LOCUS       NM_001368135            5859 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens forkhead box O3B (FOXO3B), transcript variant 2, mRNA.
ACCESSION   NM_001368135
VERSION     NM_001368135.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5859)
  AUTHORS   Santo,E.E. and Paik,J.
  TITLE     A splice junction-targeted CRISPR approach (spJCRISPR) reveals
            human FOXO3B to be a protein-coding gene
  JOURNAL   Gene 673, 95-101 (2018)
   PUBMED   29925039
  REMARK    GeneRIF: human FOXO3B locus encodes a bona fide human gene; unlike
            FOXO3A, FOXO3B is cytosolically localized in both the presence and
            absence of active Akt
REFERENCE   2  (bases 1 to 5859)
  AUTHORS   Flachsbart,F., Moller,M., Daumer,C., Gentschew,L., Kleindorp,R.,
            Krawczak,M., Caliebe,A., Schreiber,S. and Nebel,A.
  TITLE     Genetic investigation of FOXO3A requires special attention due to
            sequence homology with FOXO3B
  JOURNAL   Eur J Hum Genet 21 (2), 240-242 (2013)
   PUBMED   22588664
  REMARK    GeneRIF: our results clearly show that, for reliable genetic
            investigation of FOXO3A exonic regions, a special study design is
            mandatory accounting for the FOXO3B sequence homology
REFERENCE   3  (bases 1 to 5859)
  AUTHORS   DaSilva,L., Kirken,R.A., Taub,D.D., Evans,G.A., Duhe,R.J.,
            Bailey,M.A. and Farrar,W.L.
  TITLE     Molecular cloning of FKHRL1P2, a member of the developmentally
            regulated fork head domain transcription factor family
  JOURNAL   Gene 221 (1), 135-142 (1998)
   PUBMED   9852958
REFERENCE   4  (bases 1 to 5859)
  AUTHORS   Anderson,M.J., Viars,C.S., Czekay,S., Cavenee,W.K. and Arden,K.C.
  TITLE     Cloning and characterization of three human forkhead genes that
            comprise an FKHR-like gene subfamily
  JOURNAL   Genomics 47 (2), 187-199 (1998)
   PUBMED   9479491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026271.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.301517.1, CN399940.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395675.7/ ENSP00000499455.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC026271.6         37038-37148
            112-343             AC026271.6         37506-37737
            344-432             AC026271.6         38523-38611
            433-5859            AC026271.6         46297-51723
FEATURES             Location/Qualifiers
     source          1..5859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..5859
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /note="forkhead box O3B"
                     /db_xref="GeneID:2310"
                     /db_xref="HGNC:HGNC:3822"
                     /db_xref="MIM:620471"
     exon            1..111
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /inference="alignment:Splign:2.1.0"
     exon            112..343
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1179
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /note="forkhead(Drosophila) homolog (rhabdomyosarcoma) 1
                     like pseudogene 1; forkhead box O3B (pseudogene)"
                     /codon_start=1
                     /product="forkhead box protein O3B"
                     /protein_id="NP_001355064.1"
                     /db_xref="CCDS:CCDS92269.1"
                     /db_xref="GeneID:2310"
                     /db_xref="HGNC:HGNC:3822"
                     /db_xref="MIM:620471"
                     /translation="METDLAEMPEKGVLSSQDSPHFQEKSTEEGEVAALRLTARSQAA
                     AAAAAPGSRSLRGVHVPPPLHPAPAREESARTPAAAGRAAKMAEAPASPAPLSPLEVE
                     LDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGS
                     AMAIGGGGGSRTLVSGLLLEDSVRVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPL
                     PPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDRRLTLSQIYEWMVSCV
                     PYFKDKGNSNSSAG"
     exon            344..432
