LOCUS       NM_001170931            3479 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens forkhead box O4 (FOXO4), transcript variant 2, mRNA.
ACCESSION   NM_001170931
VERSION     NM_001170931.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3479)
  AUTHORS   Huang,Q. and Wang,J.
  TITLE     CBP-mediated FOXO4 acetylation facilitates postmenopausal
            osteoporosis (PMO) progression through the inhibition of the
            Wnt/beta-catenin signaling pathway
  JOURNAL   Histol Histopathol 39 (8), 1017-1024 (2024)
   PUBMED   38037460
  REMARK    GeneRIF: CBP-mediated FOXO4 acetylation facilitates postmenopausal
            osteoporosis (PMO) progression through the inhibition of the
            Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 3479)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 3479)
  AUTHORS   Huang,H., Dong,J., Jiang,J., Yang,F., Zheng,Y., Wang,S., Wang,N.,
            Ma,J., Hou,M., Ding,Y., Meng,L., Zhuo,W., Yang,D., Qian,W.,
            Chen,Q., You,G., Qian,G., Gu,L. and Lv,H.
  TITLE     The role of FOXO4/NFAT2 signaling pathway in dysfunction of human
            coronary endothelial cells and inflammatory infiltration of
            vasculitis in Kawasaki disease
  JOURNAL   Front Immunol 13, 1090056 (2023)
   PUBMED   36700213
  REMARK    GeneRIF: The role of FOXO4/NFAT2 signaling pathway in dysfunction
            of human coronary endothelial cells and inflammatory infiltration
            of vasculitis in Kawasaki disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3479)
  AUTHORS   Yan,B., Jin,Y., Mao,S., Zhang,Y., Yang,D., Du,M. and Yin,Y.
  TITLE     Smurf2-Mediated Ubiquitination of FOXO4 Regulates Oxygen-glucose
            Deprivation/Reperfusion-induced Pyroptosis of Cortical Neurons
  JOURNAL   Curr Neurovasc Res 20 (4), 443-452 (2023)
   PUBMED   37861000
  REMARK    GeneRIF: Smurf2-Mediated Ubiquitination of FOXO4 Regulates
            Oxygen-glucose Deprivation/Reperfusion-induced Pyroptosis of
            Cortical Neurons.
REFERENCE   5  (bases 1 to 3479)
  AUTHORS   Yang,X., Zhang,F., Liu,X., Meng,J., Du,S., Shao,J., Liu,J. and
            Fang,M.
  TITLE     FOXO4 mediates resistance to oxidative stress in lens epithelial
            cells by modulating the TRIM25/Nrf2 signaling
  JOURNAL   Exp Cell Res 420 (1), 113340 (2022)
   PUBMED   36075446
REFERENCE   6  (bases 1 to 3479)
  AUTHORS   Yang,Z., Whelan,J., Babb,R. and Bowen,B.R.
  TITLE     An mRNA splice variant of the AFX gene with altered transcriptional
            activity
  JOURNAL   J Biol Chem 277 (10), 8068-8075 (2002)
   PUBMED   11779849
  REMARK    GeneRIF: AFX zeta is a downstream target of both the
            phosphatidylinositol 3-kinase/PKB insulin signaling pathway and an
            AMP-activated protein kinase-dependent pathway.
REFERENCE   7  (bases 1 to 3479)
  AUTHORS   Kops,G.J., de Ruiter,N.D., De Vries-Smits,A.M., Powell,D.R.,
            Bos,J.L. and Burgering,B.M.
  TITLE     Direct control of the Forkhead transcription factor AFX by protein
            kinase B
  JOURNAL   Nature 398 (6728), 630-634 (1999)
   PUBMED   10217147
REFERENCE   8  (bases 1 to 3479)
  AUTHORS   Peters,U., Haberhausen,G., Kostrzewa,M., Nolte,D. and Muller,U.
  TITLE     AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as
            candidate genes of X-linked dystonia parkinsonism
  JOURNAL   Hum Genet 100 (5-6), 569-572 (1997)
   PUBMED   9341872
REFERENCE   9  (bases 1 to 3479)
  AUTHORS   Borkhardt,A., Repp,R., Haas,O.A., Leis,T., Harbott,J., Kreuder,J.,
            Hammermann,J., Henn,T. and Lampert,F.
  TITLE     Cloning and characterization of AFX, the gene that fuses to MLL in
            acute leukemias with a t(X;11)(q13;q23)
  JOURNAL   Oncogene 14 (2), 195-202 (1997)
   PUBMED   9010221
REFERENCE   10 (bases 1 to 3479)
  AUTHORS   Parry,P., Wei,Y. and Evans,G.
