LOCUS       NM_002158               5437 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens forkhead box N2 (FOXN2), transcript variant 2, mRNA.
ACCESSION   NM_002158
VERSION     NM_002158.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5437)
  AUTHORS   Song,Y., Lian,S., Fan,H., Ma,C., Zheng,L., Huang,F., Huang,S.,
            Tang,Y., Shi,A., Shu,L., Zhao,L., Xu,Y., Guo,S., Liu,Z. and
            Zhang,Z.
  TITLE     Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner
  JOURNAL   Cancer Lett 592, 216921 (2024)
   PUBMED   38705565
  REMARK    GeneRIF: Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner.
REFERENCE   2  (bases 1 to 5437)
  AUTHORS   Wang,H., Liang,C., Lin,J., Dong,Y., Wang,Y. and Xia,L.
  TITLE     Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations
            Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression
  JOURNAL   Mol Biotechnol 66 (6), 1477-1483 (2024)
   PUBMED   37318741
  REMARK    GeneRIF: Hsa_circ_0001741 Suppresses Ovarian Cancer Cell
            Proliferations Through Adsorption of miR-188-5p and Promotion of
            FOXN2 Expression.
REFERENCE   3  (bases 1 to 5437)
  AUTHORS   Li,L., Sun,X., Zhang,M., Zhang,B., Yang,Y. and Wang,S.
  TITLE     FOXN2, identified as a novel biomarker in serum, modulates the
            transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer
  JOURNAL   Growth Factors 42 (2), 62-73 (2024)
   PUBMED   38954805
  REMARK    GeneRIF: FOXN2, identified as a novel biomarker in serum, modulates
            the transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer.
REFERENCE   4  (bases 1 to 5437)
  AUTHORS   Jeong,S., Kim,S.A. and Ahn,S.G.
  TITLE     HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through
            the Inhibition of the Tumor Suppressor FOXN2
  JOURNAL   Int J Mol Sci 23 (1), 9 (2021)
   PUBMED   35008435
  REMARK    GeneRIF: HOXC6-Mediated miR-188-5p Expression Induces Cell
            Migration through the Inhibition of the Tumor Suppressor FOXN2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5437)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5437)
  AUTHORS   Cheng,C.K., Chan,N.P., Wan,T.S., Lam,L.Y., Cheung,C.H., Wong,T.H.,
            Ip,R.K., Wong,R.S. and Ng,M.H.
  TITLE     Helicase-like transcription factor is a RUNX1 target whose
            downregulation promotes genomic instability and correlates with
            complex cytogenetic features in acute myeloid leukemia
  JOURNAL   Haematologica 101 (4), 448-457 (2016)
   PUBMED   26802049
  REMARK    GeneRIF: HTLF is a RUNX1 target whose down-regulation promotes
            genomic instability and correlates with complex cytogenetic
            abnormalities in acute myeloid leukemia patients.
REFERENCE   7  (bases 1 to 5437)
  AUTHORS   Li,X., Wang,W., Wang,J., Malovannaya,A., Xi,Y., Li,W., Guerra,R.,
            Hawke,D.H., Qin,J. and Chen,J.
  TITLE     Proteomic analyses reveal distinct chromatin-associated and soluble
            transcription factor complexes
  JOURNAL   Mol Syst Biol 11 (1), 775 (2015)
   PUBMED   25609649
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5437)
  AUTHORS   Guo,W., Dong,Z., Guo,Y., Chen,Z., Kuang,G. and Yang,Z.
  TITLE     Aberrant methylation of the CpG island of HLTF gene in gastric
            cardia adenocarcinoma and dysplasia
  JOURNAL   Clin Biochem 44 (10-11), 784-788 (2011)
   PUBMED   21531217
  REMARK    GeneRIF: HLTF methylation may exist in gastric cardia dysplasia
            stages and may play important role in the development of gastric
            cardia adenocarcinoma.
REFERENCE   9  (bases 1 to 5437)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5437)
  AUTHORS   Li,C., Lusis,A.J., Sparkes,R., Tran,S.M. and Gaynor,R.
