LOCUS       NM_001415139            7362 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box O3 (FOXO3), transcript variant 3, mRNA.
ACCESSION   NM_001415139 XM_011535626
VERSION     NM_001415139.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7362)
  AUTHORS   Santana,C.V.N., Magno,L.A.V., Ramos,A.V., Rios,M.A., Sandrim,V.C.,
            De Marco,L.A., de Miranda,D.M. and Romano-Silva,M.A.
  TITLE     Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of
            Extreme Obesity
  JOURNAL   J Obes 2024, 3813621 (2024)
   PUBMED   39484290
  REMARK    GeneRIF: Genetic Variations in AMPK, FOXO3A, and POMC Increase the
            Risk of Extreme Obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7362)
  AUTHORS   Dan,Y., Chen,L., Jin,S., Xing,X., Zhu,Y., Jiang,M., Zhang,C. and
            Xiang,L.F.
  TITLE     Photobiomodulation Using 830 nm Lighting-Emitting Diode Inhibits
            Melanogenesis via FOXO3a in Human Melanocyte
  JOURNAL   Pigment Cell Melanoma Res 37 (5), 681-692 (2024)
   PUBMED   39169669
  REMARK    GeneRIF: Photobiomodulation Using 830 nm Lighting-Emitting Diode
            Inhibits Melanogenesis via FOXO3a in Human Melanocyte.
REFERENCE   3  (bases 1 to 7362)
  AUTHORS   de Almeida,T.G., Ricci,A.R., Dos Anjos,L.G., Soares Junior,J.M.,
            Maciel,G.A.R., Baracat,E.C. and Carvalho,K.C.
  TITLE     FOXO3a deregulation in uterine smooth muscle tumors
  JOURNAL   Clinics (Sao Paulo) 79, 100350 (2024)
   PUBMED   38636197
  REMARK    GeneRIF: FOXO3a deregulation in uterine smooth muscle tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7362)
  AUTHORS   Liu,Y., Qin,Y. and Zhang,Y.
  TITLE     circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression:
            implications for blood-brain barrier integrity and cognitive
            function in uremic encephalopathy
  JOURNAL   Cell Biol Toxicol 40 (1), 22 (2024)
   PUBMED   38630149
  REMARK    GeneRIF: circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1
            expression: implications for blood-brain barrier integrity and
            cognitive function in uremic encephalopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7362)
  AUTHORS   Yuan,H., Liang,Y., Hu,S., Chen,J., You,J., Jiang,J., Luo,M. and
            Zeng,M.
  TITLE     The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast
            cancer
  JOURNAL   Medicine (Baltimore) 103 (15), e37709 (2024)
   PUBMED   38608123
  REMARK    GeneRIF: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in
            breast cancer.
REFERENCE   6  (bases 1 to 7362)
  AUTHORS   Medema,R.H., Kops,G.J., Bos,J.L. and Burgering,B.M.
  TITLE     AFX-like Forkhead transcription factors mediate cell-cycle
            regulation by Ras and PKB through p27kip1
  JOURNAL   Nature 404 (6779), 782-787 (2000)
   PUBMED   10783894
REFERENCE   7  (bases 1 to 7362)
  AUTHORS   Brunet,A., Bonni,A., Zigmond,M.J., Lin,M.Z., Juo,P., Hu,L.S.,
            Anderson,M.J., Arden,K.C., Blenis,J. and Greenberg,M.E.
  TITLE     Akt promotes cell survival by phosphorylating and inhibiting a
            Forkhead transcription factor
  JOURNAL   Cell 96 (6), 857-868 (1999)
   PUBMED   10102273
REFERENCE   8  (bases 1 to 7362)
  AUTHORS   DaSilva,L., Kirken,R.A., Taub,D.D., Evans,G.A., Duhe,R.J.,
            Bailey,M.A. and Farrar,W.L.
  TITLE     Molecular cloning of FKHRL1P2, a member of the developmentally
            regulated fork head domain transcription factor family
  JOURNAL   Gene 221 (1), 135-142 (1998)
   PUBMED   9852958
REFERENCE   9  (bases 1 to 7362)
  AUTHORS   Anderson,M.J., Viars,C.S., Czekay,S., Cavenee,W.K. and Arden,K.C.
