LOCUS       NM_001369369            3521 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens forkhead box N1 (FOXN1), transcript variant 1, mRNA.
ACCESSION   NM_001369369 XM_005258046
VERSION     NM_001369369.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3521)
  AUTHORS   Moses,A., Bhalla,P., Thompson,A., Lai,L., Coskun,F.S.,
            Seroogy,C.M., de la Morena,M.T., Wysocki,C.A. and van Oers,N.S.C.
  TITLE     Comprehensive phenotypic analysis of diverse FOXN1 variants
  JOURNAL   J Allergy Clin Immunol 152 (5), 1273-1291 (2023)
   PUBMED   37419334
  REMARK    GeneRIF: Comprehensive phenotypic analysis of diverse FOXN1
            variants.
REFERENCE   2  (bases 1 to 3521)
  AUTHORS   Wang,J., Li,J. and Yao,X.
  TITLE     [Effects of FoxN1, p63 and AIRE on the process of age-related
            thymus involution: An update]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 39 (1), 88-94 (2023)
   PUBMED   36631020
  REMARK    GeneRIF: [Effects of FoxN1, p63 and AIRE on the process of
            age-related thymus involution: An update].
            Review article
REFERENCE   3  (bases 1 to 3521)
  AUTHORS   Thermos,G., Piperi,E., Tosios,K.I. and Nikitakis,N.G.
  TITLE     Expression of BMP4 and FOXN1 in orthokeratinized odontogenic cyst
            compared to odontogenic keratocyst suggests an epidermal phenotype
  JOURNAL   Biotech Histochem 97 (8), 584-592 (2022)
   PUBMED   35527675
  REMARK    GeneRIF: Expression of BMP4 and FOXN1 in orthokeratinized
            odontogenic cyst compared to odontogenic keratocyst suggests an
            epidermal phenotype.
REFERENCE   4  (bases 1 to 3521)
  AUTHORS   Giardino,G., Sharapova,S.O., Ciznar,P., Dhalla,F., Maragliano,L.,
            Radha Rama Devi,A., Islamoglu,C., Ikinciogullari,A., Haskologlu,S.,
            Dogu,F., Hanna-Wakim,R., Dbaibo,G., Chou,J., Cirillo,E.,
            Borzacchiello,C., Kreins,A.Y., Worth,A., Rota,I.A., Marques,J.G.,
            Sayitoglu,M., Firtina,S., Mahdi,M., Geha,R., Neven,B., Sousa,A.E.,
            Benfenati,F., Hollander,G.A., Davies,E.G. and Pignata,C.
  TITLE     Expanding the Nude SCID/CID Phenotype Associated with FOXN1
            Homozygous, Compound Heterozygous, or Heterozygous Mutations
  JOURNAL   J Clin Immunol 41 (4), 756-768 (2021)
   PUBMED   33464451
  REMARK    GeneRIF: Expanding the Nude SCID/CID Phenotype Associated with
            FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations.
REFERENCE   5  (bases 1 to 3521)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3521)
  AUTHORS   Adriani,M., Martinez-Mir,A., Fusco,F., Busiello,R., Frank,J.,
            Telese,S., Matrecano,E., Ursini,M.V., Christiano,A.M. and
            Pignata,C.
  TITLE     Ancestral founder mutation of the nude (FOXN1) gene in congenital
            severe combined immunodeficiency associated with alopecia in
            southern Italy population
  JOURNAL   Ann Hum Genet 68 (Pt 3), 265-268 (2004)
   PUBMED   15180707
  REMARK    GeneRIF: Mutation of the FOXN1 gene is associated with congenital
            severe combined immunodeficiency associated with alopecia
REFERENCE   7  (bases 1 to 3521)
  AUTHORS   Schlake,T., Schorpp,M., Maul-Pavicic,A., Malashenko,A.M. and
            Boehm,T.
  TITLE     Forkhead/winged-helix transcription factor Whn regulates hair
            keratin gene expression: molecular analysis of the nude skin
            phenotype
  JOURNAL   Dev Dyn 217 (4), 368-376 (2000)
   PUBMED   10767081
REFERENCE   8  (bases 1 to 3521)
  AUTHORS   Frank,J., Pignata,C., Panteleyev,A.A., Prowse,D.M., Baden,H.,
            Weiner,L., Gaetaniello,L., Ahmad,W., Pozzi,N.,
            Cserhalmi-Friedman,P.B., Aita,V.M., Uyttendaele,H., Gordon,D.,
            Ott,J., Brissette,J.L. and Christiano,A.M.
  TITLE     Exposing the human nude phenotype
  JOURNAL   Nature 398 (6727), 473-474 (1999)
   PUBMED   10206641
REFERENCE   9  (bases 1 to 3521)
  AUTHORS   Gattenlohner,S., Muller-Hermelink,H.K. and Marx,A.
  TITLE     Transcription of the nude gene (WHN) in human normal organs and
            mediastinal and pulmonary tumors
  JOURNAL   Pathol Res Pract 195 (8), 571-574 (1999)
   PUBMED   10483588
REFERENCE   10 (bases 1 to 3521)
  AUTHORS   Schorpp,M., Hofmann,M., Dear,T.N. and Boehm,T.