  TITLE     Characterization and chromosomal mapping of the gene encoding the
            cellular DNA binding protein HTLF
  JOURNAL   Genomics 13 (3), 658-664 (1992)
   PUBMED   1639393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091485.8, BC063305.1 and
            AA827684.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002158.3.
            
            Summary: This gene encodes a forkhead domain binding protein and
            may function in the transcriptional regulation of the human T-cell
            leukemia virus long terminal repeat. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.114340.1,
                                           SRR1660805.50999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340553.8/ ENSP00000343633.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC091485.8         27327-27459
            134-1061            BC063305.1         85-1012
            1062-5436           AC091485.8         87565-91939
            5437-5437           AA827684.1         10-10               c
FEATURES             Location/Qualifiers
     source          1..5437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.3"
     gene            1..5437
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="forkhead box N2"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
     exon            1..133
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            134..275
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            276..826
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1585
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="isoform a is encoded by transcript variant 2; human
                     T-cell leukemia virus enhancer factor; forkhead box
                     protein N2"
                     /codon_start=1
                     /product="forkhead box protein N2 isoform a"
                     /protein_id="NP_002149.2"
                     /db_xref="CCDS:CCDS1838.1"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
                     /translation="MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKA
                     TLVDSESADDELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEGDDVPSFGPACYQ
                     NPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSV
                     RHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSASSQNGSLSP
                     HYLSSVIKQNQVRNLKESDIDAAAAMMLLNTSIEQGILECEKPLPLKTALQKKRSYGN
                     AFHHPSAVRLQESDSLATSIDPKEDHNYSASSMAAQRCASRSSVSSLSSVDEVYEFIP
                     KNSHVGSDGSEGFHSEEDTDVDYEDDPLGDSGYASQPCAKISEKGQSGKKMRKQTCQE
                     IDEELKEAAGSLLHLAGIRTCLGSLISTAKTQNQKQRKK"
     exon            827..927
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1061
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..5437
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5301..5306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: ATTAAA"
     polyA_site      5321
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="major polyA site"
     regulatory      5414..5419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: AATAAA"
     polyA_site      5437
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
ORIGIN      
        1 actgcagctg ctgctgcctg ctggttgccg cgtcttcccg gaggcgactg ctggaagctg
       61 cagggaacag ctgcggtgct ctgccatatt gtgtcttccc cggccggtcc ctcgcctccc
