LOCUS       NM_001413928            3618 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box M1 (FOXM1), transcript variant 9, mRNA.
ACCESSION   NM_001413928
VERSION     NM_001413928.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Yildiz,B., Demirel,R., Staudacher,J.J., Beseren,H., Yildiz,G.,
            Akpinar,A.E., Park,S.H. and Ozden,O.
  TITLE     SIRT2 deacetylates and decreases the expression of FOXM1 in colon
            cancer
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70018 (2024)
   PUBMED   39425454
  REMARK    GeneRIF: SIRT2 deacetylates and decreases the expression of FOXM1
            in colon cancer.
REFERENCE   2  (bases 1 to 3618)
  AUTHORS   Wang,W., Li,H., Qian,Y., Li,M., Deng,M., Bi,D. and Zou,J.
  TITLE     ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A
            Demethylation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 34 (2024)
   PUBMED   39441582
  REMARK    GeneRIF: ALKBH5 Regulates Corneal Neovascularization by Mediating
            FOXM1 M6A Demethylation.
REFERENCE   3  (bases 1 to 3618)
  AUTHORS   Leclair,N.K., Lucas,C.G., Mirchia,K., McCortney,K., Horbinski,C.M.,
            Raleigh,D.R. and Anczukow,O.
  TITLE     The RNA-binding protein IGF2BP1 regulates stability of mRNA
            transcribed from FOXM1 target genes in hypermitotic meningiomas
  JOURNAL   Acta Neuropathol 148 (1), 28 (2024)
   PUBMED   39179895
  REMARK    GeneRIF: The RNA-binding protein IGF2BP1 regulates stability of
            mRNA transcribed from FOXM1 target genes in hypermitotic
            meningiomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3618)
  AUTHORS   Wu,Y., Luo,Y., Yao,X., Shi,X., Xu,Z., Re,J., Shi,M., Li,M., Liu,J.,
            He,Y. and Du,X.
  TITLE     KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A
            modification to promote aerobic glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Cell Biol Toxicol 40 (1), 58 (2024)
   PUBMED   39060874
  REMARK    GeneRIF: KIAA1429 increases FOXM1 expression through
            YTHDF1-mediated m6A modification to promote aerobic glycolysis and
            tumorigenesis in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3618)
  AUTHORS   Polito,M.P., Marini,G., Fabrizi,A., Sercia,L., Enzo,E. and De
            Luca,M.
  TITLE     Biochemical role of FOXM1-dependent histone linker H1B in human
            epidermal stem cells
  JOURNAL   Cell Death Dis 15 (7), 508 (2024)
   PUBMED   39019868
  REMARK    GeneRIF: Biochemical role of FOXM1-dependent histone linker H1B in
            human epidermal stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3618)
  AUTHORS   Luscher-Firzlaff,J.M., Westendorf,J.M., Zwicker,J., Burkhardt,H.,
            Henriksson,M., Muller,R., Pirollet,F. and Luscher,B.
  TITLE     Interaction of the fork head domain transcription factor MPP2 with
            the human papilloma virus 16 E7 protein: enhancement of
            transformation and transactivation
  JOURNAL   Oncogene 18 (41), 5620-5630 (1999)
   PUBMED   10523841
REFERENCE   7  (bases 1 to 3618)
  AUTHORS   Korver,W., Roose,J., Heinen,K., Weghuis,D.O., de Bruijn,D., van
            Kessel,A.G. and Clevers,H.
  TITLE     The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and
            promoter characterization
  JOURNAL   Genomics 46 (3), 435-442 (1997)
   PUBMED   9441747
REFERENCE   8  (bases 1 to 3618)
  AUTHORS   Yao,K.M., Sha,M., Lu,Z. and Wong,G.G.
  TITLE     Molecular analysis of a novel winged helix protein, WIN. Expression
            pattern, DNA binding property, and alternative splicing within the
            DNA binding domain
  JOURNAL   J Biol Chem 272 (32), 19827-19836 (1997)
   PUBMED   9242644
REFERENCE   9  (bases 1 to 3618)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol Cell Biol 17 (3), 1626-1641 (1997)
   PUBMED   9032290
REFERENCE   10 (bases 1 to 3618)
  AUTHORS   Westendorf,J.M., Rao,P.N. and Gerace,L.
