LOCUS       NM_001375444            5295 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens forkhead box N2 (FOXN2), transcript variant 4, mRNA.
ACCESSION   NM_001375444 XM_005264282
VERSION     NM_001375444.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5295)
  AUTHORS   Song,Y., Lian,S., Fan,H., Ma,C., Zheng,L., Huang,F., Huang,S.,
            Tang,Y., Shi,A., Shu,L., Zhao,L., Xu,Y., Guo,S., Liu,Z. and
            Zhang,Z.
  TITLE     Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner
  JOURNAL   Cancer Lett 592, 216921 (2024)
   PUBMED   38705565
  REMARK    GeneRIF: Bmi1 facilitates the progression of cholangiocarcinoma by
            inhibiting Foxn2 expression dependent on a histone H2A
            ubiquitination manner.
REFERENCE   2  (bases 1 to 5295)
  AUTHORS   Wang,H., Liang,C., Lin,J., Dong,Y., Wang,Y. and Xia,L.
  TITLE     Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations
            Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression
  JOURNAL   Mol Biotechnol 66 (6), 1477-1483 (2024)
   PUBMED   37318741
  REMARK    GeneRIF: Hsa_circ_0001741 Suppresses Ovarian Cancer Cell
            Proliferations Through Adsorption of miR-188-5p and Promotion of
            FOXN2 Expression.
REFERENCE   3  (bases 1 to 5295)
  AUTHORS   Li,L., Sun,X., Zhang,M., Zhang,B., Yang,Y. and Wang,S.
  TITLE     FOXN2, identified as a novel biomarker in serum, modulates the
            transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer
  JOURNAL   Growth Factors 42 (2), 62-73 (2024)
   PUBMED   38954805
  REMARK    GeneRIF: FOXN2, identified as a novel biomarker in serum, modulates
            the transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer.
REFERENCE   4  (bases 1 to 5295)
  AUTHORS   Jeong,S., Kim,S.A. and Ahn,S.G.
  TITLE     HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through
            the Inhibition of the Tumor Suppressor FOXN2
  JOURNAL   Int J Mol Sci 23 (1), 9 (2021)
   PUBMED   35008435
  REMARK    GeneRIF: HOXC6-Mediated miR-188-5p Expression Induces Cell
            Migration through the Inhibition of the Tumor Suppressor FOXN2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5295)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5295)
  AUTHORS   Cheng,C.K., Chan,N.P., Wan,T.S., Lam,L.Y., Cheung,C.H., Wong,T.H.,
            Ip,R.K., Wong,R.S. and Ng,M.H.
  TITLE     Helicase-like transcription factor is a RUNX1 target whose
            downregulation promotes genomic instability and correlates with
            complex cytogenetic features in acute myeloid leukemia
  JOURNAL   Haematologica 101 (4), 448-457 (2016)
   PUBMED   26802049
  REMARK    GeneRIF: HTLF is a RUNX1 target whose down-regulation promotes
            genomic instability and correlates with complex cytogenetic
            abnormalities in acute myeloid leukemia patients.
REFERENCE   7  (bases 1 to 5295)
  AUTHORS   Li,X., Wang,W., Wang,J., Malovannaya,A., Xi,Y., Li,W., Guerra,R.,
            Hawke,D.H., Qin,J. and Chen,J.
  TITLE     Proteomic analyses reveal distinct chromatin-associated and soluble
            transcription factor complexes
  JOURNAL   Mol Syst Biol 11 (1), 775 (2015)
   PUBMED   25609649
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5295)
  AUTHORS   Guo,W., Dong,Z., Guo,Y., Chen,Z., Kuang,G. and Yang,Z.
  TITLE     Aberrant methylation of the CpG island of HLTF gene in gastric
            cardia adenocarcinoma and dysplasia
  JOURNAL   Clin Biochem 44 (10-11), 784-788 (2011)
   PUBMED   21531217
  REMARK    GeneRIF: HLTF methylation may exist in gastric cardia dysplasia
            stages and may play important role in the development of gastric
            cardia adenocarcinoma.
REFERENCE   9  (bases 1 to 5295)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5295)
  AUTHORS   Li,C., Lusis,A.J., Sparkes,R., Tran,S.M. and Gaynor,R.
