LOCUS       NP_068772                763 aa            linear   PRI 29-APR-2025
DEFINITION  forkhead box protein M1 isoform 2 [Homo sapiens].
ACCESSION   NP_068772
VERSION     NP_068772.2
DBSOURCE    REFSEQ: accession NM_021953.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 763)
  AUTHORS   Yildiz,B., Demirel,R., Staudacher,J.J., Beseren,H., Yildiz,G.,
            Akpinar,A.E., Park,S.H. and Ozden,O.
  TITLE     SIRT2 deacetylates and decreases the expression of FOXM1 in colon
            cancer
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70018 (2024)
   PUBMED   39425454
  REMARK    GeneRIF: SIRT2 deacetylates and decreases the expression of FOXM1
            in colon cancer.
REFERENCE   2  (residues 1 to 763)
  AUTHORS   Wang,W., Li,H., Qian,Y., Li,M., Deng,M., Bi,D. and Zou,J.
  TITLE     ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A
            Demethylation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 34 (2024)
   PUBMED   39441582
  REMARK    GeneRIF: ALKBH5 Regulates Corneal Neovascularization by Mediating
            FOXM1 M6A Demethylation.
REFERENCE   3  (residues 1 to 763)
  AUTHORS   Leclair,N.K., Lucas,C.G., Mirchia,K., McCortney,K., Horbinski,C.M.,
            Raleigh,D.R. and Anczukow,O.
  TITLE     The RNA-binding protein IGF2BP1 regulates stability of mRNA
            transcribed from FOXM1 target genes in hypermitotic meningiomas
  JOURNAL   Acta Neuropathol 148 (1), 28 (2024)
   PUBMED   39179895
  REMARK    GeneRIF: The RNA-binding protein IGF2BP1 regulates stability of
            mRNA transcribed from FOXM1 target genes in hypermitotic
            meningiomas.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 763)
  AUTHORS   Wu,Y., Luo,Y., Yao,X., Shi,X., Xu,Z., Re,J., Shi,M., Li,M., Liu,J.,
            He,Y. and Du,X.
  TITLE     KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A
            modification to promote aerobic glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Cell Biol Toxicol 40 (1), 58 (2024)
   PUBMED   39060874
  REMARK    GeneRIF: KIAA1429 increases FOXM1 expression through
            YTHDF1-mediated m6A modification to promote aerobic glycolysis and
            tumorigenesis in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 763)
  AUTHORS   Polito,M.P., Marini,G., Fabrizi,A., Sercia,L., Enzo,E. and De
            Luca,M.
  TITLE     Biochemical role of FOXM1-dependent histone linker H1B in human
            epidermal stem cells
  JOURNAL   Cell Death Dis 15 (7), 508 (2024)
   PUBMED   39019868
  REMARK    GeneRIF: Biochemical role of FOXM1-dependent histone linker H1B in
            human epidermal stem cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 763)
  AUTHORS   Luscher-Firzlaff,J.M., Westendorf,J.M., Zwicker,J., Burkhardt,H.,
            Henriksson,M., Muller,R., Pirollet,F. and Luscher,B.
  TITLE     Interaction of the fork head domain transcription factor MPP2 with
            the human papilloma virus 16 E7 protein: enhancement of
            transformation and transactivation
  JOURNAL   Oncogene 18 (41), 5620-5630 (1999)
   PUBMED   10523841
REFERENCE   7  (residues 1 to 763)
  AUTHORS   Korver,W., Roose,J., Heinen,K., Weghuis,D.O., de Bruijn,D., van
            Kessel,A.G. and Clevers,H.
  TITLE     The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and
            promoter characterization
  JOURNAL   Genomics 46 (3), 435-442 (1997)
   PUBMED   9441747
REFERENCE   8  (residues 1 to 763)
  AUTHORS   Yao,K.M., Sha,M., Lu,Z. and Wong,G.G.
