LOCUS       NM_001415147            6533 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box O3 (FOXO3), transcript variant 10, mRNA.
ACCESSION   NM_001415147 XM_011535628
VERSION     NM_001415147.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6533)
  AUTHORS   Santana,C.V.N., Magno,L.A.V., Ramos,A.V., Rios,M.A., Sandrim,V.C.,
            De Marco,L.A., de Miranda,D.M. and Romano-Silva,M.A.
  TITLE     Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of
            Extreme Obesity
  JOURNAL   J Obes 2024, 3813621 (2024)
   PUBMED   39484290
  REMARK    GeneRIF: Genetic Variations in AMPK, FOXO3A, and POMC Increase the
            Risk of Extreme Obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6533)
  AUTHORS   Dan,Y., Chen,L., Jin,S., Xing,X., Zhu,Y., Jiang,M., Zhang,C. and
            Xiang,L.F.
  TITLE     Photobiomodulation Using 830 nm Lighting-Emitting Diode Inhibits
            Melanogenesis via FOXO3a in Human Melanocyte
  JOURNAL   Pigment Cell Melanoma Res 37 (5), 681-692 (2024)
   PUBMED   39169669
  REMARK    GeneRIF: Photobiomodulation Using 830 nm Lighting-Emitting Diode
            Inhibits Melanogenesis via FOXO3a in Human Melanocyte.
REFERENCE   3  (bases 1 to 6533)
  AUTHORS   de Almeida,T.G., Ricci,A.R., Dos Anjos,L.G., Soares Junior,J.M.,
            Maciel,G.A.R., Baracat,E.C. and Carvalho,K.C.
  TITLE     FOXO3a deregulation in uterine smooth muscle tumors
  JOURNAL   Clinics (Sao Paulo) 79, 100350 (2024)
   PUBMED   38636197
  REMARK    GeneRIF: FOXO3a deregulation in uterine smooth muscle tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6533)
  AUTHORS   Liu,Y., Qin,Y. and Zhang,Y.
  TITLE     circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression:
            implications for blood-brain barrier integrity and cognitive
            function in uremic encephalopathy
  JOURNAL   Cell Biol Toxicol 40 (1), 22 (2024)
   PUBMED   38630149
  REMARK    GeneRIF: circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1
            expression: implications for blood-brain barrier integrity and
            cognitive function in uremic encephalopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6533)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   6  (bases 1 to 6533)
  AUTHORS   Medema,R.H., Kops,G.J., Bos,J.L. and Burgering,B.M.
  TITLE     AFX-like Forkhead transcription factors mediate cell-cycle
            regulation by Ras and PKB through p27kip1
  JOURNAL   Nature 404 (6779), 782-787 (2000)
   PUBMED   10783894
REFERENCE   7  (bases 1 to 6533)
  AUTHORS   Brunet,A., Bonni,A., Zigmond,M.J., Lin,M.Z., Juo,P., Hu,L.S.,
            Anderson,M.J., Arden,K.C., Blenis,J. and Greenberg,M.E.
  TITLE     Akt promotes cell survival by phosphorylating and inhibiting a
            Forkhead transcription factor
  JOURNAL   Cell 96 (6), 857-868 (1999)
   PUBMED   10102273
REFERENCE   8  (bases 1 to 6533)
  AUTHORS   DaSilva,L., Kirken,R.A., Taub,D.D., Evans,G.A., Duhe,R.J.,
            Bailey,M.A. and Farrar,W.L.
  TITLE     Molecular cloning of FKHRL1P2, a member of the developmentally
            regulated fork head domain transcription factor family
  JOURNAL   Gene 221 (1), 135-142 (1998)
   PUBMED   9852958
REFERENCE   9  (bases 1 to 6533)
  AUTHORS   Anderson,M.J., Viars,C.S., Czekay,S., Cavenee,W.K. and Arden,K.C.
  TITLE     Cloning and characterization of three human forkhead genes that
            comprise an FKHR-like gene subfamily
  JOURNAL   Genomics 47 (2), 187-199 (1998)
   PUBMED   9479491
REFERENCE   10 (bases 1 to 6533)
  AUTHORS   Hillion,J., Le Coniat,M., Jonveaux,P., Berger,R. and Bernard,O.A.
  TITLE     AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23),
            defines a forkhead transcriptional factor subfamily
  JOURNAL   Blood 90 (9), 3714-3719 (1997)
   PUBMED   9345057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391646.12, AL365509.8 and
            AL096818.9.
