LOCUS       NM_202002               3666 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box M1 (FOXM1), transcript variant 1, mRNA.
ACCESSION   NM_202002
VERSION     NM_202002.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3666)
  AUTHORS   Yildiz,B., Demirel,R., Staudacher,J.J., Beseren,H., Yildiz,G.,
            Akpinar,A.E., Park,S.H. and Ozden,O.
  TITLE     SIRT2 deacetylates and decreases the expression of FOXM1 in colon
            cancer
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70018 (2024)
   PUBMED   39425454
  REMARK    GeneRIF: SIRT2 deacetylates and decreases the expression of FOXM1
            in colon cancer.
REFERENCE   2  (bases 1 to 3666)
  AUTHORS   Wang,W., Li,H., Qian,Y., Li,M., Deng,M., Bi,D. and Zou,J.
  TITLE     ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A
            Demethylation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 34 (2024)
   PUBMED   39441582
  REMARK    GeneRIF: ALKBH5 Regulates Corneal Neovascularization by Mediating
            FOXM1 M6A Demethylation.
REFERENCE   3  (bases 1 to 3666)
  AUTHORS   Leclair,N.K., Lucas,C.G., Mirchia,K., McCortney,K., Horbinski,C.M.,
            Raleigh,D.R. and Anczukow,O.
  TITLE     The RNA-binding protein IGF2BP1 regulates stability of mRNA
            transcribed from FOXM1 target genes in hypermitotic meningiomas
  JOURNAL   Acta Neuropathol 148 (1), 28 (2024)
   PUBMED   39179895
  REMARK    GeneRIF: The RNA-binding protein IGF2BP1 regulates stability of
            mRNA transcribed from FOXM1 target genes in hypermitotic
            meningiomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3666)
  AUTHORS   Wu,Y., Luo,Y., Yao,X., Shi,X., Xu,Z., Re,J., Shi,M., Li,M., Liu,J.,
            He,Y. and Du,X.
  TITLE     KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A
            modification to promote aerobic glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Cell Biol Toxicol 40 (1), 58 (2024)
   PUBMED   39060874
  REMARK    GeneRIF: KIAA1429 increases FOXM1 expression through
            YTHDF1-mediated m6A modification to promote aerobic glycolysis and
            tumorigenesis in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3666)
  AUTHORS   Polito,M.P., Marini,G., Fabrizi,A., Sercia,L., Enzo,E. and De
            Luca,M.
  TITLE     Biochemical role of FOXM1-dependent histone linker H1B in human
            epidermal stem cells
  JOURNAL   Cell Death Dis 15 (7), 508 (2024)
   PUBMED   39019868
  REMARK    GeneRIF: Biochemical role of FOXM1-dependent histone linker H1B in
            human epidermal stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3666)
  AUTHORS   Luscher-Firzlaff,J.M., Westendorf,J.M., Zwicker,J., Burkhardt,H.,
            Henriksson,M., Muller,R., Pirollet,F. and Luscher,B.
  TITLE     Interaction of the fork head domain transcription factor MPP2 with
            the human papilloma virus 16 E7 protein: enhancement of
            transformation and transactivation
  JOURNAL   Oncogene 18 (41), 5620-5630 (1999)
   PUBMED   10523841
REFERENCE   7  (bases 1 to 3666)
  AUTHORS   Korver,W., Roose,J., Heinen,K., Weghuis,D.O., de Bruijn,D., van
            Kessel,A.G. and Clevers,H.
  TITLE     The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and
            promoter characterization
  JOURNAL   Genomics 46 (3), 435-442 (1997)
   PUBMED   9441747
REFERENCE   8  (bases 1 to 3666)
  AUTHORS   Yao,K.M., Sha,M., Lu,Z. and Wong,G.G.
  TITLE     Molecular analysis of a novel winged helix protein, WIN. Expression
            pattern, DNA binding property, and alternative splicing within the
            DNA binding domain
  JOURNAL   J Biol Chem 272 (32), 19827-19836 (1997)
   PUBMED   9242644
REFERENCE   9  (bases 1 to 3666)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol Cell Biol 17 (3), 1626-1641 (1997)
   PUBMED   9032290
REFERENCE   10 (bases 1 to 3666)
  AUTHORS   Westendorf,J.M., Rao,P.N. and Gerace,L.
  TITLE     Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2
            monoclonal antibody and determination of the phosphorylated epitope
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 714-718 (1994)
   PUBMED   8290587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005911.6 and AC005841.3.
