LOCUS       NM_001291281            3086 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens forkhead box O6 (FOXO6), mRNA.
ACCESSION   NM_001291281 XM_002342102 XM_011548721
VERSION     NM_001291281.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3086)
  AUTHORS   Zheng,S., Wang,Y., Guo,W. and Tan,H.
  TITLE     FOXO6 transcription inhibition of CTRP3 promotes OGD/R-triggered
            cardiac microvascular endothelial barrier disruption via SIRT1/Nrf2
            signalling
  JOURNAL   Folia Morphol (Warsz) 83 (1), 125-138 (2024)
   PUBMED   36688407
  REMARK    GeneRIF: FOXO6 transcription inhibition of CTRP3 promotes
            OGD/R-triggered cardiac microvascular endothelial barrier
            disruption via SIRT1/Nrf2 signalling.
REFERENCE   2  (bases 1 to 3086)
  AUTHORS   Duan,Y., Wu,H., Hao,X., Li,F., Liu,J., Zhu,C. and Dong,Q.
  TITLE     Knockdown of long non-coding MIR210HG inhibits cell proliferation,
            migration, and invasion in hepatoblastoma via the
            microRNA-608-FOXO6 axis
  JOURNAL   J Int Med Res 49 (12), 3000605211054695 (2021)
   PUBMED   34918962
  REMARK    GeneRIF: Knockdown of long non-coding MIR210HG inhibits cell
            proliferation, migration, and invasion in hepatoblastoma via the
            microRNA-608-FOXO6 axis.
REFERENCE   3  (bases 1 to 3086)
  AUTHORS   Tang,Z., Zeng,X., Li,J., Qiu,S., Zhao,H., Wang,Z. and Zheng,Y.
  TITLE     LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression
            by sponging miR-4651 and subsequently upregulating FOXO6
  JOURNAL   J Pharmacol Sci 147 (3), 284-293 (2021)
   PUBMED   34507637
  REMARK    GeneRIF: LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC)
            progression by sponging miR-4651 and subsequently upregulating
            FOXO6.
REFERENCE   4  (bases 1 to 3086)
  AUTHORS   Wang,H., Liu,H., Zhao,L., Luo,S., Akinyemiju,T., Hwang,S., Yue,Y.
            and Wei,Q.
  TITLE     Association of genetic variants of FBXO32 and FOXO6 in the FOXO
            pathway with breast cancer risk
  JOURNAL   Mol Carcinog 60 (10), 661-670 (2021)
   PUBMED   34197655
  REMARK    GeneRIF: Association of genetic variants of FBXO32 and FOXO6 in the
            FOXO pathway with breast cancer risk.
REFERENCE   5  (bases 1 to 3086)
  AUTHORS   Cong,L., Zhang,X.L., Wang,X.K., Wang,Y., Jia,Y.Y., Yin,H. and
            Li,Z.H.
  TITLE     Upregulation of FoxO6 in nucleus pulposus cells promotes DNA damage
            repair via activation of RAD51
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (17), 5392-5401 (2021)
   PUBMED   34533813
  REMARK    GeneRIF: Upregulation of FoxO6 in nucleus pulposus cells promotes
            DNA damage repair via activation of RAD51.
REFERENCE   6  (bases 1 to 3086)
  AUTHORS   Kim,D.H., Perdomo,G., Zhang,T., Slusher,S., Lee,S., Phillips,B.E.,
            Fan,Y., Giannoukakis,N., Gramignoli,R., Strom,S., Ringquist,S. and
            Dong,H.H.
  TITLE     FoxO6 integrates insulin signaling with gluconeogenesis in the
            liver
  JOURNAL   Diabetes 60 (11), 2763-2774 (2011)
   PUBMED   21940782
  REMARK    GeneRIF: investigation of role of FoxO6 in liver: Data suggest that
            a FoxO6-dependent pathway in hepatocytes orchestrates insulin
            regulation of gluconeogenesis.
REFERENCE   7  (bases 1 to 3086)
  AUTHORS   Tzivion,G., Dobson,M. and Ramakrishnan,G.
  TITLE     FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
  JOURNAL   Biochim Biophys Acta 1813 (11), 1938-1945 (2011)
   PUBMED   21708191
  REMARK    GeneRIF: Studies indictet that the mammalian FoxO family consists
            of FoxO1, 3, 4 and 6 and are regulated by by AKT and 14-3-3
            proteins.
            Review article
REFERENCE   8  (bases 1 to 3086)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3086)
  AUTHORS   Kleindorp,R., Flachsbart,F., Puca,A.A., Malovini,A., Schreiber,S.
            and Nebel,A.