            
            On Dec 22, 2022 this sequence version replaced XM_011535628.4.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which are characterized by a distinct forkhead domain. This
            gene likely functions as a trigger for apoptosis through expression
            of genes necessary for cell death. Translocation of this gene with
            the MLL gene is associated with secondary acute leukemia.
            Alternatively spliced transcript variants encoding the same protein
            have been observed. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1912023.1, AK303933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL391646.12        39984-40133
            151-1585            AL365509.8         41619-43053
            1586-5495           AL365509.8         57991-61900
            5496-6533           AL096818.9         13172-14209         c
FEATURES             Location/Qualifiers
     source          1..6533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..6533
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="forkhead box O3"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
     exon            1..150
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     exon            151..1585
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1551
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="isoform 4 is encoded by transcript variant 10;
                     forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like
                     1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead
                     box O3A; forkhead box protein O3; forkhead in
                     rhabdomyosarcoma-like 1; FOXO3A-"
                     /codon_start=1
                     /product="forkhead box protein O3 isoform 4"
                     /protein_id="NP_001402076.1"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
                     /translation="MRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSR
                     GRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSG
                     RLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLND
                     GLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPS
                     SLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQA
                     STAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSV
                     SNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLD
                     LDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSW
                     VPG"
     exon            1586..6533
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5727..5732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      5751
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
     regulatory      6506..6511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      6533
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="major polyA site"
ORIGIN      
        1 aggcaggggt gactggctgt tcatgtgagt tcctgtgact gatgtctctg aagaaaccaa
       61 tgccttcttc agatccttat gggaaattta ggggactttt ggattacaca gtgttgcctt
      121 ttgctgattc taagatagag ccttccaatt aactccatcc ggcacaacct gtcactgcat
      181 agtcgattca tgcgggtcca gaatgaggga actggcaaga gctcttggtg gatcatcaac
      241 cctgatgggg ggaagagcgg aaaagccccc cggcggcggg ctgtctccat ggacaatagc
      301 aacaagtata ccaagagccg tggccgcgca gccaagaaga aggcagccct gcagacagcc
      361 cccgaatcag ctgacgacag tccctcccag ctctccaagt ggcctggcag ccccacgtca
      421 cgcagcagtg atgagctgga tgcgtggacg gacttccgtt cacgcaccaa ttctaacgcc
      481 agcacagtca gtggccgcct gtcgcccatc atggcaagca cagagttgga tgaagtccag
      541 gacgatgatg cgcctctctc gcccatgctc tacagcagct cagccagcct gtcaccttca
