LOCUS       NM_001455               7296 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box O3 (FOXO3), transcript variant 1, mRNA.
ACCESSION   NM_001455
VERSION     NM_001455.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7296)
  AUTHORS   Santana,C.V.N., Magno,L.A.V., Ramos,A.V., Rios,M.A., Sandrim,V.C.,
            De Marco,L.A., de Miranda,D.M. and Romano-Silva,M.A.
  TITLE     Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of
            Extreme Obesity
  JOURNAL   J Obes 2024, 3813621 (2024)
   PUBMED   39484290
  REMARK    GeneRIF: Genetic Variations in AMPK, FOXO3A, and POMC Increase the
            Risk of Extreme Obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7296)
  AUTHORS   Dan,Y., Chen,L., Jin,S., Xing,X., Zhu,Y., Jiang,M., Zhang,C. and
            Xiang,L.F.
  TITLE     Photobiomodulation Using 830 nm Lighting-Emitting Diode Inhibits
            Melanogenesis via FOXO3a in Human Melanocyte
  JOURNAL   Pigment Cell Melanoma Res 37 (5), 681-692 (2024)
   PUBMED   39169669
  REMARK    GeneRIF: Photobiomodulation Using 830 nm Lighting-Emitting Diode
            Inhibits Melanogenesis via FOXO3a in Human Melanocyte.
REFERENCE   3  (bases 1 to 7296)
  AUTHORS   de Almeida,T.G., Ricci,A.R., Dos Anjos,L.G., Soares Junior,J.M.,
            Maciel,G.A.R., Baracat,E.C. and Carvalho,K.C.
  TITLE     FOXO3a deregulation in uterine smooth muscle tumors
  JOURNAL   Clinics (Sao Paulo) 79, 100350 (2024)
   PUBMED   38636197
  REMARK    GeneRIF: FOXO3a deregulation in uterine smooth muscle tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7296)
  AUTHORS   Liu,Y., Qin,Y. and Zhang,Y.
  TITLE     circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression:
            implications for blood-brain barrier integrity and cognitive
            function in uremic encephalopathy
  JOURNAL   Cell Biol Toxicol 40 (1), 22 (2024)
   PUBMED   38630149
  REMARK    GeneRIF: circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1
            expression: implications for blood-brain barrier integrity and
            cognitive function in uremic encephalopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7296)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   6  (bases 1 to 7296)
  AUTHORS   Medema,R.H., Kops,G.J., Bos,J.L. and Burgering,B.M.
  TITLE     AFX-like Forkhead transcription factors mediate cell-cycle
            regulation by Ras and PKB through p27kip1
  JOURNAL   Nature 404 (6779), 782-787 (2000)
   PUBMED   10783894
REFERENCE   7  (bases 1 to 7296)
  AUTHORS   Brunet,A., Bonni,A., Zigmond,M.J., Lin,M.Z., Juo,P., Hu,L.S.,
            Anderson,M.J., Arden,K.C., Blenis,J. and Greenberg,M.E.
  TITLE     Akt promotes cell survival by phosphorylating and inhibiting a
            Forkhead transcription factor
  JOURNAL   Cell 96 (6), 857-868 (1999)
   PUBMED   10102273
REFERENCE   8  (bases 1 to 7296)
  AUTHORS   DaSilva,L., Kirken,R.A., Taub,D.D., Evans,G.A., Duhe,R.J.,
            Bailey,M.A. and Farrar,W.L.
  TITLE     Molecular cloning of FKHRL1P2, a member of the developmentally
            regulated fork head domain transcription factor family
  JOURNAL   Gene 221 (1), 135-142 (1998)
   PUBMED   9852958
REFERENCE   9  (bases 1 to 7296)
  AUTHORS   Anderson,M.J., Viars,C.S., Czekay,S., Cavenee,W.K. and Arden,K.C.