  TITLE     Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2
            monoclonal antibody and determination of the phosphorylated epitope
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 714-718 (1994)
   PUBMED   8290587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005911.6 and AC005841.3.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator involved in cell proliferation. The encoded protein is
            phosphorylated in M phase and regulates the expression of several
            cell cycle genes, such as cyclin B1 and cyclin D1. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3788855.1,
                                           SRR14038197.1268806.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC005911.6         99316-99570
            256-804             AC005841.3         1479-2027
            805-953             AC005841.3         3760-3908
            954-1145            AC005841.3         7250-7441
            1146-1274           AC005841.3         9483-9611
            1275-1344           AC005841.3         11252-11321
            1345-1520           AC005841.3         11509-11684
            1521-1634           AC005841.3         14592-14705
            1635-3618           AC005841.3         16341-18324
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..3618
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="forkhead box M1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
     exon            1..255
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            256..804
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2660
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="isoform 9 is encoded by transcript variant 9;
                     Forkhead, drosophila, homolog-like 16; M-phase
                     phosphoprotein 2; HNF-3/fork-head homolog 11;
                     transcription factor Trident; MPM-2 reactive
                     phosphoprotein 2; forkhead-related protein FKHL16;
                     winged-helix factor from INS-1 cells; hepatocyte nuclear
                     factor 3 forkhead homolog 11; forkhead box M1-D"
                     /codon_start=1
                     /product="forkhead box protein M1 isoform 9"
                     /protein_id="NP_001400857.1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
                     /translation="MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQA
                     EASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSG
                     PNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALC
                     EQKRETCDGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKV
                     EEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIA
                     KPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKQQKRPNPELR
                     RNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSS
                     ELARHSKRVRIAPKVFGEQVVFGYMSKFFSGDLRDFGTPITSLFNFIFLCLSVLLAEE
                     GIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEE
                     WPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRS
                     RRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPI
                     KETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLS
                     TTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSL
                     TEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ"
     exon            805..953
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1145
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1274
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1344
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1520
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1634
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..3618
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3596..3601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="hexamer: AATAAA"
     polyA_site      3618
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="major polyA site"
ORIGIN      
        1 aacgctccgc cggcgccaat ttcaaacagc ggaacaaact gaaagctccg gtgccagacc
       61 ccacccccgg ccccggcccg ggaccccctc ccctcccggg atcccccggg gttcccaccc
      121 cgcccgcacc gccggggacc cggccggtcc ggcgcgagcc cccgtccggg gccctggctc
