LOCUS       NM_001244810            7136 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens forkhead box P1 (FOXP1), transcript variant 4, mRNA.
ACCESSION   NM_001244810
VERSION     NM_001244810.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7136)
  AUTHORS   Wang,P., Hu,Z., Yu,S., Su,S., Wu,R., Chen,C., Ye,Y., Wang,H.,
            Ye,X., Zhou,Z., Zhou,S. and Ren,N.
  TITLE     A novel protein encoded by circFOXP1 enhances ferroptosis and
            inhibits tumor recurrence in intrahepatic cholangiocarcinoma
  JOURNAL   Cancer Lett 598, 217092 (2024)
   PUBMED   38945202
  REMARK    GeneRIF: A novel protein encoded by circFOXP1 enhances ferroptosis
            and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
REFERENCE   2  (bases 1 to 7136)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   3  (bases 1 to 7136)
  AUTHORS   Wu,M., Tang,W., Chen,Y., Xue,L., Dai,J., Li,Y., Zhu,X., Wu,C.,
            Xiong,J., Zhang,J., Wu,T., Zhou,S., Chen,D., Sun,C., Yu,J., Li,H.,
            Guo,Y., Huang,Y., Zhu,Q., Wei,S., Zhou,Z., Wu,M., Li,Y., Xiang,T.,
            Qiao,H. and Wang,S.
  TITLE     Spatiotemporal transcriptomic changes of human ovarian aging and
            the regulatory role of FOXP1
  JOURNAL   Nat Aging 4 (4), 527-545 (2024)
   PUBMED   38594460
  REMARK    GeneRIF: Spatiotemporal transcriptomic changes of human ovarian
            aging and the regulatory role of FOXP1.
REFERENCE   4  (bases 1 to 7136)
  AUTHORS   Chen,X., Hao,Y., Liu,Y., Zhong,S., You,Y., Ao,K., Chong,T., Luo,X.,
            Yin,M., Ye,M., He,H., Lu,A., Chen,J., Li,X., Zhang,J. and Guo,X.
  TITLE     NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates
            Immunosuppression by Reprogramming Glycolytic Metabolism in
            Cervical Cancer
  JOURNAL   Adv Sci (Weinh) 10 (32), e2302705 (2023)
   PUBMED   37818745
  REMARK    GeneRIF: NAT10/ac4C/FOXP1 Promotes Malignant Progression and
            Facilitates Immunosuppression by Reprogramming Glycolytic
            Metabolism in Cervical Cancer.
REFERENCE   5  (bases 1 to 7136)
  AUTHORS   Park,S.H.E., Kulkarni,A. and Konopka,G.
  TITLE     FOXP1 orchestrates neurogenesis in human cortical basal radial
            glial cells
  JOURNAL   PLoS Biol 21 (8), e3001852 (2023)
   PUBMED   37540706
  REMARK    GeneRIF: FOXP1 orchestrates neurogenesis in human cortical basal
            radial glial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7136)
  AUTHORS   Banham,A.H., Beasley,N., Campo,E., Fernandez,P.L., Fidler,C.,
            Gatter,K., Jones,M., Mason,D.Y., Prime,J.E., Trougouboff,P.,
            Wood,K. and Cordell,J.L.
  TITLE     The FOXP1 winged helix transcription factor is a novel candidate
            tumor suppressor gene on chromosome 3p
  JOURNAL   Cancer Res 61 (24), 8820-8829 (2001)
   PUBMED   11751404
  REMARK    GeneRIF: The FOXP1 winged helix transcription factor is a novel
            candidate tumor suppressor gene on chromosome 3p.
REFERENCE   7  (bases 1 to 7136)
  AUTHORS   Wolska,M.K., Bukowski,K. and Jakubczak,A.
  TITLE     [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas
            aeruginosa rods]
  JOURNAL   Med Dosw Mikrobiol 53 (1), 45-51 (2001)
   PUBMED   11757404
REFERENCE   8  (bases 1 to 7136)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 7136)
  AUTHORS   Li,C. and Tucker,P.W.
