LOCUS       NM_001375447            5448 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens forkhead box N2 (FOXN2), transcript variant 7, mRNA.
ACCESSION   NM_001375447
VERSION     NM_001375447.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5448)
  AUTHORS   Song,Y., Lian,S., Fan,H., Ma,C., Zheng,L., Huang,F., Huang,S.,
            Tang,Y., Shi,A., Shu,L., Zhao,L., Xu,Y., Guo,S., Liu,Z. and
            Zhang,Z.
  TITLE     Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner
  JOURNAL   Cancer Lett 592, 216921 (2024)
   PUBMED   38705565
  REMARK    GeneRIF: Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner.
REFERENCE   2  (bases 1 to 5448)
  AUTHORS   Wang,H., Liang,C., Lin,J., Dong,Y., Wang,Y. and Xia,L.
  TITLE     Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations
            Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression
  JOURNAL   Mol Biotechnol 66 (6), 1477-1483 (2024)
   PUBMED   37318741
  REMARK    GeneRIF: Hsa_circ_0001741 Suppresses Ovarian Cancer Cell
            Proliferations Through Adsorption of miR-188-5p and Promotion of
            FOXN2 Expression.
REFERENCE   3  (bases 1 to 5448)
  AUTHORS   Li,L., Sun,X., Zhang,M., Zhang,B., Yang,Y. and Wang,S.
  TITLE     FOXN2, identified as a novel biomarker in serum, modulates the
            transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer
  JOURNAL   Growth Factors 42 (2), 62-73 (2024)
   PUBMED   38954805
  REMARK    GeneRIF: FOXN2, identified as a novel biomarker in serum, modulates
            the transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer.
REFERENCE   4  (bases 1 to 5448)
  AUTHORS   Jeong,S., Kim,S.A. and Ahn,S.G.
  TITLE     HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through
            the Inhibition of the Tumor Suppressor FOXN2
  JOURNAL   Int J Mol Sci 23 (1), 9 (2021)
   PUBMED   35008435
  REMARK    GeneRIF: HOXC6-Mediated miR-188-5p Expression Induces Cell
            Migration through the Inhibition of the Tumor Suppressor FOXN2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5448)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5448)
  AUTHORS   Cheng,C.K., Chan,N.P., Wan,T.S., Lam,L.Y., Cheung,C.H., Wong,T.H.,
            Ip,R.K., Wong,R.S. and Ng,M.H.
  TITLE     Helicase-like transcription factor is a RUNX1 target whose
            downregulation promotes genomic instability and correlates with
            complex cytogenetic features in acute myeloid leukemia
  JOURNAL   Haematologica 101 (4), 448-457 (2016)
   PUBMED   26802049
  REMARK    GeneRIF: HTLF is a RUNX1 target whose down-regulation promotes
            genomic instability and correlates with complex cytogenetic
            abnormalities in acute myeloid leukemia patients.
REFERENCE   7  (bases 1 to 5448)
  AUTHORS   Li,X., Wang,W., Wang,J., Malovannaya,A., Xi,Y., Li,W., Guerra,R.,
            Hawke,D.H., Qin,J. and Chen,J.
  TITLE     Proteomic analyses reveal distinct chromatin-associated and soluble
            transcription factor complexes
  JOURNAL   Mol Syst Biol 11 (1), 775 (2015)
   PUBMED   25609649
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5448)
  AUTHORS   Guo,W., Dong,Z., Guo,Y., Chen,Z., Kuang,G. and Yang,Z.
  TITLE     Aberrant methylation of the CpG island of HLTF gene in gastric
            cardia adenocarcinoma and dysplasia
  JOURNAL   Clin Biochem 44 (10-11), 784-788 (2011)
   PUBMED   21531217
  REMARK    GeneRIF: HLTF methylation may exist in gastric cardia dysplasia
            stages and may play important role in the development of gastric
            cardia adenocarcinoma.
REFERENCE   9  (bases 1 to 5448)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5448)
  AUTHORS   Li,C., Lusis,A.J., Sparkes,R., Tran,S.M. and Gaynor,R.
