LOCUS       NM_005197               8021 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens forkhead box N3 (FOXN3), transcript variant 2, mRNA.
ACCESSION   NM_005197 NM_018589 XM_929939 XM_939513
VERSION     NM_005197.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8021)
  AUTHORS   Kong,D., Wu,Y., Tong,B., Liang,Y., Xu,F., Chi,X., Ni,L., Tian,G.,
            Zhang,G. and Xu,Z.
  TITLE     CHES1 modulated tumorigenesis and senescence of pancreas cancer
            cells through repressing AKR1B10
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167214 (2024)
   PUBMED   38718846
  REMARK    GeneRIF: CHES1 modulated tumorigenesis and senescence of pancreas
            cancer cells through repressing AKR1B10.
REFERENCE   2  (bases 1 to 8021)
  AUTHORS   Yang,H., Li,M. and Qi,Y.
  TITLE     FOXN3 inhibits the progression of ovarian cancer through negatively
            regulating the expression of RPS15A
  JOURNAL   Hum Cell 36 (3), 1120-1134 (2023)
   PUBMED   37016167
  REMARK    GeneRIF: FOXN3 inhibits the progression of ovarian cancer through
            negatively regulating the expression of RPS15A.
REFERENCE   3  (bases 1 to 8021)
  AUTHORS   Wang,C., Tu,H., Yang,L., Ma,C., Hu,J., Luo,J. and Wang,H.
  TITLE     FOXN3 inhibits cell proliferation and invasion via modulating the
            AKT/MDM2/p53 axis in human glioma
  JOURNAL   Aging (Albany NY) 13 (17), 21587-21598 (2021)
   PUBMED   34511432
  REMARK    GeneRIF: FOXN3 inhibits cell proliferation and invasion via
            modulating the AKT/MDM2/p53 axis in human glioma.
REFERENCE   4  (bases 1 to 8021)
  AUTHORS   Zhao,C., Mo,L., Li,C., Han,S., Zhao,W. and Liu,L.
  TITLE     FOXN3 suppresses the growth and invasion of papillary thyroid
            cancer through the inactivation of Wnt/beta-catenin pathway
  JOURNAL   Mol Cell Endocrinol 515, 110925 (2020)
   PUBMED   32619584
  REMARK    GeneRIF: FOXN3 suppresses the growth and invasion of papillary
            thyroid cancer through the inactivation of Wnt/beta-catenin
            pathway.
REFERENCE   5  (bases 1 to 8021)
  AUTHORS   Lin,Z., Chen,M., Wan,Y., Lei,L. and Ruan,H.
  TITLE     miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal
            Carcinoma Cells via Wnt/beta-Catenin Pathway
  JOURNAL   Technol Cancer Res Treat 19, 1533033820971659 (2020)
   PUBMED   33317407
  REMARK    GeneRIF: miR-574-5p Targets FOXN3 to Regulate the Invasion of
            Nasopharyngeal Carcinoma Cells via Wnt/beta-Catenin Pathway.
REFERENCE   6  (bases 1 to 8021)
  AUTHORS   Scott,K.L. and Plon,S.E.
  TITLE     CHES1/FOXN3 interacts with Ski-interacting protein and acts as a
            transcriptional repressor
  JOURNAL   Gene 359, 119-126 (2005)
   PUBMED   16102918
  REMARK    GeneRIF: Data suggest that CHES1 recruits Ski-interacting protein
            (SKIP) to repress genes important for tumorigenesis and the
            response to cancer treatments.
REFERENCE   7  (bases 1 to 8021)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (bases 1 to 8021)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   9  (bases 1 to 8021)
  AUTHORS   Pati,D., Keller,C., Groudine,M. and Plon,S.E.
  TITLE     Reconstitution of a MEC1-independent checkpoint in yeast by
            expression of a novel human fork head cDNA
  JOURNAL   Mol Cell Biol 17 (6), 3037-3046 (1997)
   PUBMED   9154802
REFERENCE   10 (bases 1 to 8021)
  AUTHORS   Field,L.L., Tobias,R., Thomson,G. and Plon,S.
  TITLE     Susceptibility to insulin-dependent diabetes mellitus maps to a
            locus (IDDM11) on human chromosome 14q24.3-q31
  JOURNAL   Genomics 33 (1), 1-8 (1996)
   PUBMED   8617492
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356805.5, CB989352.1,
            BC007506.2, AL138478.3 and AI084011.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005197.3.