  TITLE     Cloning and characterization of three human forkhead genes that
            comprise an FKHR-like gene subfamily
  JOURNAL   Genomics 47 (2), 187-199 (1998)
   PUBMED   9479491
REFERENCE   10 (bases 1 to 7362)
  AUTHORS   Hillion,J., Le Coniat,M., Jonveaux,P., Berger,R. and Bernard,O.A.
  TITLE     AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23),
            defines a forkhead transcriptional factor subfamily
  JOURNAL   Blood 90 (9), 3714-3719 (1997)
   PUBMED   9345057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391646.12, AL365509.8 and
            AL096818.9.
            
            On Dec 22, 2022 this sequence version replaced XM_011535626.3.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which are characterized by a distinct forkhead domain. This
            gene likely functions as a trigger for apoptosis through expression
            of genes necessary for cell death. Translocation of this gene with
            the MLL gene is associated with secondary acute leukemia.
            Alternatively spliced transcript variants encoding the same protein
            have been observed. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2075015.1,
                                           SRR14038196.2569246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-979               AL391646.12        11483-12461
            980-2414            AL365509.8         41619-43053
            2415-6324           AL365509.8         57991-61900
            6325-7362           AL096818.9         13172-14209         c
FEATURES             Location/Qualifiers
     source          1..7362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..7362
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="forkhead box O3"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
     exon            1..979
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             860..2380
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="isoform 2 is encoded by transcript variant 3;
                     forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like
                     1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead
                     box O3A; forkhead box protein O3; forkhead in
                     rhabdomyosarcoma-like 1; FOXO3A-"
                     /codon_start=1
                     /product="forkhead box protein O3 isoform 2"
                     /protein_id="NP_001402068.1"
                     /db_xref="GeneID:2309"
                     /db_xref="HGNC:HGNC:3821"
                     /db_xref="MIM:602681"
                     /translation="MRLPRSLGHGQVRRGGRGRRRGKGERTGVHLLDSPDSTEENSIR
                     HNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAK
                     KKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPI
                     MASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTEN
                     LMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSL
                     RQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVS
                     AQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGL
                     SESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFN
                     GSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG"