      601 gtaagcaagc cgtgcacggt ggaactgcca cggctgactg atatggcagg caccatgaat
      661 ctgaatgatg ggctgactga aaacctcatg gacgacctgc tggataacat cacgctcccg
      721 ccatcccagc catcgcccac tgggggactc atgcagcgga gctctagctt cccgtatacc
      781 accaagggct cgggcctggg ctccccaacc agctccttta acagcacggt gttcggacct
      841 tcatctctga actccctacg ccagtctccc atgcagacca tccaagagaa caagccagct
      901 accttctctt ccatgtcaca ctatggtaac cagacactcc aggacctgct cacttcggac
      961 tcacttagcc acagcgatgt catgatgaca cagtcggacc ccttgatgtc tcaggccagc
     1021 accgctgtgt ctgcccagaa ttcccgccgg aacgtgatgc ttcgcaatga tccgatgatg
     1081 tcctttgctg cccagcctaa ccagggaagt ttggtcaatc agaacttgct ccaccaccag
     1141 caccaaaccc agggcgctct tggtggcagc cgtgccttgt cgaattctgt cagcaacatg
     1201 ggcttgagtg agtccagcag ccttgggtca gccaaacacc agcagcagtc tcctgtcagc
     1261 cagtctatgc aaaccctctc ggactctctc tcaggctcct ccttgtactc aactagtgca
     1321 aacctgcccg tcatgggcca tgagaagttc cccagcgact tggacctgga catgttcaat
     1381 gggagcttgg aatgtgacat ggagtccatt atccgtagtg aactcatgga tgctgatggg
     1441 ttggatttta actttgattc cctcatctcc acacagaatg ttgttggttt gaacgtgggg
     1501 aacttcactg gtgctaagca ggcctcatct cagagctggg tgccaggctg aaggatcact
     1561 gaggaagggg aagtgggcaa agcagaccct caaactgaca caagacctac agagaaaacc
     1621 ctttgccaaa tctgctctca gcaagtggac agtgataccg tttacagctt aacacctttg
     1681 tgaatcccac gccattttcc taacccagca gagactgtta atggcccctt accctgggtg
     1741 aagcacttac ccttggaaca gaactctaaa aagtatgcaa aatcttcctt gtacagggtg
     1801 gtgagccgcc tgccagtgga ggacagcacc cctcagcacc acccaccctc attcagagca
     1861 caccgtgagc ccccgtcggc cattctgtgg tgttttaata ttgcgatggt ttatgggacg
     1921 ttttaagtgt tgttcttgtg tttgttttcc tttgactttc tgagtttttc acatgcatta
     1981 acttgcggta tttttctgtt aaaatgttaa ccgtccttcc cctagcaaat ttaaaaacag
     2041 aaagaaaatg ttgtaccagt taccattccg ggttcgagca tcacaagctt ttgagcgcat
     2101 ggaactccat aaactaacaa attacataaa ctaaaggggg attttctttc ttcttttgtt
     2161 tggtagaaaa ttatcctttt ctaaaaactg aacaatggca caattgtttg ctatgtgcac
     2221 ccgtccagga cagaaccgtg cataggcaaa aggagtggag cacagcgtcc ggcccagtgt
     2281 gtttccggtt ctgagtcagg gtgatctgtg gacgggaccc cagcaccaag tctacgggtg
     2341 ccagatcagt agggcctgtg atttcctgtc agtgtcctca gctaatgtga acagtgttgg
     2401 tctgctggtt agaaactaga atattgatat tttcaggaaa gaaatcagct cagctctcca
     2461 ctcattgcca aatgtcacta aagggtttag ttttaaggag aaagaaaagg aaaaaaaaaa
     2521 aaaacaaaaa agtcctgttt tgctttgcag aacaaatgaa cttacaggtg agcattaagc
     2581 ttgcagtgag aaatgtgcga agagtaaaaa cccaagtcaa tgctgaggca gttctaactt
     2641 cactgttttc ctaaatacac atccttgatt attttcagcc ttgctatata atctgatctg
     2701 ctagaagtgt atgagtgaga ggcaatagca tacaaactga ttttttaaat ataagcttag
     2761 gttgtaattg tacaagtgac tcaatggaag tacaaaatag ggcagtttta actttttttt
     2821 ctgcttctat ggatttcatt ttgttgtgtt ttcaaaaagt tatggtgctg tataggtgct
     2881 ttctgtttaa cctggaaagt gtgattatat tcgttacctt ctttggtaga cggaatagtt
     2941 gggaccacct ttggtacata agaaattggt ataacgatgc tctgattagc acagtatatg
     3001 catacttctc caaagtgata tatgaagact cttttctttg cataaaaagc attaggcata
     3061 taaatgtata aatatatttt atcatgtaca gtacaaaaat ggaaccttat gcatgggcct
     3121 taggaataca ggctagtatt tcagcacaga cttccctgct tgagttcttg ctgatgcttg
     3181 caccgtgaca gtgggcacca acacagacgt gccacccaac cccctgcaca caccaccggc
     3241 caccaggggc ccccttgtgc gccttggctt tataactcct ctgggggtga tattggtggt
     3301 gatcacagct cctagcataa tgagagttcc atttggtatt gtcacacgtc tcctgcctcg
     3361 cttgggttgc catgtttgag cgatggccct gttgatttca ccctgccttt tactgaatct
     3421 gtaaattgtt gtgcaattgt ggttatagta gactgtagca cattgccttt tctaaactgc
     3481 tacatgttta taatcttcat ttttaaagta tgtgtaattt ttttaagtat gtattctatt
     3541 catatggtct gcttgtcagt gagccagact tgcttactat attcctttat aataatgcta
