LOCUS       NM_005938               3644 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens forkhead box O4 (FOXO4), transcript variant 1, mRNA.
ACCESSION   NM_005938
VERSION     NM_005938.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3644)
  AUTHORS   Huang,Q. and Wang,J.
  TITLE     CBP-mediated FOXO4 acetylation facilitates postmenopausal
            osteoporosis (PMO) progression through the inhibition of the
            Wnt/beta-catenin signaling pathway
  JOURNAL   Histol Histopathol 39 (8), 1017-1024 (2024)
   PUBMED   38037460
  REMARK    GeneRIF: CBP-mediated FOXO4 acetylation facilitates postmenopausal
            osteoporosis (PMO) progression through the inhibition of the
            Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 3644)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 3644)
  AUTHORS   Huang,H., Dong,J., Jiang,J., Yang,F., Zheng,Y., Wang,S., Wang,N.,
            Ma,J., Hou,M., Ding,Y., Meng,L., Zhuo,W., Yang,D., Qian,W.,
            Chen,Q., You,G., Qian,G., Gu,L. and Lv,H.
  TITLE     The role of FOXO4/NFAT2 signaling pathway in dysfunction of human
            coronary endothelial cells and inflammatory infiltration of
            vasculitis in Kawasaki disease
  JOURNAL   Front Immunol 13, 1090056 (2023)
   PUBMED   36700213
  REMARK    GeneRIF: The role of FOXO4/NFAT2 signaling pathway in dysfunction
            of human coronary endothelial cells and inflammatory infiltration
            of vasculitis in Kawasaki disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3644)
  AUTHORS   Yan,B., Jin,Y., Mao,S., Zhang,Y., Yang,D., Du,M. and Yin,Y.
  TITLE     Smurf2-Mediated Ubiquitination of FOXO4 Regulates Oxygen-glucose
            Deprivation/Reperfusion-induced Pyroptosis of Cortical Neurons
  JOURNAL   Curr Neurovasc Res 20 (4), 443-452 (2023)
   PUBMED   37861000
  REMARK    GeneRIF: Smurf2-Mediated Ubiquitination of FOXO4 Regulates
            Oxygen-glucose Deprivation/Reperfusion-induced Pyroptosis of
            Cortical Neurons.
REFERENCE   5  (bases 1 to 3644)
  AUTHORS   Yang,X., Zhang,F., Liu,X., Meng,J., Du,S., Shao,J., Liu,J. and
            Fang,M.
  TITLE     FOXO4 mediates resistance to oxidative stress in lens epithelial
            cells by modulating the TRIM25/Nrf2 signaling
  JOURNAL   Exp Cell Res 420 (1), 113340 (2022)
   PUBMED   36075446
REFERENCE   6  (bases 1 to 3644)
  AUTHORS   Yang,Z., Whelan,J., Babb,R. and Bowen,B.R.
  TITLE     An mRNA splice variant of the AFX gene with altered transcriptional
            activity
  JOURNAL   J Biol Chem 277 (10), 8068-8075 (2002)
   PUBMED   11779849
  REMARK    GeneRIF: AFX zeta is a downstream target of both the
            phosphatidylinositol 3-kinase/PKB insulin signaling pathway and an
            AMP-activated protein kinase-dependent pathway.
REFERENCE   7  (bases 1 to 3644)
  AUTHORS   Kops,G.J., de Ruiter,N.D., De Vries-Smits,A.M., Powell,D.R.,
            Bos,J.L. and Burgering,B.M.
  TITLE     Direct control of the Forkhead transcription factor AFX by protein
            kinase B
  JOURNAL   Nature 398 (6728), 630-634 (1999)
   PUBMED   10217147
REFERENCE   8  (bases 1 to 3644)
  AUTHORS   Peters,U., Haberhausen,G., Kostrzewa,M., Nolte,D. and Muller,U.
  TITLE     AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as
            candidate genes of X-linked dystonia parkinsonism
  JOURNAL   Hum Genet 100 (5-6), 569-572 (1997)
   PUBMED   9341872
REFERENCE   9  (bases 1 to 3644)
  AUTHORS   Borkhardt,A., Repp,R., Haas,O.A., Leis,T., Harbott,J., Kreuder,J.,
            Hammermann,J., Henn,T. and Lampert,F.
  TITLE     Cloning and characterization of AFX, the gene that fuses to MLL in
            acute leukemias with a t(X;11)(q13;q23)
  JOURNAL   Oncogene 14 (2), 195-202 (1997)
   PUBMED   9010221
REFERENCE   10 (bases 1 to 3644)
  AUTHORS   Parry,P., Wei,Y. and Evans,G.