  TITLE     Cloning and characterization of the t(X;11) breakpoint from a
            leukemic cell line identify a new member of the forkhead gene
            family
  JOURNAL   Genes Chromosomes Cancer 11 (2), 79-84 (1994)
   PUBMED   7529552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590764.3, AF384029.1 and
            AW292413.1.
            
            On May 31, 2019 this sequence version replaced NM_001170931.1.
            
            Summary: This gene encodes a member of the O class of winged
            helix/forkhead transcription factor family. Proteins encoded by
            this class are regulated by factors involved in growth and
            differentiation indicating they play a role in these processes. A
            translocation involving this gene on chromosome X and the homolog
            of the Drosophila trithorax gene, encoding a DNA binding protein,
            located on chromosome 11 is associated with leukemia. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. This
            results in a shorter protein (isoform 2 also known as isoform zeta)
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF384029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-678               AL590764.3         101617-102294
            679-713             AF384029.1         1-35
            714-714             AL590764.3         102330-102330
            715-893             AF384029.1         37-215
            894-894             AL590764.3         102675-102675
            895-1777            AF384029.1         217-1099
            1778-1778           AL590764.3         107261-107261
            1779-2031           AF384029.1         1101-1353
            2032-3337           AL590764.3         107851-109156
            3338-3479           AW292413.1         20-161              c
FEATURES             Location/Qualifiers
     source          1..3479
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..3479
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="forkhead box O4"
                     /db_xref="GeneID:4303"
                     /db_xref="HGNC:HGNC:7139"
                     /db_xref="MIM:300033"
     exon            1..849
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             679..2031
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog, Drosophila); translocated to, 7; forkhead box
                     protein O4; fork head domain transcription factor AFX1"
                     /codon_start=1
                     /product="forkhead box protein O4 isoform 2"
                     /protein_id="NP_001164402.1"
                     /db_xref="CCDS:CCDS55440.1"
                     /db_xref="GeneID:4303"
                     /db_xref="HGNC:HGNC:7139"
                     /db_xref="MIM:300033"
                     /translation="MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQP
                     SEPPEVEPDLGEKAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHN
                     LSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKK
                     PSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSP
                     LRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQH
                     PGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPI
                     LSQAPTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPVMASAPIPK
                     ALGTPVLTPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP
                     "
     exon            850..966
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /inference="alignment:Splign:2.1.0"
     exon            967..2023
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..3479
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3462..3467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="hexamer: AATAAA"
     polyA_site      3479
                     /gene="FOXO4"
                     /gene_synonym="AFX; AFX1; MLLT7"
                     /note="major polyA site"
ORIGIN      
        1 gcagatggct gccccggcga gtggtaaaca gagacgtcag gagggggctg ctgcttggag
       61 caaaacaaaa gggaaacccg gggggcgggg ggtggggggg gttgataggg gaatcggtgc
      121 gggaataagg gaggccgcag ccgcggggac ccggacccta gtaagagtgg cgagaaggga
