LOCUS       NM_001413927            3621 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box M1 (FOXM1), transcript variant 8, mRNA.
ACCESSION   NM_001413927
VERSION     NM_001413927.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3621)
  AUTHORS   Yildiz,B., Demirel,R., Staudacher,J.J., Beseren,H., Yildiz,G.,
            Akpinar,A.E., Park,S.H. and Ozden,O.
  TITLE     SIRT2 deacetylates and decreases the expression of FOXM1 in colon
            cancer
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70018 (2024)
   PUBMED   39425454
  REMARK    GeneRIF: SIRT2 deacetylates and decreases the expression of FOXM1
            in colon cancer.
REFERENCE   2  (bases 1 to 3621)
  AUTHORS   Wang,W., Li,H., Qian,Y., Li,M., Deng,M., Bi,D. and Zou,J.
  TITLE     ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A
            Demethylation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 34 (2024)
   PUBMED   39441582
  REMARK    GeneRIF: ALKBH5 Regulates Corneal Neovascularization by Mediating
            FOXM1 M6A Demethylation.
REFERENCE   3  (bases 1 to 3621)
  AUTHORS   Leclair,N.K., Lucas,C.G., Mirchia,K., McCortney,K., Horbinski,C.M.,
            Raleigh,D.R. and Anczukow,O.
  TITLE     The RNA-binding protein IGF2BP1 regulates stability of mRNA
            transcribed from FOXM1 target genes in hypermitotic meningiomas
  JOURNAL   Acta Neuropathol 148 (1), 28 (2024)
   PUBMED   39179895
  REMARK    GeneRIF: The RNA-binding protein IGF2BP1 regulates stability of
            mRNA transcribed from FOXM1 target genes in hypermitotic
            meningiomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3621)
  AUTHORS   Wu,Y., Luo,Y., Yao,X., Shi,X., Xu,Z., Re,J., Shi,M., Li,M., Liu,J.,
            He,Y. and Du,X.
  TITLE     KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A
            modification to promote aerobic glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Cell Biol Toxicol 40 (1), 58 (2024)
   PUBMED   39060874
  REMARK    GeneRIF: KIAA1429 increases FOXM1 expression through
            YTHDF1-mediated m6A modification to promote aerobic glycolysis and
            tumorigenesis in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3621)
  AUTHORS   Polito,M.P., Marini,G., Fabrizi,A., Sercia,L., Enzo,E. and De
            Luca,M.
  TITLE     Biochemical role of FOXM1-dependent histone linker H1B in human
            epidermal stem cells
  JOURNAL   Cell Death Dis 15 (7), 508 (2024)
   PUBMED   39019868
  REMARK    GeneRIF: Biochemical role of FOXM1-dependent histone linker H1B in
            human epidermal stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3621)
  AUTHORS   Luscher-Firzlaff,J.M., Westendorf,J.M., Zwicker,J., Burkhardt,H.,
            Henriksson,M., Muller,R., Pirollet,F. and Luscher,B.
  TITLE     Interaction of the fork head domain transcription factor MPP2 with
            the human papilloma virus 16 E7 protein: enhancement of
            transformation and transactivation
  JOURNAL   Oncogene 18 (41), 5620-5630 (1999)
   PUBMED   10523841
REFERENCE   7  (bases 1 to 3621)
  AUTHORS   Korver,W., Roose,J., Heinen,K., Weghuis,D.O., de Bruijn,D., van
            Kessel,A.G. and Clevers,H.
  TITLE     The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and
            promoter characterization
  JOURNAL   Genomics 46 (3), 435-442 (1997)
   PUBMED   9441747
REFERENCE   8  (bases 1 to 3621)
  AUTHORS   Yao,K.M., Sha,M., Lu,Z. and Wong,G.G.
  TITLE     Molecular analysis of a novel winged helix protein, WIN. Expression
            pattern, DNA binding property, and alternative splicing within the
            DNA binding domain
  JOURNAL   J Biol Chem 272 (32), 19827-19836 (1997)
   PUBMED   9242644
REFERENCE   9  (bases 1 to 3621)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol Cell Biol 17 (3), 1626-1641 (1997)
   PUBMED   9032290
REFERENCE   10 (bases 1 to 3621)
  AUTHORS   Westendorf,J.M., Rao,P.N. and Gerace,L.
