LOCUS       NM_001413934            3375 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box M1 (FOXM1), transcript variant 15, mRNA.
ACCESSION   NM_001413934
VERSION     NM_001413934.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Yildiz,B., Demirel,R., Staudacher,J.J., Beseren,H., Yildiz,G.,
            Akpinar,A.E., Park,S.H. and Ozden,O.
  TITLE     SIRT2 deacetylates and decreases the expression of FOXM1 in colon
            cancer
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70018 (2024)
   PUBMED   39425454
  REMARK    GeneRIF: SIRT2 deacetylates and decreases the expression of FOXM1
            in colon cancer.
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Wang,W., Li,H., Qian,Y., Li,M., Deng,M., Bi,D. and Zou,J.
  TITLE     ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A
            Demethylation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 34 (2024)
   PUBMED   39441582
  REMARK    GeneRIF: ALKBH5 Regulates Corneal Neovascularization by Mediating
            FOXM1 M6A Demethylation.
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Leclair,N.K., Lucas,C.G., Mirchia,K., McCortney,K., Horbinski,C.M.,
            Raleigh,D.R. and Anczukow,O.
  TITLE     The RNA-binding protein IGF2BP1 regulates stability of mRNA
            transcribed from FOXM1 target genes in hypermitotic meningiomas
  JOURNAL   Acta Neuropathol 148 (1), 28 (2024)
   PUBMED   39179895
  REMARK    GeneRIF: The RNA-binding protein IGF2BP1 regulates stability of
            mRNA transcribed from FOXM1 target genes in hypermitotic
            meningiomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Wu,Y., Luo,Y., Yao,X., Shi,X., Xu,Z., Re,J., Shi,M., Li,M., Liu,J.,
            He,Y. and Du,X.
  TITLE     KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A
            modification to promote aerobic glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Cell Biol Toxicol 40 (1), 58 (2024)
   PUBMED   39060874
  REMARK    GeneRIF: KIAA1429 increases FOXM1 expression through
            YTHDF1-mediated m6A modification to promote aerobic glycolysis and
            tumorigenesis in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Polito,M.P., Marini,G., Fabrizi,A., Sercia,L., Enzo,E. and De
            Luca,M.
  TITLE     Biochemical role of FOXM1-dependent histone linker H1B in human
            epidermal stem cells
  JOURNAL   Cell Death Dis 15 (7), 508 (2024)
   PUBMED   39019868
  REMARK    GeneRIF: Biochemical role of FOXM1-dependent histone linker H1B in
            human epidermal stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Luscher-Firzlaff,J.M., Westendorf,J.M., Zwicker,J., Burkhardt,H.,
            Henriksson,M., Muller,R., Pirollet,F. and Luscher,B.
  TITLE     Interaction of the fork head domain transcription factor MPP2 with
            the human papilloma virus 16 E7 protein: enhancement of
            transformation and transactivation
  JOURNAL   Oncogene 18 (41), 5620-5630 (1999)
   PUBMED   10523841
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Korver,W., Roose,J., Heinen,K., Weghuis,D.O., de Bruijn,D., van
            Kessel,A.G. and Clevers,H.
  TITLE     The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and
            promoter characterization
  JOURNAL   Genomics 46 (3), 435-442 (1997)
   PUBMED   9441747
REFERENCE   8  (bases 1 to 3375)
  AUTHORS   Yao,K.M., Sha,M., Lu,Z. and Wong,G.G.
  TITLE     Molecular analysis of a novel winged helix protein, WIN. Expression
            pattern, DNA binding property, and alternative splicing within the
            DNA binding domain
  JOURNAL   J Biol Chem 272 (32), 19827-19836 (1997)
   PUBMED   9242644
REFERENCE   9  (bases 1 to 3375)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol Cell Biol 17 (3), 1626-1641 (1997)
   PUBMED   9032290
REFERENCE   10 (bases 1 to 3375)
  AUTHORS   Westendorf,J.M., Rao,P.N. and Gerace,L.