            
            Summary: This gene is a member of the forkhead/winged helix
            transcription factor family. Checkpoints are eukaryotic DNA
            damage-inducible cell cycle arrests at G1 and G2. Checkpoint
            suppressor 1 suppresses multiple yeast checkpoint mutations
            including mec1, rad9, rad53 and dun1 by activating a
            MEC1-independent checkpoint pathway. Alternative splicing is
            observed at the locus, resulting in distinct isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon and differs in the 5' UTR, compared to variant 1, resulting in
            a shorter protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007506.2, SRR18074969.843516.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557258.6/ ENSP00000452005.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL356805.5         44568-44690         c
            124-229             CB989352.1         28-133
            230-2813            BC007506.2         1-2584
            2814-7601           AL138478.3         54173-58960
            7602-8021           AI084011.1         10-429              c
FEATURES             Location/Qualifiers
     source          1..8021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.3-q32.11"
     gene            1..8021
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /note="forkhead box N3"
                     /db_xref="GeneID:1112"
                     /db_xref="HGNC:HGNC:1928"
                     /db_xref="MIM:602628"
     exon            1..363
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /inference="alignment:Splign:2.1.0"
     exon            364..920
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1784
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /note="isoform 2 is encoded by transcript variant 2;
                     checkpoint suppressor 1; forkhead box protein N3"
                     /codon_start=1
                     /product="forkhead box protein N3 isoform 2"
                     /protein_id="NP_005188.2"
                     /db_xref="CCDS:CCDS32138.1"
                     /db_xref="GeneID:1112"
                     /db_xref="HGNC:HGNC:1928"
                     /db_xref="MIM:602628"
                     /translation="MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFS
                     LPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSD
                     MPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKN
                     SVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTP
                     PTCPQAYQSTSGPPIWPGSTFFKRNGALLQVPPGVIQNGARVLSRGLFPGVRPLPITP
                     IGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSIS
                     SSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGY
                     ASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNN
                     ITNRTAKGQKEQKETTKN"
     exon            921..1057
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1122
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1228
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..8021
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7986..7991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /note="hexamer: AATAAA"
     polyA_site      8021
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /note="major polyA site"
ORIGIN      
