LOCUS       NM_001415145            6597 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box O3 (FOXO3), transcript variant 8, mRNA.
ACCESSION   NM_001415145 XM_005266868
VERSION     NM_001415145.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6597)
  AUTHORS   Santana,C.V.N., Magno,L.A.V., Ramos,A.V., Rios,M.A., Sandrim,V.C.,
            De Marco,L.A., de Miranda,D.M. and Romano-Silva,M.A.
  TITLE     Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of
            Extreme Obesity
  JOURNAL   J Obes 2024, 3813621 (2024)
   PUBMED   39484290
  REMARK    GeneRIF: Genetic Variations in AMPK, FOXO3A, and POMC Increase the
            Risk of Extreme Obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6597)
  AUTHORS   Dan,Y., Chen,L., Jin,S., Xing,X., Zhu,Y., Jiang,M., Zhang,C. and
            Xiang,L.F.
  TITLE     Photobiomodulation Using 830 nm Lighting-Emitting Diode Inhibits
            Melanogenesis via FOXO3a in Human Melanocyte
  JOURNAL   Pigment Cell Melanoma Res 37 (5), 681-692 (2024)
   PUBMED   39169669
  REMARK    GeneRIF: Photobiomodulation Using 830 nm Lighting-Emitting Diode
            Inhibits Melanogenesis via FOXO3a in Human Melanocyte.
REFERENCE   3  (bases 1 to 6597)
  AUTHORS   de Almeida,T.G., Ricci,A.R., Dos Anjos,L.G., Soares Junior,J.M.,
            Maciel,G.A.R., Baracat,E.C. and Carvalho,K.C.
  TITLE     FOXO3a deregulation in uterine smooth muscle tumors
  JOURNAL   Clinics (Sao Paulo) 79, 100350 (2024)
   PUBMED   38636197
  REMARK    GeneRIF: FOXO3a deregulation in uterine smooth muscle tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6597)
  AUTHORS   Liu,Y., Qin,Y. and Zhang,Y.
  TITLE     circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression:
            implications for blood-brain barrier integrity and cognitive
            function in uremic encephalopathy
  JOURNAL   Cell Biol Toxicol 40 (1), 22 (2024)
   PUBMED   38630149
  REMARK    GeneRIF: circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1
            expression: implications for blood-brain barrier integrity and
            cognitive function in uremic encephalopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6597)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   6  (bases 1 to 6597)
  AUTHORS   Medema,R.H., Kops,G.J., Bos,J.L. and Burgering,B.M.
  TITLE     AFX-like Forkhead transcription factors mediate cell-cycle
            regulation by Ras and PKB through p27kip1
  JOURNAL   Nature 404 (6779), 782-787 (2000)
   PUBMED   10783894
REFERENCE   7  (bases 1 to 6597)
  AUTHORS   Brunet,A., Bonni,A., Zigmond,M.J., Lin,M.Z., Juo,P., Hu,L.S.,
            Anderson,M.J., Arden,K.C., Blenis,J. and Greenberg,M.E.
  TITLE     Akt promotes cell survival by phosphorylating and inhibiting a
            Forkhead transcription factor
  JOURNAL   Cell 96 (6), 857-868 (1999)
   PUBMED   10102273
REFERENCE   8  (bases 1 to 6597)
  AUTHORS   DaSilva,L., Kirken,R.A., Taub,D.D., Evans,G.A., Duhe,R.J.,
            Bailey,M.A. and Farrar,W.L.
  TITLE     Molecular cloning of FKHRL1P2, a member of the developmentally
            regulated fork head domain transcription factor family
  JOURNAL   Gene 221 (1), 135-142 (1998)
   PUBMED   9852958
REFERENCE   9  (bases 1 to 6597)
  AUTHORS   Anderson,M.J., Viars,C.S., Czekay,S., Cavenee,W.K. and Arden,K.C.
  TITLE     Cloning and characterization of three human forkhead genes that
            comprise an FKHR-like gene subfamily
  JOURNAL   Genomics 47 (2), 187-199 (1998)
   PUBMED   9479491
REFERENCE   10 (bases 1 to 6597)
  AUTHORS   Hillion,J., Le Coniat,M., Jonveaux,P., Berger,R. and Bernard,O.A.
  TITLE     AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23),
            defines a forkhead transcriptional factor subfamily
  JOURNAL   Blood 90 (9), 3714-3719 (1997)
   PUBMED   9345057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365509.8 and AL096818.9.
            
            On Dec 22, 2022 this sequence version replaced XM_005266868.4.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which are characterized by a distinct forkhead domain. This
            gene likely functions as a trigger for apoptosis through expression
            of genes necessary for cell death. Translocation of this gene with
            the MLL gene is associated with secondary acute leukemia.
