LOCUS       NM_213596               3416 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens forkhead box N4 (FOXN4), mRNA.
ACCESSION   NM_213596
VERSION     NM_213596.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3416)
  AUTHORS   Wang,J., Deng,M., Yang,J., Zhou,X., Yang,P., Li,Y. and Zhang,G.
  TITLE     FOXN4 affects myocardial ischemia-reperfusion injury through
            HIF-1alpha/MMP2-mediated ferroptosis of cardiomyocytes
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (6), 214-225 (2023)
   PUBMED   37605566
  REMARK    GeneRIF: FOXN4 affects myocardial ischemia-reperfusion injury
            through HIF-1alpha/MMP2-mediated ferroptosis of cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3416)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3416)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3416)
  AUTHORS   Kim,J., Choi,T.I., Park,S., Kim,M.H., Kim,C.H. and Lee,S.
  TITLE     Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30177510
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3416)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3416)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3416)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   8  (bases 1 to 3416)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Characterization of human FOXN4 gene in silico
  JOURNAL   Int J Mol Med 14 (5), 949-953 (2004)
   PUBMED   15492871
REFERENCE   9  (bases 1 to 3416)
  AUTHORS   Danilova,N., Visel,A., Willett,C.E. and Steiner,L.A.
  TITLE     Expression of the winged helix/forkhead gene, foxn4, during
            zebrafish development
  JOURNAL   Brain Res Dev Brain Res 153 (1), 115-119 (2004)
   PUBMED   15464224
REFERENCE   10 (bases 1 to 3416)
  AUTHORS   Li,S., Mo,Z., Yang,X., Price,S.M., Shen,M.M. and Xiang,M.
  TITLE     Foxn4 controls the genesis of amacrine and horizontal cells by
            retinal progenitors
  JOURNAL   Neuron 43 (6), 795-807 (2004)
   PUBMED   15363391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012384.16, BC146825.1, AK131519.1, AF425596.1 and AA421288.1.
            
            On Nov 23, 2018 this sequence version replaced NM_213596.2.
            
            Summary: Members of the winged-helix/forkhead family of
            transcription factors, such as FOXN4, are characterized by a
            110-amino acid DNA-binding domain that can fold into a variant of
            the helix-turn-helix motif consisting of 3 alpha helices flanked by
            2 large loops or wings. These transcription factors are involved in
            a variety of biologic processes as key regulators in development
            and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by
            OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299162.10/ ENSP00000299162.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC012384.16        129479-129542
            65-242              BC146825.1         2-179
            243-255             AK131519.1         179-191
            256-564             BC146825.1         193-501
            565-1633            AF425596.1         276-1344
            1634-3414           BC146825.1         1571-3351
            3415-3416           AA421288.1         5-6                 c
FEATURES             Location/Qualifiers
     source          1..3416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..3416
                     /gene="FOXN4"
                     /note="forkhead box N4"
                     /db_xref="GeneID:121643"
                     /db_xref="HGNC:HGNC:21399"
                     /db_xref="MIM:609429"
     exon            1..166
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            167..255
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1723
                     /gene="FOXN4"
                     /note="forkhead/winged helix transcription factor FOXN4"
                     /codon_start=1
                     /product="forkhead box protein N4"
                     /protein_id="NP_998761.2"
                     /db_xref="CCDS:CCDS9126.2"
                     /db_xref="GeneID:121643"
                     /db_xref="HGNC:HGNC:21399"
                     /db_xref="MIM:609429"
                     /translation="MIESDTSSIMSGIIRNSGQNHHPSPQEYRLLATTSDDDLPGDLQ
                     SLSWLTAVDVPRLQQMASGRVDLGGPCVPHPHPGALAGVADLHVGATPSPLLHGPAGM
                     APRGMPGLGPITGHRDSMSQFPVGGQPSSGLQDPPHLYSPATQPQFPLPPGAQQCPPV
                     GLYGPPFGVRPPYPQPHVAVHSSQELHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSE
                     IYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNLARID
                     KMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKPGEPEAPVLTHATTV
                     AVAHGCLAVSQLPPQPLMTLSLQSVPLHHQVQPQAHLAPDSPAPAQTPPLHALPDLSP
                     SPLPHPAMGRAPVDFINISTDMNTEVDALDPSIMDFALQGNLWEEMKDEGFSLDTLGA
                     FADSPLGCDLGASGLTPASGGSDQSFPDLQVTGLYTAYSTPDSVAASGTSSSSQYLGA
                     QGNKPIALL"
     exon            256..401
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            402..526