  TITLE     Characterization and chromosomal mapping of the gene encoding the
            cellular DNA binding protein HTLF
  JOURNAL   Genomics 13 (3), 658-664 (1992)
   PUBMED   1639393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091485.8.
            
            On Oct 28, 2019 this sequence version replaced XM_005264282.2.
            
            Summary: This gene encodes a forkhead domain binding protein and
            may function in the transcriptional regulation of the human T-cell
            leukemia virus long terminal repeat. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.18083.1,
                                           SRR11853564.15357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC091485.8         27327-27459
            134-684             AC091485.8         58846-59396
            685-785             AC091485.8         71692-71792
            786-850             AC091485.8         75288-75352
            851-919             AC091485.8         85937-86005
            920-5295            AC091485.8         87565-91940
FEATURES             Location/Qualifiers
     source          1..5295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.3"
     gene            1..5295
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="forkhead box N2"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
     exon            1..133
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            134..684
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1443
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="isoform a is encoded by transcript variant 4; human
                     T-cell leukemia virus enhancer factor; forkhead box
                     protein N2"
                     /codon_start=1
                     /product="forkhead box protein N2 isoform a"
                     /protein_id="NP_001362373.1"
                     /db_xref="CCDS:CCDS1838.1"
                     /db_xref="GeneID:3344"
                     /db_xref="HGNC:HGNC:5281"
                     /db_xref="MIM:143089"
                     /translation="MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKA
                     TLVDSESADDELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEGDDVPSFGPACYQ
                     NPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSV
                     RHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSASSQNGSLSP
                     HYLSSVIKQNQVRNLKESDIDAAAAMMLLNTSIEQGILECEKPLPLKTALQKKRSYGN
                     AFHHPSAVRLQESDSLATSIDPKEDHNYSASSMAAQRCASRSSVSSLSSVDEVYEFIP
                     KNSHVGSDGSEGFHSEEDTDVDYEDDPLGDSGYASQPCAKISEKGQSGKKMRKQTCQE
                     IDEELKEAAGSLLHLAGIRTCLGSLISTAKTQNQKQRKK"
     exon            685..785
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            786..850
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            851..919
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     exon            920..5295
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5159..5164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: ATTAAA"
     polyA_site      5179
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="major polyA site"
     regulatory      5272..5277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
                     /note="hexamer: AATAAA"
     polyA_site      5295
                     /gene="FOXN2"