  TITLE     Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no
            association with human longevity in Germans
  JOURNAL   Aging Cell 10 (4), 622-628 (2011)
   PUBMED   21388494
  REMARK    GeneRIF: gene study of FOXO6, reveals no association with human
            longevity in Germans
REFERENCE   10 (bases 1 to 3086)
  AUTHORS   Jacobs,F.M., van der Heide,L.P., Wijchers,P.J., Burbach,J.P.,
            Hoekman,M.F. and Smidt,M.P.
  TITLE     FoxO6, a novel member of the FoxO class of transcription factors
            with distinct shuttling dynamics
  JOURNAL   J Biol Chem 278 (38), 35959-35967 (2003)
   PUBMED   12857750
  REMARK    GeneRIF: cloning and characterization; structural and functional
            properties related to gene regulation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FO681542.2.
            
            On Nov 3, 2018 this sequence version replaced NM_001291281.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY243080.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643531.4/ ENSP00000493960.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-911               FO681542.2         1887-2797
            912-3086            FO681542.2         22092-24266
FEATURES             Location/Qualifiers
     source          1..3086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..3086
                     /gene="FOXO6"
                     /note="forkhead box O6"
                     /db_xref="GeneID:100132074"
                     /db_xref="HGNC:HGNC:24814"
                     /db_xref="MIM:611457"
     exon            1..911
                     /gene="FOXO6"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..2177
                     /gene="FOXO6"
                     /codon_start=1
                     /product="forkhead box protein O6"
                     /protein_id="NP_001278210.2"
                     /db_xref="GeneID:100132074"
                     /db_xref="HGNC:HGNC:24814"
                     /db_xref="MIM:611457"
                     /translation="MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGA
                     GVAEGAEDCGPERRATAPAMAPAPPLGAEVGPLRKAKSSRRNAWGNLSYADLITKAIE
                     SAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTG
                     KSSWWMLNPEGGKTGKTPRRRAVSMDNGAKFLRIKGKASKKKQLQAPERSPDDSSPSA
                     PAPGPVPAAAKWAASPASHASDDYEAWADFRGGGRPLLGEAAELEDDEALEALAPSSP
                     LMYPSPASALSPALGSRCPGELPRLAELGGPLGLHGGGGAGLPEGLLDGAQDAYGPRA
                     RAGTPAYFGGCKGGAYGGGGGFGPPAMGALRRLPMQTIQENKQASFVPAAAPFRPGAL
                     PALLPPPPPAPRPGPVLGAPGELALAGAAAAYPGKGAAPYAPPAPSRSALAHPISLMT
                     LPGEAGAAGLAPSGHAAAFGGPPGGLLLDALPGPYAAAAAGPLGAAPDRFPADLDLDM
                     FSGSLECDVESIILNDFMDSDEMDFNFDSALPPPPPGLAGAPPPNQSWVPG"
     exon            912..3086
                     /gene="FOXO6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtgcagc cggcgctgag cgcggcaggc gcgggagctg gcgctggagc cggagcggcg
       61 gcggcggcag cattcaccgg gcggcggcgg cgcgggctcc ggcaccggct cgggctccgg
      121 catggtgcaa tccggcctcg tcccgggaga gcagggcccg tgcgcagggc cggcgcccgg
      181 ggagcggcgg cagcggcggt ggcggtggtg gctgcaggcg caggcaggcg gcaggtgcta
      241 gaagcggggc tgggcgaggt gtgtgcccgc tgggctcccg ggccgccgcc ccctcactgc
      301 ccaggtcttt ccctcccttc gtgctcccca gcgcgtccag ccccctgcct ccgcgcctcg
      361 gcccatggcg ccccgcggct gagacagcgc cgccagggac ccctcccgcg ggcctccccg