            
            On Jun 2, 2019 this sequence version replaced NM_202002.2.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator involved in cell proliferation. The encoded protein is
            phosphorylated in M phase and regulates the expression of several
            cell cycle genes, such as cyclin B1 and cyclin D1. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U74612.1, SRR6380202.86675.9
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC005911.6         99316-99570
            256-804             AC005841.3         1479-2027
            805-956             AC005841.3         3757-3908
            957-1148            AC005841.3         7250-7441
            1149-1277           AC005841.3         9483-9611
            1278-1322           AC005841.3         10605-10649
            1323-1392           AC005841.3         11252-11321
            1393-1568           AC005841.3         11509-11684
            1569-1682           AC005841.3         14592-14705
            1683-3666           AC005841.3         16341-18324
FEATURES             Location/Qualifiers
     source          1..3666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..3666
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="forkhead box M1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
     exon            1..255
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            256..804
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2708
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Forkhead, drosophila, homolog-like 16; M-phase
                     phosphoprotein 2; HNF-3/fork-head homolog 11;
                     transcription factor Trident; MPM-2 reactive
                     phosphoprotein 2; forkhead-related protein FKHL16;
                     winged-helix factor from INS-1 cells; hepatocyte nuclear
                     factor 3 forkhead homolog 11; forkhead box M1-D"
                     /codon_start=1
                     /product="forkhead box protein M1 isoform 1"
                     /protein_id="NP_973731.1"
                     /db_xref="CCDS:CCDS8516.1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
                     /translation="MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQA
                     EASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSG
                     PNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALC
                     EQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVK
                     VEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHI
                     AKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQL
                     PEHLESQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQ
                     PSVKVPLPLAASLMSSELARHSKRVRIAPKVFGEQVVFGYMSKFFSGDLRDFGTPITS
                     LFNFIFLCLSVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEM
                     PHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVS
                     EMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPAS
                     QLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQ
                     GASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKP
                     GSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIP
                     ELQ"
     exon            805..956
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1148
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1277
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1322
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1392
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1568
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1682
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..3666
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3644..3649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="hexamer: AATAAA"
     polyA_site      3666
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="major polyA site"
ORIGIN      
        1 aacgctccgc cggcgccaat ttcaaacagc ggaacaaact gaaagctccg gtgccagacc
       61 ccacccccgg ccccggcccg ggaccccctc ccctcccggg atcccccggg gttcccaccc
      121 cgcccgcacc gccggggacc cggccggtcc ggcgcgagcc cccgtccggg gccctggctc
      181 ggcccccagg ttggaggagc ccggagcccg ccttcggagc tacggcctaa cggcggcggc
