LOCUS       NM_001375449            5897 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens forkhead box N2 (FOXN2), transcript variant 9, mRNA.
ACCESSION   NM_001375449 XM_017003958
VERSION     NM_001375449.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5897)
  AUTHORS   Song,Y., Lian,S., Fan,H., Ma,C., Zheng,L., Huang,F., Huang,S.,
            Tang,Y., Shi,A., Shu,L., Zhao,L., Xu,Y., Guo,S., Liu,Z. and
            Zhang,Z.
  TITLE     Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner
  JOURNAL   Cancer Lett 592, 216921 (2024)
   PUBMED   38705565
  REMARK    GeneRIF: Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner.
REFERENCE   2  (bases 1 to 5897)
  AUTHORS   Wang,H., Liang,C., Lin,J., Dong,Y., Wang,Y. and Xia,L.
  TITLE     Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations
            Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression
  JOURNAL   Mol Biotechnol 66 (6), 1477-1483 (2024)
   PUBMED   37318741
  REMARK    GeneRIF: Hsa_circ_0001741 Suppresses Ovarian Cancer Cell
            Proliferations Through Adsorption of miR-188-5p and Promotion of
            FOXN2 Expression.
REFERENCE   3  (bases 1 to 5897)
  AUTHORS   Li,L., Sun,X., Zhang,M., Zhang,B., Yang,Y. and Wang,S.
  TITLE     FOXN2, identified as a novel biomarker in serum, modulates the
            transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer
  JOURNAL   Growth Factors 42 (2), 62-73 (2024)
   PUBMED   38954805
  REMARK    GeneRIF: FOXN2, identified as a novel biomarker in serum, modulates
            the transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer.
REFERENCE   4  (bases 1 to 5897)
  AUTHORS   Jeong,S., Kim,S.A. and Ahn,S.G.
  TITLE     HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through
            the Inhibition of the Tumor Suppressor FOXN2
  JOURNAL   Int J Mol Sci 23 (1), 9 (2021)
   PUBMED   35008435
  REMARK    GeneRIF: HOXC6-Mediated miR-188-5p Expression Induces Cell
            Migration through the Inhibition of the Tumor Suppressor FOXN2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5897)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5897)
  AUTHORS   Cheng,C.K., Chan,N.P., Wan,T.S., Lam,L.Y., Cheung,C.H., Wong,T.H.,
            Ip,R.K., Wong,R.S. and Ng,M.H.
  TITLE     Helicase-like transcription factor is a RUNX1 target whose
            downregulation promotes genomic instability and correlates with
            complex cytogenetic features in acute myeloid leukemia
  JOURNAL   Haematologica 101 (4), 448-457 (2016)
   PUBMED   26802049
  REMARK    GeneRIF: HTLF is a RUNX1 target whose down-regulation promotes
            genomic instability and correlates with complex cytogenetic
            abnormalities in acute myeloid leukemia patients.
REFERENCE   7  (bases 1 to 5897)
  AUTHORS   Li,X., Wang,W., Wang,J., Malovannaya,A., Xi,Y., Li,W., Guerra,R.,
            Hawke,D.H., Qin,J. and Chen,J.
  TITLE     Proteomic analyses reveal distinct chromatin-associated and soluble
            transcription factor complexes
  JOURNAL   Mol Syst Biol 11 (1), 775 (2015)
   PUBMED   25609649
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5897)
  AUTHORS   Guo,W., Dong,Z., Guo,Y., Chen,Z., Kuang,G. and Yang,Z.
  TITLE     Aberrant methylation of the CpG island of HLTF gene in gastric
            cardia adenocarcinoma and dysplasia
  JOURNAL   Clin Biochem 44 (10-11), 784-788 (2011)
   PUBMED   21531217
  REMARK    GeneRIF: HLTF methylation may exist in gastric cardia dysplasia
            stages and may play important role in the development of gastric
            cardia adenocarcinoma.
REFERENCE   9  (bases 1 to 5897)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5897)
  AUTHORS   Li,C., Lusis,A.J., Sparkes,R., Tran,S.M. and Gaynor,R.
  TITLE     Characterization and chromosomal mapping of the gene encoding the
            cellular DNA binding protein HTLF
  JOURNAL   Genomics 13 (3), 658-664 (1992)
   PUBMED   1639393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091485.8.
            
            On Oct 28, 2019 this sequence version replaced XM_017003958.1.