  TITLE     Characterization and chromosomal mapping of the gene encoding the
            cellular DNA binding protein HTLF
  JOURNAL   Genomics 13 (3), 658-664 (1992)
   PUBMED   1639393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091485.8.
            
            Summary: This gene encodes a forkhead domain binding protein and
            may function in the transcriptional regulation of the human T-cell
            leukemia virus long terminal repeat. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.237398.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC091485.8         27327-27612
            287-837             AC091485.8         58846-59396
            838-938             AC091485.8         71692-71792
            939-1003            AC091485.8         75288-75352
            1004-1072           AC091485.8         85937-86005
            1073-5448           AC091485.8         87565-91940
FEATURES             Location/Qualifiers
     source          1..5448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.3"
     gene            1..5448
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="forkhead box N2"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
     exon            1..286
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            287..837
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1596
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="isoform a is encoded by transcript variant 7; human
                     T-cell leukemia virus enhancer factor; forkhead box
                     protein N2"
                     /codon_start=1
                     /product="forkhead box protein N2 isoform a"
                     /protein_id="NP_001362376.1"
                     /db_xref="CCDS:CCDS1838.1"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
                     /translation="MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKA
                     TLVDSESADDELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEGDDVPSFGPACYQ
                     NPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSV
                     RHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSASSQNGSLSP
                     HYLSSVIKQNQVRNLKESDIDAAAAMMLLNTSIEQGILECEKPLPLKTALQKKRSYGN
                     AFHHPSAVRLQESDSLATSIDPKEDHNYSASSMAAQRCASRSSVSSLSSVDEVYEFIP
                     KNSHVGSDGSEGFHSEEDTDVDYEDDPLGDSGYASQPCAKISEKGQSGKKMRKQTCQE
                     IDEELKEAAGSLLHLAGIRTCLGSLISTAKTQNQKQRKK"
     exon            838..938
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1003
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1072
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..5448
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5312..5317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: ATTAAA"
     polyA_site      5332
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="major polyA site"
     regulatory      5425..5430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: AATAAA"
     polyA_site      5448
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
ORIGIN      
        1 actgcagctg ctgctgcctg ctggttgccg cgtcttcccg gaggcgactg ctggaagctg
       61 cagggaacag ctgcggtgct ctgccatatt gtgtcttccc cggccggtcc ctcgcctccc
      121 ggccgagctg acggtgagtc ccgggcggag cggtcccctc cagggtcggc gctccccgcc