  TITLE     Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2
            monoclonal antibody and determination of the phosphorylated epitope
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 714-718 (1994)
   PUBMED   8290587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005911.6 and AC005841.3.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator involved in cell proliferation. The encoded protein is
            phosphorylated in M phase and regulates the expression of several
            cell cycle genes, such as cyclin B1 and cyclin D1. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4142309.1,
                                           SRR18074969.1575621.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC005911.6         99316-99570
            256-804             AC005841.3         1479-2027
            805-956             AC005841.3         3757-3908
            957-1148            AC005841.3         7250-7441
            1149-1277           AC005841.3         9483-9611
            1278-1347           AC005841.3         11252-11321
            1348-1523           AC005841.3         11509-11684
            1524-1637           AC005841.3         14592-14705
            1638-3621           AC005841.3         16341-18324
FEATURES             Location/Qualifiers
     source          1..3621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..3621
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="forkhead box M1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
     exon            1..255
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            256..804
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2663
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="isoform 8 is encoded by transcript variant 8;
                     Forkhead, drosophila, homolog-like 16; M-phase
                     phosphoprotein 2; HNF-3/fork-head homolog 11;
                     transcription factor Trident; MPM-2 reactive
                     phosphoprotein 2; forkhead-related protein FKHL16;
                     winged-helix factor from INS-1 cells; hepatocyte nuclear
                     factor 3 forkhead homolog 11; forkhead box M1-D"
                     /codon_start=1
                     /product="forkhead box protein M1 isoform 8"
                     /protein_id="NP_001400856.1"
                     /db_xref="GeneID:2305"
                     /db_xref="HGNC:HGNC:3818"
                     /db_xref="MIM:602341"
                     /translation="MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQA
                     EASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSG
                     PNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALC
                     EQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVK
                     VEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHI
                     AKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKQQKRPNPEL
                     RRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMS
                     SELARHSKRVRIAPKVFGEQVVFGYMSKFFSGDLRDFGTPITSLFNFIFLCLSVLLAE
                     EGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLE
                     EWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSR
                     SRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTP
                     IKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDL
                     STTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRS
                     LTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ"
     exon            805..956
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1148
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1277
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1347
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1523
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1637
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..3621
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3599..3604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="hexamer: AATAAA"
     polyA_site      3621
                     /gene="FOXM1"
                     /gene_synonym="FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11;
                     HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29;
                     TRIDENT"
                     /note="major polyA site"
ORIGIN      
        1 aacgctccgc cggcgccaat ttcaaacagc ggaacaaact gaaagctccg gtgccagacc