            
            Summary: This gene encodes a forkhead domain binding protein and
            may function in the transcriptional regulation of the human T-cell
            leukemia virus long terminal repeat. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.783647.1,
                                           SRR14038196.3516776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AC091485.8         27327-27734
            409-550             AC091485.8         41206-41347
            551-735             AC091485.8         47139-47323
            736-1286            AC091485.8         58846-59396
            1287-1387           AC091485.8         71692-71792
            1388-1452           AC091485.8         75288-75352
            1453-1521           AC091485.8         85937-86005
            1522-5897           AC091485.8         87565-91940
FEATURES             Location/Qualifiers
     source          1..5897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.3"
     gene            1..5897
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="forkhead box N2"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
     exon            1..408
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            409..550
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            551..735
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1286
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             750..2045
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="isoform a is encoded by transcript variant 9; human
                     T-cell leukemia virus enhancer factor; forkhead box
                     protein N2"
                     /codon_start=1
                     /product="forkhead box protein N2 isoform a"
                     /protein_id="NP_001362378.1"
                     /db_xref="CCDS:CCDS1838.1"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
                     /translation="MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKA
                     TLVDSESADDELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEGDDVPSFGPACYQ
                     NPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSV
                     RHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSASSQNGSLSP
                     HYLSSVIKQNQVRNLKESDIDAAAAMMLLNTSIEQGILECEKPLPLKTALQKKRSYGN
                     AFHHPSAVRLQESDSLATSIDPKEDHNYSASSMAAQRCASRSSVSSLSSVDEVYEFIP
                     KNSHVGSDGSEGFHSEEDTDVDYEDDPLGDSGYASQPCAKISEKGQSGKKMRKQTCQE
                     IDEELKEAAGSLLHLAGIRTCLGSLISTAKTQNQKQRKK"
     exon            1287..1387
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1452
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1521
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..5897
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5761..5766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: ATTAAA"
     polyA_site      5781
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="major polyA site"
     regulatory      5874..5879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: AATAAA"
     polyA_site      5897
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
ORIGIN      
        1 actgcagctg ctgctgcctg ctggttgccg cgtcttcccg gaggcgactg ctggaagctg
       61 cagggaacag ctgcggtgct ctgccatatt gtgtcttccc cggccggtcc ctcgcctccc
      121 ggccgagctg acggtgagtc ccgggcggag cggtcccctc cagggtcggc gctccccgcc
      181 ccagcccgcg gcgcagctcc cgggcgcgga ggcagcgcga gcgacccgcg ccaggcgtgg
      241 ggcgcggagg cggctgtccc gtgacgcgcc cggacatttt tgtccagtga ggaatttgcg