      181 ggcccccagg ttggaggagc ccggagcccg ccttcggagc tacggcctaa cggcggcggc
      241 gactgcagtc tggagggtcc acacttgtga ttctcaatgg agagtgaaaa cgcagattca
      301 taatgaaaac tagcccccgt cggccactga ttctcaaaag acggaggctg ccccttcctg
      361 ttcaaaatgc cccaagtgaa acatcagagg aggaacctaa gagatcccct gcccaacagg
      421 agtctaatca agcagaggcc tccaaggaag tggcagagtc caactcttgc aagtttccag
      481 ctgggatcaa gattattaac caccccacca tgcccaacac gcaagtagtg gccatcccca
      541 acaatgctaa tattcacagc atcatcacag cactgactgc caagggaaaa gagagtggca
      601 gtagtgggcc caacaaattc atcctcatca gctgtggggg agccccaact cagcctccag
      661 gactccggcc tcaaacccaa accagctatg atgccaaaag gacagaagtg accctggaga
      721 ccttgggacc aaaacctgca gctagggatg tgaatcttcc tagaccacct ggagcccttt
      781 gcgagcagaa acgggagacc tgtgatggtg aggcagcagg ctgcactatc aacaatagcc
      841 tatccaacat ccagtggctt cgaaagatga gttctgatgg actgggctcc cgcagcatca
      901 agcaagagat ggaggaaaag gagaattgtc acctggagca gcgacaggtt aaggttgagg
      961 agccttcgag accatcagcg tcctggcaga actctgtgtc tgagcggcca ccctactctt
     1021 acatggccat gatacaattc gccatcaaca gcactgagag gaagcgcatg actttgaaag
     1081 acatctatac gtggattgag gaccactttc cctactttaa gcacattgcc aagccaggct
     1141 ggaagaactc catccgccac aacctttccc tgcacgacat gtttgtccgg gagacgtctg
     1201 ccaatggcaa ggtctccttc tggaccattc accccagtgc caaccgctac ttgacattgg
     1261 accaggtgtt taagcagcag aaacgaccga atccagagct ccgccggaac atgaccatca
     1321 aaaccgaact ccccctgggc gcacggcgga agatgaagcc actgctacca cgggtcagct
     1381 catacctggt acctatccag ttcccggtga accagtcact ggtgttgcag ccctcggtga
     1441 aggtgccatt gcccctggcg gcttccctca tgagctcaga gcttgcccgc catagcaagc
     1501 gagtccgcat tgcccccaag gtttttgggg aacaggtggt gtttggttac atgagtaagt
     1561 tctttagtgg cgatctgcga gattttggta cacccatcac cagcttgttt aattttatct
     1621 ttctttgttt atcagtgctg ctagctgagg aggggatagc tcctctttct tctgcaggac
     1681 cagggaaaga ggagaaactc ctgtttggag aagggttttc tcctttgctt ccagttcaga
     1741 ctatcaagga ggaagaaatc cagcctgggg aggaaatgcc acacttagcg agacccatca
     1801 aagtggagag ccctcccttg gaagagtggc cctccccggc cccatctttc aaagaggaat
     1861 catctcactc ctgggaggat tcgtcccaat ctcccacccc aagacccaag aagtcctaca
     1921 gtgggcttag gtccccaacc cggtgtgtct cggaaatgct tgtgattcaa cacagggaga
     1981 ggagggagag gagccggtct cggagaaaac agcatctact gcctccctgt gtggatgagc
     2041 cggagctgct cttctcagag gggcccagta cttcccgctg ggccgcagag ctcccgttcc
     2101 cagcagactc ctctgaccct gcctcccagc tcagctactc ccaggaagtg ggaggacctt
     2161 ttaagacacc cattaaggaa acgctgccca tctcctccac cccgagcaaa tctgtcctcc
     2221 ccagaacccc tgaatcctgg aggctcacgc ccccagccaa agtaggggga ctggatttca
     2281 gcccagtaca aacctcccag ggtgcctctg accccttgcc tgaccccctg gggctgatgg
     2341 atctcagcac cactcccttg caaagtgctc ccccccttga atcaccgcaa aggctcctca
     2401 gttcagaacc cttagacctc atctccgtcc cctttggcaa ctcttctccc tcagatatag
     2461 acgtccccaa gccaggctcc ccggagccac aggtttctgg ccttgcagcc aatcgttctc
     2521 tgacagaagg cctggtcctg gacacaatga atgacagcct cagcaagatc ctgctggaca
     2581 tcagctttcc tggcctggac gaggacccac tgggccctga caacatcaac tggtcccagt
     2641 ttattcctga gctacagtag agccctgccc ttgcccctgt gctcaagctg tccaccatcc
     2701 cgggcactcc aaggctcagt gcaccccaag cctctgagtg aggacagcag gcagggactg
     2761 ttctgctcct catagctccc tgctgcctga ttatgcaaaa gtagcagtca caccctagcc
     2821 actgctggga ccttgtgttc cccaagagta tctgattcct ctgctgtccc tgccaggagc
     2881 tgaagggtgg gaacaacaaa ggcaatggtg aaaagagatt aggaaccccc cagcctgttt
     2941 ccattctctg cccagcagtc tcttaccttc cctgatcttt gcagggtggt ccgtgtaaat
     3001 agtataaatt ctccaaatta tcctctaatt ataaatgtaa gcttatttcc ttagatcatt
     3061 atccagagac tgccagaagg tgggtaggat gacctggggt ttcaattgac ttctgttcct
     3121 tgcttttagt tttgatagaa gggaagacct gcagtgcacg gtttcttcca ggctgaggta
     3181 cctggatctt gggttcttca ctgcagggac ccagacaagt ggatctgctt gccagagtcc
     3241 tttttgcccc tccctgccac ctccccgtgt ttccaagtca gctttcctgc aagaagaaat
     3301 cctggttaaa aaagtctttt gtattgggtc aggagttgaa tttggggtgg gaggatggat
     3361 gcaactgaag cagagtgtgg gtgcccagat gtgcgctatt agatgtttct ctgataatgt
     3421 ccccaatcat accagggaga ctggcattga cgagaactca ggtggaggct tgagaaggcc
     3481 gaaagggccc ctgacctgcc tggcttcctt agcttgcccc tcagctttgc aaagagccac
     3541 cctaggcccc agctgaccgc atgggtgtga gccagcttga gaacactaac tactcaataa
     3601 aagcgaaggt ggacatgc
//