  TITLE     Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2
            monoclonal antibody and determination of the phosphorylated epitope
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 714-718 (1994)
   PUBMED   8290587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005911.6 and AC005841.3.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator involved in cell proliferation. The encoded protein is
            phosphorylated in M phase and regulates the expression of several
            cell cycle genes, such as cyclin B1 and cyclin D1. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3228032.1,
                                           SRR14038196.1495415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC005911.6         99316-99570
            256-804             AC005841.3         1479-2027
            805-953             AC005841.3         3760-3908
            954-1145            AC005841.3         7250-7441
            1146-1215           AC005841.3         11252-11321
            1216-1391           AC005841.3         11509-11684
            1392-3375           AC005841.3         16341-18324
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..3375
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="forkhead box M1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
     exon            1..255
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            256..804
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2417
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="isoform 15 is encoded by transcript variant 15;
                     Forkhead, drosophila, homolog-like 16; M-phase
                     phosphoprotein 2; HNF-3/fork-head homolog 11;
                     transcription factor Trident; MPM-2 reactive
                     phosphoprotein 2; forkhead-related protein FKHL16;
                     winged-helix factor from INS-1 cells; hepatocyte nuclear
                     factor 3 forkhead homolog 11; forkhead box M1-D"
                     /codon_start=1
                     /product="forkhead box protein M1 isoform 15"
                     /protein_id="NP_001400863.1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
                     /translation="MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQA
                     EASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSG
                     PNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALC
                     EQKRETCDGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKV
                     EEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIA
                     KPGWKQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQP
                     SVKVPLPLAASLMSSELARHSKRVRIAPKVLLAEEGIAPLSSAGPGKEEKLLFGEGFS
                     PLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSP
                     TPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPS
                     TSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWR
                     LTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLD
                     LISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFP
                     GLDEDPLGPDNINWSQFIPELQ"
     exon            805..953
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1145
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1215
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1391
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..3375
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3353..3358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="hexamer: AATAAA"
     polyA_site      3375
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="major polyA site"
ORIGIN      
        1 aacgctccgc cggcgccaat ttcaaacagc ggaacaaact gaaagctccg gtgccagacc
       61 ccacccccgg ccccggcccg ggaccccctc ccctcccggg atcccccggg gttcccaccc
      121 cgcccgcacc gccggggacc cggccggtcc ggcgcgagcc cccgtccggg gccctggctc
      181 ggcccccagg ttggaggagc ccggagcccg ccttcggagc tacggcctaa cggcggcggc