      301 ccggcgcggg ggtgtccccg gcgcgcgtat cgggtggtgt gtgggctccg ggggatgtcg
      361 aactgagggg agtgtggctt gtgaggagtt aggagttttt cctgagagtt ggttgaagcc
      421 atggataaca gaacccacag atgcagaggg ctgactgtac aagtctgtca aaaaaccaaa
      481 ctgctggttg gctaataatt ggtcactgta tgacttatag tacaggtgat attacttctg
      541 attctagatg cagcatggtg aaccacgtac ctggatcaag gtaccaagta ccttcagctt
      601 tctgctgaaa acaacctaaa atgctggata aaataaaatc ttaaatgcat cagtgctctg
      661 gcgcaaaggg gagagtactt aggccaggct gaattctgaa tctggctatt gctttgagga
      721 tatttgccaa atcagaactg taagagtaaa tgggtccagt aattggaatg actccagata
      781 agagagctga aaccccagga gctgaaaaga ttgcaggatt aagccagatt tacaaaatgg
      841 gaagcttgcc tgaagctgtt gatgctgcca ggccgaaggc cactctagtg gacagtgagt
      901 cagcagatga tgaactcaca aacttgaact ggcttcatga aagcactaat cttctaacaa
      961 acttcagcct cggaagtgag ggtcttccaa ttgttagtcc attgtatgac atagagggag
     1021 atgatgtgcc atcctttgga ccagcttgct accagaaccc agaaaaaaaa tcagcgactt
     1081 caaagccccc atactccttt agtcttctca tttatatggc cattgagcac tctccaaata
     1141 aatgtttgcc tgtcaaagaa atttatagct ggattctgga ccattttcca tattttgcta
     1201 ctgcaccaac aggctggaag aattctgttc gacataatct gtccctgaat aaatgttttc
     1261 agaaagtgga aagaagccat ggcaaggtta atggaaaagg ttccttatgg tgtgttgatc
     1321 cggaatataa acccaatctt atccaggcac tgaagaagca acctttttct tcagcatctt
     1381 cacaaaatgg ttctttatca cctcactatt taagctctgt aatcaagcag aaccaggtgc
     1441 gaaacctcaa agaatctgat attgatgctg ctgctgcaat gatgctttta aatacttcta
     1501 tagaacaagg aattttagaa tgtgagaagc ctcttcctct taaaacagca ttgcaaaaaa
     1561 agaggagtta cggcaatgca tttcatcatc ccagtgctgt acgattacaa gagagtgatt
     1621 ctttagccac cagcattgat ccaaaagaag atcacaatta cagtgcaagt agcatggcag
     1681 cacagcgttg tgcatccagg tctagcgtgt cttccctgtc ttctgtggat gaggtatatg
     1741 aatttatccc aaagaatagt cacgtgggaa gtgatggcag tgaaggattt cacagtgaag
     1801 aagatacaga cgttgattat gaagatgatc ctcttggaga cagtggctat gcatcacagc
     1861 cttgtgcaaa aatctctgaa aaagggcagt caggcaaaaa gatgcgaaaa cagacatgtc
     1921 aagaaattga tgaggagctc aaagaggcag ctggatctct gctccacctt gctggaattc
     1981 gtacatgttt aggttcccta ataagtactg caaagacaca aaatcaaaag caacggaaaa
     2041 aatagaaata cttaaagtgt ggcaatactc tttcacttaa ttctttacaa gggatatcaa
     2101 agccataatg gacttcatta gttttagggt agggaaggga tactaattac ttatttcttt
     2161 caaaacattt ttggtttttg gtttttaaaa tttttattaa acaattgctg ttaggatcat
     2221 gcctgatcag aaatacatga tgtgaagtcc taaaagcata atttttgtga taaatgtgtc
     2281 caagatttga aaatttttat ataagaaaat ccccagcctc tgtcttaaac ttgtgggaca
     2341 aaaatccttt cttctgttaa tatgtcagaa tgtaagattt ggcaactcga taaatttttt
     2401 tcattttctt ttccaatctg taactatagt tactgaacca gctaaaaatt ttgctgatgt
     2461 atttttcata tacttctctc ctgacacgca atccggtaac ataagattga aattttttta
     2521 ctttgtctta atttgtttct aatttttttt ttgttgtcgt gtgagcaaag acaaacataa
     2581 attgaaaaac atcctgatgt ttagaaagtt tcttttggtt acgtaggtag agaatacaac
     2641 aaagagttct aagacttaga aaagacaatt ttgtggtgtc atttcatcca agaacactcc
     2701 caattcctat tagaatggta gctttgaagt gtttttactt cagagatcct gcatagcatt
     2761 tattggggcc ttttattctt tcccaaagtg ctttgcaaac attaagtttt agccactagc
     2821 tgcctttgtt gagtataagt tatccagtga gaggatatag ccaattaagt gtgttatgga
     2881 gtacacccat tttgacacac ttgtaataag agaatctttc atttgcctgc catgtgtact
     2941 gtattatgag aatcttataa tcggaatgga gtgaaatgaa acattttgag tactgatggc
     3001 atgttatcat acataaagta ggtcatttag gaaaaaactt ctgtccaagc tttgtatgaa
     3061 ttaaattcat aagtatacca aattaaatct taatagattt aatgcaattt tacagacaca