  TITLE     Cloning and characterization of the t(X;11) breakpoint from a
            leukemic cell line identify a new member of the forkhead gene
            family
  JOURNAL   Genes Chromosomes Cancer 11 (2), 79-84 (1994)
   PUBMED   7529552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590764.3, BC106761.2 and
            AW292413.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005938.3.
            
            Summary: This gene encodes a member of the O class of winged
            helix/forkhead transcription factor family. Proteins encoded by
            this class are regulated by factors involved in growth and
            differentiation indicating they play a role in these processes. A
            translocation involving this gene on chromosome X and the homolog
            of the Drosophila trithorax gene, encoding a DNA binding protein,
            located on chromosome 11 is associated with leukemia. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1 also known as
            AFX alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.544506.1, X93996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374259.8/ ENSP00000363377.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               AL590764.3         101617-102188
            573-2387            BC106761.2         1-1815
            2388-3502           AL590764.3         108042-109156
            3503-3644           AW292413.1         20-161              c
FEATURES             Location/Qualifiers
     source          1..3644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..3644
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="forkhead box O4"
                     /db_xref="GeneID:4303"
                     /db_xref="HGNC:HGNC:7139"
                     /db_xref="MIM:300033"
     exon            1..1131
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             679..2196
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog, Drosophila); translocated to, 7; forkhead box
                     protein O4; fork head domain transcription factor AFX1"
                     /codon_start=1
                     /product="forkhead box protein O4 isoform 1"
                     /protein_id="NP_005929.2"
                     /db_xref="CCDS:CCDS43969.1"
                     /db_xref="GeneID:4303"
                     /db_xref="HGNC:HGNC:7139"
                     /db_xref="MIM:300033"
                     /translation="MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQP
                     SEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWG
                     NQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSL
                     HSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSV
                     LPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRP
                     ESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGV
                     TGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQ
                     APTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPVMASAPIPKALG
                     TPVLTPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP"
     exon            1132..2188
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..3644
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3627..3632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="hexamer: AATAAA"
     polyA_site      3644
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="major polyA site"
ORIGIN      
        1 gcagatggct gccccggcga gtggtaaaca gagacgtcag gagggggctg ctgcttggag
       61 caaaacaaaa gggaaacccg gggggcgggg ggtggggggg gttgataggg gaatcggtgc
      121 gggaataagg gaggccgcag ccgcggggac ccggacccta gtaagagtgg cgagaaggga
      181 agaggcgggg gaagggggag tcaggggagg ggcaagtgac gcgggggagc ggggcgtggg
      241 ggagggcagc aatccgggtg gaggaaattt gggaggagtg tccggggggc agcaacttaa
      301 aagggggagg gaactgcggc taaggagacg ttcggtgatg ggagcgcaat atatgagggg
      361 atacagtgcc tcaggtttaa aagagcagga agctgagtga gaggttgcag aaaaagtgtc