     exon            980..2414
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..7362
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6556..6561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      6580
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
     regulatory      7335..7340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="hexamer: AATAAA"
     polyA_site      7362
                     /gene="FOXO3"
                     /gene_synonym="AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A"
                     /note="major polyA site"
ORIGIN      
        1 aggagagcgc gagagcccca gccgcgggcg ggcgggcggc gaagatggca gaggcaccgg
       61 cttccccggc cccgctctct ccgctcgaag tggagctgga cccggagttc gagccccaga
      121 gccgtccgcg atcctgtacg tggcccctgc aaaggccgga gctccaagcg agccctgcca
      181 agccctcggg ggagacggcc gccgactcca tgatccccga ggaggaggac gatgaagacg
      241 acgaggacgg cgggggacgg gccggctcgg ccatggcgat cggcggcggc ggcgggagcg
      301 gcacgctggg ctccgggctg ctccttgagg actcggcccg ggtgctggca cccggagggc
      361 aagaccccgg gtctgggcca gccaccgcgg cgggcgggct gagcgggggt acacaggcgc
      421 tgctgcagcc tcagcaaccg ctgccaccgc cgcagccggg ggcggctggg ggctccgggc
      481 agccgaggaa atgttcgtcg cggcggaacg cctggggaaa cctgtcctac gcggacctga
      541 tcacccgcgc catcgagagc tccccggaca aacggctcac tctgtcccag atctacgagt
      601 ggatggtgcg ttgcgtgccc tacttcaagg ataagggcga cagcaacagc tctgccggct
      661 ggaaggtgcg tacccacccc gggctggcag caggacccgc cgggcctcct gcgcagcgcg
      721 agacgcgtct cggattcgtc ggagtgcgct tgcgggctcc agggcaaggg gttggcaggg
      781 ggagcctccg ctgcgaggct ttgggggtta tctttgatcc ccggagtcgg ggcacctggg
      841 gacggtctcg gaggggtgaa tgaggctccc cagaagcttg gggcatggcc aggtgaggag
      901 agggggcagg ggacgccggc gagggaaggg cgaacggaca ggagtacatt tgctggattc
      961 tccggacagc accgaggaga actccatccg gcacaacctg tcactgcata gtcgattcat
     1021 gcgggtccag aatgagggaa ctggcaagag ctcttggtgg atcatcaacc ctgatggggg
     1081 gaagagcgga aaagcccccc ggcggcgggc tgtctccatg gacaatagca acaagtatac
     1141 caagagccgt ggccgcgcag ccaagaagaa ggcagccctg cagacagccc ccgaatcagc
     1201 tgacgacagt ccctcccagc tctccaagtg gcctggcagc cccacgtcac gcagcagtga
     1261 tgagctggat gcgtggacgg acttccgttc acgcaccaat tctaacgcca gcacagtcag
     1321 tggccgcctg tcgcccatca tggcaagcac agagttggat gaagtccagg acgatgatgc
     1381 gcctctctcg cccatgctct acagcagctc agccagcctg tcaccttcag taagcaagcc
     1441 gtgcacggtg gaactgccac ggctgactga tatggcaggc accatgaatc tgaatgatgg
     1501 gctgactgaa aacctcatgg acgacctgct ggataacatc acgctcccgc catcccagcc
     1561 atcgcccact gggggactca tgcagcggag ctctagcttc ccgtatacca ccaagggctc
     1621 gggcctgggc tccccaacca gctcctttaa cagcacggtg ttcggacctt catctctgaa
     1681 ctccctacgc cagtctccca tgcagaccat ccaagagaac aagccagcta ccttctcttc
     1741 catgtcacac tatggtaacc agacactcca ggacctgctc acttcggact cacttagcca
     1801 cagcgatgtc atgatgacac agtcggaccc cttgatgtct caggccagca ccgctgtgtc
     1861 tgcccagaat tcccgccgga acgtgatgct tcgcaatgat ccgatgatgt cctttgctgc
     1921 ccagcctaac cagggaagtt tggtcaatca gaacttgctc caccaccagc accaaaccca
     1981 gggcgctctt ggtggcagcc gtgccttgtc gaattctgtc agcaacatgg gcttgagtga
     2041 gtccagcagc cttgggtcag ccaaacacca gcagcagtct cctgtcagcc agtctatgca
     2101 aaccctctcg gactctctct caggctcctc cttgtactca actagtgcaa acctgcccgt