     3121 ataccttcat gaatttcaaa attcatataa aatttgatct tatgcaatac acctttttga
     3181 ggaggcagtg taacaaccta tagtgccatt gatccatgag aaaaagattt tctggtacta
     3241 ctccaaaagt gctttgacta agtatcttaa ctatttgaac agtctgctta tatgagacag
     3301 tttttcatag tatcatttgt ataatttgat tagattattc agaaacaata ggatgctaaa
     3361 ctaattcatt gtatcttttt tttacaatgg tggaagcaac tttctgaaag ttcagtctta
     3421 tgctacatcc taagtcatag acaatgacct tgttttcatt attctgatag attgtataca
     3481 tatgtacaca tacatataca catatgcaca gtcaaggtca tgatgttgat ttgctttcag
     3541 ctgtttctgt gattataaag cattttttaa gagacaaatt ttaactttta atttttattt
     3601 tggcaaaact gtcaaatgag aaaaatgatt ttaaaaactt ttttttcaat tgacaagact
     3661 ttaagtcagg gataacagta ttaatgttct ctgttctgtt tccatgttaa atttaattta
     3721 acctggatag ccacattaat gaattggtgc tgtcaaaata tagtaatttt taaatttgtt
     3781 aataatgaaa acccttaagc atgcaggatg aggtatttgg gttttttttt tagatcgatc
     3841 acatctacag aaaatggcta aaccaagtta acttttatta tagacagtga ataaaacacc
     3901 aaaaacccaa aaatgcttta accacagtat aaataataga ttatacacat catcttaata
     3961 actattttta agttatttac catagcctct gtatagacct taggaacagt gtttcagtga
     4021 tctggcacca gtttattttg ttctgctgaa attctgtatc acaaatgtgc tacctggttt
     4081 ttgtccatta gataattact ctttataagg aaaggaaaga gaagcagagt tagttccagc
     4141 tctaataggg atcttcaaag ttattttgtc ttgatgtatg taacagtaat tctttacatc
     4201 ttttgatttt tctcttcctt tttattcact cttcccacga atttaaatgt ttaagttata
     4261 ttcatcacta gcaaggatga taaacacttg tgcactgaaa gctaacaggg agaggttaca
     4321 caatatttta cagtttctta aacataattt aatgcatcac cttccacttg ctaacatacc
     4381 aagtcagtta ttttcaaggg aagaaccttt taaattatgg tcctccattt actacttcca
     4441 ctgagagtat gctctcattc ctcaggtgtt ttgagaaaca tgactaataa ccacacaatt
     4501 aagtagagtc attccaagtc ctatggcctg gaaattgtat tccctataat atacaaattt
     4561 tcctgtaata aagtcaactt agaaactcca aggaggttac atgttttcca acatatccta
     4621 aaaactgtga tataagctaa catataattt gccttacgtc aaaagaatat gttttgttgc
     4681 agctgattcc agtttataat agatccctag taaaaagctt tgattcaaca caattgttca
     4741 tcttcacatc ccaaacagaa tcactgtttc ttgaatatat atttttgaag tttttttgtg
     4801 caatatatta ctaaatcagt tattatttta cttttccaaa ttcagagaaa gaaaacagat
     4861 tacctgaatt catggaaaag gtggatcacc tccctttttc caccttcaag cctttcctgt
     4921 cctcatagcc agcatgactt cttttaactt ggattccttt gtatatagta aagtttagta
     4981 tatatatatt tttttctttt tgctactttc tgaggcatta tgtaaagggc tcatactaga
     5041 tgttcagtta aatatacttt agcacaaagt caaactagag aatgtgttaa ggagggaatg
     5101 tatatgtctt ggtagaccag gaggcctttg ccagcaattt aagcaacaga tgtgaatact
     5161 tcacaaagct gtaaagacca ttgtcttaaa tactacaaca acttaacacc cttttgtgaa
     5221 gatcacagca tttatctaag aaactgtgag gctttctggt ttacatatat cttacaggtg
     5281 tttttttgta tttttttttt tttttagttt gaaatgtgta agctttgatt taaaccaagt
     5341 ttacttcagt atgttaatga tgtagtaaaa atatttattg aaaggtgaat tcgagtattt
     5401 taatgttata cctgccattt tttttcttaa agcatattct ttgcatctaa ctgccagtgc
     5461 cattgtcaaa acttattttt taaatcgttg tacatttctt attaaactaa gtgcttaatt
     5521 ttaaagtatt atgttgccat catatagtgt ataaaaatgt ataattgcca attgattgta
     5581 actattattt atttttaaat gaaagtgtaa gaatgctttc tgattcaaca aatttgttat
     5641 caaactgttt ccttatcctc ttttctgatg tagcataaaa attgtcccgg tttgagttat
     5701 aactgccagt agatgaccag tcacaagtga accacttctc agttgccaat ctttgctcat
     5761 attaaaaaca acttacaaat acttagtttt tgtatctaat ctctgattat taaaatgttt
     5821 ataaagttta tttttaccaa agagatgcaa ttcattatga gaaagtattg cataataaat
     5881 tttgttttat aactttt
//