  TITLE     DNA-binding properties and secondary structural model of the
            hepatocyte nuclear factor 3/fork head domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11583-11587 (1993)
   PUBMED   8265594
REFERENCE   10 (bases 1 to 7136)
  AUTHORS   Rappold,G., Siper,P., Kostic,A., Braden,R., Morgan,A., Koene,S. and
            Kolevzon,A.
  TITLE     FOXP1 Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37733892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097634.2, BC068481.1,
            AK122710.1, BC054505.1, AC103586.3 and GD144178.1.
            
            On May 20, 2020 this sequence version replaced NM_001244810.1.
            
            Summary: This gene belongs to subfamily P of the forkhead box (FOX)
            transcription factor family. Forkhead box transcription factors
            play important roles in the regulation of tissue- and cell
            type-specific gene transcription during both development and
            adulthood. Forkhead box P1 protein contains both DNA-binding- and
            protein-protein binding-domains. This gene may act as a tumor
            suppressor as it is lost in several tumor types and maps to a
            chromosomal region (3p14.1) reported to contain a tumor suppressor
            gene(s). Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon but contains another compared to variant 1. The resulting
            isoform (d, previously called 4) has the same N- and C-termini but
            is longer compared to isoform a. This variant encodes the longest
            isoform, which has been shown to enhance embryonic stem (ES) cell
            pluripotency and repress ES cell differentiation.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC097634.2         92862-92864         c
            4-1641              BC068481.1         15-1652
            1642-1681           AK122710.1         1756-1795
            1682-1902           BC068481.1         1691-1911
            1903-2045           AK122710.1         2014-2156
            2046-2653           BC054505.1         5085-5692
            2654-7032           AC103586.3         70773-75151         c
            7033-7130           GD144178.1         9-106
            7131-7136           AC103586.3         70669-70674         c
FEATURES             Location/Qualifiers
     source          1..7136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..7136
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="forkhead box P1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
     exon            1..69
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..218
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..348
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..443
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..504
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..695
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..2597
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="isoform d is encoded by transcript variant 4; fork
                     head-related protein like B; glutamine-rich factor 1;
                     mac-1-regulated forkhead"
                     /codon_start=1
                     /product="forkhead box protein P1 isoform d"
                     /protein_id="NP_001231739.1"
                     /db_xref="CCDS:CCDS74964.1"
                     /db_xref="GeneID:27086"
                     /db_xref="HGNC:HGNC:3823"
                     /db_xref="MIM:605515"
                     /translation="MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAV
                     DIGAADLAHAQQQQQQALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMM
                     TPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQ
                     QQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQP
                     LAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHAS
                     TNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALD
                     DRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLS
                     KSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSA
                     DIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAAT
                     WKGAIRTNLSLHKCFIRVEDEFGSFWTVDDEEFKRGRHIQRGRPRKYCPDENFDELVA
                     HNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNG
                     AMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRD
                     YEDEPVNEDME"
     exon            696..797
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..935
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1025
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1179
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1384
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1489
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1577
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1661
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1863
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1943
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2045
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2215
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2285
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2452
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..7136
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: ATTATA"
     polyA_site      3343
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     regulatory      5695..5700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      5724
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="major polyA site"
     polyA_site      5940
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
     regulatory      7102..7107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
                     /note="hexamer: AATAAA"
     polyA_site      7136
                     /gene="FOXP1"
                     /gene_synonym="12CC4; hFKH1B; HSPC215; MFH; QRF1"
ORIGIN      
        1 gccagcgccc cggcgaacgg caaagaggga gccgctcccg ctcggggggc cgctggagtg
       61 cccagcggga acccgaaagt ttgtaagagg aagagagcgc gcggcgagcg agcgagcggg
      121 ccgggggcag cggcagcggc gccggggacc atggtgctgc cggcgcctcc tccgcgggcg
      181 tgaaggcggc gctcctactc cctccccgga ctccgcggtg tcccagaagc ttttgttgac
      241 aattccagtt tccgaacaaa acatttcggc aatggtgagg gcttcgatcc cttctctgat
      301 ttgctgtcag ccatgaacgg atggatgtga tgcctgctag ccaaaaggct tccctctgtg
      361 tgttgcagtc ctgtggcatt atgcatgccc cctcccagtg accccaggct ttttatggct
      421 gtgagacacg ttaaaatttc aggggtaaga cgtgaccttt tgaggtgact ataactgaag
      481 attgctttac agaagccaaa aaaggttttt gagtcatgat gcaagaatct gggactgaga
      541 caaaaagtaa cggttcagcc atccagaatg ggtcgggcgg cagcaaccac ttactagagt
      601 gcggcggtct tcgggagggg cggtccaacg gagagacgcc ggccgtggac atcggggcag
      661 ctgacctcgc ccacgcccag cagcagcagc aacaggcact tcaggtggca agacagctcc
      721 ttcttcagca gcaacagcag cagcaagtta gtggattaaa atctcccaag aggaatgaca
      781 aacaaccagc tcttcaggtt cccgtgtcag tggctatgat gacacctcaa gttatcactc
      841 cccagcaaat gcagcagatc ctccagcaac aagtgctgag ccctcagcag ctccaggttc
      901 tcctccagca gcagcaggcc ctcatgcttc aacagcagca gcttcaagag ttttataaaa
      961 aacaacagga acagttgcag cttcaacttt tacaacaaca acatgctgga aaacagccta
     1021 aagagcaaca gcaggtggct acccagcagt tggcttttca gcagcagctt ttacagatgc
     1081 agcagttaca gcagcagcac ctcctgtctt tgcagcgcca aggccttctg acaattcagc
     1141 ccgggcagcc tgcccttccc cttcaacctc ttgctcaagg catgattcca acagaactgc