      121 ggccgagctg acgttggttg aagccatgga taacagaacc cacagatgca gagggctgac
      181 tgtacaagtc tgtcaaaaaa ccaaactgct ggttggctaa taattggtca ctgtatgact
      241 tatagtacag gtgatattac ttctgattct agatgaactg taagagtaaa tgggtccagt
      301 aattggaatg actccagata agagagctga aaccccagga gctgaaaaga ttgcaggatt
      361 aagccagatt tacaaaatgg gaagcttgcc tgaagctgtt gatgctgcca ggccgaaggc
      421 cactctagtg gacagtgagt cagcagatga tgaactcaca aacttgaact ggcttcatga
      481 aagcactaat cttctaacaa acttcagcct cggaagtgag ggtcttccaa ttgttagtcc
      541 attgtatgac atagagggag atgatgtgcc atcctttgga ccagcttgct accagaaccc
      601 agaaaaaaaa tcagcgactt caaagccccc atactccttt agtcttctca tttatatggc
      661 cattgagcac tctccaaata aatgtttgcc tgtcaaagaa atttatagct ggattctgga
      721 ccattttcca tattttgcta ctgcaccaac aggctggaag aattctgttc gacataatct
      781 gtccctgaat aaatgttttc agaaagtgga aagaagccat ggcaaggtta atggaaaagg
      841 ttccttatgg tgtgttgatc cggaatataa acccaatctt atccaggcac tgaagaagca
      901 acctttttct tcagcatctt cacaaaatgg ttctttatca cctcactatt taagctctgt
      961 aatcaagcag aaccaggtgc gaaacctcaa agaatctgat attgatgctg ctgctgcaat
     1021 gatgctttta aatacttcta tagaacaagg aattttagaa tgtgagaagc ctcttcctct
     1081 taaaacagca ttgcaaaaaa agaggagtta cggcaatgca tttcatcatc ccagtgctgt
     1141 acgattacaa gagagtgatt ctttagccac cagcattgat ccaaaagaag atcacaatta
     1201 cagtgcaagt agcatggcag cacagcgttg tgcatccagg tctagcgtgt cttccctgtc
     1261 ttctgtggat gaggtatatg aatttatccc aaagaatagt cacgtgggaa gtgatggcag
     1321 tgaaggattt cacagtgaag aagatacaga cgttgattat gaagatgatc ctcttggaga
     1381 cagtggctat gcatcacagc cttgtgcaaa aatctctgaa aaagggcagt caggcaaaaa
     1441 gatgcgaaaa cagacatgtc aagaaattga tgaggagctc aaagaggcag ctggatctct
     1501 gctccacctt gctggaattc gtacatgttt aggttcccta ataagtactg caaagacaca
     1561 aaatcaaaag caacggaaaa aatagaaata cttaaagtgt ggcaatactc tttcacttaa
     1621 ttctttacaa gggatatcaa agccataatg gacttcatta gttttagggt agggaaggga
     1681 tactaattac ttatttcttt caaaacattt ttggtttttg gtttttaaaa tttttattaa
     1741 acaattgctg ttaggatcat gcctgatcag aaatacatga tgtgaagtcc taaaagcata
     1801 atttttgtga taaatgtgtc caagatttga aaatttttat ataagaaaat ccccagcctc
     1861 tgtcttaaac ttgtgggaca aaaatccttt cttctgttaa tatgtcagaa tgtaagattt
     1921 ggcaactcga taaatttttt tcattttctt ttccaatctg taactatagt tactgaacca
     1981 gctaaaaatt ttgctgatgt atttttcata tacttctctc ctgacacgca atccggtaac
     2041 ataagattga aattttttta ctttgtctta atttgtttct aatttttttt ttgttgtcgt
     2101 gtgagcaaag acaaacataa attgaaaaac atcctgatgt ttagaaagtt tcttttggtt
     2161 acgtaggtag agaatacaac aaagagttct aagacttaga aaagacaatt ttgtggtgtc
     2221 atttcatcca agaacactcc caattcctat tagaatggta gctttgaagt gtttttactt
     2281 cagagatcct gcatagcatt tattggggcc ttttattctt tcccaaagtg ctttgcaaac
     2341 attaagtttt agccactagc tgcctttgtt gagtataagt tatccagtga gaggatatag
     2401 ccaattaagt gtgttatgga gtacacccat tttgacacac ttgtaataag agaatctttc
     2461 atttgcctgc catgtgtact gtattatgag aatcttataa tcggaatgga gtgaaatgaa
     2521 acattttgag tactgatggc atgttatcat acataaagta ggtcatttag gaaaaaactt
     2581 ctgtccaagc tttgtatgaa ttaaattcat aagtatacca aattaaatct taatagattt
     2641 aatgcaattt tacagacaca ataccttcat gaatttcaaa attcatataa aatttgatct
     2701 tatgcaatac acctttttga ggaggcagtg taacaaccta tagtgccatt gatccatgag