            Alternatively spliced transcript variants encoding the same protein
            have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (8) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon relative to variant 1. The encoded isoform
            (4, also known as FOXO3A-S) has a shorter N-terminus compared to
            isoform 1. A SNP in the 5' UTR of this variant, rs9400239, has been
            associated with human longevity (PMID:36617632).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749261.1, AK301304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL365509.8         34489-34702
            215-1649            AL365509.8         41619-43053
            1650-5559           AL365509.8         57991-61900
            5560-6597           AL096818.9         13172-14209         c
FEATURES             Location/Qualifiers
     source          1..6597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..6597
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="forkhead box O3"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
     exon            1..214
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     exon            215..1649
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1615
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="isoform 4 is encoded by transcript variant 8;
                     forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like
                     1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead
                     box O3A; forkhead box protein O3; forkhead in
                     rhabdomyosarcoma-like 1; FOXO3A-"
                     /codon_start=1
                     /product="forkhead box protein O3 isoform 4"
                     /protein_id="NP_001402074.1"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
                     /translation="MRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSR
                     GRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSG
                     RLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLND
                     GLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPS
                     SLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQA
                     STAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSV
                     SNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLD
                     LDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSW
                     VPG"
     exon            1650..6597
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5791..5796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      5815
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
     regulatory      6570..6575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      6597
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="major polyA site"
ORIGIN      
        1 acatgcagct ggtgtctggg tgagtggaca gtctccacaa ggtaaacatg gtttggaagg
       61 gctgaagcgg acgtagggta caaaatttaa gaaattacca gttacttctg actggcacgg
      121 cacctctgaa atactttttt aaagtttgaa atcctttcct ggaaggggcc gccctggaac
      181 cttttggctt aaagtatatg atgctcggaa aacaaactcc atccggcaca acctgtcact
      241 gcatagtcga ttcatgcggg tccagaatga gggaactggc aagagctctt ggtggatcat
      301 caaccctgat ggggggaaga gcggaaaagc cccccggcgg cgggctgtct ccatggacaa
      361 tagcaacaag tataccaaga gccgtggccg cgcagccaag aagaaggcag ccctgcagac
      421 agcccccgaa tcagctgacg acagtccctc ccagctctcc aagtggcctg gcagccccac
      481 gtcacgcagc agtgatgagc tggatgcgtg gacggacttc cgttcacgca ccaattctaa
      541 cgccagcaca gtcagtggcc gcctgtcgcc catcatggca agcacagagt tggatgaagt
      601 ccaggacgat gatgcgcctc tctcgcccat gctctacagc agctcagcca gcctgtcacc