     1201 agcagctctg gaaagaagtg acaagtgctc atactgcaga agaaaccaca ggcaacaatc
     1261 acagcagttt ggatctgacc acgacatgtg tctcctcctc tgcaccttcc aagacctcct
     1321 taataatgaa cccacatgcc tctaccaatg gacagctctc agtccacact cccaaaaggg
     1381 aaagtttgtc ccatgaggag cacccccata gccatcctct ctatggacat ggtgtatgca
     1441 agtggccagg ctgtgaagca gtgtgcgaag atttccaatc atttctaaaa catctcaaca
     1501 gtgagcatgc gctggacgat agaagtacag cccaatgtag agtacaaatg caggttgtac
     1561 agcagttaga gctacagctt gcaaaagaca aagaacgcct gcaagccatg atgacccacc
     1621 tgcatgtgaa gtctacagaa cccaaagccg cccctcagcc cttgaatctg gtatcaagtg
     1681 tcactctctc caagtccgca tcggaggctt ctccacagag cttacctcat actccaacga
     1741 ccccaaccgc ccccctgact cccgtcaccc aaggcccctc tgtcatcaca accaccagca
     1801 tgcacacggt gggacccatc cgcaggcggt actcagacaa atacaacgtg cccatttcgt
     1861 cagcagatat tgcgcagaac caagaatttt ataagaacgc agaagttaga ccaccattta
     1921 catatgcatc tttaattagg caggccattc tcgaatctcc agaaaagcag ctaacactaa
     1981 atgagatcta taactggttc acacgaatgt ttgcttactt ccgacgcaac gcggccacgt
     2041 ggaagggtgc cattcgcacc aacctctcac tgcataagtg ctttatcaga gtagaggatg
     2101 agtttgggtc cttttggaca gttgatgatg aagagtttaa acgtggccgc catattcaac
     2161 gaggccgtcc tcgcaaatac tgccccgatg aaaactttga cgagcttgtc gcacataacc
     2221 cttcccttat taaaaacatg cagagcagcc acgcctactg cacacctctc aatgcagctt
     2281 tacaggcttc aatggctgag aatagtatac ctctatacac taccgcttcc atgggaaatc
     2341 ccactctggg caacttagcc agcgcaatac gggaagagct gaacggggca atggagcata
     2401 ccaacagcaa cgagagtgac agcagtccag gcagatctcc tatgcaagcc gtgcatcctg
     2461 tacacgtcaa agaagagccc ctcgatccag aggaagctga agggcccctg tccttagtga
     2521 caacagccaa ccacagtcca gattttgacc atgacagaga ttacgaagat gaaccagtaa
     2581 acgaggacat ggagtgacta tcggggcggg ccaaccccga gaatgaagat tggaaaaagg
     2641 aaaaaaaaaa aaacacgtca aaagttagca gtgaaattgt tctccatttg ttgtacagtc
     2701 tggaggattt tcactacgtt ttgacaactc tgaaatgtgt taactcttag tgccatcaag
     2761 aaccccattt gggagtattt ttgatttttc tactttttgt tgaaaaaagg aatttgtact
     2821 ctgtgcattg gatggacttg tttggtactt gggattttcc tctcttaacc gtcaacatca
     2881 gtgttgtaaa tttgctaaac tgattcactt ttagcagcag actttgaact gcagtcctgc
     2941 caacgttgga cactgaggac gcccgacaga gcttgtgcac ctaagctgca gaccaagcct
     3001 ttgcccagaa tttaaggatt ccaatggacg acctatttgc acagtactgc atgttgatta
     3061 tcactgcctt tactcctttt tttttttttt tttttttttt ttttttgctt ccagttggga
     3121 tggggaaggc ctttgtgtgt gtattggggg gaggggttaa aaaataatta tcccaaactt
     3181 tttaatgtat tgcttttttt tttttttttt ttccttctac tataccattt taagttctga
     3241 cctcaggcct ccatttgggc cgatggcctc ttggaggctt aaagttttct gtaccttgtg
     3301 atgaatgtta ataggtgttt ttattataca aagctgaatg tcatttctcg tttgtagctt
     3361 tctgtcactc attccatctt ccttcagaca tcaccacgtt tctctaaagt cagaaaacat
     3421 tccgttttgg tctttttcaa aaaggtccca aatgctgcac tctacacatg aaggccctct
     3481 cacacagacg tgacgtcctg ccagaaagag aatgaatgac agaaaaaaaa aagagagaca
     3541 aactctagga acaatgccga ttcattccac gcagcagtat tgggggtggt tcgggggagg
     3601 ggtgtttcgg attttctttt tttcttttct tttctttttt tttttttgca gcaaccatta
     3661 ataaatgcca ccacattcta ccagcacaag gaaacatagg cagcactgaa aaaaaaaaaa
     3721 aagctcatat taattagact gacaatatgg ccttggaagg ctctcccttg tggaaccaag
     3781 ttgccatggg ccttgggtgc tctgcgataa cgggtgtggg ttggttttgt ttgcaaaatg
     3841 gccaaaaaaa aaaaccggct tccccgagca gctgccctga aagtaggggt ggcggcggcg
     3901 gcgctgagtt tatacattag ttcagaccta cttggtggca ttaaactgtt tgaatgcaaa
     3961 ttcgatttca gattgaactt gttaagggag ttaacgaggg ctgagttcag caaatgctaa
     4021 agtgttaatt tcaaatatgc aaatttggta ctgcagtttg ttatgcaata ttatatcacc
     4081 aacccagtat cacaaaaact catagaagat atcatgtagg ccctgggctt tgggggggtc
     4141 ccaaacatgg tatgcagaaa tgtgatggtt acaggtcagt acaacctcag tccttagaac
