LOCUS       NM_001040061            4094 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens FOXL2 neighbor (FOXL2NB), mRNA.
ACCESSION   NM_001040061 XM_376269 XM_940539
VERSION     NM_001040061.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4094)
  AUTHORS   Han,Y., Wu,J., Yang,W., Wang,D., Zhang,T. and Cheng,M.
  TITLE     New STAT3-FOXL2 pathway and its function in cancer cells
  JOURNAL   BMC Mol Cell Biol 20 (1), 17 (2019)
   PUBMED   31221094
  REMARK    GeneRIF: This study presents a new upstream regulator of FOXL2 and
            demonstrats that this new STAT3-FOXL2 pathway has an important
            function in HeLaHeLa cell apoptosis, providing new insights
            regarding the targeting of FOXL2 for cancer prevention and
            treatment.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092947.12, AK125319.1 and AC130416.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001040061.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125319.1, DA723950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2155974
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383165.4/ ENSP00000372651.3
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC092947.12        68604-68620
            18-2642             AK125319.1         1-2625
            2643-4094           AC130416.4         3719-5170
FEATURES             Location/Qualifiers
     source          1..4094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..4094
                     /gene="FOXL2NB"
                     /gene_synonym="C3orf72"
                     /note="FOXL2 neighbor"
                     /db_xref="GeneID:401089"
                     /db_xref="HGNC:HGNC:34428"
     exon            1..248
                     /gene="FOXL2NB"
                     /gene_synonym="C3orf72"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..676
                     /gene="FOXL2NB"
                     /gene_synonym="C3orf72"
                     /note="FLJ43329 protein"
                     /codon_start=1
                     /product="FOXL2 neighbor protein"
                     /protein_id="NP_001035150.1"
                     /db_xref="CCDS:CCDS43155.1"
                     /db_xref="GeneID:401089"
                     /db_xref="HGNC:HGNC:34428"
                     /translation="MTRTPVGSARTRPKPRKLGPQRGKALQASSRLSESPALVKKRMP
                     DACTLGRAGIGLPKMCLHMAVRHSKAQKTGPGILQQRQKPPAPRASGGPALLGKRRGC
                     SEAGSASLEPLSSSRAAAGCLNQVPLSPFLAGPRNTRRLPAPERERIELAATLCLEGW
                     PLRCLASKGKLHCVY"
     exon            249..368
                     /gene="FOXL2NB"
                     /gene_synonym="C3orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            369..4094
                     /gene="FOXL2NB"
                     /gene_synonym="C3orf72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4068..4073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXL2NB"
                     /gene_synonym="C3orf72"
                     /note="hexamer: AATAAA"
     polyA_site      4094
                     /gene="FOXL2NB"
                     /gene_synonym="C3orf72"
                     /note="major polyA site"
ORIGIN      
        1 gagttcatct ccaagtcact ttttgtaaac gccccgcaca gcctggaccg gcctgccccc
       61 gcccagcgag cctcaggggc ccagccgaca gccaggctca cgcgcccttg aaatctgccg
      121 gtactcgctc tgcgggctgg gctgggagat gacgaggacc ccggtggggt ctgcccgcac
      181 ccggccaaag cccaggaagc tcgggcccca gcgaggaaag gcgctccaag cctcctcgcg
      241 gctttcagaa tccccagccc tggtgaagaa gaggatgcct gatgcgtgca ccctgggaag
      301 ggctggaatc ggtctcccca agatgtgcct tcacatggct gtccggcatt cgaaggctca
      361 gaaaacaggg ccgggaatcc tgcaacagcg gcagaagccg cccgcgcctc gggcttccgg
      421 cggcccagct ctactaggga agcgtcgcgg ctgctctgag gcaggcagcg cttcgctaga
      481 accactcagc tcgtcccgcg ccgccgccgg ctgcctgaac caggttccgc tgtccccttt
      541 cctagcggga ccccgaaaca cccggcggct tcccgctcct gagcgggaga gaatagagct
      601 tgctgcaacc ctctgcttgg agggatggcc tctgcggtgc ttggctagca aagggaagct
      661 tcactgtgtc tattagtaca tccccataca ctccacgcct caacaactgt cagcactcac
      721 tccctcccgg cccctcacag ggccctttgc acccacacct cagggactcg gtgtccctcc