        1 atgtgtcgcc tttttttgtt tgcagtggaa acaatttctc gccgctcggc gcgccccggc
       61 ccgacgcgcc gcggcggagg cgagcgggag gcgggacggg gcggggagag cggcggggcc
      121 ggcgggagga cgcgcggcgc gcccggcgga cgccgcaggt cccatgccgc gccgcgaccc
      181 ccgcgcccct gccgcccgcg cccgcggccg ccccccgccg cccgccgccc cgggctcgcc
      241 gcgccgcgcc cgcgcgtcct tagcggggcc accgagcgat gcccgccggg cgcccgcgaa
      301 agtttgtcgg ctcctgctga agggcagcgg cgcccccgca cccccgtgcc ccgctccggc
      361 caggagcctt cacgtaaatg ggtccagtca tgcctcccag taagaagcca gaaagctcag
      421 gaattagtgt ctccagtgga ctgagtcagt gttacggggg cagcggtttc tccaaggccc
      481 ttcaggaaga cgatgacctc gacttttctc tgcctgacat ccgattagaa gagggggcca
      541 tggaagatga agagctgacc aacctgaact ggctgcacga gagcaagaac ttgctgaaga
      601 gctttgggga gtcggtcctc aggagtgtca gccccgtcca ggacctggac gatgacaccc
      661 ccccatcccc tgcccactct gacatgccct acgatgccag gcagaacccc aactgcaaac
      721 ccccctactc cttcagctgc ctcatattta tggccatcga ggactctcca accaagcgcc
      781 tgccagtgaa ggatatctac aactggatct tggaacattt tccgtatttt gcaaatgcac
      841 ctactgggtg gaaaaactca gtgagacaca atttatcatt gaataagtgt tttaagaaag
      901 tggacaaaga gaggagtcag agtattggga aagggtcgtt gtggtgcata gacccagagt
      961 atagacaaaa tctaattcag gctttgaaaa agacacctta tcacccacac ccacacgtgt
     1021 tcaatacacc tcccacctgt cctcaggcat atcaaagcac atcaggtcca cccatctggc
     1081 cgggcagtac cttcttcaag agaaatggag cccttctcca agttcctcca ggagtgatcc
     1141 aaaatggagc gcgggtcctg agccgagggc tgtttcctgg cgtgcggccg ctgccaatca
     1201 ctcccattgg ggtgacagcg gccatgagga atggcatcac cagctgccgg atgcggactg
     1261 agagtgagcc atcttgtggc tccccagtgg tcagcggaga ccccaaggag gatcacaact
     1321 acagcagtgc caagtcctcc aacgcccgga gcacctcgcc caccagcgac tccatctcct
     1381 cctcctcctc ctcagccgac gaccactatg agtttgccac caaggggagc caggagggca
     1441 gcgagggcag cgaggggagc ttccggagcc acgagagccc cagcgacacg gaagaggacg
     1501 acaggaagca cagccagaag gagcccaagg attctctggg ggacagcggg tacgcatccc
     1561 agcacaagaa gcgccagcac ttcgccaagg ccaggaaggt ccccagcgac acactgcccc
     1621 tcaaaaagag acgcaccgaa aagccccccg agagcgatga tgaggagatg aaagaagcgg
     1681 cagggtccct cctgcactta gcagggatcc ggtcctgttt gaataacatc accaatcgga
     1741 cggcaaaggg gcagaaagag caaaaggaaa ccacaaaaaa ttaaaaacaa gtcactgatt
     1801 tgttttgaac ttacgaccat ttggtttcag catgtcagga gatttctaat gatttgtggc
     1861 aatatcagca attttttttc ttttttcttg tttttggttt ggttttcttt cttttctttt
     1921 ccttttattt tgttttaatt tgccccctct tctttgtttt ggacccttaa gaattttatt
     1981 tttaaaggag attgaagcca tagaactcat attgacactc agctgtttta caaaagcttt
     2041 tcattatctg aagacaaaac cgaaaaagcc aaaattacca ttgcttcctc cagcttgtca
     2101 gaaacctgtg gctgaatccg cagggatgtc aacgtcaata tcacaggaac acacattcgg
     2161 cacctagaag gcacgtgggc aaagtaatca tcgttcaggc ccaaccctta ggtttaaaaa
     2221 gtcaggttgt ccatcccatt gggttcactg agtgaaggca cataaagcaa ttgaggagga
     2281 ggaggaaccc ctcgtccccc taggagcaga cccaagcttg tggcaccagg catctgatgg
     2341 tgccaggaaa gccactggaa ttgtcacacg gcgagcacag agggccggcc accagtcctc
     2401 gatgcttctg aaccctgaag cccgatgaca tcttacgagg tggacgttgg actgttcatg
     2461 cgcatcgggt gtcagtgact catggagaag aaatggggta aatttttagt gatgttgcta
     2521 atcattgaat tctgttctct attaaattaa gaaaatgttc caaaagccat aagcctgaag
     2581 attggccctg tgcacgcacg cacacacaca cacacacaca cacacacaca cacacacaca
     2641 cgaaggagag agagagaaaa ctgatgggga aaacaagctg tgtcttctta actgcccaag
