 ccaggcagat ctcctatgca agccgtgcat cctgtacacg tcaaagaaga gcccctcgat
     1861 ccagaggaag ctgaagggcc cctgtcctta gtgacaacag ccaaccacag tccagatttt
     1921 gaccatgaca gagattacga agatgaacca gtaaacgagg acatggagtg actatcgggg
     1981 cgggccaacc ccgagaatga agattggaaa aaggaaaaaa aaaaaaacac gtcaaaagtt
     2041 agcagtgaaa ttgttctcca tttgttgtac agtctggagg attttcacta cgttttgaca
     2101 actctgaaat gtgttaactc ttagtgccat caagaacccc atttgggagt atttttgatt
     2161 tttctacttt ttgttgaaaa aaggaatttg tactctgtgc attggatgga cttgtttggt
     2221 acttgggatt ttcctctctt aaccgtcaac atcagtgttg taaatttgct aaactgattc
     2281 acttttagca gcagactttg aactgcagtc ctgccaacgt tggacactga ggacgcccga
     2341 cagagcttgt gcacctaagc tgcagaccaa gcctttgccc agaatttaag gattccaatg
     2401 gacgacctat ttgcacagta ctgcatgttg attatcactg cctttactcc tttttttttt
     2461 tttttttttt tttttttttt gcttccagtt gggatgggga aggcctttgt gtgtgtattg
     2521 gggggagggg ttaaaaaata attatcccaa actttttaat gtattgcttt tttttttttt
     2581 ttttttcctt ctactatacc attttaagtt ctgacctcag gcctccattt gggccgatgg
     2641 cctcttggag gcttaaagtt ttctgtacct tgtgatgaat gttaataggt gtttttatta
     2701 tacaaagctg aatgtcattt ctcgtttgta gctttctgtc actcattcca tcttccttca
     2761 gacatcacca cgtttctcta aagtcagaaa acattccgtt ttggtctttt tcaaaaaggt
     2821 cccaaatgct gcactctaca catgaaggcc ctctcacaca gacgtgacgt cctgccagaa
     2881 agagaatgaa tgacagaaaa aaaaaagaga gacaaactct aggaacaatg ccgattcatt
     2941 ccacgcagca gtattggggg tggttcgggg gaggggtgtt tcggattttc tttttttctt
     3001 ttcttttctt tttttttttt tgcagcaacc attaataaat gccaccacat tctaccagca
     3061 caaggaaaca taggcagcac tgaaaaaaaa aaaaaagctc atattaatta gactgacaat
     3121 atggccttgg aaggctctcc cttgtggaac caagttgcca tgggccttgg gtgctctgcg
     3181 ataacgggtg tgggttggtt ttgtttgcaa aatggccaaa aaaaaaaacc ggcttccccg
     3241 agcagctgcc ctgaaagtag gggtggcggc ggcggcgctg agtttataca ttagttcaga
     3301 cctacttggt ggcattaaac tgtttgaatg caaattcgat ttcagattga acttgttaag
     3361 ggagttaacg agggctgagt tcagcaaatg ctaaagtgtt aatttcaaat atgcaaattt
     3421 ggtactgcag tttgttatgc aatattatat caccaaccca gtatcacaaa aactcataga
     3481 agatatcatg taggccctgg gctttggggg ggtcccaaac atggtatgca gaaatgtgat
     3541 ggttacaggt cagtacaacc tcagtcctta gaacccctcc acacttcagc tctgcaccca
     3601 ctttcctgtc atttatttat ataggactgt agtttttttt agttcgagag cctttcgaag
     3661 cttaatttat attctttctt tgtacctttt ttctaaaatt accaaagata ttacacaaag
     3721 gtaaattatg ttctctgttt tatgctttat ctgatgaagc caaatatcct cttattgttg
     3781 atcaaaggag gcaaaagaat ttagaggcaa atgacaagcg ataggctatt gcaacctgag
     3841 aaagagaact gctccttcat cgtaaattta gaagaccaag tagataatgg aaccaaagtt
     3901 gttacttttt tctagtagtt atttttcctt tttctttttg tgtacctcta cagagaccaa
     3961 aactcattct cttaaagaga ttttatgggg ctactgcaga taaaaatagg acacaatatt
     4021 aaaggagcta cagaaggaag ggagtcccat ctcaaaaaaa aaatgaatgt atgccactgc
     4081 aattagagta tccaataaag gagacagttt agagtcagga cagaaaagct tccataattg