                     /gene_synonym="HTLF"
ORIGIN      
        1 actgcagctg ctgctgcctg ctggttgccg cgtcttcccg gaggcgactg ctggaagctg
       61 cagggaacag ctgcggtgct ctgccatatt gtgtcttccc cggccggtcc ctcgcctccc
      121 ggccgagctg acgaactgta agagtaaatg ggtccagtaa ttggaatgac tccagataag
      181 agagctgaaa ccccaggagc tgaaaagatt gcaggattaa gccagattta caaaatggga
      241 agcttgcctg aagctgttga tgctgccagg ccgaaggcca ctctagtgga cagtgagtca
      301 gcagatgatg aactcacaaa cttgaactgg cttcatgaaa gcactaatct tctaacaaac
      361 ttcagcctcg gaagtgaggg tcttccaatt gttagtccat tgtatgacat agagggagat
      421 gatgtgccat cctttggacc agcttgctac cagaacccag aaaaaaaatc agcgacttca
      481 aagcccccat actcctttag tcttctcatt tatatggcca ttgagcactc tccaaataaa
      541 tgtttgcctg tcaaagaaat ttatagctgg attctggacc attttccata ttttgctact
      601 gcaccaacag gctggaagaa ttctgttcga cataatctgt ccctgaataa atgttttcag
      661 aaagtggaaa gaagccatgg caaggttaat ggaaaaggtt ccttatggtg tgttgatccg
      721 gaatataaac ccaatcttat ccaggcactg aagaagcaac ctttttcttc agcatcttca
      781 caaaatggtt ctttatcacc tcactattta agctctgtaa tcaagcagaa ccaggtgcga
      841 aacctcaaag aatctgatat tgatgctgct gctgcaatga tgcttttaaa tacttctata
      901 gaacaaggaa ttttagaatg tgagaagcct cttcctctta aaacagcatt gcaaaaaaag
      961 aggagttacg gcaatgcatt tcatcatccc agtgctgtac gattacaaga gagtgattct
     1021 ttagccacca gcattgatcc aaaagaagat cacaattaca gtgcaagtag catggcagca
     1081 cagcgttgtg catccaggtc tagcgtgtct tccctgtctt ctgtggatga ggtatatgaa
     1141 tttatcccaa agaatagtca cgtgggaagt gatggcagtg aaggatttca cagtgaagaa
     1201 gatacagacg ttgattatga agatgatcct cttggagaca gtggctatgc atcacagcct
     1261 tgtgcaaaaa tctctgaaaa agggcagtca ggcaaaaaga tgcgaaaaca gacatgtcaa
     1321 gaaattgatg aggagctcaa agaggcagct ggatctctgc tccaccttgc tggaattcgt
     1381 acatgtttag gttccctaat aagtactgca aagacacaaa atcaaaagca acggaaaaaa
     1441 tagaaatact taaagtgtgg caatactctt tcacttaatt ctttacaagg gatatcaaag
     1501 ccataatgga cttcattagt tttagggtag ggaagggata ctaattactt atttctttca
     1561 aaacattttt ggtttttggt ttttaaaatt tttattaaac aattgctgtt aggatcatgc
     1621 ctgatcagaa atacatgatg tgaagtccta aaagcataat ttttgtgata aatgtgtcca
     1681 agatttgaaa atttttatat aagaaaatcc ccagcctctg tcttaaactt gtgggacaaa
     1741 aatcctttct tctgttaata tgtcagaatg taagatttgg caactcgata aatttttttc
     1801 attttctttt ccaatctgta actatagtta ctgaaccagc taaaaatttt gctgatgtat
     1861 ttttcatata cttctctcct gacacgcaat ccggtaacat aagattgaaa tttttttact
     1921 ttgtcttaat ttgtttctaa tttttttttt gttgtcgtgt gagcaaagac aaacataaat
     1981 tgaaaaacat cctgatgttt agaaagtttc ttttggttac gtaggtagag aatacaacaa
     2041 agagttctaa gacttagaaa agacaatttt gtggtgtcat ttcatccaag aacactccca
     2101 attcctatta gaatggtagc tttgaagtgt ttttacttca gagatcctgc atagcattta
     2161 ttggggcctt ttattctttc ccaaagtgct ttgcaaacat taagttttag ccactagctg
     2221 cctttgttga gtataagtta tccagtgaga ggatatagcc aattaagtgt gttatggagt
     2281 acacccattt tgacacactt gtaataagag aatctttcat ttgcctgcca tgtgtactgt
     2341 attatgagaa tcttataatc ggaatggagt gaaatgaaac attttgagta ctgatggcat
     2401 gttatcatac ataaagtagg tcatttagga aaaaacttct gtccaagctt tgtatgaatt
     2461 aaattcataa gtataccaaa ttaaatctta atagatttaa tgcaatttta cagacacaat
     2521 accttcatga atttcaaaat tcatataaaa tttgatctta tgcaatacac ctttttgagg
     2581 aggcagtgta acaacctata gtgccattga tccatgagaa aaagattttc tggtactact