       61 ccacccccgg ccccggcccg ggaccccctc ccctcccggg atcccccggg gttcccaccc
      121 cgcccgcacc gccggggacc cggccggtcc ggcgcgagcc cccgtccggg gccctggctc
      181 ggcccccagg ttggaggagc ccggagcccg ccttcggagc tacggcctaa cggcggcggc
      241 gactgcagtc tggagggtcc acacttgtga ttctcaatgg agagtgaaaa cgcagattca
      301 taatgaaaac tagcccccgt cggccactga ttctcaaaag acggaggctg ccccttcctg
      361 ttcaaaatgc cccaagtgaa acatcagagg aggaacctaa gagatcccct gcccaacagg
      421 agtctaatca agcagaggcc tccaaggaag tggcagagtc caactcttgc aagtttccag
      481 ctgggatcaa gattattaac caccccacca tgcccaacac gcaagtagtg gccatcccca
      541 acaatgctaa tattcacagc atcatcacag cactgactgc caagggaaaa gagagtggca
      601 gtagtgggcc caacaaattc atcctcatca gctgtggggg agccccaact cagcctccag
      661 gactccggcc tcaaacccaa accagctatg atgccaaaag gacagaagtg accctggaga
      721 ccttgggacc aaaacctgca gctagggatg tgaatcttcc tagaccacct ggagcccttt
      781 gcgagcagaa acgggagacc tgtgcagatg gtgaggcagc aggctgcact atcaacaata
      841 gcctatccaa catccagtgg cttcgaaaga tgagttctga tggactgggc tcccgcagca
      901 tcaagcaaga gatggaggaa aaggagaatt gtcacctgga gcagcgacag gttaaggttg
      961 aggagccttc gagaccatca gcgtcctggc agaactctgt gtctgagcgg ccaccctact
     1021 cttacatggc catgatacaa ttcgccatca acagcactga gaggaagcgc atgactttga
     1081 aagacatcta tacgtggatt gaggaccact ttccctactt taagcacatt gccaagccag
     1141 gctggaagaa ctccatccgc cacaaccttt ccctgcacga catgtttgtc cgggagacgt
     1201 ctgccaatgg caaggtctcc ttctggacca ttcaccccag tgccaaccgc tacttgacat
     1261 tggaccaggt gtttaagcag cagaaacgac cgaatccaga gctccgccgg aacatgacca
     1321 tcaaaaccga actccccctg ggcgcacggc ggaagatgaa gccactgcta ccacgggtca
     1381 gctcatacct ggtacctatc cagttcccgg tgaaccagtc actggtgttg cagccctcgg
     1441 tgaaggtgcc attgcccctg gcggcttccc tcatgagctc agagcttgcc cgccatagca
     1501 agcgagtccg cattgccccc aaggtttttg gggaacaggt ggtgtttggt tacatgagta
     1561 agttctttag tggcgatctg cgagattttg gtacacccat caccagcttg tttaatttta
     1621 tctttctttg tttatcagtg ctgctagctg aggaggggat agctcctctt tcttctgcag
     1681 gaccagggaa agaggagaaa ctcctgtttg gagaagggtt ttctcctttg cttccagttc
     1741 agactatcaa ggaggaagaa atccagcctg gggaggaaat gccacactta gcgagaccca
     1801 tcaaagtgga gagccctccc ttggaagagt ggccctcccc ggccccatct ttcaaagagg
     1861 aatcatctca ctcctgggag gattcgtccc aatctcccac cccaagaccc aagaagtcct
     1921 acagtgggct taggtcccca acccggtgtg tctcggaaat gcttgtgatt caacacaggg
     1981 agaggaggga gaggagccgg tctcggagaa aacagcatct actgcctccc tgtgtggatg
     2041 agccggagct gctcttctca gaggggccca gtacttcccg ctgggccgca gagctcccgt
     2101 tcccagcaga ctcctctgac cctgcctccc agctcagcta ctcccaggaa gtgggaggac
     2161 cttttaagac acccattaag gaaacgctgc ccatctcctc caccccgagc aaatctgtcc
     2221 tccccagaac ccctgaatcc tggaggctca cgcccccagc caaagtaggg ggactggatt
     2281 tcagcccagt acaaacctcc cagggtgcct ctgacccctt gcctgacccc ctggggctga
     2341 tggatctcag caccactccc ttgcaaagtg ctccccccct tgaatcaccg caaaggctcc
     2401 tcagttcaga acccttagac ctcatctccg tcccctttgg caactcttct ccctcagata
     2461 tagacgtccc caagccaggc tccccggagc cacaggtttc tggccttgca gccaatcgtt
     2521 ctctgacaga aggcctggtc ctggacacaa tgaatgacag cctcagcaag atcctgctgg
     2581 acatcagctt tcctggcctg gacgaggacc cactgggccc tgacaacatc aactggtccc
     2641 agtttattcc tgagctacag tagagccctg cccttgcccc tgtgctcaag ctgtccacca
     2701 tcccgggcac tccaaggctc agtgcacccc aagcctctga gtgaggacag caggcaggga
     2761 ctgttctgct cctcatagct ccctgctgcc tgattatgca aaagtagcag tcacacccta
     2821 gccactgctg ggaccttgtg ttccccaaga gtatctgatt cctctgctgt ccctgccagg
     2881 agctgaaggg tgggaacaac aaaggcaatg gtgaaaagag attaggaacc ccccagcctg
     2941 tttccattct ctgcccagca gtctcttacc ttccctgatc tttgcagggt ggtccgtgta
     3001 aatagtataa attctccaaa ttatcctcta attataaatg taagcttatt tccttagatc
     3061 attatccaga gactgccaga aggtgggtag gatgacctgg ggtttcaatt gacttctgtt
     3121 ccttgctttt agttttgata gaagggaaga cctgcagtgc acggtttctt ccaggctgag
     3181 gtacctggat cttgggttct tcactgcagg gacccagaca agtggatctg cttgccagag
     3241 tcctttttgc ccctccctgc cacctccccg tgtttccaag tcagctttcc tgcaagaaga
     3301 aatcctggtt aaaaaagtct tttgtattgg gtcaggagtt gaatttgggg tgggaggatg
     3361 gatgcaactg aagcagagtg tgggtgccca gatgtgcgct attagatgtt tctctgataa
     3421 tgtccccaat cataccaggg agactggcat tgacgagaac tcaggtggag gcttgagaag
     3481 gccgaaaggg cccctgacct gcctggcttc cttagcttgc ccctcagctt tgcaaagagc
     3541 caccctaggc cccagctgac cgcatgggtg tgagccagct tgagaacact aactactcaa
     3601 taaaagcgaa ggtggacatg c
//