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            527..637
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            638..765
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            766..862
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1070
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1463
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..3416
                     /gene="FOXN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3399..3404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN4"
                     /note="hexamer: AATAAA"
     polyA_site      3416
                     /gene="FOXN4"
                     /note="major polyA site"
ORIGIN      
        1 atgctctgag ctggacagct ccagagaggg aaatttaaaa acggttcgag ctgcgacggc
       61 ggccaaattg cggaacgcga ggggcgagcg cgagggagcc cccctccgga acccctgccc
      121 acccccggag cgccggcagc ggcggccccg cgaggatcgg ctccaggaga tgatagaaag
      181 tgacacctca tccataatgt caggaattat tcgaaactca gggcaaaatc accacccctc
      241 tccacaggaa tacaggcttc tagccaccac cagcgatgat gaccttcccg gggacctgca
      301 gtcgctgtcg tggctcacgg cggtggatgt gcctcggctg cagcagatgg caagtggccg
      361 cgtggacctg ggtggcccct gcgtgccaca tccacaccca ggtgccttgg ctggggtggc
      421 cgacctgcat gtgggagcca ctccaagtcc ccttctccat ggcccagcag gcatggcccc
      481 ccgaggcatg ccaggtctgg gccccataac tggccacaga gacagcatga gccagttccc
      541 cgtggggggc cagccctcat ctggcctgca ggacccgccg catctgtact cacctgccac
      601 ccaaccacag ttcccgctcc ccccgggtgc ccagcagtgc cctcctgtgg gcctctatgg
      661 ccccccattt ggggtgcggc ccccctaccc ccagccccac gtggctgtgc attcatctca
      721 agaactgcac cccaaacact accccaagcc catctactcg tacagctgtc tgatcgccat
      781 ggccctgaag aacagcaaga caggcagcct gcctgtgagc gagatctaca gcttcatgaa
      841 ggagcacttc ccctacttca agacggcccc cgacgggtgg aagaactcgg tgcggcacaa
      901 cctgtctctg aacaagtgct tcgagaaggt ggagaacaag atgagcggct cctcccgcaa
      961 gggctgcctg tgggctctga acctggcccg catcgacaag atggaggagg agatgcacaa
     1021 gtggaagagg aaggacctgg ctgccatcca ccggagtatg gccaaccctg aggagttgga
     1081 caagctgatc tccgaccggc ctgaaagctg ccggcgcccc ggcaaaccgg gggaaccaga
     1141 ggcccccgtg ctgactcacg ccaccacagt ggccgtggcg catggctgcc tggctgtctc
     1201 ccagctccca ccccagccac tgatgaccct gtccctgcag tcagtccccc tgcaccacca
     1261 ggtccagccc caggcacatc ttgctccaga ctctccagca ccagcccaga ccccgccact
     1321 gcacgccctg ccggacctca gccccagccc gctcccccac cccgccatgg gaagggctcc
     1381 tgtagacttc atcaacatca gcaccgacat gaacactgag gtggatgccc tcgacccgag
     1441 catcatggac ttcgctctgc aggggaacct gtgggaggag atgaaggatg agggattcag
     1501 cttggacaca ctgggcgcct ttgcagactc cccgcttggc tgtgacctgg gggcctcagg
     1561 cctaacccct gcctcgggtg gcagcgacca gtccttccca gacttgcagg tgacgggtct
     1621 ctacacagcg tactccactc cggacagtgt ggctgcatcg ggcaccagct cctcctccca
     1681 gtacctgggt gcacagggga acaagcctat agccctgctt tgagctgtca gcctcacctg
     1741 ccctggaacc ccggcacccg gcttgggcag agaactgact agaacagggt gttcccagaa
     1801 ggcaggtccc tcattgtccc cgaagcctct cctggacctg tggcgaagtt gccggctgga
     1861 cagggaagcg gttcccctca gcagcccctc tccttctcgt gcctccccct ggagcttccg
     1921 gagcagtttc tgggggctct tccaagtcag aagaatggag gaaggtggac aagcaaccca
     1981 gcatcccccg accccttgac actcctccga ggcctgagcc gcaatgcctg cccgtgttga
     2041 gtgagacttc tccatcctgg atcctggctg cgtgacctca gtgacctgca ccccattttg
     2101 ggacaccttg gtgcattaag gaaacaccct ggggtgaaag cccttgaatt catcctcatg
     2161 ggaaatggct gagtggatca aacctcagcc gcagcctccg ggggacaggc ccagggcggg
     2221 aaatggagcc ggagaagctt gagcctctct cttggacagg acaagctgaa ctctgaaatg
     2281 ggagccggtc caggtggcct tcagccccac ctttccgata gtctgttaga attttattag
     2341 cgcagattcc tgggccatgc cgggtaccgt gaccttgtgt aaatttattt atatttattg
     2401 tggcccatcc accccacttc tgcaaaccca tcccgaggcc tctggaatgg gactccttct
     2461 ccctccctac ctcccagcca tcctaactcc tacaggccag agaatgacat ctctaactgg
     2521 ctcataatcc cttggcagcc tggggctact ttttagaacc agcaagcact gttgatactg
     2581 tgaaacatcc cattttttcc gtattagaga ccagatattt ttctacctgt tcatgattca
     2641 catctcttct tgcatgtacc taagaggggc ggtgccattg tttgggggct tggggggctt
     2701 tcaaagggga aaatgcgatg ggagagggag gaactggagg ggggtgcttt tgtactggga
     2761 tttaagacac ccctgatgga atgaaagcca actgaaccac gtaaagctcg aaccacgtgg
     2821 caagtggtgg acaaaacttc aacgcatgat atttattggc acttcctcac ctccctttgc
     2881 cctgcagctg tttttatgct tctttttctc tccttgctaa ttactgactc cccaagtggc
     2941 aagttccgca gatagctggg ttagaagaga gacaggggag tgagctagtc aaatgtgaaa
     3001 aatgctctcc cagcaaagct gagacaaaat tggagaagct gcagcctcac gcaccatccc
     3061 cctctttcca ccagatggat gttgacttgg tgtctgggag ttcccgaacc ctagagccag
     3121 gatgttctgt ttaatcaaca gctcagccag ctgcctggga gttttggcat taagccccgc
     3181 cttgaagggc gagctttaag tttttcccag ttctggaact ttctaccgag tatccaccac
     3241 ccttagacac aatcccagtg ctacccgtct gacctgcact gctcatctgc tttgtgtaac
     3301 atgacccctg ataagatgtt gaaactgtta ttcacaaaga ctccgtgttt gggcaacatc
     3361 aagactgtaa gtgtagaatt gagcaactgt cttctatcaa taaaggctga atggca
//