      661 ttcagtaagc aagccgtgca cggtggaact gccacggctg actgatatgg caggcaccat
      721 gaatctgaat gatgggctga ctgaaaacct catggacgac ctgctggata acatcacgct
      781 cccgccatcc cagccatcgc ccactggggg actcatgcag cggagctcta gcttcccgta
      841 taccaccaag ggctcgggcc tgggctcccc aaccagctcc tttaacagca cggtgttcgg
      901 accttcatct ctgaactccc tacgccagtc tcccatgcag accatccaag agaacaagcc
      961 agctaccttc tcttccatgt cacactatgg taaccagaca ctccaggacc tgctcacttc
     1021 ggactcactt agccacagcg atgtcatgat gacacagtcg gaccccttga tgtctcaggc
     1081 cagcaccgct gtgtctgccc agaattcccg ccggaacgtg atgcttcgca atgatccgat
     1141 gatgtccttt gctgcccagc ctaaccaggg aagtttggtc aatcagaact tgctccacca
     1201 ccagcaccaa acccagggcg ctcttggtgg cagccgtgcc ttgtcgaatt ctgtcagcaa
     1261 catgggcttg agtgagtcca gcagccttgg gtcagccaaa caccagcagc agtctcctgt
     1321 cagccagtct atgcaaaccc tctcggactc tctctcaggc tcctccttgt actcaactag
     1381 tgcaaacctg cccgtcatgg gccatgagaa gttccccagc gacttggacc tggacatgtt
     1441 caatgggagc ttggaatgtg acatggagtc cattatccgt agtgaactca tggatgctga
     1501 tgggttggat tttaactttg attccctcat ctccacacag aatgttgttg gtttgaacgt
     1561 ggggaacttc actggtgcta agcaggcctc atctcagagc tgggtgccag gctgaaggat
     1621 cactgaggaa ggggaagtgg gcaaagcaga ccctcaaact gacacaagac ctacagagaa
     1681 aaccctttgc caaatctgct ctcagcaagt ggacagtgat accgtttaca gcttaacacc
     1741 tttgtgaatc ccacgccatt ttcctaaccc agcagagact gttaatggcc ccttaccctg
     1801 ggtgaagcac ttacccttgg aacagaactc taaaaagtat gcaaaatctt ccttgtacag
     1861 ggtggtgagc cgcctgccag tggaggacag cacccctcag caccacccac cctcattcag
     1921 agcacaccgt gagcccccgt cggccattct gtggtgtttt aatattgcga tggtttatgg
     1981 gacgttttaa gtgttgttct tgtgtttgtt ttcctttgac tttctgagtt tttcacatgc
     2041 attaacttgc ggtatttttc tgttaaaatg ttaaccgtcc ttcccctagc aaatttaaaa
     2101 acagaaagaa aatgttgtac cagttaccat tccgggttcg agcatcacaa gcttttgagc
     2161 gcatggaact ccataaacta acaaattaca taaactaaag ggggattttc tttcttcttt
     2221 tgtttggtag aaaattatcc ttttctaaaa actgaacaat ggcacaattg tttgctatgt
     2281 gcacccgtcc aggacagaac cgtgcatagg caaaaggagt ggagcacagc gtccggccca
     2341 gtgtgtttcc ggttctgagt cagggtgatc tgtggacggg accccagcac caagtctacg
     2401 ggtgccagat cagtagggcc tgtgatttcc tgtcagtgtc ctcagctaat gtgaacagtg
     2461 ttggtctgct ggttagaaac tagaatattg atattttcag gaaagaaatc agctcagctc
     2521 tccactcatt gccaaatgtc actaaagggt ttagttttaa ggagaaagaa aaggaaaaaa
     2581 aaaaaaaaca aaaaagtcct gttttgcttt gcagaacaaa tgaacttaca ggtgagcatt
     2641 aagcttgcag tgagaaatgt gcgaagagta aaaacccaag tcaatgctga ggcagttcta
     2701 acttcactgt tttcctaaat acacatcctt gattattttc agccttgcta tataatctga
     2761 tctgctagaa gtgtatgagt gagaggcaat agcatacaaa ctgatttttt aaatataagc
     2821 ttaggttgta attgtacaag tgactcaatg gaagtacaaa atagggcagt tttaactttt
     2881 ttttctgctt ctatggattt cattttgttg tgttttcaaa aagttatggt gctgtatagg
     2941 tgctttctgt ttaacctgga aagtgtgatt atattcgtta ccttctttgg tagacggaat
     3001 agttgggacc acctttggta cataagaaat tggtataacg atgctctgat tagcacagta
     3061 tatgcatact tctccaaagt gatatatgaa gactcttttc tttgcataaa aagcattagg
     3121 catataaatg tataaatata ttttatcatg tacagtacaa aaatggaacc ttatgcatgg
     3181 gccttaggaa tacaggctag tatttcagca cagacttccc tgcttgagtt cttgctgatg
     3241 cttgcaccgt gacagtgggc accaacacag acgtgccacc caaccccctg cacacaccac
     3301 cggccaccag gggccccctt gtgcgccttg gctttataac tcctctgggg gtgatattgg
     3361 tggtgatcac agctcctagc ataatgagag ttccatttgg tattgtcaca cgtctcctgc
     3421 ctcgcttggg ttgccatgtt tgagcgatgg ccctgttgat ttcaccctgc cttttactga
     3481 atctgtaaat tgttgtgcaa ttgtggttat agtagactgt agcacattgc cttttctaaa
     3541 ctgctacatg tttataatct tcatttttaa agtatgtgta atttttttaa gtatgtattc
     3601 tattcatatg gtctgcttgt cagtgagcca gacttgctta ctatattcct ttataataat