      781 actcaggtca cgttactcca tccacttctc tctccttctc cctctgtcaa ctccaaatcc
      841 cctctagttc tccctcccct cctacttctc tcacactcac cagctacacg tactaattca
      901 gattttgcac atgttggtgg aaaacatgtc aagccaatgt gcagacccta aggcttttca
      961 cacgctgctc actttcgcat ctcacggtgc agaaggacca atgggctcca ggtttacaag
     1021 cctgactccg agaagcctgt tgattctctg atgtccttgg cctgtgattc gggtgactgg
     1081 gctgccacct gggtgttttc atgatgggac tgccgcacag accacagaga agctcaggta
     1141 ctgagcacgt tccagataca ctttaacatg cacaggccac tcacacaggc tttatctctg
     1201 tctcgaaact ctgctgagtt tgctgctcag accaacaagg tgcagcagca gacacccaca
     1261 tagcaccagg tctgaagcca gtgggtatta gtctgcctgg ttgggattag caaagtcagt
     1321 tactcacata tgtgcttggg agagaatagg ggagtggaga gagagagaga gatattgagg
     1381 aagaggaaag agaagcgacc tcctactctg ggaagaactc acacatgaga gctgtttcct
     1441 gttgttaagt gtctcactga gctcccctct ttctccccca ggaagggctt gagaggcagt
     1501 agaccagagc tctgggctcc tctttacctt gctgatgttg gggtatgagt cctccaacac
     1561 cattttgtcc caaggagtat gtgccccatc gtcaatcagg cagaatgcag ggcagttgtc
     1621 ggcctttttc atggtggagg ccaactggga aaaaggcaga agggtctggg tcctgggcca
     1681 agtgaggccc tcttccctcc aaagacccgt gggatgctct cagaggcgga ttctagggtg
     1741 gtgggagctg ctgacaagtt tcctctgata tccctcatga catctatggc ccaaagccat
     1801 tttgttcagc tctgaacagt gagtgccttg ccagtaggcc tcaggcttgc tggggaacat
     1861 gatgtgttct taaaagttgc cttgttgcct ttctccacac ccagactgta agcgctgatg
     1921 ggcagagact ctgccctcca cttctcactc agtgctcccc accaggatgg gcttaatgcc
     1981 ttttaataga attagaaaat ggttctgctg gacagaattg ggaaatgcca ctttccttat
     2041 aatgaagtta taatgaagtt agaatttcca agaaagggac tgtagctgag gaaaagcggt
     2101 ttgatcattg acagccagct caggatctga gagttctttg ccatttgggg ttattatagc
     2161 tgcatggcca tggtgctgaa ccttaggcaa gggcaaggac acctccctag ttcccagtca
     2221 tggtgaggac ctgtctgaaa cattcaaact agactttact ggaaacagag aagtctctgc
     2281 attcagggca gctggcttgc aaggtaaggc ctgcagtctc cacccgcacg ctaacccatg
     2341 aggggatgcc agagagagcc cttccccctt ggtcctcatt cctggctcaa ttttctccca
     2401 caaagcgggc actttctaaa gatgataggc aactgccatg gaggaaggca gttttagatg
     2461 cctagctggc acaaagtcca gaggaaggga gggagaaggg ctgagttttg tattactgtt
     2521 ctacctttgg agattttcct catgccaaga tagggtgtgt gtgtgtgtgt gtgtgtatgt
     2581 gtgtgtgtat gtgtgcacta taactttatg aaacactttt tttttttttg agacagggtc
     2641 tcactctgtt gcccaagctg gagtgcagtg gtgcaatctt ggcttaccgc agtctccacc
     2701 tcccaggctc aagtgatcct cccatctcag cctcagcctc ccaagtagct gggactatgg
     2761 gtgtgagcca acacactcag ctaatttttt tttttttttt ttggtatttt tggtagagac
     2821 agggttttac catgtgggcc caactggtct tgagctcctg agctcagggt gatttgcctg
     2881 cttcaacttc ccaaagtgtt gggattacag gtgtgagcca ccatgcccag tcagtttttt
     2941 attttttatt taaacagttt tgggggaaca ggtggttttt gcttacatgg ataagttctt
     3001 taatggtaat ttctgagatt ttggtgcact tgtcacccga gcattgtaca cggtacccag
     3061 tgtgtaatct tttatccctc atccccctcc tacgcttccc cccccgagtc cccattatat
     3121 aattcttttt ttcttctttt tgagacagag tctcactctg ttgcccaggc tggagtgcag
     3181 tggcatgaac ttggcttact gcagcctcct gagttcaagt gattctcctg cctgaacctc
     3241 ctgtgtagct gggactacag gcatgcacca ccatgcccag ctaatttttg tattttttgt
     3301 agagatgggg tttcaccatg ttggccaggc tagtcttgaa ctcctaacct caagtgatct
     3361 gcctattttg gcctcccaaa gtgttgggat tacaggcgtg cgccactgcg cctggtccat
     3421 tatgtcattc ttatgccttt gcatcttcat agcttagctc ccacttataa atgaaaacac
     3481 aggatatttg gttttccata cttgagttac ttcacttagt ataatggtct ccagctccat
     3541 ccaggttgct gtgaatgcca ttattttgtt cctttttatg gctgagtagt attccatggt
     3601 gtatatatat cacattttct ttatccactc attggttgat gggcatttag ccttgttcca
     3661 tatttttgta tgcagtataa cttacagatg gtaaacaata tacagcttga tgtattctga
     3721 catgtaatgc agtatgtaac caccacctgg atcaagatat ggagcatttc tggcacttca
     3781 gaaggttcct tcatatcttt ttccaatcaa tattgcctca aaagggaaac catatttgga
     3841 tttctatcac cataaataac ctttgcctgc cttgagcctc gtataaatgg agcatatagc
     3901 atgtatgcct ttatgtctag ttttttctgt gcaacatatt tttaatattc actggtcttg
     3961 ttgcatgtgt cagacattta tttcttttta ttgctgtgta atattctagt atttgcttat
     4021 ccatccatat gttgagggac atttgtttcc agtttttgga tatcataaat aaagctgctg
     4081 tgcacattgt tgta
//