      241 gactgcagtc tggagggtcc acacttgtga ttctcaatgg agagtgaaaa cgcagattca
      301 taatgaaaac tagcccccgt cggccactga ttctcaaaag acggaggctg ccccttcctg
      361 ttcaaaatgc cccaagtgaa acatcagagg aggaacctaa gagatcccct gcccaacagg
      421 agtctaatca agcagaggcc tccaaggaag tggcagagtc caactcttgc aagtttccag
      481 ctgggatcaa gattattaac caccccacca tgcccaacac gcaagtagtg gccatcccca
      541 acaatgctaa tattcacagc atcatcacag cactgactgc caagggaaaa gagagtggca
      601 gtagtgggcc caacaaattc atcctcatca gctgtggggg agccccaact cagcctccag
      661 gactccggcc tcaaacccaa accagctatg atgccaaaag gacagaagtg accctggaga
      721 ccttgggacc aaaacctgca gctagggatg tgaatcttcc tagaccacct ggagcccttt
      781 gcgagcagaa acgggagacc tgtgcagatg gtgaggcagc aggctgcact atcaacaata
      841 gcctatccaa catccagtgg cttcgaaaga tgagttctga tggactgggc tcccgcagca
      901 tcaagcaaga gatggaggaa aaggagaatt gtcacctgga gcagcgacag gttaaggttg
      961 aggagccttc gagaccatca gcgtcctggc agaactctgt gtctgagcgg ccaccctact
     1021 cttacatggc catgatacaa ttcgccatca acagcactga gaggaagcgc atgactttga
     1081 aagacatcta tacgtggatt gaggaccact ttccctactt taagcacatt gccaagccag
     1141 gctggaagaa ctccatccgc cacaaccttt ccctgcacga catgtttgtc cgggagacgt
     1201 ctgccaatgg caaggtctcc ttctggacca ttcaccccag tgccaaccgc tacttgacat
     1261 tggaccaggt gtttaagcca ctggacccag ggtctccaca attgcccgag cacttggaat
     1321 cacagcagaa acgaccgaat ccagagctcc gccggaacat gaccatcaaa accgaactcc
     1381 ccctgggcgc acggcggaag atgaagccac tgctaccacg ggtcagctca tacctggtac
     1441 ctatccagtt cccggtgaac cagtcactgg tgttgcagcc ctcggtgaag gtgccattgc
     1501 ccctggcggc ttccctcatg agctcagagc ttgcccgcca tagcaagcga gtccgcattg
     1561 cccccaaggt ttttggggaa caggtggtgt ttggttacat gagtaagttc tttagtggcg
     1621 atctgcgaga ttttggtaca cccatcacca gcttgtttaa ttttatcttt ctttgtttat
     1681 cagtgctgct agctgaggag gggatagctc ctctttcttc tgcaggacca gggaaagagg
     1741 agaaactcct gtttggagaa gggttttctc ctttgcttcc agttcagact atcaaggagg
     1801 aagaaatcca gcctggggag gaaatgccac acttagcgag acccatcaaa gtggagagcc
     1861 ctcccttgga agagtggccc tccccggccc catctttcaa agaggaatca tctcactcct
     1921 gggaggattc gtcccaatct cccaccccaa gacccaagaa gtcctacagt gggcttaggt
     1981 ccccaacccg gtgtgtctcg gaaatgcttg tgattcaaca cagggagagg agggagagga
     2041 gccggtctcg gagaaaacag catctactgc ctccctgtgt ggatgagccg gagctgctct
     2101 tctcagaggg gcccagtact tcccgctggg ccgcagagct cccgttccca gcagactcct
     2161 ctgaccctgc ctcccagctc agctactccc aggaagtggg aggacctttt aagacaccca
     2221 ttaaggaaac gctgcccatc tcctccaccc cgagcaaatc tgtcctcccc agaacccctg
     2281 aatcctggag gctcacgccc ccagccaaag tagggggact ggatttcagc ccagtacaaa
     2341 cctcccaggg tgcctctgac cccttgcctg accccctggg gctgatggat ctcagcacca
     2401 ctcccttgca aagtgctccc ccccttgaat caccgcaaag gctcctcagt tcagaaccct
     2461 tagacctcat ctccgtcccc tttggcaact cttctccctc agatatagac gtccccaagc
     2521 caggctcccc ggagccacag gtttctggcc ttgcagccaa tcgttctctg acagaaggcc
     2581 tggtcctgga cacaatgaat gacagcctca gcaagatcct gctggacatc agctttcctg
     2641 gcctggacga ggacccactg ggccctgaca acatcaactg gtcccagttt attcctgagc
     2701 tacagtagag ccctgccctt gcccctgtgc tcaagctgtc caccatcccg ggcactccaa
     2761 ggctcagtgc accccaagcc tctgagtgag gacagcaggc agggactgtt ctgctcctca
     2821 tagctccctg ctgcctgatt atgcaaaagt agcagtcaca ccctagccac tgctgggacc
     2881 ttgtgttccc caagagtatc tgattcctct gctgtccctg ccaggagctg aagggtggga
     2941 acaacaaagg caatggtgaa aagagattag gaacccccca gcctgtttcc attctctgcc
     3001 cagcagtctc ttaccttccc tgatctttgc agggtggtcc gtgtaaatag tataaattct
     3061 ccaaattatc ctctaattat aaatgtaagc ttatttcctt agatcattat ccagagactg
     3121 ccagaaggtg ggtaggatga cctggggttt caattgactt ctgttccttg cttttagttt
     3181 tgatagaagg gaagacctgc agtgcacggt ttcttccagg ctgaggtacc tggatcttgg
     3241 gttcttcact gcagggaccc agacaagtgg atctgcttgc cagagtcctt tttgcccctc
     3301 cctgccacct ccccgtgttt ccaagtcagc tttcctgcaa gaagaaatcc tggttaaaaa
     3361 agtcttttgt attgggtcag gagttgaatt tggggtggga ggatggatgc aactgaagca
     3421 gagtgtgggt gcccagatgt gcgctattag atgtttctct gataatgtcc ccaatcatac
     3481 cagggagact ggcattgacg agaactcagg tggaggcttg agaaggccga aagggcccct
     3541 gacctgcctg gcttccttag cttgcccctc agctttgcaa agagccaccc taggccccag
     3601 ctgaccgcat gggtgtgagc cagcttgaga acactaacta ctcaataaaa gcgaaggtgg
     3661 acatgc
//