  TITLE     Cloning and characterization of three human forkhead genes that
            comprise an FKHR-like gene subfamily
  JOURNAL   Genomics 47 (2), 187-199 (1998)
   PUBMED   9479491
REFERENCE   10 (bases 1 to 7296)
  AUTHORS   Hillion,J., Le Coniat,M., Jonveaux,P., Berger,R. and Bernard,O.A.
  TITLE     AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23),
            defines a forkhead transcriptional factor subfamily
  JOURNAL   Blood 90 (9), 3714-3719 (1997)
   PUBMED   9345057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF032886.1, CA389775.1,
            AL365509.8, AL096818.9 and AK024103.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001455.3.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which are characterized by a distinct forkhead domain. This
            gene likely functions as a trigger for apoptosis through expression
            of genes necessary for cell death. Translocation of this gene with
            the MLL gene is associated with secondary acute leukemia.
            Alternatively spliced transcript variants encoding the same protein
            have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' end and
            represents the longer transcript compared to variant 2.  Both
            variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.194494.1,
                                           SRR1803617.146836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406360.2/ ENSP00000385824.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               AF032886.1         633-1082
            451-611             CA389775.1         430-590
            612-2551            AF032886.1         1244-3183
            2552-6258           AL365509.8         58194-61900
            6259-6343           AL096818.9         14125-14209         c
            6344-7290           AK024103.1         2542-3488
            7291-7296           AL096818.9         13172-13177         c
FEATURES             Location/Qualifiers
     source          1..7296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..7296
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="forkhead box O3"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
     exon            1..913
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2314
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like
                     1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead
                     box O3A; forkhead box protein O3; forkhead in
                     rhabdomyosarcoma-like 1; FOXO3A-"
                     /codon_start=1
                     /product="forkhead box protein O3 isoform 1"
                     /protein_id="NP_001446.1"
                     /db_xref="CCDS:CCDS5068.1"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
                     /translation="MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
                     AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLA
                     PGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNL
                     SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHS
                     RFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQT
                     APESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELD
                     EVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLD
                     NITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQT
                     IQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRN
                     VMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLG
                     SAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDM
                     ESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG"
     exon            914..2348
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..7296
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6490..6495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      6514
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
     regulatory      7269..7274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      7296
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtctgct gcgccaggtt cgctggccgc acgtcttcag gtcctcctgt tcctgggagg
       61 cgggcgcggc aggactggga ggtggcggca gcgggcgagg actcgccgag gacggggctc
      121 cggcccggga taaccaactc tccttctctc ttctttggtg cttccccagg cggcggcggc
      181 ggcgcccggg agccggagcc ttcgcggcgt ccacgtccct cccccgctgc accccgcccc
      241 ggcgcgagag gagagcgcga gagccccagc cgcgggcggg cgggcggcga agatggcaga
      301 ggcaccggct tccccggccc cgctctctcc gctcgaagtg gagctggacc cggagttcga
      361 gccccagagc cgtccgcgat cctgtacgtg gcccctgcaa aggccggagc tccaagcgag
      421 ccctgccaag ccctcggggg agacggccgc cgactccatg atccccgagg aggaggacga
      481 tgaagacgac gaggacggcg ggggacgggc cggctcggcc atggcgatcg gcggcggcgg
      541 cgggagcggc acgctgggct ccgggctgct ccttgaggac tcggcccggg tgctggcacc
      601 cggagggcaa gaccccgggt ctgggccagc caccgcggcg ggcgggctga gcgggggtac
      661 acaggcgctg ctgcagcctc agcaaccgct gccaccgccg cagccggggg cggctggggg
      721 ctccgggcag ccgaggaaat gttcgtcgcg gcggaacgcc tggggaaacc tgtcctacgc
      781 ggacctgatc acccgcgcca tcgagagctc cccggacaaa cggctcactc tgtcccagat
      841 ctacgagtgg atggtgcgtt gcgtgcccta cttcaaggat aagggcgaca gcaacagctc
      901 tgccggctgg aagaactcca tccggcacaa cctgtcactg catagtcgat tcatgcgggt
      961 ccagaatgag ggaactggca agagctcttg gtggatcatc aaccctgatg gggggaagag
     1021 cggaaaagcc ccccggcggc gggctgtctc catggacaat agcaacaagt ataccaagag
     1081 ccgtggccgc gcagccaaga agaaggcagc cctgcagaca gcccccgaat cagctgacga
     1141 cagtccctcc cagctctcca agtggcctgg cagccccacg tcacgcagca gtgatgagct
     1201 ggatgcgtgg acggacttcc gttcacgcac caattctaac gccagcacag tcagtggccg
     1261 cctgtcgccc atcatggcaa gcacagagtt ggatgaagtc caggacgatg atgcgcctct
     1321 ctcgcccatg ctctacagca gctcagccag cctgtcacct tcagtaagca agccgtgcac
     1381 ggtggaactg ccacggctga ctgatatggc aggcaccatg aatctgaatg atgggctgac
     1441 tgaaaacctc atggacgacc tgctggataa catcacgctc ccgccatccc agccatcgcc
     1501 cactggggga ctcatgcagc ggagctctag cttcccgtat accaccaagg gctcgggcct
     1561 gggctcccca accagctcct ttaacagcac ggtgttcgga ccttcatctc tgaactccct
     1621 acgccagtct cccatgcaga ccatccaaga gaacaagcca gctaccttct cttccatgtc
     1681 acactatggt aaccagacac tccaggacct gctcacttcg gactcactta gccacagcga
     1741 tgtcatgatg acacagtcgg accccttgat gtctcaggcc agcaccgctg tgtctgccca
     1801 gaattcccgc cggaacgtga tgcttcgcaa tgatccgatg atgtcctttg ctgcccagcc
     1861 taaccaggga agtttggtca atcagaactt gctccaccac cagcaccaaa cccagggcgc
     1921 tcttggtggc agccgtgcct tgtcgaattc tgtcagcaac atgggcttga gtgagtccag