     2761 aaaaagattt tctggtacta ctccaaaagt gctttgacta agtatcttaa ctatttgaac
     2821 agtctgctta tatgagacag tttttcatag tatcatttgt ataatttgat tagattattc
     2881 agaaacaata ggatgctaaa ctaattcatt gtatcttttt tttacaatgg tggaagcaac
     2941 tttctgaaag ttcagtctta tgctacatcc taagtcatag acaatgacct tgttttcatt
     3001 attctgatag attgtataca tatgtacaca tacatataca catatgcaca gtcaaggtca
     3061 tgatgttgat ttgctttcag ctgtttctgt gattataaag cattttttaa gagacaaatt
     3121 ttaactttta atttttattt tggcaaaact gtcaaatgag aaaaatgatt ttaaaaactt
     3181 ttttttcaat tgacaagact ttaagtcagg gataacagta ttaatgttct ctgttctgtt
     3241 tccatgttaa atttaattta acctggatag ccacattaat gaattggtgc tgtcaaaata
     3301 tagtaatttt taaatttgtt aataatgaaa acccttaagc atgcaggatg aggtatttgg
     3361 gttttttttt tagatcgatc acatctacag aaaatggcta aaccaagtta acttttatta
     3421 tagacagtga ataaaacacc aaaaacccaa aaatgcttta accacagtat aaataataga
     3481 ttatacacat catcttaata actattttta agttatttac catagcctct gtatagacct
     3541 taggaacagt gtttcagtga tctggcacca gtttattttg ttctgctgaa attctgtatc
     3601 acaaatgtgc tacctggttt ttgtccatta gataattact ctttataagg aaaggaaaga
     3661 gaagcagagt tagttccagc tctaataggg atcttcaaag ttattttgtc ttgatgtatg
     3721 taacagtaat tctttacatc ttttgatttt tctcttcctt tttattcact cttcccacga
     3781 atttaaatgt ttaagttata ttcatcacta gcaaggatga taaacacttg tgcactgaaa
     3841 gctaacaggg agaggttaca caatatttta cagtttctta aacataattt aatgcatcac
     3901 cttccacttg ctaacatacc aagtcagtta ttttcaaggg aagaaccttt taaattatgg
     3961 tcctccattt actacttcca ctgagagtat gctctcattc ctcaggtgtt ttgagaaaca
     4021 tgactaataa ccacacaatt aagtagagtc attccaagtc ctatggcctg gaaattgtat
     4081 tccctataat atacaaattt tcctgtaata aagtcaactt agaaactcca aggaggttac
     4141 atgttttcca acatatccta aaaactgtga tataagctaa catataattt gccttacgtc
     4201 aaaagaatat gttttgttgc agctgattcc agtttataat agatccctag taaaaagctt
     4261 tgattcaaca caattgttca tcttcacatc ccaaacagaa tcactgtttc ttgaatatat
     4321 atttttgaag tttttttgtg caatatatta ctaaatcagt tattatttta cttttccaaa
     4381 ttcagagaaa gaaaacagat tacctgaatt catggaaaag gtggatcacc tccctttttc
     4441 caccttcaag cctttcctgt cctcatagcc agcatgactt cttttaactt ggattccttt
     4501 gtatatagta aagtttagta tatatatatt tttttctttt tgctactttc tgaggcatta
     4561 tgtaaagggc tcatactaga tgttcagtta aatatacttt agcacaaagt caaactagag
     4621 aatgtgttaa ggagggaatg tatatgtctt ggtagaccag gaggcctttg ccagcaattt
     4681 aagcaacaga tgtgaatact tcacaaagct gtaaagacca ttgtcttaaa tactacaaca
     4741 acttaacacc cttttgtgaa gatcacagca tttatctaag aaactgtgag gctttctggt
     4801 ttacatatat cttacaggtg tttttttgta tttttttttt tttttagttt gaaatgtgta
     4861 agctttgatt taaaccaagt ttacttcagt atgttaatga tgtagtaaaa atatttattg
     4921 aaaggtgaat tcgagtattt taatgttata cctgccattt tttttcttaa agcatattct
     4981 ttgcatctaa ctgccagtgc cattgtcaaa acttattttt taaatcgttg tacatttctt
     5041 attaaactaa gtgcttaatt ttaaagtatt atgttgccat catatagtgt ataaaaatgt
     5101 ataattgcca attgattgta actattattt atttttaaat gaaagtgtaa gaatgctttc
     5161 tgattcaaca aatttgttat caaactgttt ccttatcctc ttttctgatg tagcataaaa
     5221 attgtcccgg tttgagttat aactgccagt agatgaccag tcacaagtga accacttctc
     5281 agttgccaat ctttgctcat attaaaaaca acttacaaat acttagtttt tgtatctaat
     5341 ctctgattat taaaatgttt ataaagttta tttttaccaa agagatgcaa ttcattatga
     5401 gaaagtattg cataataaat tttgttttat aactttt
//
