LOCUS       NP_005188                468 aa            linear   PRI 29-APR-2025
DEFINITION  forkhead box protein N3 isoform 2 [Homo sapiens].
ACCESSION   NP_005188 NP_061059 XP_935032 XP_944606
VERSION     NP_005188.2
DBSOURCE    REFSEQ: accession NM_005197.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 468)
  AUTHORS   Kong,D., Wu,Y., Tong,B., Liang,Y., Xu,F., Chi,X., Ni,L., Tian,G.,
            Zhang,G. and Xu,Z.
  TITLE     CHES1 modulated tumorigenesis and senescence of pancreas cancer
            cells through repressing AKR1B10
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167214 (2024)
   PUBMED   38718846
  REMARK    GeneRIF: CHES1 modulated tumorigenesis and senescence of pancreas
            cancer cells through repressing AKR1B10.
REFERENCE   2  (residues 1 to 468)
  AUTHORS   Yang,H., Li,M. and Qi,Y.
  TITLE     FOXN3 inhibits the progression of ovarian cancer through negatively
            regulating the expression of RPS15A
  JOURNAL   Hum Cell 36 (3), 1120-1134 (2023)
   PUBMED   37016167
  REMARK    GeneRIF: FOXN3 inhibits the progression of ovarian cancer through
            negatively regulating the expression of RPS15A.
REFERENCE   3  (residues 1 to 468)
  AUTHORS   Wang,C., Tu,H., Yang,L., Ma,C., Hu,J., Luo,J. and Wang,H.
  TITLE     FOXN3 inhibits cell proliferation and invasion via modulating the
            AKT/MDM2/p53 axis in human glioma
  JOURNAL   Aging (Albany NY) 13 (17), 21587-21598 (2021)
   PUBMED   34511432
  REMARK    GeneRIF: FOXN3 inhibits cell proliferation and invasion via
            modulating the AKT/MDM2/p53 axis in human glioma.
REFERENCE   4  (residues 1 to 468)
  AUTHORS   Zhao,C., Mo,L., Li,C., Han,S., Zhao,W. and Liu,L.
  TITLE     FOXN3 suppresses the growth and invasion of papillary thyroid
            cancer through the inactivation of Wnt/beta-catenin pathway
  JOURNAL   Mol Cell Endocrinol 515, 110925 (2020)
   PUBMED   32619584
  REMARK    GeneRIF: FOXN3 suppresses the growth and invasion of papillary
            thyroid cancer through the inactivation of Wnt/beta-catenin
            pathway.
REFERENCE   5  (residues 1 to 468)
  AUTHORS   Lin,Z., Chen,M., Wan,Y., Lei,L. and Ruan,H.
  TITLE     miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal
            Carcinoma Cells via Wnt/beta-Catenin Pathway
  JOURNAL   Technol Cancer Res Treat 19, 1533033820971659 (2020)
   PUBMED   33317407
  REMARK    GeneRIF: miR-574-5p Targets FOXN3 to Regulate the Invasion of
            Nasopharyngeal Carcinoma Cells via Wnt/beta-Catenin Pathway.
REFERENCE   6  (residues 1 to 468)
  AUTHORS   Scott,K.L. and Plon,S.E.
  TITLE     CHES1/FOXN3 interacts with Ski-interacting protein and acts as a
            transcriptional repressor
  JOURNAL   Gene 359, 119-126 (2005)
   PUBMED   16102918
  REMARK    GeneRIF: Data suggest that CHES1 recruits Ski-interacting protein
            (SKIP) to repress genes important for tumorigenesis and the
            response to cancer treatments.
REFERENCE   7  (residues 1 to 468)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (residues 1 to 468)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y. PMID: 37491470]
REFERENCE   9  (residues 1 to 468)
  AUTHORS   Pati,D., Keller,C., Groudine,M. and Plon,S.E.
  TITLE     Reconstitution of a MEC1-independent checkpoint in yeast by
            expression of a novel human fork head cDNA
  JOURNAL   Mol Cell Biol 17 (6), 3037-3046 (1997)
   PUBMED   9154802
REFERENCE   10 (residues 1 to 468)
  AUTHORS   Field,L.L., Tobias,R., Thomson,G. and Plon,S.
  TITLE     Susceptibility to insulin-dependent diabetes mellitus maps to a
            locus (IDDM11) on human chromosome 14q24.3-q31
  JOURNAL   Genomics 33 (1), 1-8 (1996)
   PUBMED   8617492
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356805.5, CB989352.1,
            BC007506.2, AL138478.3 and AI084011.1.
            
            On or before Mar 16, 2006 this sequence version replaced
            XP_935032.1, XP_944606.1, NP_061059.1, NP_005188.1.
            
            Summary: This gene is a member of the forkhead/winged helix
            transcription factor family. Checkpoints are eukaryotic DNA
            damage-inducible cell cycle arrests at G1 and G2. Checkpoint
            suppressor 1 suppresses multiple yeast checkpoint mutations
            including mec1, rad9, rad53 and dun1 by activating a
            MEC1-independent checkpoint pathway. Alternative splicing is
            observed at the locus, resulting in distinct isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon and differs in the 5' UTR, compared to variant 1, resulting in
            a shorter protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007506.2, SRR18074969.843516.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557258.6/ ENSP00000452005.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.3-q32.11"
     Protein         1..468
                     /product="forkhead box protein N3 isoform 2"
                     /note="checkpoint suppressor 1; forkhead box protein N3"
                     /calculated_mol_wt=51403
     Region          114..203
                     /region_name="FH_FOXN3"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     N3 (FOXN3); cd20059"
                     /db_xref="CDD:410833"
     Site            order(119,137..138,141,160..161,163..164,167,174,185..187,
                     189)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410833"
     CDS             1..468
                     /gene="FOXN3"
                     /gene_synonym="C14orf116; CHES1; PRO1635"
                     /coded_by="NM_005197.4:378..1784"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS32138.1"
                     /db_xref="GeneID:1112"
                     /db_xref="HGNC:HGNC:1928"
                     /db_xref="MIM:602628"
ORIGIN      
        1 mgpvmppskk pessgisvss glsqcyggsg fskalqeddd ldfslpdirl eegamedeel
       61 tnlnwlhesk nllksfgesv lrsvspvqdl dddtppspah sdmpydarqn pnckppysfs
      121 clifmaieds ptkrlpvkdi ynwilehfpy fanaptgwkn svrhnlslnk cfkkvdkers
      181 qsigkgslwc idpeyrqnli qalkktpyhp hphvfntppt cpqayqstsg ppiwpgstff
      241 krngallqvp pgviqngarv lsrglfpgvr plpitpigvt aamrngitsc rmrtesepsc
      301 gspvvsgdpk edhnyssaks snarstspts dsissssssa ddhyefatkg sqegsegseg
      361 sfrshespsd teeddrkhsq kepkdslgds gyasqhkkrq hfakarkvps dtlplkkrrt
      421 ekppesddee mkeaagsllh lagirsclnn itnrtakgqk eqkettkn
//
