LOCUS       NM_002015               5779 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens forkhead box O1 (FOXO1), mRNA.
ACCESSION   NM_002015
VERSION     NM_002015.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5779)
  AUTHORS   Ren,C., Xi,L., Li,H., Pan,Z., Li,Y., Wang,G., Dai,J., He,D., Fan,S.
            and Wang,Q.
  TITLE     Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury
            under chronic hypoxia in Tetralogy of Fallot by maintaining
            mitochondrial quality control
  JOURNAL   Life Sci 357, 123084 (2024)
   PUBMED   39374570
  REMARK    GeneRIF: Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte
            injury under chronic hypoxia in Tetralogy of Fallot by maintaining
            mitochondrial quality control.
REFERENCE   2  (bases 1 to 5779)
  AUTHORS   Qin,H., Chen,S., Liu,X., Liang,J., Wu,H. and Zhu,X.
  TITLE     miR-132-3p downregulates FOXO1 in CD4+ T cells and is associated
            with disease manifestations in patients with lupus
  JOURNAL   J Int Med Res 52 (10), 3000605241286762 (2024)
   PUBMED   39429035
  REMARK    GeneRIF: miR-132-3p downregulates FOXO1 in CD4[+] T cells and is
            associated with disease manifestations in patients with lupus.
REFERENCE   3  (bases 1 to 5779)
  AUTHORS   Chen,J., Chen,K., Zhang,S. and Huang,X.
  TITLE     SIRT1 silencing ameliorates malignancy of non-small cell lung
            cancer via activating FOXO1
  JOURNAL   Sci Rep 14 (1), 19948 (2024)
   PUBMED   39198693
  REMARK    GeneRIF: SIRT1 silencing ameliorates malignancy of non-small cell
            lung cancer via activating FOXO1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5779)
  AUTHORS   Niu,Q., Lin,C., Yang,S., Rong,S., Wei,J., Zhao,T., Peng,Y.,
            Cheng,Z., Xie,Y. and Wang,Y.
  TITLE     FoxO1-Overexpressed Small Extracellular Vesicles Derived from
            hPDLSCs Promote Periodontal Tissue Regeneration by Reducing
            Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation
  JOURNAL   Int J Nanomedicine 19, 8751-8768 (2024)
   PUBMED   39220194
  REMARK    GeneRIF: FoxO1-Overexpressed Small Extracellular Vesicles Derived
            from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing
            Mitochondrial Dysfunction to Regulate Osteogenesis and
            Inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5779)
  AUTHORS   Shafaati,T. and Gopal,K.
  TITLE     Forkhead box O1 transcription factor; a therapeutic target for
            diabetic cardiomyopathy
  JOURNAL   J Pharm Pharm Sci 27, 13193 (2024)
   PUBMED   39206323
  REMARK    GeneRIF: Forkhead box O1 transcription factor; a therapeutic target
            for diabetic cardiomyopathy.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5779)
  AUTHORS   Scheidler,S., Fredericks,W.J., Rauscher,F.J. 3rd, Barr,F.G. and
            Vogt,P.K.
  TITLE     The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma
            transforms fibroblasts in culture
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9805-9809 (1996)
   PUBMED   8790412
REFERENCE   7  (bases 1 to 5779)
  AUTHORS   Davis,R.J., Bennicelli,J.L., Macina,R.A., Nycum,L.M., Biegel,J.A.
            and Barr,F.G.
  TITLE     Structural characterization of the FKHR gene and its rearrangement
            in alveolar rhabdomyosarcoma
  JOURNAL   Hum Mol Genet 4 (12), 2355-2362 (1995)
   PUBMED   8634710
REFERENCE   8  (bases 1 to 5779)
  AUTHORS   Sublett,J.E., Jeon,I.S. and Shapiro,D.N.
  TITLE     The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a
            transcriptional activator
  JOURNAL   Oncogene 11 (3), 545-552 (1995)
   PUBMED   7630639
REFERENCE   9  (bases 1 to 5779)
  AUTHORS   Fredericks,W.J., Galili,N., Mukhopadhyay,S., Rovera,G.,
            Bennicelli,J., Barr,F.G. and Rauscher,F.J. 3rd.
  TITLE     The PAX3-FKHR fusion protein created by the t(2;13) translocation
            in alveolar rhabdomyosarcomas is a more potent transcriptional
            activator than PAX3
  JOURNAL   Mol Cell Biol 15 (3), 1522-1535 (1995)
   PUBMED   7862145
REFERENCE   10 (bases 1 to 5779)
  AUTHORS   Galili,N., Davis,R.J., Fredericks,W.J., Mukhopadhyay,S.,
            Rauscher,F.J. 3rd, Emanuel,B.S., Rovera,G. and Barr,F.G.