      421 gggcgtgcag atcccggagc cgcccgccca ccctccgcga agcctccctc ccctcctcgc
      481 ccgagccggg cgggaccatg gctgcgaagc tgcgagcgca tcaggtggac gtggacccgg
      541 acttcgcgcc gcagagccgg ccgcgctcgt gtacctggcc cctgccgcag cctgacttgg
      601 ccggcgacga ggacggagcg ctgggcgcag gggtggccga gggcgccgag gactgcgggc
      661 cggagcgccg ggctacggcc ccggcgatgg ccccagcgcc gcccctgggc gcggaggtcg
      721 gaccgctgcg gaaagcgaag agctctcggc ggaacgcgtg ggggaacctg tcctacgccg
      781 acctcatcac caaagccatc gagagcgccc cggacaagcg gctcacgctc tcgcagatct
      841 acgactggat ggtccgttac gtgccctact tcaaggataa aggcgacagc aacagctcgg
      901 ccggctggaa gaactccatc cggcacaacc tgtcgctgca cacccgtttc atccgcgtgc
      961 agaacgaggg caccggcaag agttcgtggt ggatgctgaa ccccgagggc ggaaagacag
     1021 ggaagacccc gcggcgcagg gccgtgtcca tggacaacgg ggccaagttc ctgcgcatca
     1081 agggcaaggc gagcaagaag aagcagctgc aggcgcccga gcgaagcccg gacgacagct
     1141 ccccgagtgc gcccgccccg gggccggtgc ctgccgcagc caagtgggcc gccagccccg
     1201 cctcgcacgc cagcgacgac tacgaggctt gggccgactt ccgcggcggc gggagacccc
     1261 tgctcgggga ggcggccgag ctggaggacg acgaggccct ggaggccctg gcgccatcat
     1321 cgccgctcat gtacccaagc cccgccagcg cgctgtcgcc ggcgctgggc tcgcgctgtc
     1381 cgggtgagct gccccgcctg gccgagctgg gaggcccgct gggcctgcac ggcggcggcg
     1441 gcgcggggct gcccgagggc ctgctggacg gcgcgcagga cgcgtacggg ccgcgggccc
     1501 gcgccgggac gcccgcctac ttcggcggct gcaagggcgg cgcctacggc gggggcgggg
     1561 gcttcgggcc gccggcgatg ggcgctctgc gccgtctgcc catgcagacc atccaggaga
     1621 acaagcaggc cagcttcgtg ccggccgcgg cgcccttccg ccctggggcg ctgcccgcgc
     1681 tgctgccgcc gccgccgccc gcgcccaggc ccggcccggt gctgggtgcg ccgggggagc
     1741 tggcgctggc gggcgcagcc gccgcctacc ccggcaaagg ggcggccccg tacgcgccgc
     1801 ccgcgccctc gcgcagtgcc ttagcccacc ccatcagcct tatgacgctg cccggcgagg
     1861 cgggcgccgc gggcctggca ccgtcgggcc acgccgccgc cttcgggggc ccgcccggcg
     1921 gcctcctgct ggacgctctg ccggggccct acgctgccgc cgccgccggg ccgctgggcg
     1981 ccgcgcccga ccgcttcccg gccgacctgg acctcgacat gttcagcggg agcctcgagt
     2041 gcgacgtgga gtccatcatc ctcaacgact tcatggacag cgacgaaatg gacttcaact
     2101 tcgattcggc cctgcctcca ccgccgccgg gcctggccgg ggccccgccc cccaaccaga
     2161 gctgggtgcc gggctgaggg ccgcctcccg cctccgggcg ccccgtcccg tccccagggg
     2221 gcctctgtct tcccatcctg attcccgggt ccctgccccc gactctagct ccccaggagg
     2281 cggccccagc ccagctaggg acccctctcg gaggccggcc gccggggaag gggagggagg
     2341 ggccggggca ccccactgct cctgcccaca ctcctgagat ccaccccctt ctcctgggca
     2401 ggaagcctgg gagaggaggc tgaattccag gctggctggg agtagggagg agcggggtgg
     2461 gccgcctggt gtggacggtg gtcggggaag ccaactagga gatgggccag ggagcgttta
     2521 caaatcttca gtttcatttg cggaggccta gccgtgaccc cgcgcccacc ccaaacacgg
     2581 atctgattcc cacttgacac actttcccac tggtcttagt ctcacccacc cgaagccagc
     2641 aaccctctgc ggaaaactca cacctaccta tatccatcca ccctgagcag ccctccaccc
     2701 ccaaatcgcc ctccgacgac cgccaccccc acagttcagt ctccccctcc catccctgcc
     2761 ggccctcgct tctcccctcc cccgtcggag tcagtccctc tcttcaaccg cccccacccc
     2821 ctagtactgg tctcagcttc tccagcgggc ctcagccccg tccaccccca accccgacgc
     2881 ccctttctcc gcgccagttc tggcccttct cccatattta taagtgtccg gccgggacgg
     2941 gcggtgggcg cggcgtcccc ggcgcgtatc gtaggcagtg taccgtggcc gtgccgtcag
     3001 agtgtgcgtg tgcgtgtgtg ccgtgtcgag gctgtgtaga gtgcattgta cagcatattt
     3061 tcatgaataa aattgtttta aatatt
//