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /inference="alignment:Splign:2.1.0"
     exon            433..5859
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5839..5844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /note="hexamer: ATTAAA"
     polyA_site      5859
                     /gene="FOXO3B"
                     /gene_synonym="FKHRL1P1; ZNF286C"
                     /note="major polyA site"
ORIGIN      
        1 gtagttccgg gcggaatgag agcagcacgc ctggctccgc tccttcttac tcatgcgcga
       61 ctccgagctg gccaaagaag ttcgtcccct ttgtgaggcc cgggatggga ggctccagcg
      121 ccgtaggact gaggcagact ccacggtgag aaagagaccc gatctaaccc aggcctttca
      181 tcagagccca ggagggaagg caggaagtgg gaccacgagg cccggggggc ttctaactcg
      241 tctggccagg gagatctgaa ttggggtgaa gagcagaatc tccagaacaa ggaggaggtg
      301 gtgatcatgg agacagattt ggctgaaatg cctgagaaag gagttctgtc ttcccaggat
      361 tctccccatt tccaagagaa gagcacagaa gagggagaag tggctgctct gcgcctcacg
      421 gccagatccc aggcggcggc ggcggcggcg gcgcccggga gccggagcct tcgcggcgtc
      481 cacgtccctc ccccgctgca ccccgccccg gcgcgagagg agagcgcgag aaccccagcc
      541 gcggccgggc gggcggcgaa gatggcagag gcaccggctt ccccggcccc gctttctccg
      601 ctcgaagtgg agctggaccc ggagttcgag ccccagagcc gtccgcgatc ctgtacgtgg
      661 cccctgcaaa ggccggagct ccaagcgagc cctgccaagc cctcggggga gacggccgcc
      721 gactccatga tccccgagga ggaggacgat gaagacgacg aggacggcgg gggacgggcc
      781 ggctcggcca tggcgatcgg cggcggcggc gggagccgca cgctggtctc cgggctgctc
      841 cttgaggact cggtccgggt gctggcaccc ggagggcaag accccgggtc tgggccagcc
      901 accgcggcgg gcgggctgag cgggggtaca caggcgctgc tgcagcctca gcaaccgctg
      961 ccaccgccgc agccgggggc ggctgggggc tccgggcagc cgaggaaatg ttcgtcgcgg
     1021 cggaacgcct ggggaaacct gtcctacgcg gacctgatca cccgcgccat cgagagctcc
     1081 ccggacagac ggctcactct gtcccagatc tacgagtgga tggtgagttg cgtgccctac
     1141 ttcaaggata agggcaacag caacagctct gccggctaga agaactccat ccggcacaac
     1201 ctgtcactgc atagtcgatt catgcgggtc cagaatgagg gaactggcaa gagctcttgg
     1261 tggatcatca accctgatgg ggggaagagc ggaaaagccc cccggcggcg ggctgtctcc
     1321 atggacaata gcaacaagta taccaagagc cgtggccgca cagccaagaa gaaggcagcc
     1381 ctgcagacag cccccgaatc agctgacgac agtccctccc agctctccaa gtggtctggc
     1441 agccccacgt cacgcagcag tgatgagctg gatgcgtgga cggacttccg ttcacgcacc
     1501 aattctaacg ccagcacagt cagtggccgc ctgtcgccca tcatggcaag cacagagttg
     1561 gatgaagtcc aggacgacga tgcgcctctc tcgcccatgc tctacagcag ctcagcgagc
     1621 ctgtcacctt cagtaagcaa gccgtgcacg gtggaactgc tacggctgac tgacatggca
     1681 ggcaccatga atctgaatga tggggctgac tgaaaacctc atggacgacc tgctggataa
     1741 catcacgctc ccgccatccc agccatcgcc cactggggga ctcatgcagc ggagttctag
     1801 cttcccgtat accaccaagg gctcgggcct gagctcccca accagctcct ttaacagcac
     1861 ggtgtttgga ccttcatctc tgaactccct acgccagtct cccatgcaga ccatccaaga
     1921 gaacaagcca gctaccttct cttccatgtc acactatggt aaccagacac tccaggacct
     1981 gctcacttcg gactcactta gccacagcga tgtcatgatg acacagtcgg accccttgat
     2041 gtctcaggcc agcaccgctg tgtctgccca gaattcccgc cggaacgtga tgcttcgcaa
     2101 tgatccgatg atgtcctttg ctgcccagcc taaccaggga agtgtggtca atcagaactt
     2161 gctccaccac cagcaccaaa cccagggcgc tcttggtggc agccgtgcct tgtcgaattc
     2221 tgtcagcaac atgggcttga gtgagtccag cagccttggg tcagccaaac accagcagca
     2281 gtctcctgtc agccagtcta tgcaaaccct ctcggactct ctctcaggct cctccttgta
     2341 ctcaactagt gcaaacctgc ccgtcatggg ccatgagaag ttccccagcg acttggacct
     2401 ggacatgttc aatgggagct tggaatgtga catggagtcc attatccgta gtgaactcat
     2461 ggatgctgat gggttggatt ttaactttga ttccctcatc tccacacaga atgttgttgg
     2521 tttgaacgtg gggaacttca ctggtgctaa gcaggcctca tctcagagct gggtgccagg
     2581 ctgaaggatc actgaggaag gggaagtggg caaagcagac cctcaaactg acacaagacc
     2641 tacagagaaa accctttgcc aaatctgctc tcagcaagtg gacagtgata ccgtttacag
     2701 cttaacacct ttgtgaatcc cacgccattt tcctaaccca gcagagactg ttaatggccc