     1981 cagccttggg tcagccaaac accagcagca gtctcctgtc agccagtcta tgcaaaccct
     2041 ctcggactct ctctcaggct cctccttgta ctcaactagt gcaaacctgc ccgtcatggg
     2101 ccatgagaag ttccccagcg acttggacct ggacatgttc aatgggagct tggaatgtga
     2161 catggagtcc attatccgta gtgaactcat ggatgctgat gggttggatt ttaactttga
     2221 ttccctcatc tccacacaga atgttgttgg tttgaacgtg gggaacttca ctggtgctaa
     2281 gcaggcctca tctcagagct gggtgccagg ctgaaggatc actgaggaag gggaagtggg
     2341 caaagcagac cctcaaactg acacaagacc tacagagaaa accctttgcc aaatctgctc
     2401 tcagcaagtg gacagtgata ccgtttacag cttaacacct ttgtgaatcc cacgccattt
     2461 tcctaaccca gcagagactg ttaatggccc cttaccctgg gtgaagcact tacccttgga
     2521 acagaactct aaaaagtatg caaaatcttc cttgtacagg gtggtgagcc gcctgccagt
     2581 ggaggacagc acccctcagc accacccacc ctcattcaga gcacaccgtg agcccccgtc
     2641 ggccattctg tggtgtttta atattgcgat ggtttatggg acgttttaag tgttgttctt
     2701 gtgtttgttt tcctttgact ttctgagttt ttcacatgca ttaacttgcg gtatttttct
     2761 gttaaaatgt taaccgtcct tcccctagca aatttaaaaa cagaaagaaa atgttgtacc
     2821 agttaccatt ccgggttcga gcatcacaag cttttgagcg catggaactc cataaactaa
     2881 caaattacat aaactaaagg gggattttct ttcttctttt gtttggtaga aaattatcct
     2941 tttctaaaaa ctgaacaatg gcacaattgt ttgctatgtg cacccgtcca ggacagaacc
     3001 gtgcataggc aaaaggagtg gagcacagcg tccggcccag tgtgtttccg gttctgagtc
     3061 agggtgatct gtggacggga ccccagcacc aagtctacgg gtgccagatc agtagggcct
     3121 gtgatttcct gtcagtgtcc tcagctaatg tgaacagtgt tggtctgctg gttagaaact
     3181 agaatattga tattttcagg aaagaaatca gctcagctct ccactcattg ccaaatgtca
     3241 ctaaagggtt tagttttaag gagaaagaaa aggaaaaaaa aaaaaaacaa aaaagtcctg
     3301 ttttgctttg cagaacaaat gaacttacag gtgagcatta agcttgcagt gagaaatgtg
     3361 cgaagagtaa aaacccaagt caatgctgag gcagttctaa cttcactgtt ttcctaaata
     3421 cacatccttg attattttca gccttgctat ataatctgat ctgctagaag tgtatgagtg
     3481 agaggcaata gcatacaaac tgatttttta aatataagct taggttgtaa ttgtacaagt
     3541 gactcaatgg aagtacaaaa tagggcagtt ttaacttttt tttctgcttc tatggatttc
     3601 attttgttgt gttttcaaaa agttatggtg ctgtataggt gctttctgtt taacctggaa
     3661 agtgtgatta tattcgttac cttctttggt agacggaata gttgggacca cctttggtac
     3721 ataagaaatt ggtataacga tgctctgatt agcacagtat atgcatactt ctccaaagtg
     3781 atatatgaag actcttttct ttgcataaaa agcattaggc atataaatgt ataaatatat
     3841 tttatcatgt acagtacaaa aatggaacct tatgcatggg ccttaggaat acaggctagt
     3901 atttcagcac agacttccct gcttgagttc ttgctgatgc ttgcaccgtg acagtgggca
     3961 ccaacacaga cgtgccaccc aaccccctgc acacaccacc ggccaccagg ggcccccttg
     4021 tgcgccttgg ctttataact cctctggggg tgatattggt ggtgatcaca gctcctagca
     4081 taatgagagt tccatttggt attgtcacac gtctcctgcc tcgcttgggt tgccatgttt
     4141 gagcgatggc cctgttgatt tcaccctgcc ttttactgaa tctgtaaatt gttgtgcaat
     4201 tgtggttata gtagactgta gcacattgcc ttttctaaac tgctacatgt ttataatctt
     4261 catttttaaa gtatgtgtaa tttttttaag tatgtattct attcatatgg tctgcttgtc
     4321 agtgagccag acttgcttac tatattcctt tataataatg ctagccactt cctggattct
     4381 ttagtaatgt gctgtatgca agaactttcc agtagcagtg aaggagggtt gcctctccaa
     4441 gcttcctaag ggatgctgcc ctgtgtgggg atgcattgca gaggcactag tagcatgggg
     4501 gctagagtgg ggagcgagat gtaaaagggt ggggggatag gagaattcca gagtgcttcc
     4561 agcattaggg tcctgagaac ttctgagttc agagaaacat gcaaagtgac taacaaaata
     4621 gctacttacc tttgcagttt tacagaccct gggagctgct ttgggagtga gaaaggcaac