     2161 catgggccat gagaagttcc ccagcgactt ggacctggac atgttcaatg ggagcttgga
     2221 atgtgacatg gagtccatta tccgtagtga actcatggat gctgatgggt tggattttaa
     2281 ctttgattcc ctcatctcca cacagaatgt tgttggtttg aacgtgggga acttcactgg
     2341 tgctaagcag gcctcatctc agagctgggt gccaggctga aggatcactg aggaagggga
     2401 agtgggcaaa gcagaccctc aaactgacac aagacctaca gagaaaaccc tttgccaaat
     2461 ctgctctcag caagtggaca gtgataccgt ttacagctta acacctttgt gaatcccacg
     2521 ccattttcct aacccagcag agactgttaa tggcccctta ccctgggtga agcacttacc
     2581 cttggaacag aactctaaaa agtatgcaaa atcttccttg tacagggtgg tgagccgcct
     2641 gccagtggag gacagcaccc ctcagcacca cccaccctca ttcagagcac accgtgagcc
     2701 cccgtcggcc attctgtggt gttttaatat tgcgatggtt tatgggacgt tttaagtgtt
     2761 gttcttgtgt ttgttttcct ttgactttct gagtttttca catgcattaa cttgcggtat
     2821 ttttctgtta aaatgttaac cgtccttccc ctagcaaatt taaaaacaga aagaaaatgt
     2881 tgtaccagtt accattccgg gttcgagcat cacaagcttt tgagcgcatg gaactccata
     2941 aactaacaaa ttacataaac taaaggggga ttttctttct tcttttgttt ggtagaaaat
     3001 tatccttttc taaaaactga acaatggcac aattgtttgc tatgtgcacc cgtccaggac
     3061 agaaccgtgc ataggcaaaa ggagtggagc acagcgtccg gcccagtgtg tttccggttc
     3121 tgagtcaggg tgatctgtgg acgggacccc agcaccaagt ctacgggtgc cagatcagta
     3181 gggcctgtga tttcctgtca gtgtcctcag ctaatgtgaa cagtgttggt ctgctggtta
     3241 gaaactagaa tattgatatt ttcaggaaag aaatcagctc agctctccac tcattgccaa
     3301 atgtcactaa agggtttagt tttaaggaga aagaaaagga aaaaaaaaaa aaacaaaaaa
     3361 gtcctgtttt gctttgcaga acaaatgaac ttacaggtga gcattaagct tgcagtgaga
     3421 aatgtgcgaa gagtaaaaac ccaagtcaat gctgaggcag ttctaacttc actgttttcc
     3481 taaatacaca tccttgatta ttttcagcct tgctatataa tctgatctgc tagaagtgta
     3541 tgagtgagag gcaatagcat acaaactgat tttttaaata taagcttagg ttgtaattgt
     3601 acaagtgact caatggaagt acaaaatagg gcagttttaa cttttttttc tgcttctatg
     3661 gatttcattt tgttgtgttt tcaaaaagtt atggtgctgt ataggtgctt tctgtttaac
     3721 ctggaaagtg tgattatatt cgttaccttc tttggtagac ggaatagttg ggaccacctt
     3781 tggtacataa gaaattggta taacgatgct ctgattagca cagtatatgc atacttctcc
     3841 aaagtgatat atgaagactc ttttctttgc ataaaaagca ttaggcatat aaatgtataa
     3901 atatatttta tcatgtacag tacaaaaatg gaaccttatg catgggcctt aggaatacag
     3961 gctagtattt cagcacagac ttccctgctt gagttcttgc tgatgcttgc accgtgacag
     4021 tgggcaccaa cacagacgtg ccacccaacc ccctgcacac accaccggcc accaggggcc
     4081 cccttgtgcg ccttggcttt ataactcctc tgggggtgat attggtggtg atcacagctc
     4141 ctagcataat gagagttcca tttggtattg tcacacgtct cctgcctcgc ttgggttgcc
     4201 atgtttgagc gatggccctg ttgatttcac cctgcctttt actgaatctg taaattgttg
     4261 tgcaattgtg gttatagtag actgtagcac attgcctttt ctaaactgct acatgtttat
     4321 aatcttcatt tttaaagtat gtgtaatttt tttaagtatg tattctattc atatggtctg
     4381 cttgtcagtg agccagactt gcttactata ttcctttata ataatgctag ccacttcctg
     4441 gattctttag taatgtgctg tatgcaagaa ctttccagta gcagtgaagg agggttgcct
     4501 ctccaagctt cctaagggat gctgccctgt gtggggatgc attgcagagg cactagtagc
     4561 atgggggcta gagtggggag cgagatgtaa aagggtgggg ggataggaga attccagagt
     4621 gcttccagca ttagggtcct gagaacttct gagttcagag aaacatgcaa agtgactaac
     4681 aaaatagcta cttacctttg cagttttaca gaccctggga gctgctttgg gagtgagaaa