     2701 tgaaaagcaa ccaagtccag gaaattacaa tagctgttaa ggaaaggaaa taatggtaca
     2761 gatctttttc tgtctatcaa aactatttga tccaagtgaa aaaaaaaaaa aaactagaaa
     2821 gctacggaac ctgccattag tattgtggtg tatttttaag attaaaggta cactgatgga
     2881 caaaaaaaaa aagtaaaaca tggcaaaaaa taaaataact cctatactgc cctcaaaatg
     2941 gagtttgcaa ttaatatcag gatttatctt tgcaaaaatc agtgatttcc acattcagcc
     3001 agtatagcca gcagaaattt ctgatccaca atgcatggat tcctttgaag aaaaaaaaga
     3061 aaaagagaaa aaaatcacaa aaacaaactt tttttattca aaagtaacaa agttcttgta
     3121 aggtaaataa tgtatttagc atgaagcatg aattattttc atataaatat agaaaataga
     3181 gaaaaggcta tgcctgtaat ttttaagccc ttaggcttag agtttctttt ggttttcttc
     3241 ttttttcttt ccttttcttt gctttctttt tttccttttt gtttttgttt ttgttttttg
     3301 tttttgtttt tttttcgggt tattttgttt tggttttttg aagcaggtgt ttaaggttta
     3361 accttcttca gggacaaatt ctgactgttg gggaacttac tctgcaatat aaaaatatct
     3421 tcatgctctg gtagggcttg gatggttgaa ctctgtactg ccttgtgtgc acttcagccc
     3481 cgaccccctc tgattctctg ttgaaaagtg tgtcctttct ctctgtctgt acatgtttaa
     3541 catgacgcaa taatttgagg gcaaacttag tagtgagtgt gtatgataga atcaagagaa
     3601 ttatgggacg cttacttgag aaaatcatta ccatgatttg gttctaggaa aaaggcagtg
     3661 aataattatg caaattagcc agaagaaggg gaaccgtgct aatgggcctt attgggtgag
     3721 gggacgagat ggggttcatg tgaaggagga agcgatgccg aggtaggaaa ggccagcccc
     3781 agacatccta tcgccacaat gccatgtcgc aataggaagc aggggccggc catcgctacc
     3841 ttcagcacac tgaccaacct ggaattaaga ccacctagat tgcgagagct gaatttagaa
     3901 accagacaac gtcatgcagc ccagaaactc ctgttgttac ctttgcctaa gaaattttct
     3961 ttaatggcgg gggcgggggg cgggggtaca aagagaaatc tctaaaagaa tatgatcttc
     4021 catccaagtg gagggaaact ttaaaacaaa aacacccagt actgtggctc aggatatgat
     4081 gcgtgaggag agggagggaa cagagatgac cttaactttt aaaaaaggga ctgctgtggg
     4141 ccaaagccaa gcccatctgc caggacgagg taatgtcaga gctccatcag cccggacagt
     4201 gggaactaac tggtgcattc cccacactta ccttccggtg ggttgctgat gagagaacct
     4261 gaaaaaacct acacctctac agcaggtcga attcatgacc tgaagctgaa tacttccagc
     4321 atatttattc agggtgtagg tgggaataaa gtatcttcgc agtgctctgt tccctccgtc
     4381 tccccagaca tctgacaccc taaaagccat ccacagctat ggaacctgag cgacaccttg
     4441 atttgtgttg tcacctgacc aagcctaaag acctccagct cagtccccca ccttcatccc
     4501 accccacaga tgataaaatt cagacctctc tcctgaaagg cagaggttca acattcagga
     4561 ctgtttctgg ccgaggactt cttccaatta aaacccccac cgtgggctgt ctcccctcat
     4621 ttcatttttc taaaggggca gaggcctctt ttagaaaata ataaaatgca atgtgtgtga
     4681 tttacttttc tgatctcttt gagaaataga gaaatataaa agtgtgttct taactccaga
     4741 accactcttt ttgcataaat acctcatcgg gcagctttct aagtgtgatt ttcctgagtc
     4801 tcccttcgtt ggatctgccg gaagacttgt cggggaacct ttagtgaggg tacttcttcc
     4861 tatttttctt ctgtttttgg aggcatacac attatgcata accaaaacaa tggctcaatt
     4921 gtgtttaact ttgtattttg attgttgaga acaaaaacaa aaagtatcaa tgtgtatgtg
     4981 gctgtttgta gtgaatttat tggagaatga ggttgtccgt gtccttaaca agccaagggg
     5041 caggaggcac cctctcttat cccctcctcc aagagcagta gagaatttaa gcacaagcct
     5101 atttgtgaaa gaatattttg cttaagtgtc attcacttta gtcttggaat tccttcccaa
     5161 acgtcaggtg ttcttttagc ttccaaacta gcatatgtat ccattagtct gacagatcgc
     5221 ctgaacacca ttaagaggtg tggcgttttt gctttcattt ctcctgctgg gagaagtggc
     5281 ggttcatgtg tcattccagt atctcacata ctcacacggg gcagggggga gggggaaacg