      241 gactgcagtc tggagggtcc acacttgtga ttctcaatgg agagtgaaaa cgcagattca
      301 taatgaaaac tagcccccgt cggccactga ttctcaaaag acggaggctg ccccttcctg
      361 ttcaaaatgc cccaagtgaa acatcagagg aggaacctaa gagatcccct gcccaacagg
      421 agtctaatca agcagaggcc tccaaggaag tggcagagtc caactcttgc aagtttccag
      481 ctgggatcaa gattattaac caccccacca tgcccaacac gcaagtagtg gccatcccca
      541 acaatgctaa tattcacagc atcatcacag cactgactgc caagggaaaa gagagtggca
      601 gtagtgggcc caacaaattc atcctcatca gctgtggggg agccccaact cagcctccag
      661 gactccggcc tcaaacccaa accagctatg atgccaaaag gacagaagtg accctggaga
      721 ccttgggacc aaaacctgca gctagggatg tgaatcttcc tagaccacct ggagcccttt
      781 gcgagcagaa acgggagacc tgtgatggtg aggcagcagg ctgcactatc aacaatagcc
      841 tatccaacat ccagtggctt cgaaagatga gttctgatgg actgggctcc cgcagcatca
      901 agcaagagat ggaggaaaag gagaattgtc acctggagca gcgacaggtt aaggttgagg
      961 agccttcgag accatcagcg tcctggcaga actctgtgtc tgagcggcca ccctactctt
     1021 acatggccat gatacaattc gccatcaaca gcactgagag gaagcgcatg actttgaaag
     1081 acatctatac gtggattgag gaccactttc cctactttaa gcacattgcc aagccaggct
     1141 ggaagcagca gaaacgaccg aatccagagc tccgccggaa catgaccatc aaaaccgaac
     1201 tccccctggg cgcacggcgg aagatgaagc cactgctacc acgggtcagc tcatacctgg
     1261 tacctatcca gttcccggtg aaccagtcac tggtgttgca gccctcggtg aaggtgccat
     1321 tgcccctggc ggcttccctc atgagctcag agcttgcccg ccatagcaag cgagtccgca
     1381 ttgcccccaa ggtgctgcta gctgaggagg ggatagctcc tctttcttct gcaggaccag
     1441 ggaaagagga gaaactcctg tttggagaag ggttttctcc tttgcttcca gttcagacta
     1501 tcaaggagga agaaatccag cctggggagg aaatgccaca cttagcgaga cccatcaaag
     1561 tggagagccc tcccttggaa gagtggccct ccccggcccc atctttcaaa gaggaatcat
     1621 ctcactcctg ggaggattcg tcccaatctc ccaccccaag acccaagaag tcctacagtg
     1681 ggcttaggtc cccaacccgg tgtgtctcgg aaatgcttgt gattcaacac agggagagga
     1741 gggagaggag ccggtctcgg agaaaacagc atctactgcc tccctgtgtg gatgagccgg
     1801 agctgctctt ctcagagggg cccagtactt cccgctgggc cgcagagctc ccgttcccag
     1861 cagactcctc tgaccctgcc tcccagctca gctactccca ggaagtggga ggacctttta
     1921 agacacccat taaggaaacg ctgcccatct cctccacccc gagcaaatct gtcctcccca
     1981 gaacccctga atcctggagg ctcacgcccc cagccaaagt agggggactg gatttcagcc
     2041 cagtacaaac ctcccagggt gcctctgacc ccttgcctga ccccctgggg ctgatggatc
     2101 tcagcaccac tcccttgcaa agtgctcccc cccttgaatc accgcaaagg ctcctcagtt
     2161 cagaaccctt agacctcatc tccgtcccct ttggcaactc ttctccctca gatatagacg
     2221 tccccaagcc aggctccccg gagccacagg tttctggcct tgcagccaat cgttctctga
     2281 cagaaggcct ggtcctggac acaatgaatg acagcctcag caagatcctg ctggacatca
     2341 gctttcctgg cctggacgag gacccactgg gccctgacaa catcaactgg tcccagttta
     2401 ttcctgagct acagtagagc cctgcccttg cccctgtgct caagctgtcc accatcccgg
     2461 gcactccaag gctcagtgca ccccaagcct ctgagtgagg acagcaggca gggactgttc
     2521 tgctcctcat agctccctgc tgcctgatta tgcaaaagta gcagtcacac cctagccact
     2581 gctgggacct tgtgttcccc aagagtatct gattcctctg ctgtccctgc caggagctga
     2641 agggtgggaa caacaaaggc aatggtgaaa agagattagg aaccccccag cctgtttcca
     2701 ttctctgccc agcagtctct taccttccct gatctttgca gggtggtccg tgtaaatagt
     2761 ataaattctc caaattatcc tctaattata aatgtaagct tatttcctta gatcattatc
     2821 cagagactgc cagaaggtgg gtaggatgac ctggggtttc aattgacttc tgttccttgc
     2881 ttttagtttt gatagaaggg aagacctgca gtgcacggtt tcttccaggc tgaggtacct
     2941 ggatcttggg ttcttcactg cagggaccca gacaagtgga tctgcttgcc agagtccttt
     3001 ttgcccctcc ctgccacctc cccgtgtttc caagtcagct ttcctgcaag aagaaatcct
     3061 ggttaaaaaa gtcttttgta ttgggtcagg agttgaattt ggggtgggag gatggatgca
     3121 actgaagcag agtgtgggtg cccagatgtg cgctattaga tgtttctctg ataatgtccc
     3181 caatcatacc agggagactg gcattgacga gaactcaggt ggaggcttga gaaggccgaa
     3241 agggcccctg acctgcctgg cttccttagc ttgcccctca gctttgcaaa gagccaccct
     3301 aggccccagc tgaccgcatg ggtgtgagcc agcttgagaa cactaactac tcaataaaag
     3361 cgaaggtgga catgc
//