     4201 ccctccacac ttcagctctg cacccacttt cctgtcattt atttatatag gactgtagtt
     4261 ttttttagtt cgagagcctt tcgaagctta atttatattc tttctttgta ccttttttct
     4321 aaaattacca aagatattac acaaaggtaa attatgttct ctgttttatg ctttatctga
     4381 tgaagccaaa tatcctctta ttgttgatca aaggaggcaa aagaatttag aggcaaatga
     4441 caagcgatag gctattgcaa cctgagaaag agaactgctc cttcatcgta aatttagaag
     4501 accaagtaga taatggaacc aaagttgtta cttttttcta gtagttattt ttcctttttc
     4561 tttttgtgta cctctacaga gaccaaaact cattctctta aagagatttt atggggctac
     4621 tgcagataaa aataggacac aatattaaag gagctacaga aggaagggag tcccatctca
     4681 aaaaaaaaat gaatgtatgc cactgcaatt agagtatcca ataaaggaga cagtttagag
     4741 tcaggacaga aaagcttcca taattgaact agattacata atagtatttc tagaaaaaga
     4801 gatattttta gattgtatgc cacttttgtt taagaactgt gctgtgatca ctgtattaat
     4861 tttggtttat cttggcatat atccttcagt ttgtttttat ttttaatttt tccttttttt
     4921 ccgattaggc tttggtcagc atttttcatt taaagaaaag taacactccc atccactcat
     4981 aagcttggta caaaaacttc tctggcagtt acttttgaag cttcactctg ctttctgtat
     5041 aaagggcagt ctgtggtcac gcaagacttt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     5101 aaaaaaaaaa acttttccag gcagcttcat gatgtgcagg cagtagccag acagggtcat
     5161 gggaaggggg ccctgtgctt ctaaactgag tggttgctgg ttagtttggt attcaaaaga
     5221 ggataaaaat ctggtagatt agttcattct cagcatgtgt agctagacat gagtaaagat
     5281 aacagcatga gaaactgtta gtacgcatac ctcagttcaa acctttaggg aatgattaaa
     5341 atttaaaaaa aaaacatttc actcagttgc acttagtcgt atgtcttgca tgcttagtct
     5401 aaagactgta gcaaaaaaaa aaaaaaaaga aaaattagat tttacatatc tttgcaggta
     5461 tcacagcctt gcagaagaac caactgaaaa aaaaattctc aggctttaca gcaagcaaac
     5521 ttcactatga tttttacaat tctgattctg tatcccctgg gggttatccc agttgcttct
     5581 ttaggatggg gtttattacg ttgtacatat atcccgatgt gtctgtgtga atctttgtct
     5641 tttttggggg agggcagagg gcggttcttt ttttagatat tgttcctaaa aaggaataaa
     5701 tgcatacacc tgtttgtcaa aacacctttg ctttttgtgc aactgcttta tattaacgat
     5761 actaaaaaaa aatagctttg gaaaaaaaac tactgtatgt aacggaattg cagaatatgc
     5821 tgcacatgta ttttatttag ttatccttgc tttaagaata ttggatgaca tttcctgaca
     5881 tgtgggaggg agaaactccc taactttttt tttctgcttt taaactgtaa catagttgaa
     5941 gatttctttt ttctgttctc attgattgga gcattttgta caggttttgt gtgtgtgtgt
     6001 gtgtgtgtgt gcgcgcgtgc gtgtgtgtta atctgttttt tgatacattc ctatcccttg
     6061 tgtttatcct accactgcct tcctggctat cttaaacaag ttcatacatt tgaaaagaaa
     6121 aaaaaatgtt gtttaaaaaa tgttttctcc tgctgcagta aatattttgc atgatgaaat
     6181 tccagggtca cacttttcca agtttatcag tgaagtagtg attaacaatg gggagtgtca
     6241 aaactattga acttttgtat aaaaaaaaaa aaactttaca aggtgccaag atgtaaagaa
     6301 aatctgttac tttttttttc tcaaagaaaa gcatacatta gggaggtagt cccgtgtgtc
     6361 agacaaatgc actgtcagga atgaggatcc aacctacctg tccctagagt ccgtcttgta
     6421 agatgagtta ggctgcccct tggaccagcc acaaaatgga atatcaaggc ttatgtacat
     6481 acgtgaagag ttaccaccag tcctgccacc tttggacagc tctaacacca tccccagcat
     6541 ccagtcagac ctagtaaaga aaaccttgga ttcttaaccc aagataggct gtaaatcact
     6601 agcttttttt tcctcatgaa aaaaaataga gttaaaaaat atttcctctc ttttccatat
     6661 tccagctgaa ctccgtttcc aaaggcacaa agaagagtgt gcttattcag attttgaatc
     6721 tttttggtac cttttggtta atgacatagc ctcctgaaat tctggatgtc ttcaaagtca
     6781 gttttgcttc tttatcctga aaatcagatt tacaatgctg aaggcatttc ttgggcccag
     6841 tgtagctcac gcaatctctg ctacccataa gccttgatga agatgataca gtccggactg
     6901 tgagcatggt gcttcatgta tatgtgctgc cagtaacaag aatttttttg ttttgttttg
     6961 ttttgttttg ataaggcata aaagaaactc attccttgac atcaactgta attccatcat
     7021 tccatgtctg cggatacaga caataaaaaa aatgttgtgt agtcagtact aattactgac
     7081 attataagca ttctcaaatg caataaaaat gctggttgtt cacgctggta gtaaaa
//