     5341 gggaactata gcaatattta aagatgcttt ggaaaccaac cgtgaacaca tcaacaccac
     5401 gacgtctacg attacttgct attggccctc ggatacattt aagagaaaga gacagtcact
     5461 cttttttttc ttaaatgata tacatataaa cagttatttt tatcctatta taattgtctt
     5521 ttgtctttat ctagtactat gtggaaaggg tttgcatcat agatttttcc cagccttata
     5581 atataccata agctcctact tccctgcccc tccctaatca gtattctttc aagagttctt
     5641 tggtgaagcc atctatctga aactaaaatg aaccaaaccc atatttcact ggtggttgga
     5701 gaaaaccatg gccaaaacga ttgtggcagg tctcaatctt gggagttttt aagaaggaat
     5761 gtgccagagg ccgattccca agaacagagt tttcttttgt tttgcagagg cattcaatgt
     5821 gtctagtgct tgctggccac agcagttact accacagagc cttctgggag gggccgttgt
     5881 gttgaaggag gctcctgcct gagggacagc atcaggcagt gggctctgta gagtgagaac
     5941 caggtggagg ccttctgtgc ccagctcaga gttctgcacc acgccaggac tgcccaggcc
     6001 aagggctact gacgcaagtt ccactcattc cactctgtgg ggggcgcctt gggcctctcc
     6061 tggaagggct cttggagaag gaattggagt tacgtacaag tgacctaaat gggaagcttt
     6121 tctagatgag attggattaa attccatgtg atttctcttt ccctttaatc caggttggga
     6181 ctcgtttctt tctggtggat cacagctgcc cagatgttgc aattgatttt tatgtttctg
     6241 tagagaagta tttttctttc atcttcagga ttttttttgc caccaaaaga aaacattgga
     6301 actctgtgtt tcctcttgat tgtgacttcc cagtgttgac agttaagtcc ttagtgtcgt
     6361 aggtcccagc ccaccaatac tatatcaaac actgttatgc acataatgca gcactgtgat
     6421 ctaatttaaa taatactttt ttattattta tactactata tataatatac atcaacactt
     6481 ttgctatata acctaagtga taaccctctt ttagttacct gccaaactct ggacttggtt
     6541 tatattgcag ttaacacagt tacaaagctg taatggtgtc tttttttcct ttgtaacgga
     6601 atgtgtaaat caaagtatat acattgtgtg gtgttcctgt ttctggagtt tcatgaggat
     6661 ttacacatgg cattcagtgt tctgtataga tctgcctacc tttgtgaatt catctgttaa
     6721 cccctcttcc tttgagagag caccggcgat ggtggttaac tccttgtgtt ttctctctct
     6781 cctactggtt attcttgaat taagcacaga ctcgtcagct cggttgcttt atcatgaata
     6841 atgtgtgtga ccttgcagtt cttccacagt tcagcaaaca agtgctagct tcactgacca
     6901 aaaattaagg aaggaaaaca cagtttttaa aacgatccat cttttaacag ccgaaaccga
     6961 tgtgtctatg gtgctgcacc ttgctgttgt acttctgaaa tcagacgtgt gtgaacgatc
     7021 atttctgact taaccgtgag atgctcacga gtacccttcc tgttgttttg ttagcattga
     7081 aatcgagact atttatttgg aatatataca acagtgtttt tccactgtat ttcatttgca
     7141 aaagttgaga actgctttct ctaccttttg caaaataatt gatattccat attggattct
     7201 caaagacttc gatatggtga acctattaaa cctagaaatt gtattcatcc tttcatgact
     7261 gtggcctgag ttccccagcc cctctcctcc ttttttttag atgagattta gcacactctc
     7321 agttatttaa acatgcaaca tttcttgagt atgtatgttg aggccatctg agctcatagc
     7381 tgattcagta accagtttca tgctgtgtca ttcacactca ctacttaata ctgccatggt
     7441 gaaaatgtgg aggaaaaatg tatccatgtg tgtctgggaa gcatatacac ttgtacattt
     7501 tttaatactc tgattctgta acatttctga gttttgtttt gttttacaga aaaaaaaaaa
     7561 aagtgataaa gcaatcagaa gaccaagagg tttactattg atgcttaggg tcgtctgacc
     7621 ttggctggcc aatagaccta cacggccaaa ttaatttacg agagtaataa tttttcaaaa
     7681 gccaattttt tttctgtatt ttctgtatga aactgccaat atcatgaata gaaagggaga
     7741 accataaagg agaaagaacg tgatgttctg ttatgttcat gtaaacctaa agaaacagtg
     7801 tggaggcagg cgcgatcagc cgaactctag ggacttggtg ttgcttggaa ggcatccata
     7861 cctgcatttt gcattcttcg tatgtaatca tattgccaaa gacaaactat ttcatcattt
     7921 attgtaaata acacttttcc ccagacctac cataaagttt ctgtgatgta ttgtcttcca
     7981 gttgcaataa aaattactga gttgcatcaa ttgaagaaaa a
//