     3601 gccacttcct ggattcttta gtaatgtgct gtatgcaaga actttccagt agcagtgaag
     3661 gagggttgcc tctccaagct tcctaaggga tgctgccctg tgtggggatg cattgcagag
     3721 gcactagtag catgggggct agagtgggga gcgagatgta aaagggtggg gggataggag
     3781 aattccagag tgcttccagc attagggtcc tgagaacttc tgagttcaga gaaacatgca
     3841 aagtgactaa caaaatagct acttaccttt gcagttttac agaccctggg agctgctttg
     3901 ggagtgagaa aggcaaccct ccaatgtgtt tcaactttaa aatgttgaat tcttttcaga
     3961 catggtatct catttattct ccttttctag cgtttgttga atttcaggca gaatgtctta
     4021 cagaatgtcc tagaaccaga ttatcattta atctgaaaca gctgaggaag ggacagagaa
     4081 ggtacaaggg caaggcagca caaaacagat caggagaatg aagagggaat gctttggttt
     4141 tttgttttgt tttgtttttt ctttttcaag taactaaaac agcatctaca tgtagagtgt
     4201 tgtggagagc tgagaccagg gtaaagtcaa gtgcagcatc agtactgcga gacccaccag
     4261 cccctggaga gggtcagccg agaatctggt agtgaagcct gtctagggtc ccggcaccct
     4321 caccctcagc cacctgcaga gaggccaggg ccccagagac tagcctggtt ctgaagtggg
     4381 caggggtgct gccagagccc tctgcccctt atgttgagac cctgctttca ggacaggcca
     4441 gccgttggcc accatgtcac attctgagtg agtgtcacag gtccctaaca ataattttct
     4501 gatctggagc atatcagcag aatgcttagc ctcaaggggc ctggcagctg taatgtttga
     4561 tttatgatga gaactatccg aggccaccct tggcctctaa ataagctgct ctagggagcc
     4621 gcctactttt tgatgagaaa ttagaagagt acctaatgtt gaaaacatga catgcgctct
     4681 tgggatctgc tgttctctcc agggctccag aacctgatac ctgttaccaa agctaggaaa
     4741 gagctttatc acaagccttc actgtcctgg catgagaact ggctgccagg ctcagtgtac
     4801 cccattaact gtgaatgaat ctgagcttgg tttcctttat tgcttcctct gcaatatgat
     4861 tgctgaaaca cattttaaaa attcagaagc ttgtcactcc tgttaatggg aggatcagtc
     4921 acacatgtgt agtacaaggc ggactttgtg tttgtttttg gtgttaattt ttagcattgt
     4981 gtgtgttgct tccccaccct gaggagagga caccatggct tactactcag gacaagtatg
     5041 ccccgctcag ggtgtgattt caggtggctt ccaaacttgt acgcagttta aagatggtgg
     5101 ggacagactt tgcctctacc tagtgaaccc cacttaaaga ataaggagca tttgaatctc
     5161 ttggaaaagg ccatgaagaa taaagcagtc aaaaagaagt cctccatgtt ggtgccaagg
     5221 acttgcgagg ggaaataaaa atgttatcca gcctgaccaa catggagaaa ccccgtctcc
     5281 attaaaaata caaaattagc ctggcatggt ggcgcatgcc tgtaatccca gctactctgg
     5341 aggctgaggc aggagaatcg cttgaaccca ggaggcggag gtcgcagtga gccgagatca
     5401 tgccagtgca ctccagcctg ggtaacaaga gtgaaactcc gtgtcaaaaa aaaaaaaaaa
     5461 atgttactca tcctctctga aagcaaaaag gaaaccctaa cagctctgaa ctctggtttt
     5521 atttttcttg ctgtatttgg gtgaacattg tatgattagg cataatgtta aaaaaaaaaa
     5581 tttttttttg gtagaaatgc aatcaccagt aaagaggtac gaaaaagcta gcctctctca
     5641 gagaccgggg aggcagagta ctactagagg aagtgaagtt ctgatggaat catgcctgtc
     5701 aaatgaggtc ttgaagcgga tgcccaaata aaagagtata ttttatctaa atcttaagtg
     5761 ggtaacattt tatgcagttt aaatgaatgg aatattttcc tcttgtttag ttgtatctgt
     5821 ttgtattttt ctttgatgaa tgattggtca tgaggcctct tgccacactc cagaaatacg
     5881 tgtgcggctg cttttaagaa ctatgtgtct ggtcacttat ttctctaaaa ttatctcatt
     5941 gcctggcaat cagtcttctc ttgtatactt gtcctagcac attatgtaca tgggaaatgt
     6001 aaacaaatgt gaaggaggac cagaaaaatt agttaatatt taaaaaaatg tattgtgcat
     6061 tttggcttca catgtttaac tttttttaag aaaaaagttg catgaatgga aaaaaaaatc
     6121 tgtatacagt atctgtaaaa actatcttat ctgtttcaat tccttgctca tatcccatat
     6181 aatctagaac taaatatggt gtgtggccat atttaaacac ctgagagtca agcagttgag
     6241 actttgattt gaagcacctc atccttcttt caatgcgaac actatcatat ggcattctta
     6301 ctgaggattt tgtctaacca tatgttgcca tgaattaact ctgccgcctt tcttaaggat
     6361 caaaaccagt ttgatttggg aatcttcccc tttccaaatg aaatagagat gcagtactta
     6421 actttccttg gtgtttgtag atattgcctt gtgtattcca cttaaaaccg taatctagtt
     6481 tgtaaaagag atggtgacgc atgtaaataa agcatcagtg acactctatc tta
//