  TITLE     Fusion of a fork head domain gene to PAX3 in the solid tumour
            alveolar rhabdomyosarcoma
  JOURNAL   Nat Genet 5 (3), 230-235 (1993)
   PUBMED   8275086
  REMARK    Erratum:[Nat Genet 1994 Feb;6(2):214]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355132.19, AF032885.1 and
            AL133318.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002015.3.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which are characterized by a distinct forkhead domain.  The
            specific function of this gene has not yet been determined;
            however, it may play a role in myogenic growth and differentiation.
            Translocation of this gene with PAX3 has been associated with
            alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF032885.1, U02310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379561.6/ ENSP00000368880.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AL355132.19        61275-61318         c
            45-2542             AF032885.1         1-2498
            2543-4380           AF032885.1         2500-4337
            4381-5779           AL133318.11        39123-40521         c
FEATURES             Location/Qualifiers
     source          1..5779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..5779
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /note="forkhead box O1"
                     /db_xref="GeneID:2308"
                     /db_xref="HGNC:HGNC:3819"
                     /db_xref="MIM:136533"
     exon            1..1059
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..2397
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /note="forkhead, Drosophila, homolog of, in
                     rhabdomyosarcoma; forkhead box protein O1A"
                     /codon_start=1
                     /product="forkhead box protein O1"
                     /protein_id="NP_002006.2"
                     /db_xref="CCDS:CCDS9371.1"
                     /db_xref="GeneID:2308"
                     /db_xref="HGNC:HGNC:3819"
                     /db_xref="MIM:136533"
                     /translation="MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAP
                     SGSAAANPDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAA
                     TGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAW
                     GNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLS
                     LHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKAS
                     LQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTE
                     QDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQ
                     SSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYG
                     GMSQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYG
                     SQASHNKMMNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPL
                     PHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMD
                     GDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG"
     exon            1060..2411
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..5779
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5648..5653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /note="hexamer: TATAAA"
     regulatory      5666..5671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /note="hexamer: CATAAA"
     polyA_site      5676
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
     polyA_site      5686
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /note="major polyA site"
     regulatory      5749..5754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /note="hexamer: ATTAAA"
     polyA_site      5779