     4741 ggcaaccctc caatgtgttt caactttaaa atgttgaatt cttttcagac atggtatctc
     4801 atttattctc cttttctagc gtttgttgaa tttcaggcag aatgtcttac agaatgtcct
     4861 agaaccagat tatcatttaa tctgaaacag ctgaggaagg gacagagaag gtacaagggc
     4921 aaggcagcac aaaacagatc aggagaatga agagggaatg ctttggtttt ttgttttgtt
     4981 ttgttttttc tttttcaagt aactaaaaca gcatctacat gtagagtgtt gtggagagct
     5041 gagaccaggg taaagtcaag tgcagcatca gtactgcgag acccaccagc ccctggagag
     5101 ggtcagccga gaatctggta gtgaagcctg tctagggtcc cggcaccctc accctcagcc
     5161 acctgcagag aggccagggc cccagagact agcctggttc tgaagtgggc aggggtgctg
     5221 ccagagccct ctgcccctta tgttgagacc ctgctttcag gacaggccag ccgttggcca
     5281 ccatgtcaca ttctgagtga gtgtcacagg tccctaacaa taattttctg atctggagca
     5341 tatcagcaga atgcttagcc tcaaggggcc tggcagctgt aatgtttgat ttatgatgag
     5401 aactatccga ggccaccctt ggcctctaaa taagctgctc tagggagccg cctacttttt
     5461 gatgagaaat tagaagagta cctaatgttg aaaacatgac atgcgctctt gggatctgct
     5521 gttctctcca gggctccaga acctgatacc tgttaccaaa gctaggaaag agctttatca
     5581 caagccttca ctgtcctggc atgagaactg gctgccaggc tcagtgtacc ccattaactg
     5641 tgaatgaatc tgagcttggt ttcctttatt gcttcctctg caatatgatt gctgaaacac
     5701 attttaaaaa ttcagaagct tgtcactcct gttaatggga ggatcagtca cacatgtgta
     5761 gtacaaggcg gactttgtgt ttgtttttgg tgttaatttt tagcattgtg tgtgttgctt
     5821 ccccaccctg aggagaggac accatggctt actactcagg acaagtatgc cccgctcagg
     5881 gtgtgatttc aggtggcttc caaacttgta cgcagtttaa agatggtggg gacagacttt
     5941 gcctctacct agtgaacccc acttaaagaa taaggagcat ttgaatctct tggaaaaggc
     6001 catgaagaat aaagcagtca aaaagaagtc ctccatgttg gtgccaagga cttgcgaggg
     6061 gaaataaaaa tgttatccag cctgaccaac atggagaaac cccgtctcca ttaaaaatac
     6121 aaaattagcc tggcatggtg gcgcatgcct gtaatcccag ctactctgga ggctgaggca
     6181 ggagaatcgc ttgaacccag gaggcggagg tcgcagtgag ccgagatcat gccagtgcac
     6241 tccagcctgg gtaacaagag tgaaactccg tgtcaaaaaa aaaaaaaaaa tgttactcat
     6301 cctctctgaa agcaaaaagg aaaccctaac agctctgaac tctggtttta tttttcttgc
     6361 tgtatttggg tgaacattgt atgattaggc ataatgttaa aaaaaaaaat ttttttttgg
     6421 tagaaatgca atcaccagta aagaggtacg aaaaagctag cctctctcag agaccgggga
     6481 ggcagagtac tactagagga agtgaagttc tgatggaatc atgcctgtca aatgaggtct
     6541 tgaagcggat gcccaaataa aagagtatat tttatctaaa tcttaagtgg gtaacatttt
     6601 atgcagttta aatgaatgga atattttcct cttgtttagt tgtatctgtt tgtatttttc
     6661 tttgatgaat gattggtcat gaggcctctt gccacactcc agaaatacgt gtgcggctgc
     6721 ttttaagaac tatgtgtctg gtcacttatt tctctaaaat tatctcattg cctggcaatc
     6781 agtcttctct tgtatacttg tcctagcaca ttatgtacat gggaaatgta aacaaatgtg
     6841 aaggaggacc agaaaaatta gttaatattt aaaaaaatgt attgtgcatt ttggcttcac
     6901 atgtttaact ttttttaaga aaaaagttgc atgaatggaa aaaaaaatct gtatacagta
     6961 tctgtaaaaa ctatcttatc tgtttcaatt ccttgctcat atcccatata atctagaact
     7021 aaatatggtg tgtggccata tttaaacacc tgagagtcaa gcagttgaga ctttgatttg
     7081 aagcacctca tccttctttc aatgcgaaca ctatcatatg gcattcttac tgaggatttt
     7141 gtctaaccat atgttgccat gaattaactc tgccgccttt cttaaggatc aaaaccagtt
     7201 tgatttggga atcttcccct ttccaaatga aatagagatg cagtacttaa ctttccttgg
     7261 tgtttgtaga tattgccttg tgtattccac ttaaaaccgt aatctagttt gtaaaagaga
     7321 tggtgacgca tgtaaataaa gcatcagtga cactctatct ta
//