     2641 ccaaaagtgc tttgactaag tatcttaact atttgaacag tctgcttata tgagacagtt
     2701 tttcatagta tcatttgtat aatttgatta gattattcag aaacaatagg atgctaaact
     2761 aattcattgt atcttttttt tacaatggtg gaagcaactt tctgaaagtt cagtcttatg
     2821 ctacatccta agtcatagac aatgaccttg ttttcattat tctgatagat tgtatacata
     2881 tgtacacata catatacaca tatgcacagt caaggtcatg atgttgattt gctttcagct
     2941 gtttctgtga ttataaagca ttttttaaga gacaaatttt aacttttaat ttttattttg
     3001 gcaaaactgt caaatgagaa aaatgatttt aaaaactttt ttttcaattg acaagacttt
     3061 aagtcaggga taacagtatt aatgttctct gttctgtttc catgttaaat ttaatttaac
     3121 ctggatagcc acattaatga attggtgctg tcaaaatata gtaattttta aatttgttaa
     3181 taatgaaaac ccttaagcat gcaggatgag gtatttgggt ttttttttta gatcgatcac
     3241 atctacagaa aatggctaaa ccaagttaac ttttattata gacagtgaat aaaacaccaa
     3301 aaacccaaaa atgctttaac cacagtataa ataatagatt atacacatca tcttaataac
     3361 tatttttaag ttatttacca tagcctctgt atagacctta ggaacagtgt ttcagtgatc
     3421 tggcaccagt ttattttgtt ctgctgaaat tctgtatcac aaatgtgcta cctggttttt
     3481 gtccattaga taattactct ttataaggaa aggaaagaga agcagagtta gttccagctc
     3541 taatagggat cttcaaagtt attttgtctt gatgtatgta acagtaattc tttacatctt
     3601 ttgatttttc tcttcctttt tattcactct tcccacgaat ttaaatgttt aagttatatt
     3661 catcactagc aaggatgata aacacttgtg cactgaaagc taacagggag aggttacaca
     3721 atattttaca gtttcttaaa cataatttaa tgcatcacct tccacttgct aacataccaa
     3781 gtcagttatt ttcaagggaa gaacctttta aattatggtc ctccatttac tacttccact
     3841 gagagtatgc tctcattcct caggtgtttt gagaaacatg actaataacc acacaattaa
     3901 gtagagtcat tccaagtcct atggcctgga aattgtattc cctataatat acaaattttc
     3961 ctgtaataaa gtcaacttag aaactccaag gaggttacat gttttccaac atatcctaaa
     4021 aactgtgata taagctaaca tataatttgc cttacgtcaa aagaatatgt tttgttgcag
     4081 ctgattccag tttataatag atccctagta aaaagctttg attcaacaca attgttcatc
     4141 ttcacatccc aaacagaatc actgtttctt gaatatatat ttttgaagtt tttttgtgca
     4201 atatattact aaatcagtta ttattttact tttccaaatt cagagaaaga aaacagatta
     4261 cctgaattca tggaaaaggt ggatcacctc cctttttcca ccttcaagcc tttcctgtcc
     4321 tcatagccag catgacttct tttaacttgg attcctttgt atatagtaaa gtttagtata
     4381 tatatatttt tttctttttg ctactttctg aggcattatg taaagggctc atactagatg
     4441 ttcagttaaa tatactttag cacaaagtca aactagagaa tgtgttaagg agggaatgta
     4501 tatgtcttgg tagaccagga ggcctttgcc agcaatttaa gcaacagatg tgaatacttc
     4561 acaaagctgt aaagaccatt gtcttaaata ctacaacaac ttaacaccct tttgtgaaga
     4621 tcacagcatt tatctaagaa actgtgaggc tttctggttt acatatatct tacaggtgtt
     4681 tttttgtatt tttttttttt tttagtttga aatgtgtaag ctttgattta aaccaagttt
     4741 acttcagtat gttaatgatg tagtaaaaat atttattgaa aggtgaattc gagtatttta
     4801 atgttatacc tgccattttt tttcttaaag catattcttt gcatctaact gccagtgcca
     4861 ttgtcaaaac ttatttttta aatcgttgta catttcttat taaactaagt gcttaatttt
     4921 aaagtattat gttgccatca tatagtgtat aaaaatgtat aattgccaat tgattgtaac
     4981 tattatttat ttttaaatga aagtgtaaga atgctttctg attcaacaaa tttgttatca
     5041 aactgtttcc ttatcctctt ttctgatgta gcataaaaat tgtcccggtt tgagttataa
     5101 ctgccagtag atgaccagtc acaagtgaac cacttctcag ttgccaatct ttgctcatat
     5161 taaaaacaac ttacaaatac ttagtttttg tatctaatct ctgattatta aaatgtttat
     5221 aaagtttatt tttaccaaag agatgcaatt cattatgaga aagtattgca taataaattt
     5281 tgttttataa ctttt
//