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /note="major polyA site"
ORIGIN      
        1 gatcccgtaa gtcgggcggc ctggtagtcg cagcagccgc tgccgcagcc gccacattca
       61 acaggcagca gcgcagcggg cgcgccgctg gggagagcaa gcggcccgcg gcgtccgtcc
      121 gtccttccgt ccgcggccct gtcagctgga gcgcggcgca ggctctgccc cggcccggcg
      181 gctctggccg gccgtccagt ccgtgcggcg gaccccgagg agcctcgatg tggatggccc
      241 cgcgaagtta agttctgggc tcgcgcttcc actccgccgc gccttcctcc cagtttccgt
      301 ccgctcgccg caccggcttc gttcccccaa atctcggacc gtcccttcgc gccccctccc
      361 cgtccgcccc cagtgctgcg ttctccccct cttggctctc ctgcggctgg gggaggggcg
      421 ggggtcacca tggccgaggc gcctcaggtg gtggagatcg acccggactt cgagccgctg
      481 ccccggccgc gctcgtgcac ctggccgctg cccaggccgg agtttagcca gtccaactcg
      541 gccacctcca gcccggcgcc gtcgggcagc gcggctgcca accccgacgc cgcggcgggc
      601 ctgccctcgg cctcggctgc cgctgtcagc gccgacttca tgagcaacct gagcttgctg
      661 gaggagagcg aggacttccc gcaggcgccc ggctccgtgg cggcggcggt ggcggcggcg
      721 gccgccgcgg ccgccaccgg ggggctgtgc ggggacttcc agggcccgga ggcgggctgc
      781 ctgcacccag cgccaccgca gcccccgccg cccgggccgc tgtcgcagca cccgccggtg
      841 ccccccgccg ccgctgggcc gctcgcgggg cagccgcgca agagcagctc gtcccgccgc
      901 aacgcgtggg gcaacctgtc ctacgccgac ctcatcacca aggccatcga gagctcggcg
      961 gagaagcggc tcacgctgtc gcagatctac gagtggatgg tcaagagcgt gccctacttc
     1021 aaggataagg gtgacagcaa cagctcggcg ggctggaaga attcaattcg tcataatctg
     1081 tccctacaca gcaagttcat tcgtgtgcag aatgaaggaa ctggaaaaag ttcttggtgg
     1141 atgctcaatc cagagggtgg caagagcggg aaatctccta ggagaagagc tgcatccatg
     1201 gacaacaaca gtaaatttgc taagagccga agccgagctg ccaagaagaa agcatctctc
     1261 cagtctggcc aggagggtgc tggggacagc cctggatcac agttttccaa atggcctgca
     1321 agccctggct ctcacagcaa tgatgacttt gataactgga gtacatttcg ccctcgaact
     1381 agctcaaatg ctagtactat tagtgggaga ctctcaccca ttatgaccga acaggatgat
     1441 cttggagaag gggatgtgca ttctatggtg tacccgccat ctgccgcaaa gatggcctct
     1501 actttaccca gtctgtctga gataagcaat cccgaaaaca tggaaaatct tttggataat
     1561 ctcaaccttc tctcatcacc aacatcatta actgtttcga cccagtcctc acctggcacc
     1621 atgatgcagc agacgccgtg ctactcgttt gcgccaccaa acaccagttt gaattcaccc
     1681 agcccaaact accaaaaata tacatatggc caatccagca tgagcccttt gccccagatg
     1741 cctatacaaa cacttcagga caataagtcg agttatggag gtatgagtca gtataactgt
     1801 gcgcctggac tcttgaagga gttgctgact tctgactctc ctccccataa tgacattatg
     1861 acaccagttg atcctggggt agcccagccc aacagccggg ttctgggcca gaacgtcatg
     1921 atgggcccta attcggtcat gtcaacctat ggcagccagg catctcataa caaaatgatg
     1981 aatcccagct cccataccca ccctggacat gctcagcaga catctgcagt taacgggcgt
     2041 cccctgcccc acacggtaag caccatgccc cacacctcgg gtatgaaccg cctgacccaa
     2101 gtgaagacac ctgtacaagt gcctctgccc caccccatgc agatgagtgc cctggggggc
     2161 tactcctccg tgagcagctg caatggctat ggcagaatgg gccttctcca ccaggagaag
     2221 ctcccaagtg acttggatgg catgttcatt gagcgcttag actgtgacat ggaatccatc
     2281 attcggaatg acctcatgga tggagataca ttggatttta actttgacaa tgtgttgccc
     2341 aaccaaagct tcccacacag tgtcaagaca acgacacata gctgggtgtc aggctgaggg
     2401 ttagtgagca ggttacactt aaaagtactt cagattgtct gacagcagga actgagagaa
     2461 gcagtccaaa gatgtctttc accaactccc ttttagtttt cttggttaaa aaaaaaaaca
     2521 aaaaaaaaaa ccctcctttt ttcctttcgt cagacttggc agcaaagaca tttttcctgt
     2581 acaggatgtt tgcccaatgt gtgcaggtta tgtgctgctg tagataagga ctgtgccatt
     2641 ggaaatttca ttacaatgaa gtgccaaact cactacacca tataattgca gaaaagattt
     2701 tcagatcctg gtgtgctttc aagttttgta tataagcagt agatacagat tgtatttgtg
     2761 tgtgtttttg gtttttctaa atatccaatt ggtccaagga aagtttatac tctttttgta
     2821 atactgtgat gggcctcatg tcttgataag ttaaactttt gtttgtacta cctgttttct