      181 ccagcccgcg gcgcagctcc cgggcgcgga ggcagcgcga gcgacccgcg ccaggcgtgg
      241 ggcgcggagg cggctgtccc gtgacgcgcc cggacatttt tgtccaaact gtaagagtaa
      301 atgggtccag taattggaat gactccagat aagagagctg aaaccccagg agctgaaaag
      361 attgcaggat taagccagat ttacaaaatg ggaagcttgc ctgaagctgt tgatgctgcc
      421 aggccgaagg ccactctagt ggacagtgag tcagcagatg atgaactcac aaacttgaac
      481 tggcttcatg aaagcactaa tcttctaaca aacttcagcc tcggaagtga gggtcttcca
      541 attgttagtc cattgtatga catagaggga gatgatgtgc catcctttgg accagcttgc
      601 taccagaacc cagaaaaaaa atcagcgact tcaaagcccc catactcctt tagtcttctc
      661 atttatatgg ccattgagca ctctccaaat aaatgtttgc ctgtcaaaga aatttatagc
      721 tggattctgg accattttcc atattttgct actgcaccaa caggctggaa gaattctgtt
      781 cgacataatc tgtccctgaa taaatgtttt cagaaagtgg aaagaagcca tggcaaggtt
      841 aatggaaaag gttccttatg gtgtgttgat ccggaatata aacccaatct tatccaggca
      901 ctgaagaagc aacctttttc ttcagcatct tcacaaaatg gttctttatc acctcactat
      961 ttaagctctg taatcaagca gaaccaggtg cgaaacctca aagaatctga tattgatgct
     1021 gctgctgcaa tgatgctttt aaatacttct atagaacaag gaattttaga atgtgagaag
     1081 cctcttcctc ttaaaacagc attgcaaaaa aagaggagtt acggcaatgc atttcatcat
     1141 cccagtgctg tacgattaca agagagtgat tctttagcca ccagcattga tccaaaagaa
     1201 gatcacaatt acagtgcaag tagcatggca gcacagcgtt gtgcatccag gtctagcgtg
     1261 tcttccctgt cttctgtgga tgaggtatat gaatttatcc caaagaatag tcacgtggga
     1321 agtgatggca gtgaaggatt tcacagtgaa gaagatacag acgttgatta tgaagatgat
     1381 cctcttggag acagtggcta tgcatcacag ccttgtgcaa aaatctctga aaaagggcag
     1441 tcaggcaaaa agatgcgaaa acagacatgt caagaaattg atgaggagct caaagaggca
     1501 gctggatctc tgctccacct tgctggaatt cgtacatgtt taggttccct aataagtact
     1561 gcaaagacac aaaatcaaaa gcaacggaaa aaatagaaat acttaaagtg tggcaatact
     1621 ctttcactta attctttaca agggatatca aagccataat ggacttcatt agttttaggg
     1681 tagggaaggg atactaatta cttatttctt tcaaaacatt tttggttttt ggtttttaaa
     1741 atttttatta aacaattgct gttaggatca tgcctgatca gaaatacatg atgtgaagtc
     1801 ctaaaagcat aatttttgtg ataaatgtgt ccaagatttg aaaattttta tataagaaaa
     1861 tccccagcct ctgtcttaaa cttgtgggac aaaaatcctt tcttctgtta atatgtcaga
     1921 atgtaagatt tggcaactcg ataaattttt ttcattttct tttccaatct gtaactatag
     1981 ttactgaacc agctaaaaat tttgctgatg tatttttcat atacttctct cctgacacgc
     2041 aatccggtaa cataagattg aaattttttt actttgtctt aatttgtttc taattttttt
     2101 tttgttgtcg tgtgagcaaa gacaaacata aattgaaaaa catcctgatg tttagaaagt
     2161 ttcttttggt tacgtaggta gagaatacaa caaagagttc taagacttag aaaagacaat
     2221 tttgtggtgt catttcatcc aagaacactc ccaattccta ttagaatggt agctttgaag
     2281 tgtttttact tcagagatcc tgcatagcat ttattggggc cttttattct ttcccaaagt
     2341 gctttgcaaa cattaagttt tagccactag ctgcctttgt tgagtataag ttatccagtg
     2401 agaggatata gccaattaag tgtgttatgg agtacaccca ttttgacaca cttgtaataa
     2461 gagaatcttt catttgcctg ccatgtgtac tgtattatga gaatcttata atcggaatgg
     2521 agtgaaatga aacattttga gtactgatgg catgttatca tacataaagt aggtcattta
     2581 ggaaaaaact tctgtccaag ctttgtatga attaaattca taagtatacc aaattaaatc
     2641 ttaatagatt taatgcaatt ttacagacac aataccttca tgaatttcaa aattcatata
     2701 aaatttgatc ttatgcaata cacctttttg aggaggcagt gtaacaacct atagtgccat
     2761 tgatccatga gaaaaagatt ttctggtact actccaaaag tgctttgact aagtatctta