  TITLE     Molecular analysis of a novel winged helix protein, WIN. Expression
            pattern, DNA binding property, and alternative splicing within the
            DNA binding domain
  JOURNAL   J Biol Chem 272 (32), 19827-19836 (1997)
   PUBMED   9242644
REFERENCE   9  (residues 1 to 763)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol Cell Biol 17 (3), 1626-1641 (1997)
   PUBMED   9032290
REFERENCE   10 (residues 1 to 763)
  AUTHORS   Westendorf,J.M., Rao,P.N. and Gerace,L.
  TITLE     Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2
            monoclonal antibody and determination of the phosphorylated epitope
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 714-718 (1994)
   PUBMED   8290587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005911.6 and AC005841.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 13, 2004 this sequence version replaced NP_068772.1.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator involved in cell proliferation. The encoded protein is
            phosphorylated in M phase and regulates the expression of several
            cell cycle genes, such as cyclin B1 and cyclin D1. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U83113.1, SRR11853561.6104.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359843.8/ ENSP00000352901.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     Protein         1..763
                     /product="forkhead box protein M1 isoform 2"
                     /note="Forkhead, drosophila, homolog-like 16; M-phase
                     phosphoprotein 2; HNF-3/fork-head homolog 11;
                     transcription factor Trident; MPM-2 reactive
                     phosphoprotein 2; forkhead-related protein FKHL16;
                     winged-helix factor from INS-1 cells; hepatocyte nuclear
                     factor 3 forkhead homolog 11; forkhead box M1-D"
                     /calculated_mol_wt=84152
     Region          1..53
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08050.3)"
     Region          198..232
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08050.3)"
     Region          236..312
                     /region_name="FH_FOXM"
                     /note="Forkhead (FH) domain found in the Forkhead box
                     protein M (FOXM) subfamily; cd20029"
                     /db_xref="CDD:410803"
     Site            order(236,240..241,259..260,263,278,283..284,286..287,290,
                     297,306,308)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410803"
     Region          329..351
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08050.3)"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Site            376
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CHEK2.
                     /evidence=ECO:0000269|PubMed:17101782; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Region          402..>711
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          482..711
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08050.3)"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Site            611
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1.
                     /evidence=ECO:0000269|PubMed:19160488; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Site            620
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Site            627
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Site            662
                     /site_type="phosphorylation"
                     /note="Phosphothreonine. /evidence=ECO:0000305; propagated
                     from UniProtKB/Swiss-Prot (Q08050.3)"
     Site            693
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:19160488; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Site            730
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK1.
                     /evidence=ECO:0000269|PubMed:19160488,
                     ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     Site            739
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK1.
                     /evidence=ECO:0000269|PubMed:19160488,
                     ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q08050.3)"
     CDS             1..763
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /coded_by="NM_021953.4:303..2594"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS8515.1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
ORIGIN      
        1 mktsprrpli lkrrrlplpv qnapsetsee epkrspaqqe snqaeaskev aesnsckfpa
       61 gikiinhptm pntqvvaipn nanihsiita ltakgkesgs sgpnkfilis cggaptqppg
      121 lrpqtqtsyd akrtevtlet lgpkpaardv nlprppgalc eqkretcadg eaagctinns
      181 lsniqwlrkm ssdglgsrsi kqemeekenc hleqrqvkve epsrpsaswq nsvserppys
      241 ymamiqfain sterkrmtlk diytwiedhf pyfkhiakpg wknsirhnls lhdmfvrets
      301 angkvsfwti hpsanryltl dqvfkpldpg spqlpehles qqkrpnpelr rnmtiktelp
      361 lgarrkmkpl lprvssylvp iqfpvnqslv lqpsvkvplp laaslmssel arhskrvria
      421 pkvllaeegi aplssagpgk eekllfgegf spllpvqtik eeeiqpgeem phlarpikve
      481 sppleewpsp apsfkeessh swedssqspt prpkksysgl rsptrcvsem lviqhrerre
      541 rsrsrrkqhl lppcvdepel lfsegpstsr waaelpfpad ssdpasqlsy sqevggpfkt
      601 piketlpiss tpsksvlprt peswrltppa kvggldfspv qtsqgasdpl pdplglmdls
      661 ttplqsappl espqrllsse pldlisvpfg nsspsdidvp kpgspepqvs glaanrslte
      721 glvldtmnds lskilldisf pgldedplgp dninwsqfip elq
//