     4141 aactagatta cataatagta tttctagaaa aagagatatt tttagattgt atgccacttt
     4201 tgtttaagaa ctgtgctgtg atcactgtat taattttggt ttatcttggc atatatcctt
     4261 cagtttgttt ttatttttaa tttttccttt ttttccgatt aggctttggt cagcattttt
     4321 catttaaaga aaagtaacac tcccatccac tcataagctt ggtacaaaaa cttctctggc
     4381 agttactttt gaagcttcac tctgctttct gtataaaggg cagtctgtgg tcacgcaaga
     4441 ctttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaactttt ccaggcagct
     4501 tcatgatgtg caggcagtag ccagacaggg tcatgggaag ggggccctgt gcttctaaac
     4561 tgagtggttg ctggttagtt tggtattcaa aagaggataa aaatctggta gattagttca
     4621 ttctcagcat gtgtagctag acatgagtaa agataacagc atgagaaact gttagtacgc
     4681 atacctcagt tcaaaccttt agggaatgat taaaatttaa aaaaaaaaca tttcactcag
     4741 ttgcacttag tcgtatgtct tgcatgctta gtctaaagac tgtagcaaaa aaaaaaaaaa
     4801 aagaaaaatt agattttaca tatctttgca ggtatcacag ccttgcagaa gaaccaactg
     4861 aaaaaaaaat tctcaggctt tacagcaagc aaacttcact atgattttta caattctgat
     4921 tctgtatccc ctgggggtta tcccagttgc ttctttagga tggggtttat tacgttgtac
     4981 atatatcccg atgtgtctgt gtgaatcttt gtcttttttg ggggagggca gagggcggtt
     5041 ctttttttag atattgttcc taaaaaggaa taaatgcata cacctgtttg tcaaaacacc
     5101 tttgcttttt gtgcaactgc tttatattaa cgatactaaa aaaaaatagc tttggaaaaa
     5161 aaactactgt atgtaacgga attgcagaat atgctgcaca tgtattttat ttagttatcc
     5221 ttgctttaag aatattggat gacatttcct gacatgtggg agggagaaac tccctaactt
     5281 tttttttctg cttttaaact gtaacatagt tgaagatttc ttttttctgt tctcattgat
     5341 tggagcattt tgtacaggtt ttgtgtgtgt gtgtgtgtgt gtgtgcgcgc gtgcgtgtgt
     5401 gttaatctgt tttttgatac attcctatcc cttgtgttta tcctaccact gccttcctgg
     5461 ctatcttaaa caagttcata catttgaaaa gaaaaaaaaa tgttgtttaa aaaatgtttt
     5521 ctcctgctgc agtaaatatt ttgcatgatg aaattccagg gtcacacttt tccaagttta
     5581 tcagtgaagt agtgattaac aatggggagt gtcaaaacta ttgaactttt gtataaaaaa
     5641 aaaaaaactt tacaaggtgc caagatgtaa agaaaatctg ttactttttt tttctcaaag
     5701 aaaagcatac attagggagg tagtcccgtg tgtcagacaa atgcactgtc aggaatgagg
     5761 atccaaccta cctgtcccta gagtccgtct tgtaagatga gttaggctgc cccttggacc
     5821 agccacaaaa tggaatatca aggcttatgt acatacgtga agagttacca ccagtcctgc
     5881 cacctttgga cagctctaac accatcccca gcatccagtc agacctagta aagaaaacct
     5941 tggattctta acccaagata ggctgtaaat cactagcttt tttttcctca tgaaaaaaaa
     6001 tagagttaaa aaatatttcc tctcttttcc atattccagc tgaactccgt ttccaaaggc
     6061 acaaagaaga gtgtgcttat tcagattttg aatctttttg gtaccttttg gttaatgaca
     6121 tagcctcctg aaattctgga tgtcttcaaa gtcagttttg cttctttatc ctgaaaatca
     6181 gatttacaat gctgaaggca tttcttgggc ccagtgtagc tcacgcaatc tctgctaccc
     6241 ataagccttg atgaagatga tacagtccgg actgtgagca tggtgcttca tgtatatgtg
     6301 ctgccagtaa caagaatttt tttgttttgt tttgttttgt tttgataagg cataaaagaa
     6361 actcattcct tgacatcaac tgtaattcca tcattccatg tctgcggata cagacaataa
     6421 aaaaaatgtt gtgtagtcag tactaattac tgacattata agcattctca aatgcaataa
     6481 aaatgctggt tgttcacgct ggtagtaaaa
//
