LOCUS       NP_998761                517 aa            linear   PRI 28-APR-2025
DEFINITION  forkhead box protein N4 [Homo sapiens].
ACCESSION   NP_998761
VERSION     NP_998761.2
DBSOURCE    REFSEQ: accession NM_213596.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 517)
  AUTHORS   Wang,J., Deng,M., Yang,J., Zhou,X., Yang,P., Li,Y. and Zhang,G.
  TITLE     FOXN4 affects myocardial ischemia-reperfusion injury through
            HIF-1alpha/MMP2-mediated ferroptosis of cardiomyocytes
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (6), 214-225 (2023)
   PUBMED   37605566
  REMARK    GeneRIF: FOXN4 affects myocardial ischemia-reperfusion injury
            through HIF-1alpha/MMP2-mediated ferroptosis of cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 517)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 517)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 517)
  AUTHORS   Kim,J., Choi,T.I., Park,S., Kim,M.H., Kim,C.H. and Lee,S.
  TITLE     Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30177510
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 517)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (residues 1 to 517)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (residues 1 to 517)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   8  (residues 1 to 517)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Characterization of human FOXN4 gene in silico
  JOURNAL   Int J Mol Med 14 (5), 949-953 (2004)
   PUBMED   15492871
REFERENCE   9  (residues 1 to 517)
  AUTHORS   Danilova,N., Visel,A., Willett,C.E. and Steiner,L.A.
  TITLE     Expression of the winged helix/forkhead gene, foxn4, during
            zebrafish development
  JOURNAL   Brain Res Dev Brain Res 153 (1), 115-119 (2004)
   PUBMED   15464224
REFERENCE   10 (residues 1 to 517)
  AUTHORS   Li,S., Mo,Z., Yang,X., Price,S.M., Shen,M.M. and Xiang,M.
  TITLE     Foxn4 controls the genesis of amacrine and horizontal cells by
            retinal progenitors
  JOURNAL   Neuron 43 (6), 795-807 (2004)
   PUBMED   15363391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012384.16, BC146825.1, AK131519.1, AF425596.1 and AA421288.1.
            
            On Feb 2, 2008 this sequence version replaced NP_998761.1.
            
            Summary: Members of the winged-helix/forkhead family of
            transcription factors, such as FOXN4, are characterized by a
            110-amino acid DNA-binding domain that can fold into a variant of
            the helix-turn-helix motif consisting of 3 alpha helices flanked by
            2 large loops or wings. These transcription factors are involved in
            a variety of biologic processes as key regulators in development
            and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by
            OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299162.10/ ENSP00000299162.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     Protein         1..517
                     /product="forkhead box protein N4"
                     /note="forkhead/winged helix transcription factor FOXN4"
                     /calculated_mol_wt=55084
     Region          <84..>303
                     /region_name="COG5025"
                     /note="Transcription factor of the Forkhead/HNF3 family
                     [Transcription]"
                     /db_xref="CDD:227358"
     Region          188..293
                     /region_name="FH_FOXN4"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     N4 (FOXN4); cd20057"
                     /db_xref="CDD:410831"
     Site            order(198,216..217,220,239..240,242..243,246,253,264..266,
                     268)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410831"
     Region          317..>397
                     /region_name="FAM75"
                     /note="FAM75 family; pfam14650"
                     /db_xref="CDD:464237"
     Region          365..398
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NZ1.2)"
     Region          497..517
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NZ1.2)"
     CDS             1..517
                     /gene="FOXN4"
                     /coded_by="NM_213596.3:170..1723"
                     /db_xref="CCDS:CCDS9126.2"
                     /db_xref="GeneID:121643"
                     /db_xref="HGNC:HGNC:21399"
                     /db_xref="MIM:609429"
ORIGIN      
        1 miesdtssim sgiirnsgqn hhpspqeyrl lattsdddlp gdlqslswlt avdvprlqqm
       61 asgrvdlggp cvphphpgal agvadlhvga tpspllhgpa gmaprgmpgl gpitghrdsm
      121 sqfpvggqps sglqdpphly spatqpqfpl ppgaqqcppv glygppfgvr ppypqphvav
      181 hssqelhpkh ypkpiysysc liamalknsk tgslpvseiy sfmkehfpyf ktapdgwkns
      241 vrhnlslnkc fekvenkmsg ssrkgclwal nlaridkmee emhkwkrkdl aaihrsmanp
      301 eeldklisdr pescrrpgkp gepeapvlth attvavahgc lavsqlppqp lmtlslqsvp
      361 lhhqvqpqah lapdspapaq tpplhalpdl spsplphpam grapvdfini stdmntevda
      421 ldpsimdfal qgnlweemkd egfsldtlga fadsplgcdl gasgltpasg gsdqsfpdlq
      481 vtglytayst pdsvaasgts sssqylgaqg nkpiall
//