     3661 gctagccact tcctggattc tttagtaatg tgctgtatgc aagaactttc cagtagcagt
     3721 gaaggagggt tgcctctcca agcttcctaa gggatgctgc cctgtgtggg gatgcattgc
     3781 agaggcacta gtagcatggg ggctagagtg gggagcgaga tgtaaaaggg tggggggata
     3841 ggagaattcc agagtgcttc cagcattagg gtcctgagaa cttctgagtt cagagaaaca
     3901 tgcaaagtga ctaacaaaat agctacttac ctttgcagtt ttacagaccc tgggagctgc
     3961 tttgggagtg agaaaggcaa ccctccaatg tgtttcaact ttaaaatgtt gaattctttt
     4021 cagacatggt atctcattta ttctcctttt ctagcgtttg ttgaatttca ggcagaatgt
     4081 cttacagaat gtcctagaac cagattatca tttaatctga aacagctgag gaagggacag
     4141 agaaggtaca agggcaaggc agcacaaaac agatcaggag aatgaagagg gaatgctttg
     4201 gttttttgtt ttgttttgtt ttttcttttt caagtaacta aaacagcatc tacatgtaga
     4261 gtgttgtgga gagctgagac cagggtaaag tcaagtgcag catcagtact gcgagaccca
     4321 ccagcccctg gagagggtca gccgagaatc tggtagtgaa gcctgtctag ggtcccggca
     4381 ccctcaccct cagccacctg cagagaggcc agggccccag agactagcct ggttctgaag
     4441 tgggcagggg tgctgccaga gccctctgcc ccttatgttg agaccctgct ttcaggacag
     4501 gccagccgtt ggccaccatg tcacattctg agtgagtgtc acaggtccct aacaataatt
     4561 ttctgatctg gagcatatca gcagaatgct tagcctcaag gggcctggca gctgtaatgt
     4621 ttgatttatg atgagaacta tccgaggcca cccttggcct ctaaataagc tgctctaggg
     4681 agccgcctac tttttgatga gaaattagaa gagtacctaa tgttgaaaac atgacatgcg
     4741 ctcttgggat ctgctgttct ctccagggct ccagaacctg atacctgtta ccaaagctag
     4801 gaaagagctt tatcacaagc cttcactgtc ctggcatgag aactggctgc caggctcagt
     4861 gtaccccatt aactgtgaat gaatctgagc ttggtttcct ttattgcttc ctctgcaata
     4921 tgattgctga aacacatttt aaaaattcag aagcttgtca ctcctgttaa tgggaggatc
     4981 agtcacacat gtgtagtaca aggcggactt tgtgtttgtt tttggtgtta atttttagca
     5041 ttgtgtgtgt tgcttcccca ccctgaggag aggacaccat ggcttactac tcaggacaag
     5101 tatgccccgc tcagggtgtg atttcaggtg gcttccaaac ttgtacgcag tttaaagatg
     5161 gtggggacag actttgcctc tacctagtga accccactta aagaataagg agcatttgaa
     5221 tctcttggaa aaggccatga agaataaagc agtcaaaaag aagtcctcca tgttggtgcc
     5281 aaggacttgc gaggggaaat aaaaatgtta tccagcctga ccaacatgga gaaaccccgt
     5341 ctccattaaa aatacaaaat tagcctggca tggtggcgca tgcctgtaat cccagctact
     5401 ctggaggctg aggcaggaga atcgcttgaa cccaggaggc ggaggtcgca gtgagccgag
     5461 atcatgccag tgcactccag cctgggtaac aagagtgaaa ctccgtgtca aaaaaaaaaa
     5521 aaaaatgtta ctcatcctct ctgaaagcaa aaaggaaacc ctaacagctc tgaactctgg
     5581 ttttattttt cttgctgtat ttgggtgaac attgtatgat taggcataat gttaaaaaaa
     5641 aaaatttttt tttggtagaa atgcaatcac cagtaaagag gtacgaaaaa gctagcctct
     5701 ctcagagacc ggggaggcag agtactacta gaggaagtga agttctgatg gaatcatgcc
     5761 tgtcaaatga ggtcttgaag cggatgccca aataaaagag tatattttat ctaaatctta
     5821 agtgggtaac attttatgca gtttaaatga atggaatatt ttcctcttgt ttagttgtat
     5881 ctgtttgtat ttttctttga tgaatgattg gtcatgaggc ctcttgccac actccagaaa
     5941 tacgtgtgcg gctgctttta agaactatgt gtctggtcac ttatttctct aaaattatct
     6001 cattgcctgg caatcagtct tctcttgtat acttgtccta gcacattatg tacatgggaa
     6061 atgtaaacaa atgtgaagga ggaccagaaa aattagttaa tatttaaaaa aatgtattgt
     6121 gcattttggc ttcacatgtt taactttttt taagaaaaaa gttgcatgaa tggaaaaaaa
     6181 aatctgtata cagtatctgt aaaaactatc ttatctgttt caattccttg ctcatatccc
     6241 atataatcta gaactaaata tggtgtgtgg ccatatttaa acacctgaga gtcaagcagt
     6301 tgagactttg atttgaagca cctcatcctt ctttcaatgc gaacactatc atatggcatt
     6361 cttactgagg attttgtcta accatatgtt gccatgaatt aactctgccg cctttcttaa
     6421 ggatcaaaac cagtttgatt tgggaatctt cccctttcca aatgaaatag agatgcagta
     6481 cttaactttc cttggtgttt gtagatattg ccttgtgtat tccacttaaa accgtaatct
     6541 agtttgtaaa agagatggtg acgcatgtaa ataaagcatc agtgacactc tatctta
//