     2761 cttaccctgg gtgaagcact tacccttgga atagaactct aaaaagtatg caaaatcttc
     2821 tttgtacagg gtggtgagcc gcctgccagt ggaggacagc acccctcagc accacccacc
     2881 ctcgttcaga gcacaccgtg agccctcttc ggccattctg tggtgtttta atattgcgat
     2941 ggtttatggg atgttttaag tgttgttctt gtgtttgttt tcctttgact ttctgagttt
     3001 ttcacatgca ttaacttgcg gtatttttct gttaaaatgt taaccgtcct tcccctagca
     3061 aatttaaaaa cagaaagaca atgttgtacc agttaccatt ccaggtttga gcatcacaag
     3121 cttttgagcg catggaactc cataaactaa caaattacat aaactaaagg gggattttct
     3181 ttcttctttt gtttggtaga aaattatcct tttctaaaaa ctgaacaatg gcacaattgt
     3241 ttgctatgcg cacccgtcca ggactgaacc atgcataggc aaaacgagtg gagcacagcg
     3301 tccagcccag tgtgtttcca gttctgagtc agggtgatct gtggacggga ccccagcacc
     3361 aggtctacgg gtgccagatc agtagggcct gtgatctcct gtcagtgtcc tcagctaatg
     3421 tgaacagtgt tggtctgctg gttagaaact agaataatga tattttcagg aaagaaatca
     3481 gctcagctct ccactcattg ccaaatgtca cccaaaaagg gtttagtttt aaggagaaag
     3541 aaaaggaaaa aaaaaaaaag tcctgttttg ctttgcagaa caaatgaact tacaggtgag
     3601 cattaagctt gcagtgagaa atgtgcaaag agtaaaaacc caagtcaatg ctgaggcagt
     3661 tccaacttca ctgttttcct aaatacacat ccttgattat tttcagcctt gctatataat
     3721 ctgatctgct agaagtgtat gagtgagagg caatagcata taaactgatt ttttaaatat
     3781 aagcttaggt tgtaattgta caagcgactc aatggaagta caaaataggg cagttttaac
     3841 ttttttttct gcttctgtgg atttcatttt gttgtgtttt caaaaagtta tggtgctgta
     3901 taggtgcttt ctgtttaacc tggaaagtgt gattatattc gttaccttct ttggtagacg
     3961 gaatagttgg gaccaccttt ggtacatatg aaattggtat aacgatgctc tgattagcac
     4021 agcatatgca tacttctcca aagtgatata tgaagactct tttctttgca taaaaagcat
     4081 taggcgtata aatgtataaa tatattttat tatgtacagt acaaaaatgg aaccttatgc
     4141 atgggcctta ggaatacagg ctagtatttc agcacagact tccctgcttg agttcttgct
     4201 gatgcttgca ccgtgacagt gggcaccaac acagacgtgc cacccaaccc cctgcacaca
     4261 ccaccggcca ccaggggccc ccttgtgcgc cttggcttta taactcctct gggggtgata
     4321 ttggtggtga tcacagctcc tagcataatg agagttccat ttggtattgt cacacgtctc
     4381 ctgcctcgct tgggttgcca tgtttgagcg atggccctgt tgatttcacc ctgcctttta
     4441 ctgaatctgt aaattgttgt gcaattgtgg ttatagtaga ctgtagcaca ttgccttttc
     4501 taaactgcta catgtttata atcttcattt ttaaagtatg tataattttt taaagtatgt
     4561 attctattca tatggtctgc ttgtcagtga gccagacttg cttactatat tcctttataa
     4621 taatgctagc cacttcctgg attctttagt aatgtgctgt atgcaagaac tttccagtag
     4681 cagtgaagga gggttgcctc tccaagcttc ctaagggatg ctgccctggg tggggatgca
     4741 ttgcagaggc agtagtagca tgggggctag agtggggagc gagatggaaa agggtggggg
     4801 gataggagaa ttctagagtg cttccagcat gagggtcctg agaacttctg tcctgagttc
     4861 agagaaacat gcaaagtaac taacaaaatc gctacttgcc tttgcagttt tacagaccca
     4921 gggagctgct ttgggagtga gaaaggcaac cctccaatgt gtttcaactt taaaatgttg
     4981 aattcttttc agacatgtgg tatctcattt attctccttt tctagcgttt gttgaatttc
     5041 aggcagaatg tcttacagaa tgtcctagaa ccagattatc atttaatccg aaacagctga
     5101 ggaagggaca gagaaggtac aagggcaagg cagcataaaa cagatcagga gaatgaagag
     5161 ggaatgcttt ggttttttgt tctgttttgt tttttctttt tcaagtaact aaaacagcat
     5221 ctacatgtag agtgtcgtgg agagctgaga ccagggtaaa gtcaagtgca gcatcagtac
     5281 tgcgagaccc accagcccct ggagagggtc agctgagaat ctggtagtga agcctgtgta
     5341 gggtcccggc accctcaccc tcagccacct gcagagaggc cagggcccca gagactagcc
     5401 cggttctgaa gtgggcaggg gtgctgccag agccttccgc cccttatatt gagaccctgc
     5461 tttcaggaca ggccagccgt tggccaccat gtcacattct gagtgagtgt cacgggtccc
     5521 taacaataat tttctgatct ggagcatatc agcagaatgc ttagcctcaa ggggcctggc
     5581 agctgtaatg tttgatttat gatgagaact atccgaggcc acacttggcc tctaaataag
     5641 ctgctctagg gagccgccta ctttttggtg agaaattaga agagtaccta atgttgaaaa
     5701 catgacatgc gctcttggga tctgctgttc tctccagggc tccagaacct gatacctgtt
     5761 accaaagcta ggaaagagct ttatcacaag ccttcactgt cctggcatga gaactggctg
     5821 ccaggctcag tgtaccccat taaatgtgaa tgaatctga
//