     2821 actatttgaa cagtctgctt atatgagaca gtttttcata gtatcatttg tataatttga
     2881 ttagattatt cagaaacaat aggatgctaa actaattcat tgtatctttt ttttacaatg
     2941 gtggaagcaa ctttctgaaa gttcagtctt atgctacatc ctaagtcata gacaatgacc
     3001 ttgttttcat tattctgata gattgtatac atatgtacac atacatatac acatatgcac
     3061 agtcaaggtc atgatgttga tttgctttca gctgtttctg tgattataaa gcatttttta
     3121 agagacaaat tttaactttt aatttttatt ttggcaaaac tgtcaaatga gaaaaatgat
     3181 tttaaaaact tttttttcaa ttgacaagac tttaagtcag ggataacagt attaatgttc
     3241 tctgttctgt ttccatgtta aatttaattt aacctggata gccacattaa tgaattggtg
     3301 ctgtcaaaat atagtaattt ttaaatttgt taataatgaa aacccttaag catgcaggat
     3361 gaggtatttg ggtttttttt ttagatcgat cacatctaca gaaaatggct aaaccaagtt
     3421 aacttttatt atagacagtg aataaaacac caaaaaccca aaaatgcttt aaccacagta
     3481 taaataatag attatacaca tcatcttaat aactattttt aagttattta ccatagcctc
     3541 tgtatagacc ttaggaacag tgtttcagtg atctggcacc agtttatttt gttctgctga
     3601 aattctgtat cacaaatgtg ctacctggtt tttgtccatt agataattac tctttataag
     3661 gaaaggaaag agaagcagag ttagttccag ctctaatagg gatcttcaaa gttattttgt
     3721 cttgatgtat gtaacagtaa ttctttacat cttttgattt ttctcttcct ttttattcac
     3781 tcttcccacg aatttaaatg tttaagttat attcatcact agcaaggatg ataaacactt
     3841 gtgcactgaa agctaacagg gagaggttac acaatatttt acagtttctt aaacataatt
     3901 taatgcatca ccttccactt gctaacatac caagtcagtt attttcaagg gaagaacctt
     3961 ttaaattatg gtcctccatt tactacttcc actgagagta tgctctcatt cctcaggtgt
     4021 tttgagaaac atgactaata accacacaat taagtagagt cattccaagt cctatggcct
     4081 ggaaattgta ttccctataa tatacaaatt ttcctgtaat aaagtcaact tagaaactcc
     4141 aaggaggtta catgttttcc aacatatcct aaaaactgtg atataagcta acatataatt
     4201 tgccttacgt caaaagaata tgttttgttg cagctgattc cagtttataa tagatcccta
     4261 gtaaaaagct ttgattcaac acaattgttc atcttcacat cccaaacaga atcactgttt
     4321 cttgaatata tatttttgaa gtttttttgt gcaatatatt actaaatcag ttattatttt
     4381 acttttccaa attcagagaa agaaaacaga ttacctgaat tcatggaaaa ggtggatcac
     4441 ctcccttttt ccaccttcaa gcctttcctg tcctcatagc cagcatgact tcttttaact
     4501 tggattcctt tgtatatagt aaagtttagt atatatatat ttttttcttt ttgctacttt
     4561 ctgaggcatt atgtaaaggg ctcatactag atgttcagtt aaatatactt tagcacaaag
     4621 tcaaactaga gaatgtgtta aggagggaat gtatatgtct tggtagacca ggaggccttt
     4681 gccagcaatt taagcaacag atgtgaatac ttcacaaagc tgtaaagacc attgtcttaa
     4741 atactacaac aacttaacac ccttttgtga agatcacagc atttatctaa gaaactgtga
     4801 ggctttctgg tttacatata tcttacaggt gtttttttgt attttttttt ttttttagtt
     4861 tgaaatgtgt aagctttgat ttaaaccaag tttacttcag tatgttaatg atgtagtaaa
     4921 aatatttatt gaaaggtgaa ttcgagtatt ttaatgttat acctgccatt ttttttctta
     4981 aagcatattc tttgcatcta actgccagtg ccattgtcaa aacttatttt ttaaatcgtt
     5041 gtacatttct tattaaacta agtgcttaat tttaaagtat tatgttgcca tcatatagtg
     5101 tataaaaatg tataattgcc aattgattgt aactattatt tatttttaaa tgaaagtgta
     5161 agaatgcttt ctgattcaac aaatttgtta tcaaactgtt tccttatcct cttttctgat
     5221 gtagcataaa aattgtcccg gtttgagtta taactgccag tagatgacca gtcacaagtg
     5281 aaccacttct cagttgccaa tctttgctca tattaaaaac aacttacaaa tacttagttt
     5341 ttgtatctaa tctctgatta ttaaaatgtt tataaagttt atttttacca aagagatgca
     5401 attcattatg agaaagtatt gcataataaa ttttgtttta taactttt
//