  TITLE     Characterization of mouse and human nude genes
  JOURNAL   Immunogenetics 46 (6), 509-515 (1997)
   PUBMED   9321431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313878.1, Y11739.1,
            AC005726.1 and AI288186.1.
            
            On Apr 8, 2019 this sequence version replaced XM_005258046.3.
            
            Summary: Mutations in the winged-helix transcription factor gene at
            the nude locus in mice and rats produce the pleiotropic phenotype
            of hairlessness and athymia, resulting in a severely compromised
            immune system. This gene is orthologous to the mouse and rat genes
            and encodes a similar DNA-binding transcription factor that is
            thought to regulate keratin gene expression. A mutation in this
            gene has been correlated with T-cell immunodeficiency, the skin
            disorder congenital alopecia, and nail dystrophy. Alternative
            splicing in the 5' UTR of this gene has been observed. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579795.6/ ENSP00000464645.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1609              AK313878.1         89-1697
            1610-1610           Y11739.1           1529-1529
            1611-2057           AK313878.1         1699-2145
            2058-3176           AC005726.1         119257-120375       c
            3177-3517           AI288186.1         24-364              c
            3518-3521           AC005726.1         118912-118915       c
FEATURES             Location/Qualifiers
     source          1..3521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3521
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /note="forkhead box N1"
                     /db_xref="GeneID:8456"
                     /db_xref="HGNC:HGNC:12765"
                     /db_xref="MIM:600838"
     exon            1..96
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     exon            97..233
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2057
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /note="winged-helix nude; Rowett nude; winged-helix
                     transcription factor nude"
                     /codon_start=1
                     /product="forkhead box protein N1"
                     /protein_id="NP_001356298.1"
                     /db_xref="CCDS:CCDS11232.1"
                     /db_xref="GeneID:8456"
                     /db_xref="HGNC:HGNC:12765"
                     /db_xref="MIM:600838"
                     /translation="MVSLPPPQSDVTLPGPTRLEGERQGDLMQAPGLPGSPAPQSKHA
                     GFSCSSFVSDGPPERTPSLPPHSPRIASPGPEQVQGHCPAGPGPGPFRLSPSDKYPGF
                     GFEEAAASSPGRFLKGSHAPFHPYKRPFHEDVFPEAETTLALKGHSFKTPGPLEAFEE
                     IPVDVAEAEAFLPGFSAEAWCNGLPYPSQEHGPQVLGSEVKVKPPVLESGAGMFCYQP
                     PLQHMYCSSQPPFHQYSPGGGSYPIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSY
                     SILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVEN
                     KSGSSSRKGCLWALNPAKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKL
                     GSPLLGCPPPGLSGSGPIRPLAPPAGLSPPLHSLHPAPGPIPGKNPLQDLLMGHTPSC
                     YGQTYLHLSPGLAPPGPPQPLFPQPDGHLELRAQPGTPQDSPLPAHTPPSHSAKLLAE
                     PSPARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSP
                     TSSSMPPPQPPPHCFPPGPCLTETGSGAGDLAAPGSGGSGALGDLHLTTLYSAFMELE
                     PTPPTAPAGPSVYLSPSSKPVALA"
     exon            234..698
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     exon            699..809
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     exon            810..940
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1037
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1245
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1737
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..3521
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /note="hexamer: AATAAA"
     polyA_site      3521
                     /gene="FOXN1"
                     /gene_synonym="FKHL20; RONU; TIDAND; TLIND; WHN"
                     /note="major polyA site"
ORIGIN      
        1 acagacacag gacggccgag ctgacggact gacagacgga cagagctcct ggccccccag
       61 acccgggccc ccacgccgac ctgcttcact gagcaggcca ggactgggtg atggtgtcgc