      181 agaggcgggg gaagggggag tcaggggagg ggcaagtgac gcgggggagc ggggcgtggg
      241 ggagggcagc aatccgggtg gaggaaattt gggaggagtg tccggggggc agcaacttaa
      301 aagggggagg gaactgcggc taaggagacg ttcggtgatg ggagcgcaat atatgagggg
      361 atacagtgcc tcaggtttaa aagagcagga agctgagtga gaggttgcag aaaaagtgtc
      421 ttcgctcggc agaggttaca ggtggcatct cagaaagagc tttgaggcta caggctgtag
      481 tcgggaaggg gatcggagaa ctgtgtgaag ggacagctta gggactagcg tcctgggact
      541 agggggaagt tcgcgacttt ctgaagactg gcaggaatgt gcctcctggc cctcgatgct
      601 tcccccctga ggggaggcat cgtgagggac tgtggcaggc ttcactgaac gctgagccgg
      661 ggaggtccaa ctccacgtat ggatccgggg aatgagaatt cagccacaga ggctgccgcg
      721 atcatagacc tagatcccga cttcgaaccc cagagccgtc cccgctcctg cacctggccc
      781 cttccccgac cagagatcgc taaccagccg tccgagccgc ccgaggtgga gccagatctg
      841 ggggaaaagg ccattgaaag cgccccggag aagcgactga cacttgccca gatctacgag
      901 tggatggtcc gtactgtacc ctacttcaag gacaagggtg acagcaacag ctcagcagga
      961 tggaagaact cgatccgcca caacctgtcc ctgcacagca agttcatcaa ggttcacaac
     1021 gaggccaccg gcaaaagctc ttggtggatg ctgaaccctg agggaggcaa gagcggcaaa
     1081 gccccccgcc gccgggccgc ctccatggat agcagcagca agctgctccg gggccgcagt
     1141 aaagccccca agaagaaacc atctgtgctg ccagctccac ccgaaggtgc cactccaacg
     1201 agccctgtcg gccactttgc caagtggtca ggcagccctt gctctcgaaa ccgtgaagaa
     1261 gccgatatgt ggaccacctt ccgtccacga agcagttcaa atgccagcag tgtcagcacc
     1321 cggctgtccc ccttgaggcc agagtctgag gtgctggcgg aggaaatacc agcttcagtc
     1381 agcagttatg cagggggtgt ccctcccacc ctcaatgaag gtctagagct gttagatggg
     1441 ctcaatctca cctcttccca ttccctgcta tctcggagtg gtctctctgg cttctctttg
     1501 cagcatcctg gggttaccgg ccccttacac acctacagca gctccctttt cagcccagca
     1561 gaggggcccc tgtcagcagg agaagggtgc ttctccagct cccaggctct ggaggccctg
     1621 ctcacctctg atacgccacc accccctgct gacgtcctca tgacccaggt agatcccatt
     1681 ctgtcccagg ctccgactct tctgttgctg ggggggcttc cttcctccag taagctggcc
     1741 acgggcgtcg gcctgtgtcc caagccccta gaggctccag gccccagcag tctggttccc
     1801 accctttcta tgatagcacc acctccagtc atggcaagtg cccccatccc caaggctctg
     1861 gggactcctg tgctcacacc ccctactgaa gctgcaagcc aagacagaat gcctcaggat
     1921 ctagatcttg atatgtatat ggagaacctg gagtgtgaca tggataacat catcagtgac
     1981 ctcatggatg agggcgaggg actggacttc aactttgagc cagatccctg agtcatgcct
     2041 ggaagctttg tcccctgctt cagatgtgga gccaggcgtg ttcatatcta ctctttaccc
     2101 ttgagccctc cccaggaatt tgggaccctg ctttagagct agggtggggt ctggtcacac
     2161 acaggtgttg aagaaattat aaagataaag ctgccccatc tggggacgat atggggaggg
     2221 agatgggagg ggaaagggga gagggttttt ctcactgtgc caattagggg gtaaggcccc
     2281 ctctcaggag ccatcatcgg ctttccccat tcctacccac ttaggctttg tagcaagatg
     2341 agcaatgctg ttggaaatgt gaagtcacca gtggccttac ccctgccttt gggagcagga
     2401 tttttttgta gagagtctta tctgagctga gccaggctag ctggagcctg ggatttctat
     2461 gcagtggccc cttaggccag tgatgtgcgg tgggtgggct gtttagggga tctggaaggg
     2521 ccaaggtctg agcactggag tggctcgcca ggccaaatca cccttagaag gctgcagata
     2581 acagaaaggc tttttataaa cttttaaaga aatataaaca caaatataga gattttttaa
     2641 ccatggcagg gtgctagtgg tgggcagaat gctttttttt ctttctgaag gctttgtgat
     2701 agtgacatga tacaaacact acagacaata aatattagga gacacaggga agtggggaga
     2761 ggtggggagt aatagtaaac acagggaaga gctcccctac ggaccaggta tagagaaagg
     2821 tctatgcaga aataggttag agtttcccta acaaaaaagc taacccaggt cccctcattc
     2881 cttcaacttg tgcctgggag tgtgtggtgt tagggtgcag ccacactctt ctatgaccca
     2941 gcatgggtta gtgctatggt gggagagtac attgaaggcc tggaattagc ttggggccag
     3001 ggaagggact gggaggggag agaagagaag gagggaagga tttaggatgg taaagttagg
     3061 tacagagacc tccctgttca aggcccctga cagctgtccc tgcccttctt ccccttccct
     3121 gactgcaggg gttatgtgga agtgtgtgtg gcagcaggca gcggggaggg gaggaacagg
     3181 gaagggggag ctggggagct tggctgaggg tctgggaaat gagcagggat ggggggggat
     3241 gtggatcagg tttactagca cctgccaggg aggccatctg gggctccttc tccaccccag
     3301 cccccaaagc agcccttccc ccagtgccct ttgcatcgtc ccctccccca cccctgctgt
     3361 gggttcccat catttcctgt gtcagcgcct ggcctaccca gattgtatca tgtgctagat
     3421 tggagtgggg aagtgtgtca aatcaataaa tgaataaatt caataaatgc ctataacca
//