      421 ttcgctcggc agaggttaca ggtggcatct cagaaagagc tttgaggcta caggctgtag
      481 tcgggaaggg gatcggagaa ctgtgtgaag ggacagctta gggactagcg tcctgggact
      541 agggggaagt tcgcgacttt ctgaagactg gcaggaatgt gcctcctggc cctcgatgct
      601 tcccccctga ggggaggcat cgtgagggac tgtggcaggc ttcactgaac gctgagccgg
      661 ggaggtccaa ctccacgtat ggatccgggg aatgagaatt cagccacaga ggctgccgcg
      721 atcatagacc tagatcccga cttcgaaccc cagagccgtc cccgctcctg cacctggccc
      781 cttccccgac cagagatcgc taaccagccg tccgagccgc ccgaggtgga gccagatctg
      841 ggggaaaagg tacacacgga ggggcgctca gagccgatcc tgttgccctc tcggctccca
      901 gagccggccg ggggccccca gcccggaatc ctgggggctg taacaggtcc tcggaaggga
      961 ggctcccgcc ggaatgcctg gggaaatcag tcatatgcag aactcatcag ccaggccatt
     1021 gaaagcgccc cggagaagcg actgacactt gcccagatct acgagtggat ggtccgtact
     1081 gtaccctact tcaaggacaa gggtgacagc aacagctcag caggatggaa gaactcgatc
     1141 cgccacaacc tgtccctgca cagcaagttc atcaaggttc acaacgaggc caccggcaaa
     1201 agctcttggt ggatgctgaa ccctgaggga ggcaagagcg gcaaagcccc ccgccgccgg
     1261 gccgcctcca tggatagcag cagcaagctg ctccggggcc gcagtaaagc ccccaagaag
     1321 aaaccatctg tgctgccagc tccacccgaa ggtgccactc caacgagccc tgtcggccac
     1381 tttgccaagt ggtcaggcag cccttgctct cgaaaccgtg aagaagccga tatgtggacc
     1441 accttccgtc cacgaagcag ttcaaatgcc agcagtgtca gcacccggct gtcccccttg
     1501 aggccagagt ctgaggtgct ggcggaggaa ataccagctt cagtcagcag ttatgcaggg
     1561 ggtgtccctc ccaccctcaa tgaaggtcta gagctgttag atgggctcaa tctcacctct
     1621 tcccattccc tgctatctcg gagtggtctc tctggcttct ctttgcagca tcctggggtt
     1681 accggcccct tacacaccta cagcagctcc cttttcagcc cagcagaggg gcccctgtca
     1741 gcaggagaag ggtgcttctc cagctcccag gctctggagg ccctgctcac ctctgatacg
     1801 ccaccacccc ctgctgacgt cctcatgacc caggtagatc ccattctgtc ccaggctccg
     1861 actcttctgt tgctgggggg gcttccttcc tccagtaagc tggccacggg cgtcggcctg
     1921 tgtcccaagc ccctagaggc tccaggcccc agcagtctgg ttcccaccct ttctatgata
     1981 gcaccacctc cagtcatggc aagtgccccc atccccaagg ctctggggac tcctgtgctc
     2041 acacccccta ctgaagctgc aagccaagac agaatgcctc aggatctaga tcttgatatg
     2101 tatatggaga acctggagtg tgacatggat aacatcatca gtgacctcat ggatgagggc
     2161 gagggactgg acttcaactt tgagccagat ccctgagtca tgcctggaag ctttgtcccc
     2221 tgcttcagat gtggagccag gcgtgttcat atctactctt tacccttgag ccctccccag
     2281 gaatttggga ccctgcttta gagctagggt ggggtctggt cacacacagg tgttgaagaa
     2341 attataaaga taaagctgcc ccatctgggg acgatatggg gagggagatg ggaggggaaa
     2401 ggggagaggg tttttctcac tgtgccaatt agggggtaag gccccctctc aggagccatc
     2461 atcggctttc cccattccta cccacttagg ctttgtagca agatgagcaa tgctgttgga
     2521 aatgtgaagt caccagtggc cttacccctg cctttgggag caggattttt ttgtagagag
     2581 tcttatctga gctgagccag gctagctgga gcctgggatt tctatgcagt ggccccttag
     2641 gccagtgatg tgcggtgggt gggctgttta ggggatctgg aagggccaag gtctgagcac
     2701 tggagtggct cgccaggcca aatcaccctt agaaggctgc agataacaga aaggcttttt
     2761 ataaactttt aaagaaatat aaacacaaat atagagattt tttaaccatg gcagggtgct
     2821 agtggtgggc agaatgcttt tttttctttc tgaaggcttt gtgatagtga catgatacaa
     2881 acactacaga caataaatat taggagacac agggaagtgg ggagaggtgg ggagtaatag
     2941 taaacacagg gaagagctcc cctacggacc aggtatagag aaaggtctat gcagaaatag
     3001 gttagagttt ccctaacaaa aaagctaacc caggtcccct cattccttca acttgtgcct
     3061 gggagtgtgt ggtgttaggg tgcagccaca ctcttctatg acccagcatg ggttagtgct
     3121 atggtgggag agtacattga aggcctggaa ttagcttggg gccagggaag ggactgggag
     3181 gggagagaag agaaggaggg aaggatttag gatggtaaag ttaggtacag agacctccct
     3241 gttcaaggcc cctgacagct gtccctgccc ttcttcccct tccctgactg caggggttat
     3301 gtggaagtgt gtgtggcagc aggcagcggg gaggggagga acagggaagg gggagctggg
     3361 gagcttggct gagggtctgg gaaatgagca gggatggggg gggatgtgga tcaggtttac
     3421 tagcacctgc cagggaggcc atctggggct ccttctccac cccagccccc aaagcagccc
     3481 ttcccccagt gccctttgca tcgtcccctc ccccacccct gctgtgggtt cccatcattt
     3541 cctgtgtcag cgcctggcct acccagattg tatcatgtgc tagattggag tggggaagtg
     3601 tgtcaaatca ataaatgaat aaattcaata aatgcctata acca
//