     2881 gcggaactga cggatcacaa agaactgaat ctccattctg catctccatt gaacagcctt
     2941 ggacctgttc acgttgccac agaattcaca tgagaaccaa gtagcctgtt atcaatctgc
     3001 taaattaatg gacttgttaa acttttggaa aaaaaaagat taaatgccag ctttgtacag
     3061 gtcttttcta tttttttttg tttattttgt tatttgcaaa tttgtacaaa catttaaatg
     3121 gttctaattt ccagataaat gatttttgat gttattgttg ggacttaaga acatttttgg
     3181 aatagatatt gaactgtaat aatgttttct taaaactaga gtctactttg ttacatagtc
     3241 agcttgtaaa ttttgtggaa ccacaggtat ttggggcagc attcataatt ttcattttgt
     3301 attctaactg gattagtact aattttatac atgcttaact ggtttgtaca ctttgggatg
     3361 ctacttagtg atgtttctga ctaatcttaa atcattgtaa ttagtacttg catattcaac
     3421 gtttcaggcc ctggttgggc aggaaagtga tgtatagtta tggacacttt gcgtttctta
     3481 tttaggataa cttaatatgt ttttatgtat gtattttaaa gaaatttcat ctgcttctac
     3541 tgaactatgc gtactgcata gcatcaagtc ttctctagag acctctgtag tcctgggagg
     3601 cctcataatg tttgtagatc agaaaaggga gatctgcatc taaagcaatg gtcctttgtc
     3661 aaacgaggga ttttgatcca cttcaccatt ttgagttgag ctttagcaaa agtttcccct
     3721 cataattctt tgctcttgtt tcagtccagg tggaggttgg ttttgtagtt ctgccttgag
     3781 gaattatgtc aacactcata cttcatctca ttctcccttc tgccctgcag attagattac
     3841 ttagcacact gtggaagttt aagtggaagg agggaattta aaaatgggac ttgagtggtt
     3901 tgtagaattt gtgttcataa gttcagatgg gtagcaaatg gaatagaact tacttaaaaa
     3961 ttggggagat ttatttgaaa accagctgta agttgtgcat tgagattatg ttaaaagcct
     4021 tggcttaaga atttgaaaat ttctttagcc tgtagcaacc taaactgtaa ttcctatcat
     4081 tatgttttat tactttccaa ttacctgtaa ctgacagacc aaattaattg gctttgtgtc
     4141 ctatttagtc catcagtatt ttcaagtcat gtggaaagcc caaagtcatc acaatgaaga
     4201 gaacaggtgc acagcactgt tcctcttgtg ttcttgagaa ggatctaatt tttctgtata
     4261 tagcccacat cacacttgct ttgtcttgta tgttaattgc atcttcattg gcttggtatt
     4321 tcctaaatgt ttaacaagaa cacaagtgtt cctgataaga tttcctacag taagccagct
     4381 ctattgtaag cttcccactg tgatgatcat ttttttgaag attcattgaa cagccaccac
     4441 tctatcatcc tcattttggg gcagtccaag acatagctgg ttttagaaac ccaagttcct
     4501 ctaagcacag cctcccgggt atgtaactga acttggtgcc aaagtacttg tgtactaatt
     4561 tctattacta cgtactgtca ctttcctccc gtgccattac tgcatcataa tacaaggaac
     4621 ctcagagccc ccatttgttc attaaagagg caactacagc caaaatcact gttaaaatct
     4681 tactacttca tggagtagct cttaggaaaa tatatcttcc tcctgagtct gggtaattat
     4741 acctctccca agcccccatt gtgtgttgaa atcctgtcat gaatccttgg tagctctctg
     4801 agaacagtga agtccaggga aaggcatctg gtctgtctgg aaagcaaaca ttatgtggcc
     4861 tctggtagtt tttttcctgt aagaatactg actttctgga gtaatgagta tatatcagtt
     4921 attgtacatg attgctttgt gaaatgtgca aatgatatca cctatgcagc cttgtttgat
     4981 ttattttctc tggtttgtac tgttattaaa agcatattgt attatagagc tattcagata
     5041 ttttaaatat aaagatgtat tgtttccgta atatagacgt atggaatata tttaggtaat
     5101 agatgtatta cttggaaagt tctgctttga caaactgaca aagtctaaat gagcacatgt
     5161 atcccagtga gcagtaaatc aatggaacat cccaagaaga ggataaggat gcttaaaatg
     5221 gaaatcattc tccaacgata tacaaattgg acttgttcaa ctgctggata tatgctacca
     5281 ataaccccag ccccaactta aaattcttac attcaagctc ctaagagttc ttaatttata
     5341 actaatttta aaagagaagt ttcttttctg gttttagttt gggaataatc attcattaaa
     5401 aaaaatgtat tgtggtttat gcgaacagac caacctggca ttacagttgg cctctccttg
     5461 aggtgggcac agcctggcag tgtggccagg ggtggccatg taagtcccat caggacgtag
     5521 tcatgcctcc tgcatttcgc tacccgagtt tagtaacagt gcagattcca cgttcttgtt
     5581 ccgatactct gagaagtgcc tgatgttgat gtacttacag acacaagaac aatctttgct
     5641 ataattgtat aaagccataa atgtacataa attatgttta aatggcttgg tgtctttctt
     5701 ttctaattat gcagaataag ctctttatta ggaatttttt gtgaagctat taaatacttg
     5761 agttaagtct tgtcagcca
//