      121 tacccccgcc gcagtctgac gtcacgctgc cgggccccac cagactggag ggcgagcgcc
      181 aaggggacct catgcaggca ccgggcctcc caggctcccc tgccccacag agtaagcatg
      241 ccggcttcag ctgctcgtca tttgtgtccg acggccctcc agagaggaca ccctcactgc
      301 ccccacacag cccccgcatt gcgtcaccag ggcccgagca agtccagggc cactgcccag
      361 ccggccccgg ccctgggccc ttcaggctct caccctcaga caagtatcct ggctttggct
      421 ttgaggaggc cgcagcaagc agccctgggc gattcctcaa gggcagccac gcgcccttcc
      481 acccgtacaa gcggcctttc catgaggacg tcttcccaga ggccgagacc accctggccc
      541 tcaaaggaca ctcctttaag accccagggc cgctggaggc cttcgaggag atcccagtgg
      601 acgtggcgga ggccgaggcc ttcctgcctg gcttctcagc agaggcctgg tgtaacgggc
      661 tcccctaccc cagccaggag catggccccc aagtcctggg ttcagaggtc aaagtcaagc
      721 ccccagttct ggagagtggt gctgggatgt tctgctacca gcctcccttg cagcatatgt
      781 actgctcctc ccagcccccc ttccaccagt actcgccagg tggtggcagc taccccatac
      841 cctacctggg ctcctcacac tatcagtacc agcgaatggc accccaggcc agcaccgatg
      901 ggcaccagcc tctcttccca aaacccatct attcctacag catcctcatc ttcatggccc
      961 ttaagaacag taaaactggg agccttcccg tcagcgagat ctacaatttt atgacggagc
     1021 actttcctta cttcaagaca gcacccgatg gctggaagaa ttctgtccgg cacaacctat
     1081 ccctcaacaa gtgcttcgag aaggtggaga acaaatcagg aagttcctcc cgcaagggct
     1141 gcctgtgggc cctcaatccg gccaagatcg acaagatgca agaggagctg caaaaatgga
     1201 agaggaaaga tcccattgct gtgcgcaaaa gcatggccaa gccagaagag ctggacagcc
     1261 tcattggaga caagagagaa aagctgggct ccccactcct gggctgtccg ccccctgggc
     1321 tgtccggctc aggccccatc cggcccctgg cacccccagc tggcctctcc ccaccactgc
     1381 actcactcca cccagctcca ggccccattc ctggcaagaa ccccctgcag gacctactta
     1441 tggggcacac accctcctgc tatgggcaga catacttgca cctctcacca ggcctggccc
     1501 ctcctggacc cccgcagcca ttgttcccac agccggacgg gcaccttgag ctgcgggccc
     1561 agccaggcac cccccaggac tcgcctctgc ctgcccacac cccacccagc cacagtgcca
     1621 agctactggc cgagccttcc ccagccagga ctatgcacga caccctgctg ccagatggag
     1681 accttggcac tgacctggat gccatcaatc cctcactcac tgacttcgac ttccagggaa
     1741 acctgtggga acagttgaag gatgatagct tggccctcga ccccctggta ctggtgacct
     1801 catccccgac atcatcttcg atgccaccac cccagccacc acctcactgc ttcccccctg
     1861 ggccctgtct gacagagaca ggcagtgggg caggtgactt ggcagccccg ggcagtggtg
     1921 gctccggggc actgggtgac ctgcacctca ccaccctcta ctctgccttt atggagctgg
     1981 agcccacgcc ccccacggcc cctgcaggcc cctctgtgta cctcagcccc agctccaagc
     2041 ccgtggccct ggcatgagct gtgcccagct tcgtcagctc cagcgtttgc ctggtctgga
     2101 agtcctggcc ggccgcccac atcgggctca ccttaaaggt caaggaagga aaatactacc
     2161 tgtcccctat gccactaagc caacgtgtgt gtcagctggt agctgggggc gcagaggaca
     2221 tcacctgggg tgctgcctct cacacatttc tgccacgtgg tggcccagct cctcacccag
     2281 ggcccccaaa gagcaagcgt ctgggcaaga ggaaaatgcc ctgtccctag ctcacactca
     2341 tccacactta agccctcgtg cacacacaca aattattcag atgtacaccc acccacatat
     2401 cttacagcca gaggaaccag cactccatca ctgagagccc gacttcgttt ctggggcaac
     2461 tgagagctga gcgctttgct taccaaaagc tcagggccct gtgccaggcc aaagatcccc
     2521 ccagaccccc attctgacat ccacatgctc tgcagtcctg gccccctcgt cattttcttt
     2581 cccagaagcg ccctgtattt attcccccat cttcatccca acagcccagc aagaaggagg
     2641 agacagagag ctcctccctg ggttgtctgt ggaccccccc aggagctgct aattggcagc
     2701 acccactcag ccattctcta cccatcctta gtacatgctc tgtccagctt tccccagggt
     2761 gacatacaga aggggcaaca tctacccggg caccaaactg agcccaattc cgaagcagtg
     2821 tttggaaaag cccttgccct cggaaacttg aacatgtcct ttttccccag tcccgggtgc
     2881 aggaagggcc ccctccaggt caccacaatc tcactcctcc tccagaaaga aaagttcaca
     2941 tagtttaggt cctggcttaa ctctacttat gatggttcaa cttacacttt ttcaacttta
     3001 agatggtgca aaagcaatac acattcagta tgttcctcga cttaggatgc ggttatgtcc
     3061 gataaaccca ttgtaaattg aaaccaccga aagtcaaaaa ccactttcga cttacgatgt
     3121 ttcccactca cgatgggttt ctccggatgt agccccatca taagttgagg agcacctgtt
     3181 agttacttcc aactgtctca ggcaacctgg gcattcagga gaaaagcctg gcacagggtg
     3241 acagggaagc acccatgcaa agcacccccg ctttgactgc ttggcagacc tagggtgccc
     3301 gggaagcaca agggataccc ttggccctgc ggggtgtggc ccaggtgcct gccatgagcc
     3361 tgaccccatc gagggggaac ctcagcccac cctgggcctg ggggtgacaa gaacttccac
     3421 aggttggccc caggcttata ggaggcataa gcagatcccg cgatggcttg tcattgtccc
     3481 ctgtcctgga acaataaagc aagtgccttg tggtctcact a
//