     4681 cctccaatgt gtttcaactt taaaatgttg aattcttttc agacatggta tctcatttat
     4741 tctccttttc tagcgtttgt tgaatttcag gcagaatgtc ttacagaatg tcctagaacc
     4801 agattatcat ttaatctgaa acagctgagg aagggacaga gaaggtacaa gggcaaggca
     4861 gcacaaaaca gatcaggaga atgaagaggg aatgctttgg ttttttgttt tgttttgttt
     4921 tttctttttc aagtaactaa aacagcatct acatgtagag tgttgtggag agctgagacc
     4981 agggtaaagt caagtgcagc atcagtactg cgagacccac cagcccctgg agagggtcag
     5041 ccgagaatct ggtagtgaag cctgtctagg gtcccggcac cctcaccctc agccacctgc
     5101 agagaggcca gggccccaga gactagcctg gttctgaagt gggcaggggt gctgccagag
     5161 ccctctgccc cttatgttga gaccctgctt tcaggacagg ccagccgttg gccaccatgt
     5221 cacattctga gtgagtgtca caggtcccta acaataattt tctgatctgg agcatatcag
     5281 cagaatgctt agcctcaagg ggcctggcag ctgtaatgtt tgatttatga tgagaactat
     5341 ccgaggccac ccttggcctc taaataagct gctctaggga gccgcctact ttttgatgag
     5401 aaattagaag agtacctaat gttgaaaaca tgacatgcgc tcttgggatc tgctgttctc
     5461 tccagggctc cagaacctga tacctgttac caaagctagg aaagagcttt atcacaagcc
     5521 ttcactgtcc tggcatgaga actggctgcc aggctcagtg taccccatta actgtgaatg
     5581 aatctgagct tggtttcctt tattgcttcc tctgcaatat gattgctgaa acacatttta
     5641 aaaattcaga agcttgtcac tcctgttaat gggaggatca gtcacacatg tgtagtacaa
     5701 ggcggacttt gtgtttgttt ttggtgttaa tttttagcat tgtgtgtgtt gcttccccac
     5761 cctgaggaga ggacaccatg gcttactact caggacaagt atgccccgct cagggtgtga
     5821 tttcaggtgg cttccaaact tgtacgcagt ttaaagatgg tggggacaga ctttgcctct
     5881 acctagtgaa ccccacttaa agaataagga gcatttgaat ctcttggaaa aggccatgaa
     5941 gaataaagca gtcaaaaaga agtcctccat gttggtgcca aggacttgcg aggggaaata
     6001 aaaatgttat ccagcctgac caacatggag aaaccccgtc tccattaaaa atacaaaatt
     6061 agcctggcat ggtggcgcat gcctgtaatc ccagctactc tggaggctga ggcaggagaa
     6121 tcgcttgaac ccaggaggcg gaggtcgcag tgagccgaga tcatgccagt gcactccagc
     6181 ctgggtaaca agagtgaaac tccgtgtcaa aaaaaaaaaa aaaatgttac tcatcctctc
     6241 tgaaagcaaa aaggaaaccc taacagctct gaactctggt tttatttttc ttgctgtatt
     6301 tgggtgaaca ttgtatgatt aggcataatg ttaaaaaaaa aaattttttt ttggtagaaa
     6361 tgcaatcacc agtaaagagg tacgaaaaag ctagcctctc tcagagaccg gggaggcaga
     6421 gtactactag aggaagtgaa gttctgatgg aatcatgcct gtcaaatgag gtcttgaagc
     6481 ggatgcccaa ataaaagagt atattttatc taaatcttaa gtgggtaaca ttttatgcag
     6541 tttaaatgaa tggaatattt tcctcttgtt tagttgtatc tgtttgtatt tttctttgat
     6601 gaatgattgg tcatgaggcc tcttgccaca ctccagaaat acgtgtgcgg ctgcttttaa
     6661 gaactatgtg tctggtcact tatttctcta aaattatctc attgcctggc aatcagtctt
     6721 ctcttgtata cttgtcctag cacattatgt acatgggaaa tgtaaacaaa tgtgaaggag
     6781 gaccagaaaa attagttaat atttaaaaaa atgtattgtg cattttggct tcacatgttt
     6841 aacttttttt aagaaaaaag ttgcatgaat ggaaaaaaaa atctgtatac agtatctgta
     6901 aaaactatct tatctgtttc aattccttgc tcatatccca tataatctag aactaaatat
     6961 ggtgtgtggc catatttaaa cacctgagag tcaagcagtt gagactttga tttgaagcac
     7021 ctcatccttc tttcaatgcg aacactatca tatggcattc ttactgagga ttttgtctaa
     7081 ccatatgttg ccatgaatta actctgccgc ctttcttaag gatcaaaacc agtttgattt
     7141 gggaatcttc ccctttccaa atgaaataga gatgcagtac ttaactttcc ttggtgtttg
     7201 tagatattgc cttgtgtatt ccacttaaaa ccgtaatcta gtttgtaaaa gagatggtga
     7261 cgcatgtaaa taaagcatca gtgacactct atctta
//
